-
1
-
-
0027361175
-
Mechanisms underlying developmental changes in the expression of metabotropic glutamate receptors in cultured cerebellar granule cells: Homologous desensitization and interactive effects involving N-methyl-D- aspartate receptors
-
E. Aronica, P. Dell'Albani, D.F. Condorelli, F. Nicoletti, N. Hack, and R. Balázs Mechanisms underlying developmental changes in the expression of metabotropic glutamate receptors in cultured cerebellar granule cells: homologous desensitization and interactive effects involving N-methyl-D-aspartate receptors Mol. Pharmacol 44 1993 981 989 (Pubitemid 23344964)
-
(1993)
Molecular Pharmacology
, vol.44
, Issue.5
, pp. 981-989
-
-
Aronica, E.1
Dell'Albani, P.2
Condorelli, D.F.3
Nicoletti, F.4
Hack, N.5
Balazs, R.6
-
2
-
-
0031020921
-
Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: Effects of pretreatment with saline or diazepam
-
DOI 10.1016/S0306-4522(96)00435-6, PII S0306452296004356
-
J. Bagley, and B. Moghaddam Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: effects of pretreatment with saline or diazepam Neuroscience 77 1997 65 73 (Pubitemid 27060307)
-
(1997)
Neuroscience
, vol.77
, Issue.1
, pp. 65-73
-
-
Bagley, J.1
Moghaddam, B.2
-
3
-
-
33749245129
-
Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory
-
DOI 10.1016/j.neuroscience.2006.06.043, PII S0306452206008815
-
D. Balschun, W. Zuschratter, and W. Wetzel Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory Neuroscience 142 2006 691 702 (Pubitemid 44485913)
-
(2006)
Neuroscience
, vol.142
, Issue.3
, pp. 691-702
-
-
Balschun, D.1
Zuschratter, W.2
Wetzel, W.3
-
4
-
-
52549089917
-
Mechanisms of synaptic depression triggered by metabotropic glutamate receptors
-
C. Bellone, C. Luscher, and M. Mameli Mechanisms of synaptic depression triggered by metabotropic glutamate receptors Cell. Mol. Life Sci. 65 2008 2913 2923
-
(2008)
Cell. Mol. Life Sci.
, vol.65
, pp. 2913-2923
-
-
Bellone, C.1
Luscher, C.2
Mameli, M.3
-
5
-
-
0032005315
-
Seizures and neuronal damage induced in the rat by activation of group I metabotropic glutamate receptors with their selective agonist 3,5- dihydroxyphenylglycine
-
DOI 10.1002/(SICI)1097-4547(19980201)51:3<339::AID-JNR7>3.0.CO;2-H
-
L. Camon, P. Vives, N. de Vera, and E. Martinez Seizures and neuronal damage induced in the rat by activation of group I metabotropic glutamate receptors with their selective agonist 3,5-dihydroxyphenylglycine J. Neurosci. Res. 51 1998 339 348 (Pubitemid 28078465)
-
(1998)
Journal of Neuroscience Research
, vol.51
, Issue.3
, pp. 339-348
-
-
Camon, L.1
Vives, P.2
De Vera, N.3
Martinez, E.4
-
6
-
-
43049118188
-
Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice
-
M.H. Chan, P.H. Chiu, J.H. Sou, and H.H. Chen Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice Psychopharmacology (Berl.) 198 2008 141 148
-
(2008)
Psychopharmacology (Berl.)
