메뉴 건너뛰기




Volumn 167, Issue 4, 2016, Pages 1001-1013.e7

Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

Author keywords

DNA repair; DSB repair; genome stability; homologous recombination; R loops; RNA DNA hybrids; RNase H; RPA

Indexed keywords

RIBONUCLEASE H; DNA; RIBONUCLEASE HI; RIBONUCLEASE HII; RNA; RNA POLYMERASE II;

EID: 84995654423     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.10.001     Document Type: Article
Times cited : (297)

References (45)
  • 2
    • 84860338675 scopus 로고    scopus 로고
    • R loops: from transcription byproducts to threats to genome stability
    • Aguilera, A., García-Muse, T., R loops: from transcription byproducts to threats to genome stability. Mol. Cell 46 (2012), 115–124.
    • (2012) Mol. Cell , vol.46 , pp. 115-124
    • Aguilera, A.1    García-Muse, T.2
  • 3
    • 0033756041 scopus 로고    scopus 로고
    • The absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate: implications for roles of RNases H in DNA replication and repair
    • Arudchandran, A., Cerritelli, S., Narimatsu, S., Itaya, M., Shin, D.Y., Shimada, Y., Crouch, R.J., The absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate: implications for roles of RNases H in DNA replication and repair. Genes Cells 5 (2000), 789–802.
    • (2000) Genes Cells , vol.5 , pp. 789-802
    • Arudchandran, A.1    Cerritelli, S.2    Narimatsu, S.3    Itaya, M.4    Shin, D.Y.5    Shimada, Y.6    Crouch, R.J.7
  • 4
    • 84873635660 scopus 로고    scopus 로고
    • Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks
    • Belotserkovskii, B.P., Neil, A.J., Saleh, S.S., Shin, J.H., Mirkin, S.M., Hanawalt, P.C., Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks. Nucleic Acids Res. 41 (2013), 1817–1828.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 1817-1828
    • Belotserkovskii, B.P.1    Neil, A.J.2    Saleh, S.S.3    Shin, J.H.4    Mirkin, S.M.5    Hanawalt, P.C.6
  • 7
    • 61349102407 scopus 로고    scopus 로고
    • Ribonuclease H: the enzymes in eukaryotes
    • Cerritelli, S.M., Crouch, R.J., Ribonuclease H: the enzymes in eukaryotes. FEBS J. 276 (2009), 1494–1505.
    • (2009) FEBS J. , vol.276 , pp. 1494-1505
    • Cerritelli, S.M.1    Crouch, R.J.2
  • 8
    • 0345354684 scopus 로고    scopus 로고
    • Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice
    • Cerritelli, S.M., Frolova, E.G., Feng, C., Grinberg, A., Love, P.E., Crouch, R.J., Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice. Mol. Cell 11 (2003), 807–815.
    • (2003) Mol. Cell , vol.11 , pp. 807-815
    • Cerritelli, S.M.1    Frolova, E.G.2    Feng, C.3    Grinberg, A.4    Love, P.E.5    Crouch, R.J.6
  • 10
    • 84865364870 scopus 로고    scopus 로고
    • Playing the end game: DNA double-strand break repair pathway choice
    • Chapman, J.R., Taylor, M.R., Boulton, S.J., Playing the end game: DNA double-strand break repair pathway choice. Mol. Cell 47 (2012), 497–510.
    • (2012) Mol. Cell , vol.47 , pp. 497-510
    • Chapman, J.R.1    Taylor, M.R.2    Boulton, S.J.3
  • 11
    • 84875458403 scopus 로고    scopus 로고
    • Charity begins at home: non-coding RNA functions in DNA repair
    • Chowdhury, D., Choi, Y.E., Brault, M.E., Charity begins at home: non-coding RNA functions in DNA repair. Nat. Rev. Mol. Cell Biol. 14 (2013), 181–189.
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 181-189
