Glucocorticoid induces apoptosis of osteoblast cells through the activation of glycogen synthase kinase 3β

Journal of Bone and Mineral Metabolism

Volumn 27, Issue 2, 2009, Pages 140-148

  Yun, Sun Il ^a   Yoon, Hyung Young ^a   Jeong, Seon Yong ^a   Chung, Yoon Sok ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Apoptosis; Dexamethasone; GSK3 ; Osteoblasts; P38 MAPK

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; MIFEPRISTONE; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CASPASES; DEXAMETHASONE; ENZYME ACTIVATION; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; GLYCOGEN SYNTHASE KINASE 3; MICE; OSTEOBLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, GLUCOCORTICOID;

EID: 60849090734     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-008-0019-5     Document Type: Article

References (34)

1. E Canalis 1996 Clinical review 83: mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis J Clin Endocrinol Metab 81 3441 3447
2. CJ Hurson JS Butler DT Keating DW Murray DM Sadlier JM O'Byrne PP Doran 2007 Gene expression analysis in human osteoblasts exposed to dexamethasone identifies altered developmental pathways as putative drivers of osteoporosis BMC Musculoskelet Disord 8 12
3. K Ohnaka M Tanabe H Kawate H Nawata R Takayanagi 2005 Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts Biochem Biophys Res Commun 329 177 181
4. K Ohnaka H Taniguchi H Kawate H Nawata R Takayanagi 2004 Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: novel mechanism of glucocorticoid-induced osteoporosis Biochem Biophys Res Commun 318 259 264
5. V Krishnan HU Bryant OA Macdougald 2006 Regulation of bone mass by Wnt signaling J Clin Invest 116 1202 1209
6. E Beurel RS Jope 2006 The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways Prog Neurobiol 79 173 189
7. RS Jope GV Johnson 2004 The glamour and gloom of glycogen synthase kinase-3 Trends Biochem Sci 29 95 102
8. K Hughes E Nikolakaki SE Plyte NF Totty JR Woodgett 1993 Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation EMBO J 12 803 808
9. L Song P De Sarno RS Jope 2002 Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation J Biol Chem 277 44701 44708
10. ZH Jin T Kurosu M Yamaguchi A Arai O Miura 2005 Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis Oncogene 24 1973 1981
11. GN Bijur P De Sarno RS Jope 2000 Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium J Biol Chem 275 7583 7590
12. GN Bijur RS Jope 2001 Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 beta J Biol Chem 276 37436 37442
13. Y Hu E Chan SX Wang B Li 2003 Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiation Endocrinology 144 2068 2074
14. SS Hsu CJ Huang HH Cheng CT Chou HY Lee JL Wang IS Chen SI Liu YC Lu HT Chang JK Huang JS Chen CR Jan 2007 Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells Toxicology 231 21 29
15. O Kozawa M Niwa D Hatakeyama H Tokuda Y Oiso H Matsuno K Kato T Uematsu 2002 Specific induction of heat shock protein 27 by glucocorticoid in osteoblasts J Cell Biochem 86 357 364
16. M Alikhani Z Alikhani C Boyd CM MacLellan M Raptis R Liu N Pischon PC Trackman L Gerstenfeld DT Graves 2007 Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways Bone 40 345 353
17. HJ Chae SC Kim KS Han SW Chae NH An HM Kim HH Kim ZH Lee HR Kim 2001 Hypoxia induces apoptosis by caspase activation accompanying cytochrome C release from mitochondria in MC3T3E1 osteoblasts. p38 MAPK is related in hypoxia-induced apoptosis Immunopharmacol Immunotoxicol 23 133 152
18. AL Miller MS Webb AJ Copik Y Wang BH Johnson R Kumar EB Thompson 2005 p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211 Mol Endocrinol 19 1569 1583
19. J Lu B Quearry H Harada 2006 p38-MAP kinase activation followed by BIM induction is essential for glucocorticoid-induced apoptosis in lymphoblastic leukemia cells FEBS Lett 580 3539 3544
20. MG Cifone G Migliorati R Parroni C Marchetti D Millimaggi A Santoni C Riccardi 1999 Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases Blood 93 2282 2296
21. O Al-Assar DH Crouch 2005 Inactivation of MAP kinase signalling in Myc transformed cells and rescue by LiCl inhibition of GSK3 Mol Cancer 4 13
22. CA Grimes RS Jope 2001 The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling Prog Neurobiol 65 391 426
23. B Cai SH Chang EB Becker A Bonni Z Xia 2006 p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65 J Biol Chem 281 25215 25222
24. A Gohel MB McCarthy G Gronowicz 1999 Estrogen prevents glucocorticoid-induced apoptosis in osteoblasts in vivo and in vitro Endocrinology 140 5339 5347
25. A Spreafico B Frediani C Capperucci A Leonini D Gambera P Ferrata S Rosini A Di Stefano M Galeazzi R Marcolongo 2006 Osteogenic growth peptide effects on primary human osteoblast cultures: potential relevance for the treatment of glucocorticoid-induced osteoporosis J Cell Biochem 98 1007 1020
26. G Kogianni V Mann F Ebetino M Nuttall P Nijweide H Simpson B Noble 2004 Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis Life Sci 75 2879 2895
27. S Schmidt J Rainer C Ploner E Presul S Riml R Kofler 2004 Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance Cell Death Differ 11 Suppl 1 S45 S55
28. T Ni Chonghaile CG Concannon E Szegezdi AM Gorman A Samali 2006 Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL Apoptosis 11 1247 1255
29. BW Doble JR Woodgett 2003 GSK-3: tricks of the trade for a multi-tasking kinase J Cell Sci 116 1175 1186
30. RS Jope CJ Yuskaitis E Beurel 2007 Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics Neurochem Res 32 577 595
31. HS Kim C Skurk SR Thomas A Bialik T Suhara Y Kureishi M Birnbaum JF Keaney Jr K Walsh 2002 Regulation of angiogenesis by glycogen synthase kinase-3beta J Biol Chem 277 41888 41896
32. JW Kim JE Lee MJ Kim EG Cho SG Cho EJ Choi 2003 Glycogen synthase kinase 3 beta is a natural activator of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1) J Biol Chem 278 13995 14001
33. E Smith GA Coetzee B Frenkel 2002 Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3beta J Biol Chem 277 18191 18197
34. R Dajani E Fraser SM Roe N Young V Good TC Dale LH Pearl 2001 Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition Cell 105 721 732