, vol.198
, pp. 141-148
-
-
Chan, M.H.1
Chiu, P.H.2
Sou, J.H.3
Chen, H.H.4
-
7
-
-
34247477329
-
Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses
-
DOI 10.1124/mol.106.032425
-
Y. Chen, Y. Nong, C. Goudet, K. Hemstapat, T. de Paulis, J.P. Pin, and P.J. Conn Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses Mol. Pharmacol 71 2007 1389 1398 (Pubitemid 46661543)
-
(2007)
Molecular Pharmacology
, vol.71
, Issue.5
, pp. 1389-1398
-
-
Chen, Y.1
Nong, Y.2
Goudet, C.3
Hemstapat, K.4
De Paulis, T.5
Pin, J.-P.6
Conn, P.J.7
-
8
-
-
0036490942
-
Allosteric binding sites on cell-surface receptors: Novel targets for drug discovery
-
A. Christopoulos Allosteric binding sites on cell-surface receptors: novel targets for drug discovery Nat. Rev. Drug Discov. 1 2002 198 210 (Pubitemid 37361423)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.3
, pp. 198-210
-
-
Christopoulos, A.1
-
9
-
-
43449131567
-
Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm
-
DOI 10.1097/FBP.0b013e3282feb0ac, PII 0000887720080500000007
-
J.M. Darrah, M.R. Stefani, and B. Moghaddam Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm Behav. Pharmacol. 19 2008 225 234 (Pubitemid 351670403)
-
(2008)
Behavioural Pharmacology
, vol.19
, Issue.3
, pp. 225-234
-
-
Darrah, J.M.1
Stefani, M.R.2
Moghaddam, B.3
-
10
-
-
37049032616
-
Correction of Fragile X Syndrome in Mice
-
DOI 10.1016/j.neuron.2007.12.001, PII S0896627307009646
-
G. Dölen, E. Osterweil, B.S. Rao, G.B. Smith, B.D. Auerbach, S. Chattarji, and M.F. Bear Correction of fragile X syndrome in mice Neuron 56 2007 955 962 (Pubitemid 350251119)
-
(2007)
Neuron
, vol.56
, Issue.6
, pp. 955-962
-
-
Dolen, G.1
Osterweil, E.2
Rao, B.S.S.3
Smith, G.B.4
Auerbach, B.D.5
Chattarji, S.6
Bear, M.F.7
-
11
-
-
4444361472
-
The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region
-
DOI 10.1016/j.brainres.2004.06.060, PII S000689930401042X
-
W. Francesconi, M. Cammalleri, and P.P. Sanna The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region Brain Res. 1022 2004 12 18 (Pubitemid 39194979)
-
(2004)
Brain Research
, vol.1022
, Issue.1-2
, pp. 12-18
-
-
Francesconi, W.1
Cammalleri, M.2
Sanna, P.P.3
-
12
-
-
0031932286
-
Role of protein kinase C phosphorylation in rapid desensitization of metabotropic glutamate receptor 5
-
DOI 10.1016/S0896-6273(00)80442-0
-
R.W. Gereau 4th, and S.F. Heinemann Role of protein kinase C phosphorylation in rapid desensitization of metabotropic glutamate receptor 5 Neuron 20 1998 143 151 (Pubitemid 28078357)
-
(1998)
Neuron
, vol.20
, Issue.1
, pp. 143-151
-
-
Gereau IV, R.W.1
Heinemann, S.F.2
-
13
-
-
73449137227
-
Metabotropic glutamate receptor-mediated long-term depression: Molecular mechanisms
-
C.M. Gladding, S.M. Fitzjohn, and E. Molnar Metabotropic glutamate receptor-mediated long-term depression: molecular mechanisms Pharmacol. Rev. 61 2009 395 412
-
(2009)
Pharmacol. Rev.
