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Volumn 32, Issue , 2017, Pages 49-55

Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MODULATOR; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 4; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR 7; METABOTROPIC RECEPTOR AGONIST; ORTHOSTERIC AGONIST; UNCLASSIFIED DRUG;

EID: 84994761123     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2016.10.007     Document Type: Review
Times cited : (12)

References (49)
  • 1
    • 84888040704 scopus 로고    scopus 로고
    • Development of allosteric modulators of GPCRs for treatment of CNS disorders
    • 1 Nickols, H.H., Conn, P.J., Development of allosteric modulators of GPCRs for treatment of CNS disorders. Neurobiol Dis 61 (2014), 55–71.
    • (2014) Neurobiol Dis , vol.61 , pp. 55-71
    • Nickols, H.H.1    Conn, P.J.2
  • 2
    • 84979246804 scopus 로고    scopus 로고
    • Neurobiological insights from mGlu receptor allosteric modulation
    • 2 O'Brien, D.E., Conn, P.J., Neurobiological insights from mGlu receptor allosteric modulation. Int J Neuropsychopharmacol, 19, 2016, pyv133.
    • (2016) Int J Neuropsychopharmacol , vol.19 , pp. pyv133
    • O'Brien, D.E.1    Conn, P.J.2
  • 3
    • 84974602761 scopus 로고    scopus 로고
    • Practical strategies and concepts in GPCR allosteric modulator discovery: recent advances with metabotropic glutamate receptors
    • An excellent review of advanced aspects of mGlu signaling and the development of subtype-specific allosteric ligands.
    • 3• Lindsley, C.W., Emmitte, K.A., Hopkins, C.R., Bridges, T.M., Gregory, K.J., Niswender, C.M., Conn, P.J., Practical strategies and concepts in GPCR allosteric modulator discovery: recent advances with metabotropic glutamate receptors. Chem Rev 116 (2016), 6707–6741 An excellent review of advanced aspects of mGlu signaling and the development of subtype-specific allosteric ligands.
    • (2016) Chem Rev , vol.116 , pp. 6707-6741
    • Lindsley, C.W.1    Emmitte, K.A.2    Hopkins, C.R.3    Bridges, T.M.4    Gregory, K.J.5    Niswender, C.M.6    Conn, P.J.7
  • 4
    • 84906827756 scopus 로고    scopus 로고
    • Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders
    • 4 Conn, P.J., Lindsley, C.W., Meiler, J., Niswender, C.M., Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders. Nat Rev Drug Discov 13 (2014), 692–708.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 692-708
    • Conn, P.J.1    Lindsley, C.W.2    Meiler, J.3    Niswender, C.M.4
  • 5
    • 84875227396 scopus 로고    scopus 로고
    • Signalling bias in new drug discovery: detection, quantification and therapeutic impact
    • 5 Kenakin, T., Christopoulos, A., Signalling bias in new drug discovery: detection, quantification and therapeutic impact. Nat Rev Drug Discov 12 (2013), 205–216.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 205-216
    • Kenakin, T.1    Christopoulos, A.2
  • 6
    • 84994766337 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias
    • 6 Sengmany, K., Gregory, K.J., Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias. Br J Pharmacol, 2015.
    • (2015) Br J Pharmacol
    • Sengmany, K.1    Gregory, K.J.2
  • 9
    • 84918494690 scopus 로고    scopus 로고
    • Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7
    • 9 Jalan-Sakrikar, N., Field, J.R., Klar, R., Mattmann, M.E., Gregory, K.J., Zamorano, R., Engers, D.W., Bollinger, S.R., Weaver, C.D., Days, E.L., et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem Neurosci 5 (2014), 1221–1237.
    • (2014) ACS Chem Neurosci , vol.5 , pp. 1221-1237
    • Jalan-Sakrikar, N.1    Field, J.R.2    Klar, R.3    Mattmann, M.E.4    Gregory, K.J.5    Zamorano, R.6    Engers, D.W.7    Bollinger, S.R.8    Weaver, C.D.9    Days, E.L.10
  • 10
    • 84994757273 scopus 로고    scopus 로고
    • Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery
    • Excellent manuscript in which authors defined the effects of mGlu5 PAMs on multiple signaling pathways to rigorously analyse biased allosteric agonism and modulation in recombinant cells and primary neuronal cultures.
