Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity

Biological Psychiatry

Volumn 73, Issue 6, 2013, Pages 501-509

  Rook, Jerri M ^a   Noetzel, Meredith J ^a   Pouliot, Wendy A ^b   Bridges, Thomas M ^a   Vinson, Paige N ^a   Cho, Hyekyung P ^a,c   Zhou, Ya ^a   Gogliotti, Rocco D ^a   Manka, Jason T ^a   Gregory, Karen J ^a,d   Stauffer, Shaun R ^a,c   Dudek, F Edward ^b   Xiang, Zixiu ^a   Niswender, Colleen M ^a   Daniels, J Scott ^a   Jones, Carrie K ^a   Lindsley, Craig W ^a,c   Conn, P Jeffrey ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d MONASH UNIVERSITY   (Australia)

Author keywords

Agonist; allosteric modulators; convulsions; glutamate; mGlu5; schizophrenia; seizure

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; GLUTAMIC ACID; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR AGONIST; NEUROLEPTIC AGENT; UNCLASSIFIED DRUG; VU 0361747; VU 0422465; (6-((3-FLUOROPHENYL)ETHYNYL)PYRIDIN-3-YL)(4-HYDROXYPIPERIDIN-1-YL)METHANONE; 5-((3-FLUOROPHENYL)ETHYNYL)-N-(3-HYDROXY-3-METHYLBUTAN-2-YL)PICOLINAMIDE; AMINO ACID RECEPTOR STIMULATING AGENT; NICOTINAMIDE; PICOLINIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BINDING SITE; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; CALCIUM MOBILIZATION; CELL STRAIN HEK293; COGNITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CONVULSION; ELECTROENCEPHALOGRAPHY; EPILEPTIC DISCHARGE; EXCITOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MUTAGENESIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; AGONISTS; ALLOSTERISM; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; HEK293 CELL LINE; HIPPOCAMPUS; METABOLISM; PHYSIOLOGY; SEIZURE;

ALLOSTERIC REGULATION; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; HEK293 CELLS; HIPPOCAMPUS; HUMANS; MALE; NIACINAMIDE; PICOLINIC ACIDS; RATS; RECEPTOR, METABOTROPIC GLUTAMATE 5; SEIZURES;

EID: 84874540963     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.09.012     Document Type: Article

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