, vol.61
, pp. 395-412
-
-
Gladding, C.M.1
Fitzjohn, S.M.2
Molnar, E.3
-
14
-
-
0029658545
-
Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia
-
U. Heresco-Levy, D.C. Javitt, M. Ermilov, C. Mordel, A. Horowitz, and D. Kelly Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia Br. J. Psychiatry 169 1996 610 617
-
(1996)
Br. J. Psychiatry
, vol.169
, pp. 610-617
-
-
Heresco-Levy, U.1
Javitt, D.C.2
Ermilov, M.3
Mordel, C.4
Horowitz, A.5
Kelly, D.6
-
15
-
-
0036184549
-
Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia
-
DOI 10.1176/appi.ajp.159.3.480
-
U. Heresco-Levy, M. Ermilov, J. Shimoni, B. Shapira, G. Silipo, and D.C. Javitt Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia American J. Psychiatry 159 2002 480 482 (Pubitemid 34184748)
-
(2002)
American Journal of Psychiatry
, vol.159
, Issue.3
, pp. 480-482
-
-
Heresco-Levy, U.1
Ermilov, M.2
Shimoni, J.3
Shapira, B.4
Silipo, G.5
Javitt, D.C.6
-
16
-
-
0032925438
-
Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia
-
DOI 10.1001/archpsyc.56.1.29
-
U. Heresco-Levy, D.C. Javitt, M. Ermilov, C. Mordel, G. Silipo, and M. Lichtenstein Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia Arch. Gen. Psychiatry 56 1999 29 36 (Pubitemid 29055047)
-
(1999)
Archives of General Psychiatry
, vol.56
, Issue.1
, pp. 29-36
-
-
Heresco-Levy, U.1
Javitt, D.C.2
Ermilov, M.3
Mordel, C.4
Silipo, G.5
Lichtenstein, M.6
-
17
-
-
0035504328
-
Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: Prototypic family C G-protein-coupled receptors
-
DOI 10.1042/0264-6021:3590465
-
E. Hermans, and R.A. Challiss Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors Biochem. J. 359 2001 465 484 (Pubitemid 33063371)
-
(2001)
Biochemical Journal
, vol.359
, Issue.3
, pp. 465-484
-
-
Hermans, E.1
Challiss, R.A.J.2
-
18
-
-
0026614196
-
3,5-Dihydroxyphenyl-glycine: A potent agonist of metabotropic glutamate receptors
-
I. Ito, A. Kohda, S. Tanabe, E. Hirose, M. Hayashi, S. Mitsunaga, and H. Sugiyama 3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors Neuroreport 3 1992 1013 1016
-
(1992)
Neuroreport
, vol.3
, pp. 1013-1016
-
-
Ito, I.1
Kohda, A.2
Tanabe, S.3
Hirose, E.4
Hayashi, M.5
Mitsunaga, S.6
Sugiyama, H.7
-
19
-
-
0023082787
-
Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia
-
D.C. Javitt Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia Hillside J. Clinic. Psychiatry 9 1987 12 35
-
(1987)
Hillside J. Clinic. Psychiatry
, vol.9
, pp. 12-35
-
-
Javitt, D.C.1
-
20
-
-
0032457339
-
Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5
-
Z. Jia, Y. Lu, J. Henderson, F. Taverna, C. Romano, W. Abramow-Newerly, J.M. Wojtowicz, and J. Roder Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5 Learn. Mem. 5 1998 331 343 (Pubitemid 29115263)
-
(1998)
Learning and Memory
, vol.5
, Issue.4-5
, pp. 331-343
-
-
Jia, Z.1
Lu, Y.2
Henderson, J.3
Taverna, F.4
Romano, C.5
Abramow-Newerly, W.6
Wojtowicz, J.M.7
Roder, J.8
-
21
-
-
0037665283
-
Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents
-
DOI 10.1124/jpet.103.048702
-
G.G. Kinney, M. Burno, U.C. Campbell, L.M. Hernandez, D. Rodriguez, L.J. Bristow, and P.J. Conn Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents J. Pharmacol. Exp. Ther. 306 2003 116 123 (Pubitemid 36734364)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.306
, Issue.1
, pp. 116-123
-
-
Kinney, G.G.1
Burno, M.2
Campbell, U.C.3
Hernandez, L.M.4
Rodriguez, D.5
Bristow, L.J.6
Conn, P.J.7
-
22
-
-
20144381462
-
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models
-
DOI 10.1124/jpet.104.079244
-
