Fibroblast growth factors preserve blood-brain barrier integrity through RhoA inhibition after intracerebral hemorrhage in mice

Neurobiology of Disease

Volumn 46, Issue 1, 2012, Pages 204-214

  Huang, Bin ^a,b   Krafft, Paul R ^a   Ma, Qingyi ^a   Rolland, William B ^a   Caner, Basak ^a   Lekic, Tim ^a   Manaenko, Anatol ^a   Le, Mai ^a   Tang, Jiping ^a   Zhang, John H ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Behavior; Blood brain barrier; Brain edema; Brain injury; Fibroblast growth factor; Intracerebral hemorrhage; Rac1; RhoA; Thrombin

Indexed keywords

1 TERT BUTYL 3 [6 (3,5 DIMETHOXYPHENYL) 2 (4 DIETHYLAMINOBUTYLAMINO)PYRIDO[2,3 D]PYRIMIDIN 7 YL]UREA; 2 MORPHOLINO 8 PHENYLCHROMONE; BCR ABL PROTEIN; BETA CATENIN; CATENIN; CLOSTRIDIOPEPTIDASE A; EVANS BLUE; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE INHIBITOR; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN DYSFUNCTION; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN INJURY; BRAIN WATER; CELL JUNCTION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOOD-BRAIN BARRIER; CEREBRAL HEMORRHAGE, TRAUMATIC; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; INFUSIONS, INTRAVENTRICULAR; MALE; MICE; MICE, INBRED STRAINS; RECOMBINANT PROTEINS; RHOA GTP-BINDING PROTEIN;

EID: 84862784791     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.01.008     Document Type: Article

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