High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Lee, Hyun Jik ^a   Ryu, Jung Min ^b   Jung, Young Hyun ^a   Lee, Sei Jung ^a   Kim, Jeong Yeon ^a   Lee, Sang Hun ^c   Hwang, In Koo ^a   Seong, Je Kyung ^a   Han, Ho Jae ^a  

^a Seoul National University   (South Korea)

^b Chonnam National University   (South Korea)

^c Soonchunhyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ABCA1 PROTEIN, HUMAN; AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; GLUCOSE; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIVER X RECEPTOR; REACTIVE OXYGEN METABOLITE; SECRETASE;

ALZHEIMER DISEASE; ANIMAL; APOPTOSIS; BIOSYNTHESIS; BLOOD; CACO-2 CELL LINE; DIABETES MELLITUS; DIABETIC COMPLICATION; FEMALE; GENETICS; GLUCOSE BLOOD LEVEL; HIPPOCAMPUS; HUMAN; MALE; MEMBRANE MICRODOMAIN; METABOLISM; MOUSE; NERVE CELL; OXIDATIVE STRESS; PHYSIOLOGY; SECRETION (PROCESS); UPREGULATION; ZUCKER RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOPTOSIS; ASPARTIC ACID ENDOPEPTIDASES; ATP BINDING CASSETTE TRANSPORTER 1; BLOOD GLUCOSE; CACO-2 CELLS; DIABETES COMPLICATIONS; DIABETES MELLITUS; FEMALE; GLUCOSE; HIPPOCAMPUS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER X RECEPTORS; MALE; MEMBRANE MICRODOMAINS; MICE; NEURONS; OXIDATIVE STRESS; RATS, ZUCKER; REACTIVE OXYGEN SPECIES; UP-REGULATION;

EID: 84995519769     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep36746     Document Type: Article

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