G.G. Kinney, J.A. O'Brien, W. Lemaire, M. Burno, D.J. Bickel, M.K. Clements, T.B. Chen, D.D. Wisnoski, C.W. Lindsley, P.R. Tiller, S. Smith, M.A. Jacobson, C. Sur, M.E. Duggan, D.J. Pettibone, P.J. Conn, and D.L. Williams Jr. A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models J. Pharmacol. Exp. Ther. 313 2005 199 206 (Pubitemid 40411343)
-
(2005)
Journal of Pharmacology and Experimental Therapeutics
, vol.313
, Issue.1
, pp. 199-206
-
-
Kinney, G.G.1
O'Brien, J.A.2
Lemaire, W.3
Burno, M.4
Bickel, D.J.5
Clements, M.K.6
Chen, T.-B.7
Wisnoski, D.D.8
Lindsley, C.W.9
Tiller, P.R.10
Smith, S.11
Jacobson, M.A.12
Sur, C.13
Duggan, M.E.14
Pettibone, D.J.15
Conn, P.J.16
Williams Jr., D.L.17
-
23
-
-
0028323167
-
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses
-
J.H. Krystal, L.P. Karper, J.P. Seibyl, G.K. Freeman, R. Delaney, J.D. Bremner, G.R. Heninger, M.B. Bowers Jr., and D.S. Charney Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses Arch. Gen. Psychiatry 51 1994 199 214 (Pubitemid 24081509)
-
(1994)
Archives of General Psychiatry
, vol.51
, Issue.3
, pp. 199-214
-
-
Krystal, J.H.1
Karper, L.P.2
Seibyl, J.P.3
Freeman, G.K.4
Delaney, R.5
Bremner, J.D.6
Heninger, G.R.7
Bowers Jr., M.B.8
Charney, D.S.9
-
24
-
-
0034851624
-
Effects of ketamine in normal and schizophrenic volunteers
-
DOI 10.1016/S0893-133X(01)00243-3, PII S0893133X01002433
-
A.C. Lahti, M.A. Weiler, B.A. Tamara Michaelidis, A. Parwani, and C.A. Tamminga Effects of ketamine in normal and schizophrenic volunteers Neuropsychopharmacology 25 2001 455 467 (Pubitemid 32830950)
-
(2001)
Neuropsychopharmacology
, vol.25
, Issue.4
, pp. 455-467
-
-
Lahti, A.C.1
Weiler, M.A.2
Michaelidis, T.3
Parwani, A.4
Tamminga, C.A.5
-
25
-
-
8644252687
-
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H-pyrazol-5-yl) benzamides that potentiate receptor function in vivo
-
DOI 10.1021/jm049400d
-
C.W. Lindsley, D.D. Wisnoski, W.H. Leister, J.A. O'Brien, W. Lemaire, D.L. Williams Jr., M. Burno, C. Sur, G.G. Kinney, D.J. Pettibone, P.R. Tiller, S. Smith, M.E. Duggan, G.D. Hartman, P.J. Conn, and J.R. Huff Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo J. Med. Chem. 47 2004 5825 5828 (Pubitemid 39507327)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.24
, pp. 5825-5828
-
-
Lindsley, C.W.1
Wisnoski, D.D.2
Leister, W.H.3
O'Brien, J.A.4
Lemaire, W.5
Williams Jr., D.L.6
Burno, M.7
Sur, C.8
Kinney, G.G.9
Pettibone, D.J.10
Tiller, P.R.11
Smith, S.12
Duggan, M.E.13
Hartman, G.D.14
Conn, P.J.15
Huff, J.R.16
-
26
-
-
57349174038
-
ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol- 5-yl]-piper idin-1-yl}-methanone]: A novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities
-
F. Liu, S. Grauer, C. Kelley, R. Navarra, R. Graf, G. Zhang, P.J. Atkinson, M. Popiolek, C. Wantuch, X. Khawaja, D. Smith, M. Olsen, E. Kouranova, M. Lai, F. Pruthi, C. Pulicicchio, M. Day, A. Gilbert, M.H. Pausch, N.J. Brandon, C.E. Beyer, T.A. Comery, S. Logue, S. Rosenzweig-Lipson, and K.L. Marquis ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol- 5-yl]-piper idin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities J. Pharmacol. Exp. Ther. 327 2008 827 839
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.327
, pp. 827-839
-
-
Liu, F.1
Grauer, S.2
Kelley, C.3
Navarra, R.4
Graf, R.5
Zhang, G.6
Atkinson, P.J.7
Popiolek, M.8
Wantuch, C.9
Khawaja, X.10
Smith, D.11
Olsen, M.12
Kouranova, E.13
Lai, M.14
Pruthi, F.15
Pulicicchio, C.16
Day, M.17
Gilbert, A.18
Pausch, M.H.19
Brandon, N.J.20
Beyer, C.E.21
Comery, T.A.22
Logue, S.23
Rosenzweig-Lipson, S.24
Marquis, K.L.25
more..
