A-769662 protects osteoblasts from hydrogen dioxide-induced apoptosis through activating of AMP-activated protein kinase (AMPK)

International Journal of Molecular Sciences

Volumn 15, Issue 6, 2014, Pages 11190-11203

  Zhu, Yalong ^a   Zhou, Jianhua ^a   Rongguang, A O ^a   Yu, Baoqing ^a  

^a FUDAN UNIVERSITY PUDONG MEDICAL CENTER   (China)

Author keywords

A 769662; AMPK; Osteonecrosis; Oxidative stress and apoptosis

Indexed keywords

6, 7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1, 1' BIPHENYL 4 YL) 6 OXOTHIENO [2, 3 B] PYRIDINE 5 CARBONITRILE; 6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ADENOSINE TRIPHOSPHATE; HYDROGEN PEROXIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ENZYME ACTIVATOR; PYRONE DERIVATIVE; SMALL INTERFERING RNA; THIOPHENE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; BONE NECROSIS; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MOUSE; MTT ASSAY; NONHUMAN; OSTEOBLAST; OXIDATIVE STRESS; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; RNA INTERFERENCE; TOXICITY;

ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; CELL LINE; ENZYME ACTIVATION; ENZYME ACTIVATORS; HUMANS; HYDROGEN PEROXIDE; MICE; OSTEOBLASTS; PYRONES; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; THIOPHENES;

EID: 84903119684     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms150611190     Document Type: Article

References (32)

