-
1
-
-
0031008896
-
ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
-
Morris SW, Naeve C, Mathew P, James PL, Kirstein MN, Cui X, et al. ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene 1997;14:2175-88.
-
(1997)
Oncogene
, vol.14
, pp. 2175-2188
-
-
Morris, S.W.1
Naeve, C.2
Mathew, P.3
James, P.L.4
Kirstein, M.N.5
Cui, X.6
-
2
-
-
0031035052
-
Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system
-
Iwahara T, Fujimoto J, Wen D, Cupples R, Bucay N, Arakawa T, et al. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene 1997;14:439-49.
-
(1997)
Oncogene
, vol.14
, pp. 439-449
-
-
Iwahara, T.1
Fujimoto, J.2
Wen, D.3
Cupples, R.4
Bucay, N.5
Arakawa, T.6
-
3
-
-
0027193209
-
An adhesive domain detected in functionally diverse receptors
-
Beckmann G, Bork P. An adhesive domain detected in functionally diverse receptors. Trends Biochem Sci 1993;18:40-1.
-
(1993)
Trends Biochem Sci
, vol.18
, pp. 40-41
-
-
Beckmann, G.1
Bork, P.2
-
4
-
-
0031055562
-
Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1
-
Pulford K, Lamant L, Morris SW, Butler LH, Wood KM, Stroud D, et al. Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1. Blood 1997;89:1394-404.
-
(1997)
Blood
, vol.89
, pp. 1394-1404
-
-
Pulford, K.1
Lamant, L.2
Morris, S.W.3
Butler, L.H.4
Wood, K.M.5
Stroud, D.6
-
5
-
-
38149121417
-
Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications
-
Bilsland JG, Wheeldon A, Mead A, Znamenskiy P, Almond S, Waters KA, et al. Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications. Neuropsychopharmacology 2008;33:685-700.
-
(2008)
Neuropsychopharmacology
, vol.33
, pp. 685-700
-
-
Bilsland, J.G.1
Wheeldon, A.2
Mead, A.3
Znamenskiy, P.4
Almond, S.5
Waters, K.A.6
-
6
-
-
79960673330
-
An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol
-
Lasek AW, Lim J, Kliethermes CL, Berger KH, Joslyn G, Brush G, et al. An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol. PLoS One 2011;6:e22636.
-
(2011)
PLoS One
, vol.6
-
-
Lasek, A.W.1
Lim, J.2
Kliethermes, C.L.3
Berger, K.H.4
Joslyn, G.5
Brush, G.6
-
7
-
-
0141998608
-
Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers
-
Lee HH, Norris A, Weiss JB, Frasch M. Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers. Nature 2003;425:507-12.
-
(2003)
Nature
, vol.425
, pp. 507-512
-
-
Lee, H.H.1
Norris, A.2
Weiss, J.B.3
Frasch, M.4
-
8
-
-
0035907231
-
Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin
-
Stoica GE, Kuo A, Aigner A, Sunitha I, Souttou B, Malerczyk C, et al. Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin. J Biol Chem 2001;276:16772-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 16772-16779
-
-
Stoica, G.E.1
Kuo, A.2
Aigner, A.3
Sunitha, I.4
Souttou, B.5
Malerczyk, C.6
-
9
-
-
0037184128
-
Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
-
Stoica GE, Kuo A, Powers C, Bowden ET, Sale EB, Riegel AT, et al. Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types. J Biol Chem 2002;277:35990-8.
-
(2002)
J Biol Chem
, vol.277
, pp. 35990-35998
-
-
Stoica, G.E.1
Kuo, A.2
Powers, C.3
Bowden, E.T.4
Sale, E.B.5
Riegel, A.T.6
-
10
-
-
35148838039
-
In contrast to agonist monoclonal antibodies, both C-terminal truncated form and full length form of Pleiotrophin failed to activate vertebrate ALK (anaplastic lymphoma kinase)
-
Mathivet T, Mazot P, Vigny M. In contrast to agonist monoclonal antibodies, both C-terminal truncated form and full length form of Pleiotrophin failed to activate vertebrate ALK (anaplastic lymphoma kinase)? Cell Signal 2007;19:2434-43.
