NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury

Brain, Behavior, and Immunity

Volumn 58, Issue , 2016, Pages 291-309

  Kumar, Alok ^a   Barrett, James P ^a   Alvarez Croda, Dulce Mariely ^a,b   Stoica, Bogdan A ^a   Faden, Alan I ^a   Loane, David J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSIDAD VERACRUZANA   (Mexico)

Author keywords

M1 M2 like; Macrophage; Microglia; NADPH oxidase; Neurodegeneration; Neuroinflammation; NOX2; Traumatic brain injury

Indexed keywords

INTERLEUKIN 4 RECEPTOR ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; CYBB PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CELL ACTIVATION; CELL INFILTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; ENZYME REGULATION; EXPERIMENTAL TRAUMATIC BRAIN INJURY; FLOW CYTOMETRY; KNOCKOUT MOUSE; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MOTOR PERFORMANCE; MOUSE; NERVE DEGENERATION; NERVE INJURY; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; WILD TYPE MOUSE; ANIMAL; BRAIN CORTEX; C57BL MOUSE; ENCEPHALITIS; GENETICS; MACROPHAGE; METABOLISM; PATHOLOGY; SPATIAL MEMORY; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN INJURIES, TRAUMATIC; CEREBRAL CORTEX; ENCEPHALITIS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NADPH OXIDASE 2; SPATIAL MEMORY;

EID: 84995395337     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2016.07.158     Document Type: Article

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