-
27
-
-
0029014381
-
Effect of acute stress on hippocampal glutamate levels and spectrin proteolysis in young and aged rats
-
M.T. Lowy, L. Wittenberg, and B.K. Yamamoto Effect of acute stress on hippocampal glutamate levels and spectrin proteolysis in young and aged rats J. Neurochem. 65 1995 268 274
-
(1995)
J. Neurochem.
, vol.65
, pp. 268-274
-
-
Lowy, M.T.1
Wittenberg, L.2
Yamamoto, B.K.3
-
28
-
-
0030954048
-
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
-
Y.M. Lu, Z. Jia, C. Janus, J.T. Henderson, R. Gerlai, J.M. Wojtowicz, and J.C. Roder Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP J. Neurosci. 17 1997 5196 5205 (Pubitemid 27263833)
-
(1997)
Journal of Neuroscience
, vol.17
, Issue.13
, pp. 5196-5205
-
-
Lu, Y.-M.1
Jia, Z.2
Janus, C.3
Henderson, J.T.4
Gerlai, R.5
Wojtowicz, J.M.6
Roder, J.C.7
-
30
-
-
26844466906
-
The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity
-
DOI 10.1093/cercor/bhi047
-
D. Manahan-Vaughan, and K.H. Braunewell The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity. Cereb Cortex 15 2005 1703 1713 (Pubitemid 41447035)
-
(2005)
Cerebral Cortex
, vol.15
, Issue.11
, pp. 1703-1713
-
-
Manahan-Vaughan, D.1
Braunewell, K.-H.2
-
31
-
-
0035882474
-
Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function
-
G. Mannaioni, M.J. Marino, O. Valenti, S.F. Traynelis, and P.J. Conn Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function J. Neurosci. 21 2001 5925 5934 (Pubitemid 32737725)
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.16
, pp. 5925-5934
-
-
Mannaioni, G.1
Marino, M.J.2
Valenti, O.3
Traynelis, S.F.4
Conn, P.J.5
-
32
-
-
84859628864
-
Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice
-
A. Michalon, M. Sidorov, T.M. Ballard, L. Ozmen, W. Spooren, J.G. Wettstein, G. Jaeschke, M.F. Bear, and L. Lindemann1 Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice Neuron 74 2012 49 56
-
(2012)
Neuron
, vol.74
, pp. 49-56
-
-
Michalon, A.1
Sidorov, M.2
Ballard, T.M.3
Ozmen, L.4
Spooren, W.5
Wettstein, J.G.6
Jaeschke, G.7
Bear, M.F.8
Lindemann, L.9
-
33
-
-
49949090270
-
Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings
-
V. Musante, E. Neri, M. Feligioni, A. Puliti, M. Pedrazzi, V. Conti, C. Usai, A. Diaspro, R. Ravazzolo, J.M. Henley, G. Battaglia, and A. Pittaluga Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings Neuropharmacology 55 2008 474 482
-
(2008)
Neuropharmacology
, vol.55
, pp. 474-482
-
-
Musante, V.1
Neri, E.2
Feligioni, M.3
Puliti, A.4
Pedrazzi, M.5
Conti, V.6
Usai, C.7
Diaspro, A.8
Ravazzolo, R.9
Henley, J.M.10
Battaglia, G.11
Pittaluga, A.12
-
34
-
-
77949516412
-
Metabotropic glutamate receptors: Physiology, pharmacology, and disease
-
C.M. Niswender, and P.J. Conn Metabotropic glutamate receptors: physiology, pharmacology, and disease Annu. Rev. Pharmacol. Toxicol. 50 2010 295 322
-
(2010)
Annu. Rev. Pharmacol. Toxicol.