    • 10•• Sengmany, K., Singh, J., Stewart, G.D., Conn, P.J., Christopoulos, A., Gregory, K.J., Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery. Neuropharmacology, 2016 Excellent manuscript in which authors defined the effects of mGlu5 PAMs on multiple signaling pathways to rigorously analyse biased allosteric agonism and modulation in recombinant cells and primary neuronal cultures.
    • (2016) Neuropharmacology
    • Sengmany, K.1    Singh, J.2    Stewart, G.D.3    Conn, P.J.4    Christopoulos, A.5    Gregory, K.J.6
  • 11
    • 84874540963 scopus 로고    scopus 로고
    • Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity
    • Authors demonstrated the antipsychotic properties of a biased mGlu5 PAM and showed for the first time that mGlu5 PAM antipsychotic efficacy does not require potentiation of NMDA currents.
    • 11•• Rook, J.M., Noetzel, M.J., Pouliot, W.A., Bridges, T.M., Vinson, P.N., Cho, H.P., Zhou, Y., Gogliotti, R.D., Manka, J.T., Gregory, K.J., et al. Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity. Biol Psychiatry 73 (2013), 501–509 Authors demonstrated the antipsychotic properties of a biased mGlu5 PAM and showed for the first time that mGlu5 PAM antipsychotic efficacy does not require potentiation of NMDA currents.
    • (2013) Biol Psychiatry , vol.73 , pp. 501-509
    • Rook, J.M.1    Noetzel, M.J.2    Pouliot, W.A.3    Bridges, T.M.4    Vinson, P.N.5    Cho, H.P.6    Zhou, Y.7    Gogliotti, R.D.8    Manka, J.T.9    Gregory, K.J.10
  • 12
    • 84886019044 scopus 로고    scopus 로고
    • N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement
    • 12 Gregory, K.J., Herman, E.J., Ramsey, A.J., Hammond, A.S., Byun, N.E., Stauffer, S.R., Manka, J.T., Jadhav, S., Bridges, T.M., Weaver, C.D., et al. N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement. J Pharmacol Exp Ther 347 (2013), 438–457.
    • (2013) J Pharmacol Exp Ther , vol.347 , pp. 438-457
    • Gregory, K.J.1    Herman, E.J.2    Ramsey, A.J.3    Hammond, A.S.4    Byun, N.E.5    Stauffer, S.R.6    Manka, J.T.7    Jadhav, S.8    Bridges, T.M.9    Weaver, C.D.10
  • 13
  • 14
    • 27744558560 scopus 로고    scopus 로고
    • Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes
    • 14 Zhang, Y., Rodriguez, A.L., Conn, P.J., Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes. J Pharmacol Exp Ther 315 (2005), 1212–1219.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 1212-1219
    • Zhang, Y.1    Rodriguez, A.L.2    Conn, P.J.3
  • 15
    • 84867831749 scopus 로고    scopus 로고
    • Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships
    • 15 Gregory, K.J., Noetzel, M.J., Rook, J.M., Vinson, P.N., Stauffer, S.R., Rodriguez, A.L., Emmitte, K.A., Zhou, Y., Chun, A.C., Felts, A.S., et al. Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships. Mol Pharmacol 82 (2012), 860–875.
    • (2012) Mol Pharmacol , vol.82 , pp. 860-875
    • Gregory, K.J.1    Noetzel, M.J.2    Rook, J.M.3    Vinson, P.N.4    Stauffer, S.R.5    Rodriguez, A.L.6    Emmitte, K.A.7    Zhou, Y.8    Chun, A.C.9    Felts, A.S.10
  • 17
    • 84875416160 scopus 로고    scopus 로고
    • A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling
    • 17 Noetzel, M.J., Gregory, K.J., Vinson, P.N., Manka, J.T., Stauffer, S.R., Lindsley, C.W., Niswender, C.M., Xiang, Z., Conn, P.J., A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling. Mol Pharmacol 83 (2013), 835–847.