-
(2007)
Cell Signal
, vol.19
, pp. 2434-2443
-
-
Mathivet, T.1
Mazot, P.2
Vigny, M.3
-
11
-
-
0028198206
-
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
-
Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 1994;263:1281-4.
-
(1994)
Science
, vol.263
, pp. 1281-1284
-
-
Morris, S.W.1
Kirstein, M.N.2
Valentine, M.B.3
Dittmer, K.G.4
Shapiro, D.N.5
Saltman, D.L.6
-
12
-
-
0028275645
-
Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3
-
Shiota M, Fujimoto J, Semba T, Satoh H, Yamamoto T, Mori S. Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3. Oncogene 1994;9:1567-74.
-
(1994)
Oncogene
, vol.9
, pp. 1567-1574
-
-
Shiota, M.1
Fujimoto, J.2
Semba, T.3
Satoh, H.4
Yamamoto, T.5
Mori, S.6
-
13
-
-
12144258439
-
The emerging normal and disease-related roles of anaplastic lymphoma kinase
-
Pulford K, Lamant L, Espinos E, Jiang Q, Xue L, Turturro F, et al. The emerging normal and disease-related roles of anaplastic lymphoma kinase. Cell Mol Life Sci 2004;61:2939-53.
-
(2004)
Cell Mol Life Sci
, vol.61
, pp. 2939-2953
-
-
Pulford, K.1
Lamant, L.2
Espinos, E.3
Jiang, Q.4
Xue, L.5
Turturro, F.6
-
14
-
-
0033890820
-
TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors
-
Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL, et al. TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. Am J Pathol 2000;157:377-84.
-
(2000)
Am J Pathol
, vol.157
, pp. 377-384
-
-
Lawrence, B.1
Perez-Atayde, A.2
Hibbard, M.K.3
Rubin, B.P.4
Dal Cin, P.5
Pinkus, J.L.6
-
15
-
-
33845419068
-
Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer
-
Jazii FR, Najafi Z, Malekzadeh R, Conrads TP, Ziaee AA, Abnet C, et al. Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer. World J Gastroenterol 2006;12:7104-12.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 7104-7112
-
-
Jazii, F.R.1
Najafi, Z.2
Malekzadeh, R.3
Conrads, T.P.4
Ziaee, A.A.5
Abnet, C.6
-
16
-
-
84856978417
-
Identification of anaplastic lymphoma kinase fusions in renal cancer: Large-scale immunohistochemical screening by the intercalated antibodyenhanced polymer method
-
Jan 7. [Epub ahead of print]
-
Sugawara E, Togashi Y, Kuroda N, Sakata S, Hatano S, Asaka R, et al. Identification of anaplastic lymphoma kinase fusions in renal cancer: large-scale immunohistochemical screening by the intercalated antibodyenhanced polymer method. Cancer. 2012 Jan 7. [Epub ahead of print]
-
(2012)
Cancer
-
-
Sugawara, E.1
Togashi, Y.2
Kuroda, N.3
Sakata, S.4
Hatano, S.5
Asaka, R.6
-
17
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007;448:561-6.
-
(2007)
Nature
, vol.448
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
Takada, S.4
Yamashita, Y.5
Ishikawa, S.6
-
18
-
-
54049094708
-
Identification of ALK as a major familial neuroblastoma predisposition gene
-
Mosse YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, et al. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature 2008;455:930-5.
-
(2008)
Nature
, vol.455
, pp. 930-935
-
-
Mosse, Y.P.1
Laudenslager, M.2
Longo, L.3
Cole, K.A.4
Wood, A.5
Attiyeh, E.F.6
-
19
-
-
54049149961
-
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
-
Janoueix-Lerosey I, Lequin D, Brugieres L, Ribeiro A, de Pontual L, Combaret V, et al. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature 2008;455:967-70.
-
(2008)
Nature
, vol.455
, pp. 967-970
-
-
Janoueix-Lerosey, I.1
Lequin, D.2
Brugieres, L.3
Ribeiro, A.4
de Pontual, L.5
Combaret, V.6
-
20
-
-
54049120220
-
Activating mutations in ALK provide a therapeutic target in neuroblastoma
-
George RE, Sanda T, Hanna M, Frohling S, Luther W II, Zhang J, et al. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature 2008;455:975-8.
