Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes: Salicylate alleviates this stress

Biochemical and Biophysical Research Communications

Volumn 397, Issue 3, 2010, Pages 472-478

  Alhusaini, Saif ^a   McGee, Kirsty ^a   Schisano, Bruno ^a   Harte, Alison ^a   McTernan, Philip ^a   Kumar, Sudhesh ^a   Tripathi, Gyanendra ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Adipocytes; Endotoxemia and lipotoxicity; ER stress; Hyperglycaemia; Obesity

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 ALPHA; GLUCOSE; INITIATION FACTOR; LIPOPOLYSACCHARIDE; PROTEIN KINASE B; SALICYLIC ACID; SATURATED FATTY ACID; SERINE; TUNICAMYCIN; UNCLASSIFIED DRUG;

ABDOMINAL SUBCUTANEOUS FAT; ADIPOCYTE; ADIPOSE TISSUE; ADULT; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERGLYCEMIA; LEAN BODY WEIGHT; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ACTIVATING TRANSCRIPTION FACTOR 6; ADIPOCYTES; ADIPOSE TISSUE; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; FATTY ACIDS; GLUCOSE; HUMANS; LIPOPOLYSACCHARIDES; MIDDLE AGED; OBESITY; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SALICYLATES; STRESS, PHYSIOLOGICAL;

EUKARYOTA;

EID: 77954218373     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.05.138     Document Type: Article

References (30)

1. Hotamisligil G.S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140:900-917.
2. Ozcan U., Cao Q., Yilmaz E., Lee A.H., Iwakoshi N.N., Ozdelen E., Tuncman G., Gorgun C., Glimcher L.H., Hotamisligil G.S. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004, 306:457-461.
3. Scheuner D., Kaufman R.J. The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr. Rev. 2008, 29:317-333.
4. van der Kallen C.J., van Greevenbroek M.M., Stehouwer C.D., Schalkwijk C.G. Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver?. Apoptosis 2009, 14:1424-1434.
5. Harding H.P., Zhang Y., Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999, 397:271-274.
6. Harding H.P., Novoa I., Zhang Y., Zeng H., Wek R., Schapira M., Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 2000, 6:1099-1108.
7. Boden G., Duan X., Homko C., Molina E.J., Song W., Perez O., Cheung P., Merali S. Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 2008, 57:2438-2444.
8. Gregor M.F., Yang L., Fabbrini E., Mohammed B.S., Eagon J.C., Hotamisligil G.S., Klein S. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 2009, 58:693-700.
9. Sharma N.K., Das S.K., Mondal A.K., Hackney O.G., Chu W.S., Kern P.A., Rasouli N., Spencer H.J., Yao-Borengasser A., Elbein S.C. Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J. Clin. Endocrinol. Metab. 2008, 93:4532-4541.
10. van Huizen R., Martindale J.L., Gorospe M., Holbrook N.J. P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling. J. Biol. Chem. 2003, 278:15558-15564.
11. Baron S.H. Salicylates as hypoglycemic agents. Diabetes Care 1982, 5:64-71.
12. Yuan M., Konstantopoulos N., Lee J., Hansen L., Li Z.W., Karin M., Shoelson S.E. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001, 293:1673-1677.
13. Kopp E., Ghosh S. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 1994, 265:956-959.
14. Zuk P.A., Zhu M., Ashjian P., De Ugarte D.A., Huang J.I., Mizuno H., Alfonso Z.C., Fraser J.K., Benhaim P., Hedrick M.H. Human adipose tissue is a source of multipotent stem cells. Mol. Biol. Cell 2002, 13:4279-4295.
15. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
16. Kusminski C.M., da Silva N.F., Creely S.J., Fisher F.M., Harte A.L., Baker A.R., Kumar S., McTernan P.G. The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes. J. Clin. Endocrinol. Metab. 2007, 92:270-276.
17. Anderson L.A., McTernan P.G., Barnett A.H., Kumar S. The effects of androgens and estrogens on preadipocyte proliferation in human adipose tissue: influence of gender and site. J. Clin. Endocrinol. Metab. 2001, 86:5045-5051.
18. Namba T., Ishihara T., Tanaka K., Hoshino T., Mizushima T. Transcriptional activation of ATF6 by endoplasmic reticulum stressors. Biochem. Biophys. Res. Commun. 2007, 355:543-548.
19. Hu P., Han Z., Couvillon A.D., Exton J.H. Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J. Biol. Chem. 2004, 279:49420-49429.
20. Mehta N.N., McGillicuddy F.C., Anderson P.D., Hinkle C.C., Shah R., Pruscino L., Tabita-Martinez J., Sellers K.F., Rickels M.R., Reilly M.P. Experimental endotoxemia induces adipose inflammation and insulin resistance in humans. Diabetes 2010, 59:172-181.
21. Belfiore F., Iannello S., Camuto M., Fagone S., Cavaleri A. Insulin sensitivity of blood glucose versus insulin sensitivity of blood free fatty acids in normal, obese, and obese-diabetic subjects. Metabolism 2001, 50:573-582.
22. Boden G. Free fatty acids and insulin secretion in humans. Curr. Diab. Rep. 2005, 5:167-170.
23. Silva A.M., Wang D., Komar A.A., Castilho B.A., Williams B.R. Salicylates trigger protein synthesis inhibition in a protein kinase R-like endoplasmic reticulum kinase-dependent manner. J. Biol. Chem. 2007, 282:10164-10171.
24. Szegezdi E., Logue S.E., Gorman A.M., Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 2006, 7:880-885.
25. Zhang L., Lai E., Teodoro T., Volchuk A. GRP78, but not protein-disulfide isomerase, partially reverses hyperglycemia-induced inhibition of insulin synthesis and secretion in pancreatic {beta}-cells. J. Biol. Chem. 2009, 284:5289-5298.
26. Bertolotti A., Zhang Y., Hendershot L.M., Harding H.P., Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2000, 2:326-332.
27. Ho F.M., Lin W.W., Chen B.C., Chao C.M., Yang C.R., Lin L.Y., Lai C.C., Liu S.H., Liau C.S. High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway. Cell Signal 2006, 18:391-399.
28. Patel T.R., Corbett S.A. Simvastatin suppresses LPS-induced Akt phosphorylation in the human monocyte cell line THP-1. J. Surg. Res. 2004, 116:116-120.
29. Pierce J.W., Read M.A., Ding H., Luscinskas F.W., Collins T. Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration. J. Immunol. 1996, 156:3961-3969.
30. Yin M.J., Yamamoto Y., Gaynor R.B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 1998, 396:77-80.