Stearoyl-coA desaturase-1 protects cells against lipotoxicity-mediated apoptosis in proximal tubular cells

International Journal of Molecular Sciences

Volumn 17, Issue 11, 2016, Pages

  Iwai, Tamaki ^a   Kume, Shinji ^a   Chin Kanasaki, Masami ^a   Kuwagata, Shogo ^a   Araki, Hisazumi ^a   Takeda, Naoko ^a   Sugaya, Takeshi ^b   Uzu, Takashi ^a   Maegawa, Hiroshi ^a   Shin Ichi, Araki ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Desaturation; Free fatty acid; Lipid droplet; Lipotoxicity; Proximal tubular epithelial cells

Indexed keywords

ACYL COENZYME A DESATURASE; MONOUNSATURATED FATTY ACID; SMALL INTERFERING RNA; ADIPOPHILIN; FAT DROPLET; FATTY ACID; GLUCOSE BLOOD LEVEL; PLIN2 PROTEIN, MOUSE; SCD1 PROTEIN, MOUSE;

ANIMAL CELL; APOPTOSIS; ARTICLE; ENDOPLASMIC RETICULUM STRESS; EXPERIMENTAL DIABETIC NEPHROPATHY; FATTY ACID METABOLISM; GENE TRANSFER; GENETIC TRANSFECTION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULE CELL; LIPID DIET; LIPID METABOLISM; LIPOTOXICITY; MALE; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; TUNEL ASSAY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; DIABETIC NEPHROPATHY; DIET RESTRICTION; DISEASE MODEL; ENZYMOLOGY; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; GLUCOSE BLOOD LEVEL; HEK293 CELL LINE; HUMAN; KIDNEY PROXIMAL TUBULE; METABOLISM; PATHOLOGY;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; CELL LINE; DIABETIC NEPHROPATHIES; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL CELLS; FASTING; FATTY ACIDS; FATTY ACIDS, MONOUNSATURATED; GENE EXPRESSION; HEK293 CELLS; HUMANS; KIDNEY TUBULES, PROXIMAL; LIPID DROPLETS; LIPID METABOLISM; MICE; MICE, INBRED C57BL; PERILIPIN-2; RNA, SMALL INTERFERING; STEAROYL-COA DESATURASE;

EID: 84994893548     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17111868     Document Type: Article

References (36)