-
(2008)
Nature
, vol.455
, pp. 975-978
-
-
George, R.E.1
Sanda, T.2
Hanna, M.3
Frohling, S.4
Luther II, W.5
Zhang, J.6
-
21
-
-
54049118823
-
Oncogenic mutations of ALK kinase in neuroblastoma
-
Chen Y, Takita J, Choi YL, Kato M, Ohira M, Sanada M, et al. Oncogenic mutations of ALK kinase in neuroblastoma. Nature 2008;455:971-4.
-
(2008)
Nature
, vol.455
, pp. 971-974
-
-
Chen, Y.1
Takita, J.2
Choi, Y.L.3
Kato, M.4
Ohira, M.5
Sanada, M.6
-
22
-
-
79961088497
-
Anaplastic lymphoma kinase in human cancer
-
Barreca A, Lasorsa E, Riera L, Machiorlatti R, Piva R, Ponzoni M, et al. Anaplastic lymphoma kinase in human cancer. J Mol Endocrinol 2011;47:R11-23.
-
(2011)
J Mol Endocrinol
, vol.47
-
-
Barreca, A.1
Lasorsa, E.2
Riera, L.3
Machiorlatti, R.4
Piva, R.5
Ponzoni, M.6
-
23
-
-
2342635959
-
Anaplastic lymphoma kinase proteins in growth control and cancer
-
Pulford K, Morris SW, Turturro F. Anaplastic lymphoma kinase proteins in growth control and cancer. J Cell Physiol 2004;199:330-58.
-
(2004)
J Cell Physiol
, vol.199
, pp. 330-358
-
-
Pulford, K.1
Morris, S.W.2
Turturro, F.3
-
24
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001;344:1031-7.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
-
25
-
-
27344451557
-
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
-
Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 2005;310:644-8.
-
(2005)
Science
, vol.310
, pp. 644-648
-
-
Tomlins, S.A.1
Rhodes, D.R.2
Perner, S.3
Dhanasekaran, S.M.4
Mehra, R.5
Sun, X.W.6
-
26
-
-
48549098388
-
Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer
-
Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, et al. Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res 2008;68:4971-6.
-
(2008)
Cancer Res
, vol.68
, pp. 4971-4976
-
-
Choi, Y.L.1
Takeuchi, K.2
Soda, M.3
Inamura, K.4
Togashi, Y.5
Hatano, S.6
-
27
-
-
48249114422
-
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
-
Koivunen JP, Mermel C, Zejnullahu K, Murphy C, Lifshits E, Holmes AJ, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 2008;14:4275-83.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4275-4283
-
-
Koivunen, J.P.1
Mermel, C.2
Zejnullahu, K.3
Murphy, C.4
Lifshits, E.5
Holmes, A.J.6
-
28
-
-
58149382583
-
A mouse model for EML4-ALK-positive lung cancer
-
Soda M, Takada S, Takeuchi K, Choi YL, Enomoto M, Ueno T, et al. A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci U S A 2008;105:19893-7.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 19893-19897
-
-
Soda, M.1
Takada, S.2
Takeuchi, K.3
Choi, Y.L.4
Enomoto, M.5
Ueno, T.6
-
29
-
-
78649973178
-
Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene
-
Chen Z, Sasaki T, Tan X, Carretero J, Shimamura T, Li D, et al. Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene. Cancer Res 2010;70:9827-36.
-
(2010)
Cancer Res
, vol.70
, pp. 9827-9836
-
-
Chen, Z.1
Sasaki, T.2
Tan, X.3
Carretero, J.4
Shimamura, T.5
Li, D.6
-
30
-
-
57349113565
-
Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts
-
Takeuchi K, Choi YL, Soda M, Inamura K, Togashi Y, Hatano S, et al. Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts. Clin Cancer Res 2008;14:6618-24.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6618-6624
-
-
Takeuchi, K.1
Choi, Y.L.2
Soda, M.3
Inamura, K.4
Togashi, Y.5
Hatano, S.6
-
31
-
-
65249095599
-
The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS
-
Wong DW, Leung EL, So KK, Tam IY, Sihoe AD, Cheng LC, et al. The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer 2009;115:1723-33.
