VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy

The Journal of pharmacology and experimental therapeutics

Volumn 356, Issue 1, 2016, Pages 123-136

  Nickols, Hilary Highfield ^a   Yuh, Joannes P ^a   Gregory, Karen J ^a   Morrison, Ryan D ^a   Bates, Brittney S ^a   Stauffer, Shaun R ^a   Emmitte, Kyle A ^a   Bubser, Michael ^a   Peng, Weimin ^a   Nedelcovych, Michael T ^a   Thompson, Analisa ^a   Lv, Xiaohui ^a   Xiang, Zixiu ^a   Daniels, J Scott ^a   Niswender, Colleen M ^a   Lindsley, Craig W ^a   Jones, Carrie K ^a   Conn, P Jeffrey ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 6-METHYL-2-(PHENYLETHYNYL)PYRIDINE; ANXIOLYTIC AGENT; INOSITOL PHOSPHATE; METABOTROPIC RECEPTOR 5; N,N-DIETHYL-5-((3-FLUOROPHENYL)ETHYNYL)PICOLINAMIDE; PICOLINIC ACID DERIVATIVE; PYRIDINE DERIVATIVE;

ALLOSTERISM; ANIMAL; ANIMAL BEHAVIOR; ASTROCYTE; BRAIN; C57BL MOUSE; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; HEK293 CELL LINE; HUMAN; MEMBRANE POTENTIAL; METABOLISM; MOUSE; RADIOASSAY; RAT; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

ALLOSTERIC REGULATION; ANIMALS; ANTI-ANXIETY AGENTS; ASTROCYTES; BEHAVIOR, ANIMAL; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; GABA AGONISTS; HEK293 CELLS; HUMANS; INOSITOL PHOSPHATES; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; PICOLINIC ACIDS; PYRIDINES; RADIOLIGAND ASSAY; RATS; RECEPTOR, METABOTROPIC GLUTAMATE 5; SYNAPTIC TRANSMISSION;

EID: 84964560415     PISSN: None     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.115.226597     Document Type: Article

References (0)