Type I CRISPR-Cas targets endogenous genes and regulates virulence to evade mammalian host immunity

Cell Research

Volumn 26, Issue 12, 2016, Pages 1273-1287

  Li, Rongpeng ^a   Fang, Lizhu ^a   Tan, Shirui ^a   Yu, Min ^a,b   Li, Xuefeng ^a,b   He, Sisi ^a,b   Wei, Yuquan ^b   Li, Guoping ^c   Jiang, Jianxin ^d   Wu, Min ^a,b  

^a UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b SICHUAN UNIVERSITY   (China)

^c THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIVERSITY   (China)

^d THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Endogenous targeting; LasR; Pseudomonas aeruginosa; Quorum sensing; Type I CRISPR

Indexed keywords

BACTERIAL PROTEIN; CRISPR ASSOCIATED PROTEIN; LASR PROTEIN, PSEUDOMONAS AERUGINOSA; MESSENGER RNA; TRANSACTIVATOR PROTEIN;

ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; CELL CULTURE; CHEMISTRY; CRISPR CAS SYSTEM; CYTOLOGY; FEMALE; GENE TARGETING; GENETICS; IMMUNOLOGY; INFLAMMATION; INNATE IMMUNITY; LUNG; MACROPHAGE; METABOLISM; MICROBIOLOGY; MORTALITY; MOUSE; NUCLEOTIDE MOTIF; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PATHOLOGY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; SIGNAL TRANSDUCTION; VETERINARY; VIRULENCE;

ANIMALS; BACTERIAL PROTEINS; BASE SEQUENCE; BRONCHOALVEOLAR LAVAGE FLUID; CELLS, CULTURED; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; FEMALE; GENE TARGETING; IMMUNITY, INNATE; INFLAMMATION; LUNG; MACROPHAGES; MICE; MICE, INBRED C57BL; NUCLEOTIDE MOTIFS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; VIRULENCE;

EID: 84995755265     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2016.135     Document Type: Article

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