-
(2009)
Cancer
, vol.115
, pp. 1723-1733
-
-
Wong, D.W.1
Leung, E.L.2
So, K.K.3
Tam, I.Y.4
Sihoe, A.D.5
Cheng, L.C.6
-
32
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, Shaw AT, Solomon B, Maki RG, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010;363:1693-703.
-
(2010)
N Engl J Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
Shaw, A.T.4
Solomon, B.5
Maki, R.G.6
-
33
-
-
78650950138
-
EGFR and EML4-ALK gene mutations in NSCLC: A case report of erlotinib-resistant patient with both concomitant mutations
-
Tiseo M, Gelsomino F, Boggiani D, Bortesi B, Bartolotti M, Bozzetti C, et al. EGFR and EML4-ALK gene mutations in NSCLC: a case report of erlotinib-resistant patient with both concomitant mutations. Lung Cancer 2011;71:241-3.
-
(2011)
Lung Cancer
, vol.71
, pp. 241-243
-
-
Tiseo, M.1
Gelsomino, F.2
Boggiani, D.3
Bortesi, B.4
Bartolotti, M.5
Bozzetti, C.6
-
34
-
-
63949086127
-
KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer
-
Takeuchi K, Choi YL, Togashi Y, Soda M, Hatano S, Inamura K, et al. KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer. Clin Cancer Res 2009;15:3143-9.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3143-3149
-
-
Takeuchi, K.1
Choi, Y.L.2
Togashi, Y.3
Soda, M.4
Hatano, S.5
Inamura, K.6
-
35
-
-
77649091118
-
A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry
-
Mino-Kenudson M, Chirieac LR, Law K, Hornick JL, Lindeman N, Mark EJ, et al. A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry. Clin Cancer Res 2010;16:1561-71.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1561-1571
-
-
Mino-Kenudson, M.1
Chirieac, L.R.2
Law, K.3
Hornick, J.L.4
Lindeman, N.5
Mark, E.J.6
-
36
-
-
79961099514
-
Comprehensive histologic analysis of ALK-rearranged lung carcinomas
-
Yoshida A, Tsuta K, Nakamura H, Kohno T, Takahashi F, Asamura H, et al. Comprehensive histologic analysis of ALK-rearranged lung carcinomas. Am J Surg Pathol 2011;35:1226-34.
-
(2011)
Am J Surg Pathol
, vol.35
, pp. 1226-1234
-
-
Yoshida, A.1
Tsuta, K.2
Nakamura, H.3
Kohno, T.4
Takahashi, F.5
Asamura, H.6
-
37
-
-
70349510460
-
Exon array profiling detects EML4-ALK fusion in breast, colorectal, and nonsmall cell lung cancers
-
Lin E, Li L, Guan Y, Soriano R, Rivers CS, Mohan S, et al. Exon array profiling detects EML4-ALK fusion in breast, colorectal, and nonsmall cell lung cancers. Mol Cancer Res 2009;7:1466-76.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1466-1476
-
-
Lin, E.1
Li, L.2
Guan, Y.3
Soriano, R.4
Rivers, C.S.5
Mohan, S.6
-
38
-
-
79955656623
-
Exon scanning by reverse transcriptase-polymerase chain reaction for detection of known and novel EML4-ALK fusion variants in non-small cell lung cancer
-
Sanders HR, Li HR, Bruey JM, Scheerle JA, Meloni-Ehrig AM, Kelly JC, et al. Exon scanning by reverse transcriptase-polymerase chain reaction for detection of known and novel EML4-ALK fusion variants in non-small cell lung cancer. Cancer Genet 2011;204:45-52.
-
(2011)
Cancer Genet
, vol.204
, pp. 45-52
-
-
Sanders, H.R.1
Li, H.R.2
Bruey, J.M.3
Scheerle, J.A.4
Meloni-Ehrig, A.M.5
Kelly, J.C.6
-
39
-
-
37549059613
-
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
-
Christensen JG, Zou HY, Arango ME, Li Q, Lee JH, McDonnell SR, et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther 2007;6:3314-22.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 3314-3322
-
-
Christensen, J.G.1
Zou, H.Y.2
Arango, M.E.3
Li, Q.4
Lee, J.H.5
McDonnell, S.R.6
-
40
-
-
80053386829
-
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: A retrospective analysis
-
Shaw AT, Yeap BY, Solomon BJ, Riely GJ, Gainor J, Engelman JA, et al. Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. Lancet Oncol 2011;12:1004-12.