, vol.50
, pp. 295-322
-
-
Niswender, C.M.1
Conn, P.J.2
-
35
-
-
11144354887
-
A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain
-
DOI 10.1124/jpet.103.061747
-
J.A. O'Brien, W. Lemaire, M. Wittmann, M.A. Jacobson, S.N. Ha, D.D. Wisnoski, C.W. Lindsley, H.J. Schaffhauser, B. Rowe, C. Sur, M.E. Duggan, D.J. Pettibone, P.J. Conn, and D.L. Williams Jr. A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain J. Pharmacol. Exp. Ther. 309 2004 568 577 (Pubitemid 38542609)
-
(2004)
Journal of Pharmacology and Experimental Therapeutics
, vol.309
, Issue.2
, pp. 568-577
-
-
O'Brien, J.A.1
Lemaire, W.2
Wittmann, M.3
Jacobson, M.A.4
Ha, S.N.5
Wisnoski, D.D.6
Lindsley, C.W.7
Schaffhauser, H.J.8
Rowe, B.9
Sur, C.10
Duggan, M.E.11
Pettibone, D.J.12
Conn, P.J.13
Williams Jr., D.L.14
-
36
-
-
35848943027
-
18F]F-PEB
-
DOI 10.1016/j.nucmedbio.2007.07.009, PII S0969805107001898
-
S. Patel, T.G. Hamill, B. Connolly, E. Jagoda, W. Li, and R.E. Gibson Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F]F-PEB Nucl. Med. Biol. 34 2007 1009 1017 (Pubitemid 350061172)
-
(2007)
Nuclear Medicine and Biology
, vol.34
, Issue.8
, pp. 1009-1017
-
-
Patel, S.1
Hamill, T.G.2
Connolly, B.3
Jagoda, E.4
Li, W.5
Gibson, R.E.6
-
38
-
-
0036789065
-
Differential regulation of metabotropic glutamate receptor 5-mediated phosphoinositide hydrolysis and extracellular signal-regulated kinase responses by protein kinase C in cultured astrocytes
-
R.D. Peavy, S.D. Sorensen, and P.J. Conn Differential regulation of metabotropic glutamate receptor 5-mediated phosphoinositide hydrolysis and extracellular signal-regulated kinase responses by protein kinase C in cultured astrocytes J. Neurochem. 83 2002 110 118
-
(2002)
J. Neurochem.
, vol.83
, pp. 110-118
-
-
Peavy, R.D.1
Sorensen, S.D.2
Conn, P.J.3
-
39
-
-
0028912822
-
The metabotropic glutamate receptors: Structure and functions
-
J.P. Pin, and R. Duvoisin The metabotropic glutamate receptors: structure and functions Neuropharmacology 34 1995 1 26
-
(1995)
Neuropharmacology
, vol.34
, pp. 1-26
-
-
Pin, J.P.1
Duvoisin, R.2
-
40
-
-
34250015821
-
Acute stress-mediated increases in extracellular glutamate levels in the rat amygdala: Differential effects of antidepressant treatment
-
DOI 10.1111/j.1460-9568.2007.05560.x
-
L.R. Reznikov, C.A. Grillo, G.G. Piroli, R.K. Pasumarthi, L.P. Reagan, and J. Fadel Acute stress-mediated increases in extracellular glutamate levels in the rat amygdala: differential effects of antidepressant treatment Eur. J. Neurosci. 25 2007 3109 3114 (Pubitemid 46888811)
-
(2007)
European Journal of Neuroscience
, vol.25
, Issue.10
, pp. 3109-3114
-
-
Reznikov, L.R.1
Grillo, C.A.2
Piroli, G.G.3
Pasumarthi, R.K.4
Reagan, L.P.5
Fadel, J.6
-
41
-
-
0037452854
-
