-
1
-
-
85047682984
-
Regulation of oxygen homeostasis by hypoxia-inducible factor 1
-
PMID: 19364912
-
Semenza GL (2009) Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda) 24:97-106. doi: 10.1152/physiol.00045.2008 PMID: 19364912
-
(2009)
Physiology (Bethesda)
, vol.24
, pp. 97-106
-
-
Semenza, G.L.1
-
2
-
-
79952534509
-
Opposite functions of HIF-alpha isoforms in VEGF induction by TGF-beta1 under non-hypoxic conditions
-
PMID: 21057546
-
Chae KS, Kang MJ, Lee JH, Ryu BK, Lee MG, et al. (2011) Opposite functions of HIF-alpha isoforms in VEGF induction by TGF-beta1 under non-hypoxic conditions. Oncogene 30:1213-1228. doi: 10.1038/onc.2010.498 PMID: 21057546
-
(2011)
Oncogene
, vol.30
, pp. 1213-1228
-
-
Chae, K.S.1
Kang, M.J.2
Lee, J.H.3
Ryu, B.K.4
Lee, M.G.5
-
3
-
-
20744445650
-
Contrasting properties of hypoxiainducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
-
PMID: 15964822
-
Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, et al. (2005) Contrasting properties of hypoxiainducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 25:5675-5686. PMID: 15964822
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5675-5686
-
-
Raval, R.R.1
Lau, K.W.2
Tran, M.G.3
Sowter, H.M.4
Mandriota, S.J.5
-
4
-
-
58149478525
-
HIF-1alpha and HIF-2alpha have divergent roles in colon cancer
-
PMID: 19030186
-
Imamura T, Kikuchi H, Herraiz MT, Park DY, Mizukami Y, et al. (2009) HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer 124:763-771. doi: 10.1002/ijc.24032 PMID: 19030186
-
(2009)
Int J Cancer
, vol.124
, pp. 763-771
-
-
Imamura, T.1
Kikuchi, H.2
Herraiz, M.T.3
Park, D.Y.4
Mizukami, Y.5
-
5
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
PMID: 11641274
-
Mahon PC, Hirota K, Semenza GL (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15:2675-2686. PMID: 11641274
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
6
-
-
18544386401
-
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
PMID: 12042299
-
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, et al. (2002) Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem 277:26351-26355. PMID: 12042299
-
(2002)
J Biol Chem
, vol.277
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
Tian, Y.M.4
Bullock, A.N.5
-
7
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
PMID: 12080085
-
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, et al. (2002) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16:1466-1471. PMID: 12080085
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
-
8
-
-
84865773630
-
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling
-
PMID: 22807441
-
Chen R, Xu M, Hogg RT, Li J, Little B, et al. (2012) The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling. J Biol Chem 287:30800-30811. doi: 10. 1074/jbc. M111.244780 PMID: 22807441
-
(2012)
J Biol Chem
, vol.287
, pp. 30800-30811
-
-
Chen, R.1
Xu, M.2
Hogg, R.T.3
Li, J.4
Little, B.5
-
9
-
-
66749129781
-
Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1
-
PMID: 19498162
-
Dioum EM, Chen R, Alexander MS, Zhang Q, Hogg RT, et al. (2009) Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 324:1289-1293. doi: 10.1126/science.1169956 PMID: 19498162
-
(2009)
Science
, vol.324
, pp. 1289-1293
-
-
Dioum, E.M.1
Chen, R.2
Alexander, M.S.3
Zhang, Q.4
Hogg, R.T.5
-
10
-
-
84908323382
-
An acetate switch regulates stress erythropoiesis
-
PMID: 25108527
-
Xu M, Nagati JS, Xie J, Li J, Walters H, et al. (2014) An acetate switch regulates stress erythropoiesis. Nat Med 20:1018-1026. doi: 10.1038/nm.3587 PMID: 25108527
-
(2014)
Nat Med
, vol.20
, pp. 1018-1026
-
-
Xu, M.1
Nagati, J.S.2
Xie, J.3
Li, J.4
Walters, H.5