-
(2011)
Lancet Oncol
, vol.12
, pp. 1004-1012
-
-
Shaw, A.T.1
Yeap, B.Y.2
Solomon, B.J.3
Riely, G.J.4
Gainor, J.5
Engelman, J.A.6
-
41
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007;316:1039-43.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Park, J.O.6
-
42
-
-
84863338079
-
ROS1 rearrangements define a unique molecular class of lung cancers
-
Bergethon K, Shaw AT, Ignatius Ou SH, Katayama R, Lovly CM, McDonald NT, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol 2012;30:863-70.
-
(2012)
J Clin Oncol
, vol.30
, pp. 863-870
-
-
Bergethon, K.1
Shaw, A.T.2
Ignatius Ou, S.H.3
Katayama, R.4
Lovly, C.M.5
McDonald, N.T.6
-
43
-
-
84857985225
-
RET, ROS1 and ALK fusions in lung cancer
-
Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med 2012;18:378-81.
-
(2012)
Nat Med
, vol.18
, pp. 378-381
-
-
Takeuchi, K.1
Soda, M.2
Togashi, Y.3
Suzuki, R.4
Sakata, S.5
Hatano, S.6
-
44
-
-
78650026375
-
ALK inhibition for non-small cell lung cancer: From discovery to therapy in record time
-
Gerber DE, Minna JD. ALK inhibition for non-small cell lung cancer: from discovery to therapy in record time. Cancer Cell 2010;18:548-51.
-
(2010)
Cancer Cell
, vol.18
, pp. 548-551
-
-
Gerber, D.E.1
Minna, J.D.2
-
45
-
-
79955973559
-
A novel KIF5B-ALK variant in nonsmall cell lung cancer
-
Wong DW, Leung EL, Wong SK, Tin VP, Sihoe AD, Cheng LC, et al. A novel KIF5B-ALK variant in nonsmall cell lung cancer. Cancer 2011;117:2709-18.
-
(2011)
Cancer
, vol.117
, pp. 2709-2718
-
-
Wong, D.W.1
Leung, E.L.2
Wong, S.K.3
Tin, V.P.4
Sihoe, A.D.5
Cheng, L.C.6
-
46
-
-
84856695102
-
KLC1-ALK: A novel fusion in lung cancer identified using a formalinfixed paraffin-embedded tissue only
-
Togashi Y, Soda M, Sakata S, Sugawara E, Hatano S, Asaka R, et al. KLC1-ALK: a novel fusion in lung cancer identified using a formalinfixed paraffin-embedded tissue only. PLoS One 2012;7:e31323.
-
(2012)
PLoS One
, vol.7
-
-
Togashi, Y.1
Soda, M.2
Sakata, S.3
Sugawara, E.4
Hatano, S.5
Asaka, R.6
-
47
-
-
79952192916
-
Renal cell carcinoma with novel VCL-ALK fusion: New representative of ALK-associated tumor spectrum
-
Debelenko LV, Raimondi SC, Daw N, Shivakumar BR, Huang D, Nelson M, et al. Renal cell carcinoma with novel VCL-ALK fusion: new representative of ALK-associated tumor spectrum. Mod Pathol 2011;24:430-42.
-
(2011)
Mod Pathol
, vol.24
, pp. 430-442
-
-
Debelenko, L.V.1
Raimondi, S.C.2
Daw, N.3
Shivakumar, B.R.4
Huang, D.5
Nelson, M.6
-
48
-
-
78650963448
-
ALK rearrangement in sickle cell trait-associated renal medullary carcinoma
-
Marino-Enriquez A, Ou WB, Weldon CB, Fletcher JA, Perez-Atayde AR. ALK rearrangement in sickle cell trait-associated renal medullary carcinoma. Genes Chromosomes Cancer 2011;50:146-53.
-
(2011)
Genes Chromosomes Cancer
, vol.50
, pp. 146-153
-
-
Marino-Enriquez, A.1
Ou, W.B.2
Weldon, C.B.3
Fletcher, J.A.4
Perez-Atayde, A.R.5
-
49
-
-
81055126433
-
Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma
-
Bresler SC, Wood AC, Haglund EA, Courtright J, Belcastro LT, Plegaria JS, et al. Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma. Sci Transl Med 2011;3:108ra14.