Glutamate receptor function in learning and memory
-
DOI 10.1016/S0166-4328(02)00272-3, PII S0166432802002723
-
G. Riedel, B. Platt, and J. Micheau Glutamate receptor function in learning and memory Behav. Brain Res. 140 2003 1 47 (Pubitemid 36313239)
-
(2003)
Behavioural Brain Research
, vol.140
, Issue.1-2
, pp. 1-47
-
-
Riedel, G.1
Platt, B.2
Micheau, J.3
-
42
-
-
0029872230
-
Enhanced early developmental expression of the metabotropic glutamate receptor mGluR5 in rat brain: Protein, mRNA splice variants, and regional distribution
-
DOI 10.1002/(SICI)1096-9861(19960408)367:3<403::AID-CNE6>3.0.CO;2-9
-
C. Romano, A.N. van den Pol, and K.L. O'Malley Enhanced early developmental expression of the metabotropic glutamate receptor mGluR5 in rat brain: protein, mRNA splice variants, and regional distribution J. Comp. Neurol. 367 1996 403 412 (Pubitemid 26107127)
-
(1996)
Journal of Comparative Neurology
, vol.367
, Issue.3
, pp. 403-412
-
-
Romano, C.1
Van Den Pol, A.N.2
O'Malley, K.L.3
-
43
-
-
0026513647
-
Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage
-
A.I. Sacaan, and D.D. Schoepp Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage Neurosci. Lett. 139 1992 77 82
-
(1992)
Neurosci. Lett.
, vol.139
, pp. 77-82
-
-
Sacaan, A.I.1
Schoepp, D.D.2
-
44
-
-
77249083031
-
Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia
-
C. Schlumberger, M. Pietraszek, A. Gravius, and W. Danysz Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia Pharmacol. Biochem. Behav. 95 2010 23 30
-
(2010)
Pharmacol. Biochem. Behav.
, vol.95
, pp. 23-30
-
-
Schlumberger, C.1
Pietraszek, M.2
Gravius, A.3
Danysz, W.4
-
45
-
-
33749626310
-
Signal transduction mechanisms in memory disorders
-
S.C. Shalin, R. Egli, S.G. Birnbaum, T.L. Roth, J.M. Levenson, and J.D. Sweatt Signal transduction mechanisms in memory disorders Prog. Brain Res. 157 2006 25 41
-
(2006)
Prog. Brain Res.
, vol.157
, pp. 25-41
-
-
Shalin, S.C.1
Egli, R.2
Birnbaum, S.G.3
Roth, T.L.4
Levenson, J.M.5
Sweatt, J.D.6
-
46
-
-
30444460573
-
The role of metabotropic glutamate receptor 5 in learning and memory processes
-
DOI 10.1358/dnp.2005.18.6.927927
-
A. Simonyi, T.R. Schachtman, and G.R. Christoffersen The role of metabotropic glutamate receptor 5 in learning and memory processes Drug News Perspect. 18 2005 353 361 (Pubitemid 43073869)
-
(2005)
Drug News and Perspectives
, vol.18
, Issue.6
, pp. 353-361
-
-
Simonyi, A.1
Schachtman, T.R.2
Christoffersen, G.R.J.3
-
47
-
-
79955941160
-
Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator
-
N. Spear, R.A. Gadient, D.E. Wilkins, M. Do, J.S. Smith, K.L. Zeller, P. Schroeder, M. Zhang, J. Arora, and V. Chhajlani Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator Eur. J. Pharmacol. 659 2011 146 154
-
(2011)
Eur. J. Pharmacol.