-
11
-
-
0035914436
-
Hypoxia-inducible factor-2a (HIF-2 a) is involved in the apoptotic response to hypoglycemia but not to hypoxia
-
PMID: 11546756
-
Brusselmans K, Bono F, Maxwell P, Dor Y, Dewerchin M, et al. (2001) Hypoxia-inducible factor-2a (HIF-2 a) is involved in the apoptotic response to hypoglycemia but not to hypoxia. Journal of Biological Chemistry 276:39192-39196. PMID: 11546756
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 39192-39196
-
-
Brusselmans, K.1
Bono, F.2
Maxwell, P.3
Dor, Y.4
Dewerchin, M.5
-
12
-
-
77954560445
-
Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: Regulation and phenotypic effects of Hypoxia-Inducible Factor
-
PMID: 20637078
-
Knowles HJ, Schaefer KL, Dirksen U, Athanasou NA (2010) Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor. BMC Cancer 10:372. doi: 10.1186/1471-2407-10-372 PMID: 20637078
-
(2010)
BMC Cancer
, vol.10
, pp. 372
-
-
Knowles, H.J.1
Schaefer, K.L.2
Dirksen, U.3
Athanasou, N.A.4
-
13
-
-
27144439058
-
Glucose requirement for hypoxic accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha)
-
PMID: 16253768
-
Vordermark D, Kraft P, Katzer A, Bolling T, Willner J, et al. (2005) Glucose requirement for hypoxic accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha). Cancer Lett 230:122-133. PMID: 16253768
-
(2005)
Cancer Lett
, vol.230
, pp. 122-133
-
-
Vordermark, D.1
Kraft, P.2
Katzer, A.3
Bolling, T.4
Willner, J.5
-
14
-
-
79954609893
-
Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner
-
PMID: 21345792
-
Chen R, Dioum EM, Hogg RT, Gerard RD, Garcia JA (2011) Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. J Biol Chem 286:13869-13878. doi: 10.1074/jbc. M110.175414 PMID: 21345792
-
(2011)
J Biol Chem
, vol.286
, pp. 13869-13878
-
-
Chen, R.1
Dioum, E.M.2
Hogg, R.T.3
Gerard, R.D.4
Garcia, J.A.5
-
15
-
-
0034714382
-
Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins
-
PMID: 10843999
-
Luong A, Hannah VC, Brown MS, Goldstein JL (2000) Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. J Biol Chem 275:26458-26466. PMID: 10843999
-
(2000)
J Biol Chem
, vol.275
, pp. 26458-26466
-
-
Luong, A.1
Hannah, V.C.2
Brown, M.S.3
Goldstein, J.L.4
-
16
-
-
0033955099
-
The levels and kinetics of oxygen tension detectable at the surface of human dermal fibroblast cultures
-
PMID: 10653608
-
Tokuda Y, Crane S, Yamaguchi Y, Zhou L, Falanga V (2000) The levels and kinetics of oxygen tension detectable at the surface of human dermal fibroblast cultures. J Cell Physiol 182:414-420. PMID: 10653608
-
(2000)
J Cell Physiol
, vol.182
, pp. 414-420
-
-
Tokuda, Y.1
Crane, S.2
Yamaguchi, Y.3
Zhou, L.4
Falanga, V.5
-
17
-
-
34249309925
-
Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway
-
PMID: 17307335
-
Jin HO, An S, Lee HC, Woo SH, Seo SK, et al. (2007) Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway. Cell Signal 19:1393-1403. PMID: 17307335
-
(2007)
Cell Signal
, vol.19
, pp. 1393-1403
-
-
Jin, H.O.1
An, S.2
Lee, H.C.3
Woo, S.H.4
Seo, S.K.5
-
18
-
-
49649090182
-
Regulation of hypoxia-inducible genes by ETS1 transcription factor
-
PMID: 18381358
-
Salnikow K, Aprelikova O, Ivanov S, Tackett S, Kaczmarek M, et al. (2008) Regulation of hypoxia-inducible genes by ETS1 transcription factor. Carcinogenesis 29:1493-1499. doi: 10.1093/carcin/bgn088 PMID: 18381358
-
(2008)
Carcinogenesis
, vol.29
, pp. 1493-1499
-
-
Salnikow, K.1
Aprelikova, O.2
Ivanov, S.3
Tackett, S.4
Kaczmarek, M.5
-
19
-
-
85047695603
-
Cell density mediated pericellular hypoxia leads to induction of HIF-1alpha via nitric oxide and Ras/MAP kinase mediated signaling pathways
-
PMID: 11753640
-