    • (2013) Mol Pharmacol , vol.83 , pp. 835-847
    • Noetzel, M.J.1    Gregory, K.J.2    Vinson, P.N.3    Manka, J.T.4    Stauffer, S.R.5    Lindsley, C.W.6    Niswender, C.M.7    Xiang, Z.8    Conn, P.J.9
  • 19
    • 84865263040 scopus 로고    scopus 로고
    • Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers
    • 19 Kammermeier, P.J., Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers. Mol Pharmacol 82 (2012), 438–447.
    • (2012) Mol Pharmacol , vol.82 , pp. 438-447
    • Kammermeier, P.J.1
  • 22
    • 84945359287 scopus 로고    scopus 로고
    • Development of novel, CNS penetrant positive allosteric modulators for the metabotropic glutamate receptor subtype 1 (mGlu1), based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide scaffold, that potentiate wild type and mutant mGlu1 receptors found in schizophrenics
    • 22 Garcia-Barrantes, P.M., Cho, H.P., Niswender, C.M., Byers, F.W., Locuson, C.W., Blobaum, A.L., Xiang, Z., Rook, J.M., Conn, P.J., Lindsley, C.W., Development of novel, CNS penetrant positive allosteric modulators for the metabotropic glutamate receptor subtype 1 (mGlu1), based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide scaffold, that potentiate wild type and mutant mGlu1 receptors found in schizophrenics. J Med Chem 58 (2015), 7959–7971.
    • (2015) J Med Chem , vol.58 , pp. 7959-7971
    • Garcia-Barrantes, P.M.1    Cho, H.P.2    Niswender, C.M.3    Byers, F.W.4    Locuson, C.W.5    Blobaum, A.L.6    Xiang, Z.7    Rook, J.M.8    Conn, P.J.9    Lindsley, C.W.10
  • 25
    • 27144537834 scopus 로고    scopus 로고
    • Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity
    • 25 Porter, R.H., Jaeschke, G., Spooren, W., Ballard, T.M., Buttelmann, B., Kolczewski, S., Peters, J.U., Prinssen, E., Wichmann, J., Vieira, E., et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther 315 (2005), 711–721.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 711-721
    • Porter, R.H.1    Jaeschke, G.2    Spooren, W.3    Ballard, T.M.4    Buttelmann, B.5    Kolczewski, S.6    Peters, J.U.7    Prinssen, E.8    Wichmann, J.9    Vieira, E.10
  • 26
    • 5544228283 scopus 로고    scopus 로고
    • The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats
    • 26 Campbell, U.C., Lalwani, K., Hernandez, L., Kinney, G.G., Conn, P.J., Bristow, L.J., The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats. Psychopharmacology (Berl) 175 (2004), 310–318.
    • (2004) Psychopharmacology (Berl) , vol.175 , pp. 310-318
    • Campbell, U.C.1    Lalwani, K.2    Hernandez, L.3    Kinney, G.G.4    Conn, P.J.5    Bristow, L.J.6
  • 27
    • 78649919580 scopus 로고    scopus 로고
    • Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity
    • 27 Rodriguez, A.L., Grier, M.D., Jones, C.K., Herman, E.J., Kane, A.S., Smith, R.L., Williams, R., Zhou, Y., Marlo, J.E., Days, E.L., et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol 78 (2010), 1105–1123.
    • (2010) Mol Pharmacol , vol.78 , pp. 1105-1123
    • Rodriguez, A.L.1    Grier, M.D.2    Jones, C.K.3    Herman, E.J.4    Kane, A.S.5    Smith, R.L.6    Williams, R.7    Zhou, Y.8    Marlo, J.E.9    Days, E.L.10
  • 30
    • 84921026192 scopus 로고    scopus 로고
    • Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors
    • 30 Copeland, C.S., Neale, S.A., Salt, T.E., Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors. Neuropharmacology 92 (2015), 16–24.
    • (2015) Neuropharmacology , vol.92 , pp. 16-24
    • Copeland, C.S.1    Neale, S.A.2    Salt, T.E.3
  • 31
    • 84921782484 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction
    • 31 Walker, A.G., Wenthur, C.J., Xiang, Z., Rook, J.M., Emmitte, K.A., Niswender, C.M., Lindsley, C.W., Conn, P.J., Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction. Proc Natl Acad Sci U S A 112 (2015), 1196–1201.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 1196-1201
    • Walker, A.G.1    Wenthur, C.J.2    Xiang, Z.3    Rook, J.M.4    Emmitte, K.A.5    Niswender, C.M.6    Lindsley, C.W.7    Conn, P.J.8
  • 32
    • 84933678040 scopus 로고    scopus 로고
    • Development of thalamocortical connections between the mediodorsal thalamus and the prefrontal cortex and its implication in cognition
    • 32 Ferguson, B.R., Gao, W.J., Development of thalamocortical connections between the mediodorsal thalamus and the prefrontal cortex and its implication in cognition. Front Hum Neurosci, 8, 2014, 1027.
