Exogenous Basic Fibroblast Growth Factor Inhibits ER Stress-Induced Apoptosis and Improves Recovery from Spinal Cord Injury

CNS Neuroscience and Therapeutics

Volumn 19, Issue 1, 2013, Pages 20-29

  Zhang, Hong Yu ^a   Zhang, Xie ^b   Wang, Zhou Guang ^a   Shi, Hong Xue ^a   Wu, Fen Zan ^a   Lin, Bei Bei ^a   Xu, Xin Long ^a   Wang, Xiao Jie ^a   Fu, Xiao Bing ^c   Li, Zhao Yu ^a   Shen, Chen Jie ^a   Li, Xiao Kun ^a,d   Xiao, Jian ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b Ningbo Medical Treatment Center Li Huili Hospital   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d JILIN AGRICULTURAL UNIVERSITY   (China)

Author keywords

Apoptosis; BFGF; ER stress; ERK1 2; PI3K Akt; Spinal cord injury

Indexed keywords

CASPASE 12; FIBROBLAST GROWTH FACTOR 2; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; NEUROMODULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY;

ANIMALS; APOPTOSIS; CASPASE 12; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; FEMALE; FIBROBLAST GROWTH FACTOR 2; GAP-43 PROTEIN; HEAT-SHOCK PROTEINS; IN SITU NICK-END LABELING; LOCOMOTION; NEURONS; PC12 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; SPINAL CORD INJURIES; TIME FACTORS; TRANSCRIPTION FACTOR CHOP; UP-REGULATION;

EID: 84871394941     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12013     Document Type: Article

References (46)