Sheta EA, Trout H, Gildea JJ, Harding MA, Theodorescu D (2001) Cell density mediated pericellular hypoxia leads to induction of HIF-1alpha via nitric oxide and Ras/MAP kinase mediated signaling pathways. Oncogene 20:7624-7634. PMID: 11753640
-
(2001)
Oncogene
, vol.20
, pp. 7624-7634
-
-
Sheta, E.A.1
Trout, H.2
Gildea, J.J.3
Harding, M.A.4
Theodorescu, D.5
-
20
-
-
44749093281
-
The specific contribution of hypoxiainducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell typespecific and exogenous factors
-
PMID: 18420194
-
Warnecke C, Weidemann A, Volke M, Schietke R, Wu X, et al. (2008) The specific contribution of hypoxiainducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell typespecific and exogenous factors. Exp Cell Res 314:2016-2027. doi: 10.1016/j.yexcr.2008.03.003 PMID: 18420194
-
(2008)
Exp Cell Res
, vol.314
, pp. 2016-2027
-
-
Warnecke, C.1
Weidemann, A.2
Volke, M.3
Schietke, R.4
Wu, X.5
-
21
-
-
25644446862
-
Progress toward acetate supplementation therapy for Canavan disease: Glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brain
-
PMID: 16002461
-
Mathew R, Arun P, Madhavarao CN, Moffett JR, Namboodiri MA (2005) Progress toward acetate supplementation therapy for Canavan disease: glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brain. J Pharmacol Exp Ther 315:297-303. PMID: 16002461
-
(2005)
J Pharmacol Exp Ther
, vol.315
, pp. 297-303
-
-
Mathew, R.1
Arun, P.2
Madhavarao, C.N.3
Moffett, J.R.4
Namboodiri, M.A.5
-
22
-
-
14944368136
-
The acetate switch
-
PMID: 15755952
-
Wolfe AJ (2005) The acetate switch. Microbiol Mol Biol Rev 69:12-50. PMID: 15755952
-
(2005)
Microbiol Mol Biol Rev
, vol.69
, pp. 12-50
-
-
Wolfe, A.J.1
-
23
-
-
77956191450
-
Acetate metabolism and aging: An emerging connection
-
PMID: 20478325
-
Shimazu T, Hirschey MD, Huang JY, Ho LT, Verdin E (2010) Acetate metabolism and aging: An emerging connection. Mech Ageing Dev 131:511-516. doi: 10.1016/j.mad.2010.05.001 PMID: 20478325
-
(2010)
Mech Ageing Dev
, vol.131
, pp. 511-516
-
-
Shimazu, T.1
Hirschey, M.D.2
Huang, J.Y.3
Ho, L.T.4
Verdin, E.5
-
24
-
-
66249105703
-
ATP-citrate lyase links cellular metabolism to histone acetylation
-
PMID: 19461003
-
Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, et al. (2009) ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324:1076-1080. doi: 10.1126/science.1164097 PMID: 19461003
-
(2009)
Science
, vol.324
, pp. 1076-1080
-
-
Wellen, K.E.1
Hatzivassiliou, G.2
Sachdeva, U.M.3
Bui, T.V.4
Cross, J.R.5
-
25
-
-
84855453655
-
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
-
PMID: 22225880
-
Le A, Lane AN, Hamaker M, Bose S, Gouw A, et al. (2012) Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab 15:110-121. doi: 10.1016/j.cmet. 2011.12.009 PMID: 22225880
-
(2012)
Cell Metab
, vol.15
, pp. 110-121
-
-
Le, A.1
Lane, A.N.2
Hamaker, M.3
Bose, S.4
Gouw, A.5
-
26
-
-
84856014884
-
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
-
PMID: 22101433
-
Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, et al. (2012) Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 481:380-384. doi: 10.1038/nature10602 PMID: 22101433
-
(2012)
Nature
, vol.481
, pp. 380-384
-
-
Metallo, C.M.1
Gameiro, P.A.2
Bell, E.L.3
Mattaini, K.R.4
Yang, J.5
-
27
-
-
83755178091
-
Hypoxia promotes isocitrate dehydrogenasedependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability
-
PMID: 22106302
-
Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, et al. (2011) Hypoxia promotes isocitrate dehydrogenasedependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A 108:19611-19616. doi: 10.1073/pnas.1117773108 PMID: 22106302
