Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling

Marine Drugs

Volumn 13, Issue 4, 2015, Pages 2376-2389

  Namba, Takushi ^a   Kodama, Rika ^a  

^a KOCHI UNIVERSITY   (Japan)

Author keywords

Avarol; CHOP; ER stress; Pancreatic ductal adenocarcinomas

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; AVAROL; CCAAT ENHANCER BINDING PROTEIN; DIMETHYL SULFOXIDE; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; PHOSPHOTRANSFERASE; PROTEIN IRE1; PROTEIN KINASE R LIKE ER KINASE; THAPSIGARGIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; DDIT3 PROTEIN, HUMAN; EIF2AK3 PROTEIN, HUMAN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN; INITIATION FACTOR 2; MOLECULAR CHAPERONE GRP78; PROTEIN KINASE R; SESQUITERPENE; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; PANCREAS ADENOCARCINOMA; PANCREAS DUCTAL ADENOCARCINOMA; PANCREATIC CANCER CELL LINE; SIGNAL TRANSDUCTION; UPREGULATION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; DYSIDEA; GENE EXPRESSION REGULATION; GENETICS; IC50; METABOLISM; PANCREATIC NEOPLASMS; RNA INTERFERENCE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOMARKERS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE; CELL LINE, TUMOR; DYSIDEA; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAT-SHOCK PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; NEOPLASM PROTEINS; PANCREATIC NEOPLASMS; RNA INTERFERENCE; SESQUITERPENES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; UP-REGULATION;

EID: 84928604866     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md13042376     Document Type: Article

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