Selective toxicity of Apigenin on cancerous Hepatocytes by directly targeting their mitochondria

Anti-Cancer Agents in Medicinal Chemistry

Volumn 16, Issue 12, 2016, Pages 1576-1586

  Seydi, Enayatollah ^a,b   Rasekh, Hamid R ^a   Salimi, Ahmad ^a,c   Mohsenifar, Zhaleh ^a   Pourahmad, Jalal ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ALBORZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ARDABIL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Apigenin; Apoptosis; Hepatocellular carcinoma; Hepatocytes; Mitochondria

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA FETOPROTEIN; APIGENIN; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CYTOCHROME C; DIETHYLNITROSAMINE; N (2 FLUORENYL)ACETAMIDE; REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE; ANTINEOPLASTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOCHEMICAL ANALYSIS; CELL VIABILITY; CONTROLLED STUDY; DRUG TARGETING; FLOW CYTOMETRY; HISTOPATHOLOGY; IC50; LIVER CELL CARCINOMA; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION SWELLING; MORTALITY RATE; MTT ASSAY; NONHUMAN; TOXICITY; ANIMAL; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; LIVER NEOPLASMS; METABOLISM; MITOCHONDRION; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APIGENIN; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; LIVER NEOPLASMS; MALE; MITOCHONDRIA; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84995902668     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520616666160425110839     Document Type: Article

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