bFGF Protects Against Blood-Brain Barrier Damage Through Junction Protein Regulation via PI3K-Akt-Rac1 Pathway Following Traumatic Brain Injury

Molecular Neurobiology

Volumn 53, Issue 10, 2016, Pages 7298-7311

  Wang, Zhou Guang ^a   Cheng, Yi ^a,b   Yu, Xi Chong ^a   Ye, Li Bing ^a   Xia, Qing Hai ^a   Johnson, Noah R ^c   Wei, Xiaojie ^a   Chen, Da Qing ^a   Cao, Guodong ^d   Fu, Xiao Bing ^e   Li, Xiao Kun ^a   Zhang, Hong Yu ^a   Xiao, Jian ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b Department of Pharmacy Longyou People's Hospital   (China)

^c MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

bFGF; Blood brain barrier; PI3K Akt Rac 1; RhoA; Tight junction; Traumatic brain injury

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADHERENS JUNCTION PROTEIN; BETA CATENIN; CATENIN; CLAUDIN 5; ENZYME INHIBITOR; FIBROBLAST GROWTH FACTOR 2; MEMBRANE PROTEIN; OCCLUDIN; P120 CATENIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN ZO1; RAC1 PROTEIN; RECOMBINANT FIBROBLAST GROWTH FACTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIRAC 1 INHIBITOR; TIGHT JUNCTION PROTEIN; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; GLUCOSE; GUANOSINE TRIPHOSPHATE; NEUROPROTECTIVE AGENT; OXYGEN;

ADHERENS JUNCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REOXYGENATION; SIGNAL TRANSDUCTION; TRAUMATIC BRAIN INJURY; UPREGULATION; ANIMAL; C57BL MOUSE; CELL JUNCTION; DEFICIENCY; DRUG EFFECTS; ENDOTHELIUM CELL; INJURIES; METABOLISM; PATHOLOGY;

ANIMALS; BIOMARKERS; BLOOD-BRAIN BARRIER; BRAIN INJURIES, TRAUMATIC; ENDOTHELIAL CELLS; FIBROBLAST GROWTH FACTOR 2; GLUCOSE; GUANOSINE TRIPHOSPHATE; HUMANS; INTERCELLULAR JUNCTIONS; MALE; MEMBRANE PROTEINS; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; OXYGEN; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RAC1 GTP-BINDING PROTEIN; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 84994765027     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9583-6     Document Type: Article

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