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 19611-19616
-
-
Wise, D.R.1
Ward, P.S.2
Shay, J.E.3
Cross, J.R.4
Gruber, J.J.5
-
28
-
-
84855987831
-
Reductive carboxylation supports growth in tumour cells with defective mitochondria
-
PMID: 22101431
-
Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, et al. (2012) Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 481:385-388. doi: 10.1038/nature10642 PMID: 22101431
-
(2012)
Nature
, vol.481
, pp. 385-388
-
-
Mullen, A.R.1
Wheaton, W.W.2
Jin, E.S.3
Chen, P.H.4
Sullivan, L.B.5
-
29
-
-
65349155747
-
Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: The possible function in tumor acetyl-CoA/acetate metabolism
-
PMID: 19445015
-
Yoshii Y, Furukawa T, Yoshii H, Mori T, Kiyono Y, et al. (2009) Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism. Cancer Sci 100:821-827. PMID: 19445015
-
(2009)
Cancer Sci
, vol.100
, pp. 821-827
-
-
Yoshii, Y.1
Furukawa, T.2
Yoshii, H.3
Mori, T.4
Kiyono, Y.5
-
30
-
-
69249232029
-
Tumor uptake of radiolabeled acetate reflects the expression of cytosolic acetyl-CoA synthetase: Implications for the mechanism of acetate PET
-
PMID: 19720289
-
Yoshii Y, Waki A, Furukawa T, Kiyono Y, Mori T, et al. (2009) Tumor uptake of radiolabeled acetate reflects the expression of cytosolic acetyl-CoA synthetase: implications for the mechanism of acetate PET. Nucl Med Biol 36:771-777. doi: 10.1016/j.nucmedbio.2009.05.006 PMID: 19720289
-
(2009)
Nucl Med Biol
, vol.36
, pp. 771-777
-
-
Yoshii, Y.1
Waki, A.2
Furukawa, T.3
Kiyono, Y.4
Mori, T.5
-
31
-
-
33745840203
-
5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments
-
PMID: 16809770
-
Laderoute KR, Amin K, Calaoagan JM, Knapp M, Le T, et al. (2006) 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol 26:5336-5347. PMID: 16809770
-
(2006)
Mol Cell Biol
, vol.26
, pp. 5336-5347
-
-
Laderoute, K.R.1
Amin, K.2
Calaoagan, J.M.3
Knapp, M.4
Le, T.5
-
32
-
-
79960745146
-
Hypoxia-inducible transcription factor 2alpha promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis
-
PMID: 21538443
-
Qu A, Taylor M, Xue X, Matsubara T, Metzger D, et al. (2011) Hypoxia-inducible transcription factor 2alpha promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis. Hepatology 54:472-483. doi: 10.1002/hep. 24400 PMID: 21538443
-
(2011)
Hepatology
, vol.54
, pp. 472-483
-
-
Qu, A.1
Taylor, M.2
Xue, X.3
Matsubara, T.4
Metzger, D.5
-
33
-
-
68949098346
-
Hypoxia-inducible factor 2 regulates hepatic lipid metabolism
-
PMID: 19528226
-
Rankin EB, Rha J, Selak MA, Unger TL, Keith B, et al. (2009) Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. Mol Cell Biol 29:4527-4538. doi: 10.1128/MCB.00200-09 PMID: 19528226
-
(2009)
Mol Cell Biol
, vol.29
, pp. 4527-4538
-
-
Rankin, E.B.1
Rha, J.2
Selak, M.A.3
Unger, T.L.4
Keith, B.5
-
34
-
-
0344826529
-
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/-mice
-
PMID: 14608355
-
Scortegagna M, Ding K, Oktay Y, Gaur A, Thurmond F, et al. (2003) Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/-mice. Nat Genet 35:331-340. PMID: 14608355
-
(2003)
Nat Genet
, vol.35
, pp. 331-340
-
-
Scortegagna, M.1
Ding, K.2
Oktay, Y.3
Gaur, A.4
Thurmond, F.5
-
35
-
-
8444238235
-
S-peptide epitope tagging for protein purification, expression monitoring, and localization in mammalian cells
-
PMID: 15560139
-
Hackbarth JS, Lee SH, Meng XW, Vroman BT, Kaufmann SH, et al. (2004) S-peptide epitope tagging for protein purification, expression monitoring, and localization in mammalian cells. Biotechniques 37:835-839. PMID: 15560139
-
(2004)
Biotechniques
, vol.37
, pp. 835-839
-
-
Hackbarth, J.S.1
Lee, S.H.2
Meng, X.W.3
Vroman, B.T.4
Kaufmann, S.H.5
|