    • Chowdhury, D.1    Choi, Y.E.2    Brault, M.E.3
  • 12
    • 33746522835 scopus 로고    scopus 로고
    • Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection
    • Crow, Y.J., Leitch, A., Hayward, B.E., Garner, A., Parmar, R., Griffith, E., Ali, M., Semple, C., Aicardi, J., Babul-Hirji, R., et al. Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection. Nat. Genet. 38 (2006), 910–916.
    • (2006) Nat. Genet. , vol.38 , pp. 910-916
    • Crow, Y.J.1    Leitch, A.2    Hayward, B.E.3    Garner, A.4    Parmar, R.5    Griffith, E.6    Ali, M.7    Semple, C.8    Aicardi, J.9    Babul-Hirji, R.10
  • 13
    • 84869080625 scopus 로고    scopus 로고
    • Causes and consequences of ribonucleotide incorporation into nuclear DNA
    • Dalgaard, J.Z., Causes and consequences of ribonucleotide incorporation into nuclear DNA. Trends Genet. 28 (2012), 592–597.
    • (2012) Trends Genet. , vol.28 , pp. 592-597
    • Dalgaard, J.Z.1
  • 14
    • 84868694661 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae chromatin remodeler Fun30 regulates DNA end resection and checkpoint deactivation
    • Eapen, V.V., Sugawara, N., Tsabar, M., Wu, W.H., Haber, J.E., The Saccharomyces cerevisiae chromatin remodeler Fun30 regulates DNA end resection and checkpoint deactivation. Mol. Cell. Biol. 32 (2012), 4727–4740.
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 4727-4740
    • Eapen, V.V.1    Sugawara, N.2    Tsabar, M.3    Wu, W.H.4    Haber, J.E.5
  • 15
    • 84908343019 scopus 로고    scopus 로고
    • Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria
    • El Hage, A., Webb, S., Kerr, A., Tollervey, D., Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria. PLoS Genet., 10, 2014, e1004716.
    • (2014) PLoS Genet. , vol.10 , pp. e1004716
    • El Hage, A.1    Webb, S.2    Kerr, A.3    Tollervey, D.4
  • 18
    • 84876188716 scopus 로고    scopus 로고
    • Transcription-replication encounters, consequences and genomic instability
    • Helmrich, A., Ballarino, M., Nudler, E., Tora, L., Transcription-replication encounters, consequences and genomic instability. Nat. Struct. Mol. Biol. 20 (2013), 412–418.
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 412-418
    • Helmrich, A.1    Ballarino, M.2    Nudler, E.3    Tora, L.4
  • 19
    • 41549112501 scopus 로고    scopus 로고
    • FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16
    • Heo, K., Kim, H., Choi, S.H., Choi, J., Kim, K., Gu, J., Lieber, M.R., Yang, A.S., An, W., FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol. Cell 30 (2008), 86–97.
    • (2008) Mol. Cell , vol.30 , pp. 86-97
    • Heo, K.1    Kim, H.2    Choi, S.H.3    Choi, J.4    Kim, K.5    Gu, J.6    Lieber, M.R.7    Yang, A.S.8    An, W.9
  • 20
    • 84919485360 scopus 로고    scopus 로고
    • Chromatin modifications and DNA repair: beyond double-strand breaks
    • House, N.C.M., Koch, M.R., Freudenreich, C.H., Chromatin modifications and DNA repair: beyond double-strand breaks. Front. Genet., 5, 2014, 296.
    • (2014) Front. Genet. , vol.5 , pp. 296
    • House, N.C.M.1    Koch, M.R.2    Freudenreich, C.H.3
  • 21
    • 0020479047 scopus 로고
    • Studies of in vitro transcription by calf thymus RNA polymerase II using a novel duplex DNA template
    • Kadesch, T.R., Chamberlin, M.J., Studies of in vitro transcription by calf thymus RNA polymerase II using a novel duplex DNA template. J. Biol. Chem. 257 (1982), 5286–5295.