-
(2011)
Sci Transl Med
, vol.3
-
-
Bresler, S.C.1
Wood, A.C.2
Haglund, E.A.3
Courtright, J.4
Belcastro, L.T.5
Plegaria, J.S.6
-
50
-
-
82455184976
-
Activating ALK mutations found in neuroblastoma are inhibited by crizotinib and NVP-TAE684
-
Schonherr C, Ruuth K, Yamazaki Y, Eriksson T, Christensen J, Palmer RH, et al. Activating ALK mutations found in neuroblastoma are inhibited by crizotinib and NVP-TAE684. Biochem J 2011;440:405-13.
-
(2011)
Biochem J
, vol.440
, pp. 405-413
-
-
Schonherr, C.1
Ruuth, K.2
Yamazaki, Y.3
Eriksson, T.4
Christensen, J.5
Palmer, R.H.6
-
51
-
-
79960288043
-
The neuroblastoma ALK(I1250T) mutation is a kinase-dead RTK in vitro and in vivo
-
Schonherr C, Ruuth K, Eriksson T, Yamazaki Y, Ottmann C, Combaret V, et al. The neuroblastoma ALK(I1250T) mutation is a kinase-dead RTK in vitro and in vivo. Transl Oncol 2011;4:258-65.
-
(2011)
Transl Oncol
, vol.4
, pp. 258-265
-
-
Schonherr, C.1
Ruuth, K.2
Eriksson, T.3
Yamazaki, Y.4
Ottmann, C.5
Combaret, V.6
-
52
-
-
79959890277
-
Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene
-
Murugan AK, Xing M. Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene. Cancer Res 2011;71:4403-11.
-
(2011)
Cancer Res
, vol.71
, pp. 4403-4411
-
-
Murugan, A.K.1
Xing, M.2
-
53
-
-
84856343080
-
Copy number status and mutation analyses of anaplastic lymphoma kinase (ALK) gene in 90 sporadic neuroblastoma tumors
-
Bagci O, Tumer S, Olgun N, Altungoz O. Copy number status and mutation analyses of anaplastic lymphoma kinase (ALK) gene in 90 sporadic neuroblastoma tumors. Cancer Lett 2012;317:72-7.
-
(2012)
Cancer Lett
, vol.317
, pp. 72-77
-
-
Bagci, O.1
Tumer, S.2
Olgun, N.3
Altungoz, O.4
-
54
-
-
84855993158
-
Anaplastic lymphoma kinase aberrations in rhabdomyosarcoma: Clinical and prognostic implications
-
van Gaal JC, Flucke UE, Roeffen MH, de Bont ES, Sleijfer S, Mavinkurve-Groothuis AM, et al. Anaplastic lymphoma kinase aberrations in rhabdomyosarcoma: clinical and prognostic implications. J Clin Oncol 2012;30:308-15.
-
(2012)
J Clin Oncol
, vol.30
, pp. 308-315
-
-
van Gaal, J.C.1
Flucke, U.E.2
Roeffen, M.H.3
de Bont, E.S.4
Sleijfer, S.5
Mavinkurve-Groothuis, A.M.6
-
55
-
-
78049426513
-
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
-
Choi YL, Soda M, Yamashita Y, Ueno T, Takashima J, Nakajima T, et al. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med 2010;363:1734-9.
-
(2010)
N Engl J Med
, vol.363
, pp. 1734-1739
-
-
Choi, Y.L.1
Soda, M.2
Yamashita, Y.3
Ueno, T.4
Takashima, J.5
Nakajima, T.6
-
56
-
-
23344440655
-
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
-
Carter TA, Wodicka LM, Shah NP, Velasco AM, Fabian MA, Treiber DK, et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci U S A 2005;102:11011-6.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 11011-11016
-
-
Carter, T.A.1
Wodicka, L.M.2
Shah, N.P.3
Velasco, A.M.4
Fabian, M.A.5
Treiber, D.K.6
-
57
-
-
80052793410
-
A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
-
Sasaki T, Koivunen J, Ogino A, Yanagita M, Nikiforow S, Zheng W, et al. A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res 2011;71:6051-60.