    • (2014) Front Hum Neurosci , vol.8 , pp. 1027
    • Ferguson, B.R.1    Gao, W.J.2
  • 33
    • 84901269216 scopus 로고    scopus 로고
    • Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence
    • 33 Dhanya, R.P., Sheffler, D.J., Dahl, R., Davis, M., Lee, P.S., Yang, L., Nickols, H.H., Cho, H.P., Smith, L.H., D'Souza, M.S., et al. Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence. J Med Chem 57 (2014), 4154–4172.
    • (2014) J Med Chem , vol.57 , pp. 4154-4172
    • Dhanya, R.P.1    Sheffler, D.J.2    Dahl, R.3    Davis, M.4    Lee, P.S.5    Yang, L.6    Nickols, H.H.7    Cho, H.P.8    Smith, L.H.9    D'Souza, M.S.10
  • 35
    • 84941026458 scopus 로고    scopus 로고
    • The novel metabotropic glutamate receptor 2 positive allosteric modulator, AZD8529, decreases nicotine self-administration and relapse in squirrel monkeys
    • 35 Justinova, Z., Panlilio, L.V., Secci, M.E., Redhi, G.H., Schindler, C.W., Cross, A.J., Mrzljak, L., Medd, A., Shaham, Y., Goldberg, S.R., The novel metabotropic glutamate receptor 2 positive allosteric modulator, AZD8529, decreases nicotine self-administration and relapse in squirrel monkeys. Biol Psychiatry 78 (2015), 452–462.
    • (2015) Biol Psychiatry , vol.78 , pp. 452-462
    • Justinova, Z.1    Panlilio, L.V.2    Secci, M.E.3    Redhi, G.H.4    Schindler, C.W.5    Cross, A.J.6    Mrzljak, L.7    Medd, A.8    Shaham, Y.9    Goldberg, S.R.10
  • 36
    • 84957954822 scopus 로고    scopus 로고
    • Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats
    • 36 Li, X., D'Souza, M.S., Nino, A.M., Doherty, J., Cross, A., Markou, A., Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats. Psychopharmacology (Berl) 233 (2016), 1801–1814.
    • (2016) Psychopharmacology (Berl) , vol.233 , pp. 1801-1814
    • Li, X.1    D'Souza, M.S.2    Nino, A.M.3    Doherty, J.4    Cross, A.5    Markou, A.6
  • 37
    • 84941100399 scopus 로고    scopus 로고
    • Effect of the novel positive allosteric modulator of metabotropic glutamate receptor 2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence in a rat model
    • 37 Caprioli, D., Venniro, M., Zeric, T., Li, X., Adhikary, S., Madangopal, R., Marchant, N.J., Lucantonio, F., Schoenbaum, G., Bossert, J.M., et al. Effect of the novel positive allosteric modulator of metabotropic glutamate receptor 2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence in a rat model. Biol Psychiatry 78 (2015), 463–473.
    • (2015) Biol Psychiatry , vol.78 , pp. 463-473
    • Caprioli, D.1    Venniro, M.2    Zeric, T.3    Li, X.4    Adhikary, S.5    Madangopal, R.6    Marchant, N.J.7    Lucantonio, F.8    Schoenbaum, G.9    Bossert, J.M.10
  • 38
    • 33746233386 scopus 로고    scopus 로고
    • Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • 38 Battaglia, G., Busceti, C.L., Molinaro, G., Biagioni, F., Traficante, A., Nicoletti, F., Bruno, V., Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Neurosci 26 (2006), 7222–7229.