    • (1982) J. Biol. Chem. , vol.257 , pp. 5286-5295
    • Kadesch, T.R.1    Chamberlin, M.J.2
  • 22
    • 0037147329 scopus 로고    scopus 로고
    • p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex
    • Keller, D.M., Lu, H., p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. J. Biol. Chem. 277 (2002), 50206–50213.
    • (2002) J. Biol. Chem. , vol.277 , pp. 50206-50213
    • Keller, D.M.1    Lu, H.2
  • 24
    • 84899806551 scopus 로고    scopus 로고
    • Ribosomal RNA gene repeats, their stability and cellular senescence
    • Kobayashi, T., Ribosomal RNA gene repeats, their stability and cellular senescence. Proc. Jpn. Acad. Ser. B, Phys. Biol. Sci. 90 (2014), 119–129.
    • (2014) Proc. Jpn. Acad. Ser. B, Phys. Biol. Sci. , vol.90 , pp. 119-129
    • Kobayashi, T.1
  • 25
    • 84859210032 scopus 로고    scopus 로고
    • Fast gapped-read alignment with Bowtie 2
    • Langmead, B., Salzberg, S.L., Fast gapped-read alignment with Bowtie 2. Nat Methods 9 (2012), 357–359.
    • (2012) Nat Methods , vol.9 , pp. 357-359
    • Langmead, B.1    Salzberg, S.L.2
  • 29
    • 84892895021 scopus 로고    scopus 로고
    • PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry
    • Maréchal, A., Li, J.M., Ji, X.Y., Wu, C.S., Yazinski, S.A., Nguyen, H.D., Liu, S., Jiménez, A.E., Jin, J., Zou, L., PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Mol. Cell 53 (2014), 235–246.
    • (2014) Mol. Cell , vol.53 , pp. 235-246
    • Maréchal, A.1    Li, J.M.2    Ji, X.Y.3    Wu, C.S.4    Yazinski, S.A.5    Nguyen, H.D.6    Liu, S.7    Jiménez, A.E.8    Jin, J.9    Zou, L.10
  • 30
    • 53649104599 scopus 로고    scopus 로고
    • Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    • Mimitou, E.P., Symington, L.S., Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455 (2008), 770–774.
    • (2008) Nature , vol.455 , pp. 770-774
    • Mimitou, E.P.1    Symington, L.S.2
  • 31
    • 65549095526 scopus 로고    scopus 로고
    • Nucleases and helicases take center stage in homologous recombination
    • Mimitou, E.P., Symington, L.S., Nucleases and helicases take center stage in homologous recombination. Trends Biochem. Sci. 34 (2009), 264–272.
    • (2009) Trends Biochem. Sci. , vol.34 , pp. 264-272
    • Mimitou, E.P.1    Symington, L.S.2
  • 32
    • 79951857925 scopus 로고    scopus 로고
    • DNA end resection-unraveling the tail
    • Mimitou, E.P., Symington, L.S., DNA end resection-unraveling the tail. DNA Repair (Amst.) 10 (2011), 344–348.
    • (2011) DNA Repair (Amst.) , vol.10 , pp. 344-348
    • Mimitou, E.P.1    Symington, L.S.2
  • 33
    • 84883509035 scopus 로고    scopus 로고
    • At the intersection of non-coding transcription, DNA repair, chromatin structure, and cellular senescence
    • Ohsawa, R., Seol, J.H., Tyler, J.K., At the intersection of non-coding transcription, DNA repair, chromatin structure, and cellular senescence. Front. Genet., 4, 2013, 136.
    • (2013) Front. Genet. , vol.4 , pp. 136
    • Ohsawa, R.1    Seol, J.H.2    Tyler, J.K.3
  • 35
    • 84862829622 scopus 로고    scopus 로고
    • DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks
    • Pankotai, T., Bonhomme, C., Chen, D., Soutoglou, E., DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks. Nat. Struct. Mol. Biol. 19 (2012), 276–282.
