Therapeutic targeting of anaplastic lymphoma kinase in lung cancer: A paradigm for precision cancer medicine

Clinical Cancer Research

Volumn 21, Issue 10, 2015, Pages 2227-2235

  Katayama, Ryohei ^a   Lovly, Christine M ^b   Shaw, Alice T ^c,d  

^a CANCER CHEMOTHERAPY CENTER   (Japan)

^b VANDERBILT UNIVERSITY   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 AMINO 5 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] N [4 (4 METHYL 1 PIPERAZINYLCARBONYL)PHENYL] 3 PYRIDAZINECARBOXAMIDE; ALECTINIB; AMINOTRANSFERASE; ANAPLASTIC LYMPHOMA KINASE; ANAPLASTIC LYMPHOMA KINASE INHIBITOR; ANTINEOPLASTIC AGENT; BRIGATINIB; CARBOPLATIN; CERITINIB; CISPLATIN; CKIT INHIBITOR; CREATINE KINASE; CREATININE; CRIZOTINIB; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; HEAT SHOCK PROTEIN 90 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE INHIBITOR; PEMETREXED; PF 06463922; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; ONCOPROTEIN; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

ADVANCED CANCER; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CANCER RECURRENCE; CANCER RESISTANCE; CANCER SURVIVAL; CHROMOSOME REARRANGEMENT; CREATINE KINASE BLOOD LEVEL; CREATININE BLOOD LEVEL; DRUG EFFICACY; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG TARGETING; DRUG TREATMENT FAILURE; GENE AMPLIFICATION; GENE REARRANGEMENT; HUMAN; IC50; LARGE CELL LYMPHOMA; LIVER FUNCTION TEST; LUNG CANCER; MULTICENTER STUDY (TOPIC); NEUROBLASTOMA; NEUTROPHIL COUNT; NON SMALL CELL LUNG CANCER; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PLASMA CELL GRANULOMA; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); TUMOR BIOPSY; ANIMAL; ANTAGONISTS AND INHIBITORS; CARCINOMA, NON-SMALL-CELL LUNG; DRUG RESISTANCE; ENZYMOLOGY; GENETICS; LUNG NEOPLASMS; MOLECULARLY TARGETED THERAPY; MUTATION; PERSONALIZED MEDICINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; DRUG RESISTANCE, NEOPLASM; HUMANS; LUNG NEOPLASMS; MOLECULAR TARGETED THERAPY; MUTATION; ONCOGENE PROTEINS, FUSION; PRECISION MEDICINE; PROTEIN KINASE INHIBITORS; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 84939575246     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-14-2791     Document Type: Article

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