, vol.659
, pp. 146-154
-
-
Spear, N.1
Gadient, R.A.2
Wilkins, D.E.3
Do, M.4
Smith, J.S.5
Zeller, K.L.6
Schroeder, P.7
Zhang, M.8
Arora, J.9
Chhajlani, V.10
-
48
-
-
0032402917
-
Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice
-
DOI 10.1016/S0028-3908(98)00138-5, PII S0028390898001385
-
C. Thomsen, and N.O. Dalby Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice Neuropharmacology 37 1998 1465 1473 (Pubitemid 28550420)
-
(1998)
Neuropharmacology
, vol.37
, Issue.12
, pp. 1465-1473
-
-
Thomsen, C.1
Ole Dalby, N.2
-
49
-
-
0029097032
-
Induction or protection of limbic seizures in mice by mGluR subtype selective agonists
-
J.P. Tizzano, K.I. Griffey, and D.D. Schoepp Induction or protection of limbic seizures in mice by mGluR subtype selective agonists Neuropharmacology 34 1995 1063 1067
-
(1995)
Neuropharmacology
, vol.34
, pp. 1063-1067
-
-
Tizzano, J.P.1
Griffey, K.I.2
Schoepp, D.D.3
-
50
-
-
33747607690
-
Polymorphisms in glycine transporter with schizophrenia
-
S.J. Tsai, C.Y. Cheng, C.J. Hong, D.L. Liao, and Y.J. Liou Polymorphisms in glycine transporter with schizophrenia Neuropsychopharmacol. Hung. 8 2006 17 21
-
(2006)
Neuropsychopharmacol. Hung.
, vol.8
, pp. 17-21
-
-
Tsai, S.J.1
Cheng, C.Y.2
Hong, C.J.3
Liao, D.L.4
Liou, Y.J.5
-
51
-
-
0032403626
-
D-serine added to antipsychotics for the treatment of schizophrenia
-
DOI 10.1016/S0006-3223(98)00279-0, PII S0006322398002790
-
G. Tsai, P. Yang, L.C. Chung, N. Lange, and J.T. Coyle D-serine added to antipsychotics for the treatment of schizophrenia Biol. Psychiatry 44 1998 1081 1089 (Pubitemid 28547143)
-
(1998)
Biological Psychiatry
, vol.44
, Issue.11
, pp. 1081-1089
-
-
Tsai, G.1
Yang, P.2
Chung, L.-C.3
Lange, N.4
Coyle, J.T.5
-
52
-
-
69649104858
-
Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus
-
J.M. Uslaner, S. Parmentier-Batteur, R.B. Flick, N.O. Surles, J.S. Lam, C.H. McNaughton, M.A. Jacobson, and P.H. Hutson Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus Neuropharmacology 57 2009 531 538
-
(2009)
Neuropharmacology
, vol.57
, pp. 531-538
-
-
Uslaner, J.M.1
Parmentier-Batteur, S.2
Flick, R.B.3
Surles, N.O.4
Lam, J.S.5
McNaughton, C.H.6
Jacobson, M.A.7
Hutson, P.H.8
-
53
-
-
0033834545
-
The relationship between audiogenic seizure (AGS) susceptibility and forebrain tone-responsiveness in genetically AGS-prone Wistar rats
-
Antti Valjakka, Marjut Jaakkola, Jukka Vartiainen, Hannu Olkkonen, Antonina Semiokhina, Irina Fedotova, Jussi Virkkala, Jukka Ylikoski, and Leena Tuomisto The relationship between audiogenic seizure (AGS) susceptibility and forebrain tone-responsiveness in genetically AGS-prone Wistar rats Physiol. Behav. 70 2000 297 309
-
(2000)
Physiol. Behav.
, vol.70
, pp. 297-309
-
-
Valjakka, A.1
Jaakkola, M.2
Vartiainen, J.3
Olkkonen, H.4
Semiokhina, A.5
Fedotova, I.6
Virkkala, J.7
Ylikoski, J.8
Tuomisto, L.9
-
54
-
-
76949085425
-
MK-801 produces a deficit in sucrose preference that is reversed by clozapine, D-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: Relevance to negative symptoms associated with schizophrenia?
-
J.D. Vardigan, S.L. Huszar, C.H. McNaughton, P.H. Hutson, and J.M. Uslaner MK-801 produces a deficit in sucrose preference that is reversed by clozapine, D-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: relevance to negative symptoms associated with schizophrenia? Pharmacol. Biochem. Behav. 95 2010 223 229
-
(2010)
Pharmacol. Biochem. Behav.
, vol.95
, pp. 223-229
-
-
Vardigan, J.D.1
Huszar, S.L.2
McNaughton, C.H.3
Hutson, P.H.4
Uslaner, J.M.5
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