Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells

Oncotarget

Volumn 7, Issue 43, 2016, Pages 70546-70558

  Catena, Valeria ^a   Bruno, Tiziana ^a   De Nicola, Francesca ^a   Goeman, Frauke ^a   Pallocca, Matteo ^a   Iezzi, Simona ^a   Sorino, Cristina ^a   Cigliana, Giovanni ^a   Floridi, Aristide ^a   Blandino, Giovanni ^a   Fanciulli, Maurizio ^a  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Deptor; ER stress; Homeostasis; Multiple myeloma; Transcription

Indexed keywords

BORTEZOMIB; DEPTOR; DNA; NUCLEAR PROTEIN; TEMSIROLIMUS; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DEPTOR PROTEIN, HUMAN; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; DRUG SENSITIZATION; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; MULTIPLE MYELOMA; MULTIPLE MYELOMA CELL LINE; NONHUMAN; PROTEIN DEPLETION; PROTEIN DNA BINDING; TRANSCRIPTION REGULATION; ANIMAL; CELL SURVIVAL; DRUG EFFECTS; ENDOPLASMIC RETICULUM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; METABOLISM; PATHOLOGY; PROCEDURES; RNA INTERFERENCE; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BORTEZOMIB; CELL LINE, TUMOR; CELL SURVIVAL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEOSTASIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE, TRANSGENIC; MULTIPLE MYELOMA; RNA INTERFERENCE;

EID: 84994338967     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.12060     Document Type: Article

References (50)