1. Park, B.G.; Yoo, C.I.; Kim, H.T.; Kwon, C.H.; Kim, Y.K. Role of mitogen-activated protein kinases in hydrogen peroxide-induced cell death in osteoblastic cells. Toxicology 2005, 215, 115-125.
2. Fatokun, A.A.; Stone, T.W.; Smith, R.A. Hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells: The effects of glutamate and protection by purines. Bone 2006, 39, 542-551.
3. Wang, S.; Song, P.; Zou, M.H. AMP-activated protein kinase, stress responses and cardiovascular diseases. Clin. Sci. 2012, 122, 555-573.
4. Mihaylova, M.M.; Shaw, R.J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat. Cell Biol. 2011, 13, 1016-1023.
5. Jeon, S.M.; Chandel, N.S.; Hay, N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 2012, 485, 661-665.
6. Inoki, K.; Zhu, T.; Guan, K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115, 577-590.
7. Baur, J.A.; Pearson, K.J.; Price, N.L.; Jamieson, H.A.; Lerin, C.; Kalra, A.; Prabhu, V.V.; Allard, J.S.; Lopez-Lluch, G.; Lewis, K. et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444, 337-342.
8. Chen, M.B.; Zhang, Y.; Wei, M.X.; Shen, W.; Wu, X.Y.; Yao, C.; Lu, P.H. Activation of AMP-activated protein kinase (AMPK) mediates plumbagin-induced apoptosis and growth inhibition in cultured human colon cancer cells. Cell Signal. 2013, 25, 1993-2002.
9. Chen, M.B.; Wu, X.Y.; Gu, J.H.; Guo, Q.T.; Shen, W.X.; Lu, P.H. Activation of AMP-activated protein kinase contributes to doxorubicin-induced cell death and apoptosis in cultured myocardial H9c2 cells. Cell Biochem. Biophys. 2011, 60, 311-322.
10. Chen, M.B.; Shen, W.X.; Yang, Y.; Wu, X.Y.; Gu, J.H.; Lu, P.H. Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell. J. Cell Physiol. 2011, 226, 1915-1925.
11. Chen, L.; Xu, B.; Liu, L.; Luo, Y.; Yin, J.; Zhou, H.; Chen, W.; Shen, T.; Han, X.; Huang, S. Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab. Investig. 2010, 90, 762-773.
12. Chen, Z.; Shen, X.; Shen, F.; Zhong, W.; Wu, H.; Liu, S.; Lai, J. TAK1 activates AMPK-dependent cell death pathway in hydrogen peroxide-treated cardiomyocytes, inhibited by heat shock protein-70. Mol. Cell. Biochem. 2013, 377, 35-44.
13. Liangpunsakul, S.; Wou, S.E.; Zeng, Y.; Ross, R.A.; Jayaram, H.N.; Crabb, D.W. Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 295, G1173-G1181.
14. Maiuri, M.C.; Zalckvar, E.; Kimchi, A.; Kroemer, G. Self-eating and self-killing: Crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 2007, 8, 741-752.
15. Codogno, P.; Meijer, A.J. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ. 2005, 12, 1509-1518.
16. Klionsky, D.J.; Emr, S.D. Autophagy as a regulated pathway of cellular degradation. Science 2000, 290, 1717-1721.
17. Levine, B.; Yuan, J. Autophagy in cell death: an innocent convict? J. Clin. Investig. 2005, 115, 2679-2688.
18. Kimura, N.; Tokunaga, C.; Dalal, S.; Richardson, C.; Yoshino, K.; Hara, K.; Kemp, B.E.; Witters, L.A.; Mimura, O.; Yonezawa, K. A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells 2003, 8, 65-79.
19. Luo, Z.; Saha, A.K.; Xiang, X.; Ruderman, N.B. AMPK, the metabolic syndrome and cancer. Trends Pharmacol. Sci. 2005, 26, 69-76.
20. Egan, D.F.; Shackelford, D.B.; Mihaylova, M.M.; Gelino, S.; Kohnz, R.A.; Mair, W.; Vasquez, D.S.; Joshi, A.; Gwinn, D.M.; Taylor, R. et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011, 331, 456-461.
21. Kim, J.; Kundu, M.; Viollet, B.; Guan, K.L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 2011, 13, 132-141.
22. Russell, R.R., 3rd; Bergeron, R.; Shulman, G.I.; Young, L.H. Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR. Am. J. Physiol. 1999, 277, H643-H649.
23. Cool, B.; Zinker, B.; Chiou, W.; Kifle, L.; Cao, N.; Perham, M.; Dickinson, R.; Adler, A.; Gagne, G.; Iyengar, R. et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab. 2006, 3, 403-416.
24. De Meester, C.; Timmermans, A.D.; Balteau, M.; Ginion, A.; Roelants, V.; Noppe, G.; Porporato, P.E.; Sonveaux, P.; Viollet, B.; Sakamoto, K. et al. Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells. Cardiovasc. Res. 2014, 101, 20-29.
25. Ducommun, S.; Ford, R.J.; Bultot, L.; Deak, M.; Bertrand, L.; Kemp, B.E.; Steinberg, G.R.; Sakamoto, K. Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662. Am. J. Physiol. Endocrinol. Metab. 2014, 306, E688-E696.
26. George, R.E.; Sanda, T.; Hanna, M.; Frohling, S.; Luther, W., 2nd; Zhang, J.; Ahn, Y.; Zhou, W.; London, W.B.; McGrady, P. et al. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature 2008, 455, 975-978.
27. Fulda, S. The PI3K/Akt/mTOR pathway as therapeutic target in neuroblastoma. Curr. Cancer Drug Targets 2009, 9, 729-737.
28. Matsui, T.; Sano, K.; Tsukamoto, T.; Ito, M.; Takaishi, T.; Nakata, H.; Nakamura, H.; Chihara, K. Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling. J. Clin. Investig. 1993, 92, 1153-1160.
29. Wang, B.; Wang, X.B.; Chen, L.Y.; Huang, L.; Dong, R.Z. Belinostat-induced apoptosis and growth inhibition in pancreatic cancer cells involve activation of TAK1-AMPK signaling axis. Biochem. Biophys. Res. Commun. 2013, 437, 1-6.
30. Matthew, E.M.; Hart, L.S.; Astrinidis, A.; Navaraj, A.; Dolloff, N.G.; Dicker, D.T.; Henske, E.P.; El-Deiry, W.S. The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions. Cell Cycle 2009, 8, 4168-4175.
31. Tsarouhas, V.; Yao, L.; Samakovlis, C. Src-kinases and ERK activate distinct responses to Stitcher receptor tyrosine kinase signaling during wound healing in Drosophila. J. Cell Sci. 2014, 127, 1829-1839.
32. Yang, Y.; Li, X.J.; Chen, Z.; Zhu, X.X.; Wang, J.; Zhang, L.B.; Qiang, L.; Ma, Y.J.; Li, Z.Y.; Guo, Q.L. et al. Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner. PLoS One 2012, 7, doi:10.1371/journal.pone.0050811.