PI 3-Kinase/Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at ser10 by KIS and at Thr187 by Cdc25A/Cdk2

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 1, 2011, Pages 417-426

  Lee, Jeong Goo ^a   Kay, Eunduck P ^b  

^a DOHENY EYE INSTITUTE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYCLIN DEPENDENT KINASE 2; FIBROBLAST GROWTH FACTOR 2; GUANOSINE TRIPHOSPHATE; KINASE INTERACTING STATHMIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN CDC25A; PROTEIN P27; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE PHOSPHATASE; RAC1 PROTEIN; SERINE; SMALL INTERFERING RNA; THREONINE; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MITOGEN ACTIVATED PROTEIN KINASE; STATHMIN;

ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENETIC TRANSFECTION; IMMUNOBLOTTING; MOLECULAR MECHANICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; RABBIT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CDC25 PHOSPHATASES; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOTHELIUM, CORNEAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLAST GROWTH FACTOR 2; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; RABBITS; RAC1 GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; SERINE; STATHMIN; THREONINE; TRANSFECTION;

EID: 79952260445     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6140     Document Type: Article

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