Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway

British Journal of Cancer

Volumn 103, Issue 3, 2010, Pages 370-381

  Kamura, S ^a   Matsumoto, Y ^a   Fukushi, J I ^a   Fujiwara, T ^a   Iida, K ^a   Okada, Y ^a   Iwamoto, Y ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

basic fibroblast growth factor; bone microenvironment; cell motility; Ewing's sarcoma family of tumours; PI3K; Rac1

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; RAC1 PROTEIN;

ARTICLE; CANCER CELL; CELL INVASION; CELL MOTILITY; CELL STRUCTURE; CHEMOTAXIS; CONTROLLED STUDY; EWING SARCOMA; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WOUND HEALING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BONE MARROW; CELL LINE, TUMOR; CELL MOVEMENT; CYTOSKELETON; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; OSTEOSARCOMA; POLYMERASE CHAIN REACTION; RAC1 GTP-BINDING PROTEIN; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3; RECOMBINANT PROTEINS; SARCOMA, EWING'S; WOUND HEALING;

EID: 77955055849     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605775     Document Type: Article

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