Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production

Biochemical Pharmacology

Volumn 64, Issue 12, 2002, Pages 1713-1724

  Chen, Yen Chou ^a   Shen, Shing Chuan ^b,c   Lee, Woan Ruoh ^a   Hsu, Foun Lin ^a   Lin, Hui Yi ^a   Ko, Ching Huai ^a   Tseng, Shi Wen ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Caspase 3; Catalase; Emodin; ROS; SOD

Indexed keywords

ACETYLCYSTEINE; ALLOPURINOL; ANTHRAQUINONE DERIVATIVE; CASPASE 3 INHIBITOR; CATALASE; CHRYSOPHANIC ACID; DIPHENYLIODONIUM SALT; EMODIN; HYDROGEN PEROXIDE; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; N(G) NITROARGININE METHYL ESTER; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHYSCION; PROTEIN; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN D4 GDI; PROTEIN MCL 1; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIPLOIDY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INDUCTION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TIME;

APOPTOSIS; CASPASE 1; CASPASE 3; CASPASES; CATALASE; CYSTEINE PROTEINASE INHIBITORS; DRUG INTERACTIONS; EMODIN; ENZYME ACTIVATION; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID; NEOPLASM PROTEINS; OLIGOPEPTIDES; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 0037114436     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01386-2     Document Type: Article

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