1. Penas C, Guzman MS, Verdu E, et al. Spinal cord injury induces endoplasmic reticulum stress with different cell-type dependent response. J Neurochem 2007;102:1242-1255.
2. Dasari VR, Veeravalli KK, Tsung AJ, et al. Neuronal apoptosis is inhibited by cord blood stem cells after spinal cord injury. J Neurotrauma 2009;26:2057-2069.
3. Beattie MS. Inflammation and apoptosis: linked therapeutic targets in spinal cord injury. Trends Mol Med 2004;10:580-583.
4. Jing G, Wang JJ, Zhang SX. ER stress and apoptosis: a new mechanism for retinal cell death. Exp Diabetes Res 2012; 2012: 589589.
5. Badiola N, Penas C, Minano-Molina A, et al. Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12. Cell Death Dis 2011;2:e149.
6. Zha BS, Zhou HP. ER Stress and Lipid Metabolism in Adipocytes. Biochem Res Int 2012; 2012: 312943.
7. Ding W, Yang L, Zhang M, Gu Y. Reactive oxygen species-mediated endoplasmic reticulum stress contributes to aldosterone-induced apoptosis in tubular epithelial cells. Biochem Biophys Res Commun 2012;418:451-456.
8. Liu XD, Ko S, Xu Y, et al. Transient aggregation of Ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and ER stress. J Biol Chem 2012;287:19687-19698.
9. Zhang Z, Tong N, Gong Y, et al. Valproate protects the retina from endoplasmic reticulum stress-induced apoptosis after ischemia-reperfusion injury. Neurosci Lett 2011;504:88-92.
10. Valenzuela V, Collyer E, Armentano D, et al. Activation of the unfolded protein response enhances motor recovery after spinal cord injury. Cell Death Dis 2012;3:e272.
11. Ohri SS, Maddie MA, Zhao Y, et al. Attenuating the endoplasmic reticulum stress response improves functional recovery after spinal cord injury. Glia 2011;59:1489-1502.
12. Ohri SS, Maddie MA, Zhang Y, et al. Deletion of the pro-apoptotic endoplasmic reticulum stress response effector CHOP does not result in improved locomotor function after severe contusive spinal cord injury. J Neurotrauma 2012;29:579-588.
13. Itoh N, Ornitz DM. Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. J Biochem 2011;149:121-130.
14. Beenken A, Mohammadi M. The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov 2009;8:235-253.
15. Xiao J, Lv Y, Lin S, et al. Cardiac protection by basic fibroblast growth factor from ischemia/reperfusion-induced injury in diabetic rats. Biol Pharm Bull 2010;33:444-449.
16. Abe K, Saito H. Effects of basic fibroblast growth factor on central nervous system functions. Pharmacol Res 2001;43:307-312.
17. Yu Y, Gu S, Huang H, Wen T. Combination of bFGF, heparin and laminin induce the generation of dopaminergic neurons from rat neural stem cells both in vitro and in vivo. J Neurol Sci 2007;255:81-86.
18. Liu WG, Wang ZY, Huang ZS. Bone marrow-derived mesenchymal stem cells expressing the bFGF transgene promote axon regeneration and functional recovery after spinal cord injury in rats. Neurol Res 2011;33:686-693.
19. Karimi-Abdolrezaee S, Eftekharpour E, Wang J, Schut D, Fehlings MG. Synergistic effects of transplanted adult neural stem/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord. J Neurosci 2010;30:1657-1676.
20. Kishi S, Shimoke K, Nakatani Y, et al. Nerve growth factor attenuates 2-deoxy-d-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78. Neurosci Res 2010;66:14-21.
21. de Oliveira MR, da Rocha RF, Stertz L, et al. Total and mitochondrial nitrosative stress, decreased brain-derived neurotrophic factor (BDNF) levels and glutamate uptake, and evidence of endoplasmic reticulum stress in the hippocampus of vitamin A-treated rats. Neurochem Res 2011;36:506-517.
22. Wang Z, Zhang H, Xu X, et al. bFGF inhibits ER stress induced by ischemic oxidative injury via activation of the PI3K/Akt and ERK1/2 pathways. Toxicol Lett 2012;212:137-146.
23. Jameson MJ, Beckler AD, Taniguchi LE, et al. Activation of the insulin-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells. Mol Cancer Ther 2011;10:2124-2134.
24. Echeverria V, Zeitlin R. Cotinine: a potential new therapeutic agent against Alzheimer's disease. CNS Neurosci Ther 2012;18:517-23.
25. Pisanti S, Picardi P, Prota L, et al. Genetic and pharmacologic inactivation of cannabinoid CB1 receptor inhibits angiogenesis. Blood 2011;117:5541-5550.
26. Shimoke K, Kishi S, Utsumi T, et al. NGF-induced phosphatidylinositol 3-kinase signaling pathway prevents thapsigargin-triggered ER stress-mediated apoptosis in PC12 cells. Neurosci Lett 2005;389:124-128.
27. Szegezdi E, Herbert KR, Kavanagh ET, Samali A, Gorman AM. Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim. J Cell Mol Med 2008;12:2482-2496.
28. Xu R, Chen J, Cong X, Hu S, Chen X. Lovastatin protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt and ERK1/2. J Cell Biochem 2008;103:256-269.
29. Cevikbas F, Steinhoff M, Ikoma A. Role of spinal neurotransmitter receptors in itch: new insights into therapies and drug development. CNS Neurosci Ther 2011;17:742-749.
30. Moon YJ, Lee JY, Oh MS, et al. Inhibition of inflammation and oxidative stress by Angelica dahuricae radix extract decreases apoptotic cell death and improves functional recovery after spinal cord injury. J Neurosci Res 2012;90:243-256.
31. Gelfo F, Tirassa P, De Bartolo P, et al. NPY intraperitoneal injections produce antidepressant-like effects and downregulate BDNF in the rat hypothalamus. CNS Neurosci Ther 2012;18:487-492.
32. Zhang L, Ma Z, Smith GM, et al. GDNF-enhanced axonal regeneration and myelination following spinal cord injury is mediated by primary effects on neurons. Glia 2009;57:1178-1191.
33. Appenzeller-Herzog C, Hall MN. Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. Trends Cell Biol 2012;22:274-282.
34. Yamauchi T, Sakurai M, Abe K, Matsumiya G, Sawa Y. Impact of the endoplasmic reticulum stress response in spinal cord after transient ischemia. Brain Res 2007;1169:24-33.
35. Hetz C. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 2012;13:89-102.
36. Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999;96:857-868.
37. Yuan Y, Xue X, Guo RB, et al. Resveratrol Enhances the Antitumor Effects of Temozolomide in Glioblastoma via ROS-dependent AMPK-TSC-mTOR Signaling Pathway. CNS Neurosci Ther 2012;18:536-546.
38. Zhang H, Kong X, Kang J, et al. Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci 2009;110:376-388.
39. Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-241.
40. Roy SK, Srivastava RK, Shankar S. Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal 2010;5:10.
41. Meyer-Franke A, Wilkinson GA, Kruttgen A, et al. Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. Neuron 1998;21:681-693.
42. Yoshii A, Constantine-Paton M. BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation. Nat Neurosci 2007;10:702-711.
43. Nguyen TL, Kim CK, Cho JH, Lee KH, Ahn JY. Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7/IGF-IR [corrected]. Exp Mol Med 2010;42:583-595.
44. Juhaszova M, Zorov DB, Yaniv Y, et al. Role of glycogen synthase kinase-3beta in cardioprotection. Circ Res 2009;104:1240-1252.
45. Miura T, Miki T. GSK-3beta, a therapeutic target for cardiomyocyte protection. Circ J 2009;73:1184-1192.
46. Xia Y, Wang CZ, Liu J, Anastasio NC, Johnson KM. Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways. Neuropharmacology 2010;58:330-336.