1. Palumbo A, Anderson K. Multiple myeloma. N Engl J Med. 2011; 364:1046-1060
2. Landgren O, Gridley G, Turesson I, Caporaso NE, Goldin LR, Baris D, Fears TR, Hoover RN, Linet MS. Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African American and white veterans in the United States. Blood. 2006 107:904-906.
3. National Cancer Institute. Surveillance epidemiology and end results program. SEER stat fact sheets on multiple myeloma. http://seer.cancer.gov/statfacts/html/mulmy.html. Accessed April 24, 2013.
4. Lee HC, Shah JJ, Orlowski RZ. Novel approaches to treatment of double-refractory multiple myeloma. Am Scoc Clin Oncol Educ Book. 2013; 2013:302-306.
5. Eslick R, Talaulikar D. Multiple myeloma: from diagnosis to treatment. Aust Fam Physician. 2013; 42:684-688.
6. Obeng EA, Carlson LM, Gutman DM, Harrington WJ Jr, Lee KP, Boise LH. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Neoplasia. 2006; 107:4907-4916.
7. Logue SE, Cleary P, Saveljeva S, Samali A. New directions in ER stress-induced cell death. Apoptosis. 2013; 18:537-546.
8. Pincus D, Chevalier MW, Aragon T, van Anken E, Vidal SE, El-Samad H, Walter P. PBiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response. PloS Biol. 2010; 8: e1000415.
9. Wang S, Kaufman RJ. The impact of the unfolded protein response on human disease. J Cell Biol. 2012; 197: 857-867.
10. Nakamura M, Gotoh T, Okuno Y, Tatetsu H, Sonoki T, Uneda S, Mori M, Mitsuya H, Hata H. Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells. Leuk Lymphoma. 2006; 47:531-539.
11. Zhang P, Sun Q, Zhao C, Ling S, Li Q, Chang YZ, Li Y. HDAC4 protect cells from ER stress induced apoptosis through interaction with ATF4. Cell Signal. 2014; 26:556-563.
12. Vincenz L, Jager R, O'Dwyer M, Samali A. Endoplasmic reticulum stress and the Unfolded Protein Response: targeting the Achiles Heel of Multiple Myeloma. Mol Cancer Therap. 2013; 12:831-843.
13. Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SE, Kuehl WM, Gray NS, Sabatini DM. DEPTOR is an mTOR inhibitor whose frequent overexpression in Multiple Myeloma cells promotes their survival. Cell. 2009; 137:873-886.
14. Duan S, Skaar JR, Kuchay S, Toschi A, Kanarek N, Ben-Neriah Y, Pagano M. mTOR generates an auto-amplification loop by triggering the bTrCP-and CK1a-dependent degradation of DEPTOR. Mol Cell. 2011; 44:317-324.
15. Zhao Y, Xiong X, Sun Y. DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(bTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Mol Cell. 2011; 44: 304-316.
16. Wang Z, Zhong J, Inuzuka H, Gao D, Shaik S, Sarkar FH, Wei W. An evolving role for DEPTOR in tumor development and progression. Neoplasia. 2012; 14:368-375.
17. Carrasco DR, Tonon G, Huang Y, Zhang Y, Sinha R, Feng B, Stewart JP, Zhan F, Khatry D, Protopopova M, Protopopov A, Sukhdeo K, Hanamura I, et al. High-resolution genomic profiles define distinct clinic-pathogenetic subgroups of multiple myeloma patients. Cancer Cell. 2006; 9:313-325.
18. Meister S, Schubeert U, Neubert K, Herrmann K, Burger R, Gramatzki M, Hahn S, Schreiber S, Wilhelm S, Herrmann M, Jack HM, Voll RE. Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition. Cancer Res. 2007; 67:1783-1792.
19. Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, Sorino C, Ponzoni M, Bossi G, Federico V, La Rosa F, Ricciardi MR, Lesma E, et al. Che-1-induced inhibition of mTOR pathway enables stress.-induced autophagy. EMBO J. 2015a; 34:1214-1230.
20. Bruno T, De Nicola F, Iezzi S, Lecis D, D'Angelo C, Di Padova M, Corbi N, Dimiziani L, Zannini L, Jekimovs C, Scarsella M, Porrello A, Chersi A, et al. Che-1 phosphorylation by ATM and Chk2 kinases activates p53 transcription and the G2/M checkpoint. Cancer Cell. 2006; 10:479-486.
21. Sorino C, Bruno T, Desantis A, Di Certo MG, Iezzi S, De Nicola F, Catena V, Floridi A, Chessa L, Passananti C, Cundari E, Fanciulli M. Centrosomal Che-1 Protein Is Involved in the Regulation of Mitosis and DNA Damage Response by Mediating Pericentrin (PCNT)-dependent Chk1 Protein Localization. J Biol Chem. 2013; 288:23348-23357.
22. Chesi M, Robbiani DF, Sebag M, Chng WJ, Affer M, Tiedemann R, Valdez R, Palmer SE, Haas SS, Stewart AK, Fonseca R, Kremer R, Cattoretti G, et al. AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal malignancies. Cancer Cell. 2008; 13:167-180.
23. Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PloS Biol. 2010; 8: e1000412.
24. Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, et al. Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb. Cancer Cell. 2002; 2:387-99.
25. Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, Sorino C, Gentileschi MP, Germoni S, Monteleone V, Pellegrino M, Kann M, De Meo PD, et al. Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53. Cell Death Dis. 2015b; 6: e1764.
26. D'Antonio M, D'Onorio De Meo P, Pallocca M, Picardi E, D'Erchia AM, Calogero RA, Castrignanò T, Pesole G. RAP: RNA-Seq Analysis Pipeline, a new cloud-based NGS web application. BMC Genomics. 2015; 16: S3.
27. Trapnell C, Roberts A, GoffL, Perteag G, Kim D, Kelley DR, Pimentel M, Salzberg SL, Rinn JL, Pachter L. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc. 2012; 7:562-578.
28. Zhan F, Huang Y, Stewart JP, Stewart JP, Hanamura I, Gupta S, Epstein J, Yaccoby S, Sawyer J, Burington B, Anaissie E, Hollmig K, Pineda-Roman M. The molecular classification of multiple myeloma. Blood. 2006; 108: 2020-2028.
29. R2: Genomics Analysis an visualization platform (http://r2.amc.nl).
30. Bravo R, Parra V, Gatica D, Rodriguez AE, Torrealba N, Paredes F, Wang ZV, Zorzano A, Hill JA, Jaimovich E, Quest AF, Lavandero S. Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Mol Biol. 2013; 301:215-290.
31. Oda Y, Okada T, Yoshida H, Kaufman RJ, Nagata K, Mori K. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. J Cell Biol. 2006; 172:383-393.
32. Tuffy KM and Planey SL. Cytoskeleton-Associated Protein 4: Functions Beyond the Endoplasmic Reticulum in Physiology and Disease. Cell Biology. 2012; doi:10.5402/2012/142313.
33. Oslowski C, Urano F. Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol. 2011; 490:71-92.
34. Namba T, Kodama R. Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2a-CHOP signaling. Mar Drugs. 2015; 13:2376-2389.
35. Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 2007; 8:519-529.
36. Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis at metabolic disease. Cell. 2010; 140:900-917.
37. Hideshima T, Richardson PG, Anderson KC. Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma. Mol Cancer Ther. 2011; 10: 2034-2042.
38. Laplante M and Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012; 149:274-293.
39. Meng ZX, Li HF, Wang L, Ko HJ, Lee Y, Jung DY, Okutsu M, Yan Z, Kim JK, Lin JD. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nat Med. 2013; 19:640-645.
40. Guglielmelli T, Giugliano E, Brunetto V, Rapa I, Cappia S, Giorcelli J, Rrodhe S, Papotti M, Saglio G. mTOR pathway activation in multiple myeloma cell lines and primary tumour cells: pomalidomide enhances cytoplasmic-nuclear shuttling of mTOR protein. Oncoscience. 2015; 2:382-394. doi: 10.18632/oncoscience.148.
41. Kim JE, Chen J. Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycinsensitive signaling and translation initiation. PNAS. 2000; 97:14340-14345.
42. Kantidakis T, Ramsbottom BA, Birch JL, Dowding SN, White RJ. mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1. PNAS. 2010; 107:11823-11828.
43. Tsang CK, Liu H, Zheng XF. mTOR binds to the promoters of RNA polymerase I-and III-transcribed genes. Cell Cycle. 2010; 9:953-957.
44. Shor B, Wu J, Shakey Q, Toral-Barza L, Shi C, Follettie M, Yu K. Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells. J Biol Chem. 2010; 285:15380-15392.
45. Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, Hogenesch JB. A gene atlas of the mouse and human protein-endcoding transcriptomes. PNAS. 2004; 101:6062-6067.
46. Appenzeller-Herzog C, Hall MN. Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. Trends Cell Biol. 2012; 22:274-282.
47. Hoang B, Benavides A, Shi Y, Frost P, Lichtenstein A. Effect of autophagy on multiple myeloma cell viability. Mol Coan Ther. 2009; 8:1974-1984.
48. Gao D, Inuzuka H, Tan M-KM, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, et al. mTOR drives its own activation via SCFβ-TRCP-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell. 2011; 44:290-303.
49. Zhao Y, Xiong X, Jia L, Sun Y. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death Dis. 2012; 3: e386.
50. Lee AH, Iwakoshi NN, Anderson KC, Glimcher LH. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. PNAS. 2003; 100:9946-9951.