-
(2011)
Cancer Res
, vol.71
, pp. 6051-6060
-
-
Sasaki, T.1
Koivunen, J.2
Ogino, A.3
Yanagita, M.4
Nikiforow, S.5
Zheng, W.6
-
58
-
-
78649475696
-
The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers
-
Sasaki T, Okuda K, Zheng W, Butrynski J, Capelletti M, Wang L, et al. The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers. Cancer Res 2010;70:10038-43.
-
(2010)
Cancer Res
, vol.70
, pp. 10038-10043
-
-
Sasaki, T.1
Okuda, K.2
Zheng, W.3
Butrynski, J.4
Capelletti, M.5
Wang, L.6
-
59
-
-
84856999699
-
Mechanisms of acquired crizotinib resistance in ALKrearranged lung cancers
-
Katayama R, Shaw AT, Khan TM, Mino-Kenudson M, Solomon BJ, Halmos B, et al. Mechanisms of acquired crizotinib resistance in ALKrearranged lung cancers. Sci Transl Med 2012;4:120ra17.
-
(2012)
Sci Transl Med
, vol.4
-
-
Katayama, R.1
Shaw, A.T.2
Khan, T.M.3
Mino-Kenudson, M.4
Solomon, B.J.5
Halmos, B.6
-
60
-
-
84856990335
-
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
-
Doebele RC, Pilling AB, Aisner DL, Kutateladze TG, Le AT, Weickhardt AJ, et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res 2012;18:1472-82.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1472-1482
-
-
Doebele, R.C.1
Pilling, A.B.2
Aisner, D.L.3
Kutateladze, T.G.4
Le, A.T.5
Weickhardt, A.J.6
-
61
-
-
79956318797
-
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
-
Katayama R, Khan TM, Benes C, Lifshits E, Ebi H, Rivera VM, et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A 2011;108:7535-40.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 7535-7540
-
-
Katayama, R.1
Khan, T.M.2
Benes, C.3
Lifshits, E.4
Ebi, H.5
Rivera, V.M.6
-
62
-
-
79955964568
-
CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant
-
Sakamoto H, Tsukaguchi T, Hiroshima S, Kodama T, Kobayashi T, Fukami TA, et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell 2011;19: 679-90.
-
(2011)
Cancer Cell
, vol.19
, pp. 679-690
-
-
Sakamoto, H.1
Tsukaguchi, T.2
Hiroshima, S.3
Kodama, T.4
Kobayashi, T.5
Fukami, T.A.6
-
63
-
-
78049428879
-
Crizotinib in ALK-rearranged inflammatory myofi-broblastic tumor
-
Butrynski JE, D'Adamo DR, Hornick JL, Dal Cin P, Antonescu CR, Jhanwar SC, et al. Crizotinib in ALK-rearranged inflammatory myofi-broblastic tumor. N Engl J Med 2010;363:1727-33.
-
(2010)
N Engl J Med
, vol.363
, pp. 1727-1733
-
-
Butrynski, J.E.1
D'Adamo, D.R.2
Hornick, J.L.3
Dal Cin, P.4
Antonescu, C.R.5
Jhanwar, S.C.6
-
65
-
-
79952422786
-
Hunting ALK to feed targeted cancer therapy
-
Wellstein A, Toretsky JA. Hunting ALK to feed targeted cancer therapy. Nat Med 2011;17:290-1.
-
(2011)
Nat Med
, vol.17
, pp. 290-291
-
-
Wellstein, A.1
Toretsky, J.A.2
-
66
-
-
70349256226
-
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
-
Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009;114:937-51.
-
(2009)
Blood
, vol.114
, pp. 937-951
-
-
Vardiman, J.W.1
Thiele, J.2
Arber, D.A.3
Brunning, R.D.4
Borowitz, M.J.5
Porwit, A.6
-
67
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-57.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
Yang, C.H.4
Chu, D.T.5
Saijo, N.6
-
68
-
-
34249324494
-
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
-
Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, Yamazaki S, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res 2007;67: 4408-17.
-
(2007)
Cancer Res
, vol.67
, pp. 4408-4417
-
-
Zou, H.Y.1
Li, Q.2
Lee, J.H.3
Arango, M.E.4
McDonnell, S.R.5
Yamazaki, S.6
|