    • (2012) Nat. Struct. Mol. Biol. , vol.19 , pp. 276-282
    • Pankotai, T.1    Bonhomme, C.2    Chen, D.3    Soutoglou, E.4
  • 36
    • 84930632519 scopus 로고    scopus 로고
    • Interaction with single-stranded DNA binding protein stimulates Escherichia coli ribonuclease HI enzymatic activity
    • Petzold, C., Marceau, A.H., Miller, K.H., Marqusee, S., Keck, J.L., Interaction with single-stranded DNA binding protein stimulates Escherichia coli ribonuclease HI enzymatic activity. J. Biol. Chem. 290 (2015), 14626–14636.
    • (2015) J. Biol. Chem. , vol.290 , pp. 14626-14636
    • Petzold, C.1    Marceau, A.H.2    Miller, K.H.3    Marqusee, S.4    Keck, J.L.5
  • 37
    • 84873020117 scopus 로고    scopus 로고
    • ChIP-exo method for identifying genomic location of DNA-binding proteins with near-single-nucleotide accuracy
    • Chapter 21, Unit 21.24
    • Rhee, H.S., Pugh, B.F., ChIP-exo method for identifying genomic location of DNA-binding proteins with near-single-nucleotide accuracy. Curr. Protoc. Mol. Biol., 2012 Chapter 21, Unit 21.24.
    • (2012) Curr. Protoc. Mol. Biol.
    • Rhee, H.S.1    Pugh, B.F.2
  • 38
    • 79959345878 scopus 로고    scopus 로고
    • Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination
    • Skourti-Stathaki, K., Proudfoot, N.J., Gromak, N., Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination. Mol. Cell 42 (2011), 794–805.
    • (2011) Mol. Cell , vol.42 , pp. 794-805
    • Skourti-Stathaki, K.1    Proudfoot, N.J.2    Gromak, N.3
  • 39
    • 84923172195 scopus 로고    scopus 로고
    • R-loops induce repressive chromatin marks over mammalian gene terminators
    • Skourti-Stathaki, K., Kamieniarz-Gdula, K., Proudfoot, N.J., R-loops induce repressive chromatin marks over mammalian gene terminators. Nature 516 (2014), 436–439.
    • (2014) Nature , vol.516 , pp. 436-439
    • Skourti-Stathaki, K.1    Kamieniarz-Gdula, K.2    Proudfoot, N.J.3
  • 40
    • 84873635293 scopus 로고    scopus 로고
    • Genome instability and aging
    • Vijg, J., Suh, Y., Genome instability and aging. Annu. Rev. Physiol. 75 (2013), 645–668.
    • (2013) Annu. Rev. Physiol. , vol.75 , pp. 645-668
    • Vijg, J.1    Suh, Y.2
  • 42
    • 84876829295 scopus 로고    scopus 로고
    • Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA
    • Williams, J.S., Smith, D.J., Marjavaara, L., Lujan, S.A., Chabes, A., Kunkel, T.A., Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA. Mol. Cell 49 (2013), 1010–1015.
    • (2013) Mol. Cell , vol.49 , pp. 1010-1015
    • Williams, J.S.1    Smith, D.J.2    Marjavaara, L.3    Lujan, S.A.4    Chabes, A.5    Kunkel, T.A.6
  • 43
    • 84953897634 scopus 로고    scopus 로고
    • SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination
    • Zhao, D.Y., Gish, G., Braunschweig, U., Li, Y., Ni, Z., Schmitges, F.W., Zhong, G., Liu, K., Li, W., Moffat, J., et al. SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination. Nature 529 (2016), 48–53.
    • (2016) Nature , vol.529 , pp. 48-53
    • Zhao, D.Y.1    Gish, G.2    Braunschweig, U.3    Li, Y.4    Ni, Z.5    Schmitges, F.W.6    Zhong, G.7    Liu, K.8    Li, W.9    Moffat, J.10
  • 45
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    • Zhu, Z., Chung, W.H., Shim, E.Y., Lee, S.E., Ira, G., Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134 (2008), 981–994.
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.