The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

Journal of Medicinal Chemistry

Volumn 59, Issue 21, 2016, Pages 9967-9973

  Benchekroun, Mohamed ^a   Romero, Alejandro ^b   Egea, Javier ^c,d   León, Rafael ^c,d   Michalska, Patrycja ^c,d   Buendía, Izaskun ^c,d   Jimeno, María Luisa ^e   Jun, Daniel ^f   Janockova, Jana ^g   Sepsova, Vendula ^f   Soukup, Ondrej ^g   Bautista Aguilera, Oscar M ^a   Refouvelet, Bernard ^a   Ouari, Olivier ^h   Marco Contelles, José ⁱ   Ismaili, Lhassane ^a  

^a University Hospital of Besançon   (France)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d INSTITUTO TEÓFILO HERNANDO   (Spain)

^e CSIC Centro de Quimica Organica Lora Tamayo CENQUIOR   (Spain)

^f UNIVERSITY OF DEFENCE   (Czech Republic)

^g UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^h AIX MARSEILLE UNIV   (France)

ⁱ INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; ANTIOXIDANT; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; FERULIC ACID; FORMALDEHYDE; HYDROGEN PEROXIDE; ISOCYANIDE DERIVATIVE; MELATONIN; NEUROPROTECTIVE AGENT; NOOTROPIC AGENT; OLIGOMYCIN; ROTENONE; TACRINE DERIVATIVE; TERT BUTYLHYDROQUINONE; THIOCTIC ACID; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; COUMARIC ACID;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CELL VIABILITY; CHOLINESTERASE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG PENETRATION; DRUG SYNTHESIS; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER TOXICITY; MOLECULAR DOCKING; NEUROPROTECTION; ORAC ASSAY; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; AGONISTS; CELL DEATH; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HEP-G2 CELL LINE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALZHEIMER DISEASE; ANTIOXIDANTS; CELL DEATH; CELL SURVIVAL; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; COUMARIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEP G2 CELLS; HUMANS; MELATONIN; MOLECULAR STRUCTURE; NF-E2-RELATED FACTOR 2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84994877088     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b01178     Document Type: Article

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