Anti-tumour screening of Brazilian plants

Pharmaceutical Biology

Volumn 40, Issue 8, 2002, Pages 603-616

  Monks, Noel R ^a,c   Bordignon, Sergio A L ^a   Ferraz, Alexandre ^b   Machado, Katia R ^a   Faria, Denise H ^a   Lopes, Rafael M ^a   Mondin, Claudio A ^b   De Souza, Izabel C C ^a   Lima, Martha F S ^a   Da Rocha, Adriana B ^a,b   Schwartsmann, Gilberto ^a,b  

^a UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Brazil; Cytotoxic activity; Human tumour cell lines; Organic and aqueous extracts

Indexed keywords

ALOE ARBORESCENS EXTRACT; ALOE VERA EXTRACT; ANNONA CACANS EXTRACT; BACCHARIS CORIDIFOLIA EXTRACT; BACCHARIS MESONEURA EXTRACT; BACCHARIS OCHRACEA EXTRACT; BACCHARIS SPICATA EXTRACT; BACCHARIS TRIMERA EXTRACT; BACCHARIS USTERII EXTRACT; CHAPTALIA NUTANS EXTRACT; DASYPHYLLUM BRASILIENSE EXTRACT; DASYPHYLLUM SPINESCENS EXTRACT; DUGUETIA FLAGELLARIS EXTRACT; ERYNGIUM EBRACTEATUM EXTRACT; ERYNGIUM ELEGANS EXTRACT; ERYNGIUM HORRIDUM EXTRACT; ERYNGIUM NUDICALE EXTRACT; EUPATORIUM CASARETTOI EXTRACT; GUATTERIA AUSTRALIS EXTRACT; HYDROCOTYLE BONARIENSIS EXTRACT; LITHRAEA BRASILIENSIS EXTRACT; MACROSIPHONIA LONGIFLORA EXTRACT; ORGANIC SOLVENT; PLANT EXTRACT; ROLLINIA RUGULOSA EXTRACT; ROLLINIA SALICIFOLIA EXTRACT; ROLLINIA SILVATICA EXTRACT; SCHINUS MOLLE EXTRACT; SCHINUS WEINMANNIFOLIUS EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALOE ARBORESCENS; ALOE VERA; ANACARDIACEAE; ANNONA CACANS; ANNONACEAE; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; ASTERACEAE; BACCHARIS MESONEURA; BACCHARIS OCHRACEA; BACCHARIS SPICATA; BACCHARIS TRIMERA; BACCHARIS USTERII; BRAZIL; CELESTRACEAE; CHAPTALIA NUTANS; CYTOTOXICITY; DASYPHYLLUM BRASILIENSE; DASYPHYLLUM SPINESCENS; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG SCREENING; DUGUETIA FLAGELLARIS; ERYNGIUM EBRACTEATUM; ERYNGIUM ELEGANS; ERYNGIUM HORRIDUM; ERYNGIUM NUDICALE; EUPATORIUM CASARETTOI; GUATTERIA AUSTRALIS; HUMAN; HUMAN CELL; HYDROCOTYLE BONARIENSIS; LEGUME; LITHRAEA BRASILIENSIS; MACROSIPHONIA LONGIFLORA; MELIACEAE; MYRTACEAE; NONHUMAN; PHARMACOPHORE; PLANT; ROLLINIA RUGULOSA; ROLLINIA SALICIFOLIA; ROLLINIA SILVATICA; SCHINUS MOLLE; SCHINUS WEINMANNIFOLIUS; TUMOR CELL LINE;

ALOE ARBORESCENS; ALOE VERA; ANACARDIACEAE; ANNONA; ANNONACEAE; ASTERACEAE; BACCHARIS; BACCHARIS CORIDIFOLIA; BACCHARIS OCHRACEA; BACCHARIS TRIMERA; CHAPTALIA NUTANS; DASYPHYLLUM BRASILIENSE; DASYPHYLLUM SPINESCENS; DUGUETIA; ERYNGIUM; ERYNGIUM HORRIDUM; EUPATORIUM; FABACEAE; GUATTERIA; HYDROCOTYLE BONARIENSIS; LITHRAEA; LITHRAEA BRASILIENSIS; MACROSIPHONIA LONGIFLORA; MELIACEAE; MYRTACEAE; ROLLINIA; SCHINUS; SCHINUS MOLLE;

EID: 0037000761     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1076/phbi.40.8.603.14658     Document Type: Article

References (17)

1. Balandrin MF, Kinghorn AD, Farnsworth NR (1993): Plant-derived natural products in drug discovery and development. An overview. In: Kinghorn AD, Balandrin MF, eds., Human Medicinal Agents from Plants, American Chemical Society Symposium Series 534. Washington, DC, American Chemical Society, pp. 2-12.
2. Cragg GM (1998): Paclitaxel (Taxol): a success story with valuable lessons for natural product drug discovery and development. Med Res Rev 18: 315-331.
3. Cragg GM, Newman DJ (1999): Discovery and development of antineoplastic agents from natural sources. Cancer Invest 17: 153-163.
4. da Rocha AB, Lopes RM, Schwartsmann G (2001): Natural products in anticancer therapy. Curr Opin Pharmacol 1: 364-369.
5. Farnsworth NR (1994): Ethnopharmacology and drug devlopment. In: Chadwick DJ, Marsh J, eds., Ethnobotany and the Search for New Drugs, Chichester, UK, Wiley.
6. Grabley S, Thiericke R (1999): Bioactive agents and natural sources: trends in discovery and application. Adv Biochem Eng Biotechnol 64: 101-154.
7. Harvey AL (1999): Medicines from nature: are natural products still relevant to drug discovery? Trends Pharmacol Sci 20: 196-198.
8. Mans DRA, da Rocha AB, Schwartsmann G (2000): Anti-cancer drug discovery and development in Brazil: Targeted plant collection as a rational strategy to acquire candidate anticancer compounds. Oncologist 5: 185-198.
9. Mans DRA, Jung FA, Schwartsmann G (1994): Anticancer drug discovery and development. Ciência e Cultura 46: 70-81.
10. Monks A, Scudiero DA, Johnson GS, Paull KD, Sausville EA (1997): The NCI anti-cancer drug screen: a smart screen to identify effectors of novel targets. Anticancer Drug Des 12: 533-541.
11. Sausville EA, Feigal E (1999): Evolving approaches to cancer drug discovery and development at the National Cancer Institute, USA. Ann Oncol 10: 1287-1291.
12. Sausville EA, Johnson JI (2000): Molecules for the millennium: how will they look? New drug discovery year 2000. Br J Cancer 83: 1401-1404.
13. Schultes RE (1994): Amazonian ethnobotany and the search for new drugs. In: Chadwick DJ, Marsh J, eds., Ethnobotany and the Search for New Drugs, Ciba Foundation Symposium 185. Chichester, Wiley, pp. 106-115.
14. Schwartsmann G (2000): Marine organisms and other novel natural sources of new cancer drugs. Ann Oncol 11: 235-243.
15. Shoemaker RH, Monks A, Alley MC, Scudiero DA, Fine DL, McLemore TL, Abbott BJ, Paull KD, Mayo JG, Boyd MR (1988): Development of human tumor cell line panels for use in disease-oriented drug screening. Prog Clin Biol Res 276: 265-286.
16. Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR (1990): New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 82: 1107-1112.
17. Workman P (2001): Scoring a bulls-eye against cancer genome targets. Curr Opin Pharmacol 1: 342-352.