1. Nath, K.A. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am. J. Kidney Dis. 1992, 20, 1-17.
2. Abbate, M.; Zoja, C.; Remuzzi, G. How does proteinuria cause progressive renal damage? J. Am. Soc. Nephrol. 2006, 17, 2974-2984.
3. Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The diabetes control and complications trial research group. N. Engl. J. Med. 1993, 329, 977-986.
4. Brenner, B.M.; Cooper, M.E.; de Zeeuw, D.; Keane, W.F.; Mitch, W.E.; Parving, H.H.; Remuzzi, G.; Snapinn, S.M.; Zhang, Z.; Shahinfar, S. et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N. Engl. J. Med. 2001, 345, 861-869.
5. Araki, S.; Haneda, M.; Sugimoto, T.; Isono, M.; Isshiki, K.; Kashiwagi, A.; Koya, D. Factors associated with frequent remission of microalbuminuria in patients with type 2 diabetes. Diabetes 2005, 54, 2983-2987.
6. Yokoyama, H.; Araki, S.; Honjo, J.; Okizaki, S.; Yamada, D.; Shudo, R.; Shimizu, H.; Sone, H.; Moriya, T.; Haneda, M. Association between remission of macroalbuminuria and preservation of renal function in patients with type 2 diabetes with overt proteinuria. Diabetes Care 2013, 36, 3227-3233.
7. Adler, A.I.; Stevens, R.J.; Manley, S.E.; Bilous, R.W.; Cull, C.A.; Holman, R.R. Development and progression of nephropathy in type 2 diabetes: The united kingdom prospective diabetes study (ukpds 64). Kidney Int. 2003, 63, 225-232.
8. Yamahara, K.; Kume, S.; Koya, D.; Tanaka, Y.; Morita, Y.; Chin-Kanasaki, M.; Araki, H.; Isshiki, K.; Araki, S.; Haneda, M. et al. Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions. J. Am. Soc. Nephrol. 2013, 24, 1769-1781.
9. Mattson, F.H.; Grundy, S.M. Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. J. Lipid Res. 1985, 26, 194-202.
10. Klein-Platat, C.; Drai, J.; Oujaa, M.; Schlienger, J.L.; Simon, C. Plasma fatty acid composition is associated with the metabolic syndrome and low-grade inflammation in overweight adolescents. Am. J. Clin. Nutr. 2005, 82, 1178-1184.
11. Floegel, A.; Stefan, N.; Yu, Z.; Mühlenbruch, K.; Drogan, D.; Joost, H.G.; Fritsche, A.; Häring, H.U.; Hrabě de Angelis, M.; Peters, A. et al. Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes 2013, 62, 639-648.
12. Clore, J.N.; Allred, J.; White, D.; Li, J.; Stillman, J. The role of plasma fatty acid composition in endogenous glucose production in patients with type 2 diabetes mellitus. Metabolism 2002, 51, 1471-1477.
13. Soumura, M.; Kume, S.; Isshiki, K.; Takeda, N.; Araki, S.; Tanaka, Y.; Sugimoto, T.; Chin-Kanasaki, M.; Nishio, Y.; Haneda, M. et al. Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell. Biochem. Biophys. Res. Commun. 2010, 402, 265-271.
14. Eguchi, K.; Manabe, I.; Oishi-Tanaka, Y.; Ohsugi, M.; Kono, N.; Ogata, F.; Yagi, N.; Ohto, U.; Kimoto, M.; Miyake, K. et al. Saturated fatty acid and tlr signaling link β cell dysfunction and islet inflammation. Cell Metab. 2012, 15, 518-533.
15. Coll, T.; Eyre, E.; Rodríguez-Calvo, R.; Palomer, X.; Sánchez, R.M.; Merlos, M.; Laguna, J.C.; Vázquez-Carrera, M. Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells. J. Biol. Chem. 2008, 283, 11107-11116.
16. Kamijo, A.; Kimura, K.; Sugaya, T.; Yamanouchi, M.; Hase, H.; Kaneko, T.; Hirata, Y.; Goto, A.; Fujita, T.; Omata, M. Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage. Kidney Int. 2002, 62, 1628-1637.
17. Thomas, M.E.; Harris, K.P.; Walls, J.; Furness, P.N.; Brunskill, N.J. Fatty acids exacerbate tubulointerstitial injury in protein-overload proteinuria. Am. J. Physiol. Ren. Physiol. 2002, 283, F640-F647.
18. Sasaki, H.; Kamijo-Ikemori, A.; Sugaya, T.; Yamashita, K.; Yokoyama, T.; Koike, J.; Sato, T.; Yasuda, T.; Kimura, K. Urinary fatty acids and liver-type fatty acid binding protein in diabetic nephropathy. Nephron Clin. Pract. 2009, 112, c148-c156.