    • (2006) J Neurosci , vol.26 , pp. 7222-7229
    • Battaglia, G.1    Busceti, C.L.2    Molinaro, G.3    Biagioni, F.4    Traficante, A.5    Nicoletti, F.6    Bruno, V.7
  • 40
    • 84949591462 scopus 로고    scopus 로고
    • Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: in vitro and in vivo studies
    • 40 Domin, H., Przykaza, L., Jantas, D., Kozniewska, E., Boguszewski, P.M., Smialowska, M., Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: in vitro and in vivo studies. Neuropharmacology 102 (2016), 276–294.
    • (2016) Neuropharmacology , vol.102 , pp. 276-294
    • Domin, H.1    Przykaza, L.2    Jantas, D.3    Kozniewska, E.4    Boguszewski, P.M.5    Smialowska, M.6
  • 41
    • 84928795485 scopus 로고    scopus 로고
    • Neuroprotective effects of the allosteric agonist of metabotropic glutamate receptor 7 AMN082 on oxygen-glucose deprivation- and kainate-induced neuronal cell death
    • 41 Domin, H., Jantas, D., Smialowska, M., Neuroprotective effects of the allosteric agonist of metabotropic glutamate receptor 7 AMN082 on oxygen-glucose deprivation- and kainate-induced neuronal cell death. Neurochem Int 88 (2015), 110–123.
    • (2015) Neurochem Int , vol.88 , pp. 110-123
    • Domin, H.1    Jantas, D.2    Smialowska, M.3
  • 42
    • 29444435620 scopus 로고    scopus 로고
    • A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo
    • 42 Mitsukawa, K., Yamamoto, R., Ofner, S., Nozulak, J., Pescott, O., Lukic, S., Stoehr, N., Mombereau, C., Kuhn, R., McAllister, K.H., et al. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. PNAS 102 (2005), 18712–18717.
    • (2005) PNAS , vol.102 , pp. 18712-18717
    • Mitsukawa, K.1    Yamamoto, R.2    Ofner, S.3    Nozulak, J.4    Pescott, O.5    Lukic, S.6    Stoehr, N.7    Mombereau, C.8    Kuhn, R.9    McAllister, K.H.10
  • 43
    • 84929380172 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus
    • An elegant manuscript using a combination of optogenetic and pharmacological techniques to show that mGlu7 receptor activation disinhibits interneurons and enhances LTP at hippocampal synapses.
    • 43•• Klar, R., Walker, A.G., Ghose, D., Grueter, B.A., Engers, D.W., Hopkins, C.R., Lindsley, C.W., Xiang, Z., Conn, P.J., Niswender, C.M., Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus. J Neurosci 35 (2015), 7600–7615 An elegant manuscript using a combination of optogenetic and pharmacological techniques to show that mGlu7 receptor activation disinhibits interneurons and enhances LTP at hippocampal synapses.
    • (2015) J Neurosci , vol.35 , pp. 7600-7615
    • Klar, R.1    Walker, A.G.2    Ghose, D.3    Grueter, B.A.4    Engers, D.W.5    Hopkins, C.R.6    Lindsley, C.W.7    Xiang, Z.8    Conn, P.J.9    Niswender, C.M.10
  • 46
    • 84934775969 scopus 로고    scopus 로고
    • MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice
    • 46 Palazzo, E., Romano, R., Luongo, L., Boccella, S., De Gregorio, D., Giordano, M.E., Rossi, F., Marabese, I., Scafuro, M.A., de Novellis, V., et al. MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. Pain 156 (2015), 1060–1073.
    • (2015) Pain , vol.156 , pp. 1060-1073
    • Palazzo, E.1    Romano, R.2    Luongo, L.3    Boccella, S.4    De Gregorio, D.5    Giordano, M.E.6    Rossi, F.7    Marabese, I.8    Scafuro, M.A.9    de Novellis, V.10
  • 47
    • 84927539538 scopus 로고    scopus 로고
    • Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain
    • 47 Moloney, R.D., Golubeva, A.V., O'Connor, R.M., Kalinichev, M., Dinan, T.G., Cryan, J.F., Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain. Neurobiol Stress 2 (2015), 28–33.
    • (2015) Neurobiol Stress , vol.2 , pp. 28-33
    • Moloney, R.D.1    Golubeva, A.V.2    O'Connor, R.M.3    Kalinichev, M.4    Dinan, T.G.5    Cryan, J.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.