19. Ruggiero, C.; Elks, C.M.; Kruger, C.; Cleland, E.; Addison, K.; Noland, R.C.; Stadler, K. Albumin-bound fatty acids but not albumin itself alter redox balance in tubular epithelial cells and induce a peroxide-mediated redox-sensitive apoptosis. Am. J. Physiol. Ren. Physiol. 2014, 306, F896-F906.
20. Khan, S.; Abu Jawdeh, B.G.; Goel, M.; Schilling, W.P.; Parker, M.D.; Puchowicz, M.A.; Yadav, S.P.; Harris, R.C.; El-Meanawy, A.; Hoshi, M. et al. Lipotoxic disruption of nhe1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis. J. Clin. Investig. 2014, 124, 1057-1068.
21. Wang, Z.; Jiang, T.; Li, J.; Proctor, G.; McManaman, J.L.; Lucia, S.; Chua, S.; Levi, M. Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Diabetes 2005, 54, 2328-2335.
22. Kume, S.; Uzu, T.; Araki, S.; Sugimoto, T.; Isshiki, K.; Chin-Kanasaki, M.; Sakaguchi, M.; Kubota, N.; Terauchi, Y.; Kadowaki, T. et al. Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet. J. Am. Soc. Nephrol. 2007, 18, 2715-2723.
23. Kang, H.M.; Ahn, S.H.; Choi, P.; Ko, Y.A.; Han, S.H.; Chinga, F.; Park, A.S.; Tao, J.; Sharma, K.; Pullman, J. et al. Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development. Nat. Med. 2015, 21, 37-46.
24. Tanaka, Y.; Kume, S.; Araki, S.; Isshiki, K.; Chin-Kanasaki, M.; Sakaguchi, M.; Sugimoto, T.; Koya, D.; Haneda, M.; Kashiwagi, A. et al. Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis. Kidney Int. 2011, 79, 871-882.
25. Paton, C.M.; Ntambi, J.M. Biochemical and physiological function of stearoyl-coa desaturase. Am. J. Physiol. Endocrinol. Metab. 2009, 297, E28-E37.
26. Karaskov, E.; Scott, C.; Zhang, L.; Teodoro, T.; Ravazzola, M.; Volchuk, A. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis. Endocrinology 2006, 147, 3398-3407.
27. Alhusaini, S.; McGee, K.; Schisano, B.; Harte, A.; McTernan, P.; Kumar, S.; Tripathi, G. Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes: Salicylate alleviates this stress. Biochem. Biophys. Res. Commun. 2010, 397, 472-478.
28. Wei, Y.; Wang, D.; Topczewski, F.; Pagliassotti, M.J. Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am. J. Physiol. Endocrinol. Metab. 2006, 291, E275-E281.
29. Londos, C.; Brasaemle, D.L.; Schultz, C.J.; Segrest, J.P.; Kimmel, A.R. Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells. Semin. Cell Dev. Biol. 1999, 10, 51-58.
30. Sieber, J.; Weins, A.; Kampe, K.; Gruber, S.; Lindenmeyer, M.T.; Cohen, C.D.; Orellana, J.M.; Mundel, P.; Jehle, A.W. Susceptibility of podocytes to palmitic acid is regulated by stearoyl-coa desaturases 1 and 2. Am. J. Pathol. 2013, 183, 735-744.
31. Hassan, I.R.; Gronert, K. Acute changes in dietary ω-3 and ω-6 polyunsaturated fatty acids have a pronounced impact on survival following ischemic renal injury and formation of renoprotective docosahexaenoic acid-derived protectin D1. J. Immunol. 2009, 182, 3223-3232.
32. Busch, A.K.; Gurisik, E.; Cordery, D.V.; Sudlow, M.; Denyer, G.S.; Laybutt, D.R.; Hughes, W.E.; Biden, T.J. Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme a desaturase protects pancreatic β-cells from lipoapoptosis. Diabetes 2005, 54, 2917-2924.
33. Pinnamaneni, S.K.; Southgate, R.J.; Febbraio, M.A.; Watt, M.J. Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro. Diabetologia 2006, 49, 3027-3037.
34. Matsui, H.; Yokoyama, T.; Sekiguchi, K.; Iijima, D.; Sunaga, H.; Maniwa, M.; Ueno, M.; Iso, T.; Arai, M.; Kurabayashi, M. Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes. PLoS ONE 2012, 7, e33283.
35. Ntambi, J.M.; Miyazaki, M.; Stoehr, J.P.; Lan, H.; Kendziorski, C.M.; Yandell, B.S.; Song, Y.; Cohen, P.; Friedman, J.M.; Attie, A.D. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc. Natl. Acad. Sci. USA 2002, 99, 11482-11486.
36. Kume, S.; Haneda, M.; Kanasaki, K.; Sugimoto, T.; Araki, S.; Isshiki, K.; Isono, M.; Uzu, T.; Guarente, L.; Kashiwagi, A. et al. SIRT1 inhibits transforming growth factor β-induced apoptosis in glomerular mesangial cells via smad7 deacetylation. J. Biol. Chem. 2007, 282, 151-158.