Matrix mechanics controls FHL2 movement to the nucleus to activate p21 expression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 44, 2016, Pages E6813-E6822

  Nakazawa, Naotaka ^a   Sathe, Aneesh R ^a   Shivashankar, G V ^a,b,c   Sheetz, Michael P ^a,b,d  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^d NONE   (United States)

Author keywords

Focal adhesion kinase; Four and a half LIM domains 2; Gene expression; Mechanotransduction; Substrate rigidity

Indexed keywords

FOUR AND A HALF LIM DOMAINS 2 PROTEIN; LIM PROTEIN; MYOSIN II; PROTEIN P21; RNA POLYMERASE II; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYTOSKELETON PROTEIN; FHL2 PROTEIN, HUMAN; FOCAL ADHESION KINASE; LIM HOMEODOMAIN PROTEIN; MUSCLE PROTEIN; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR; TYROSINE;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ATOMIC FORCE MICROSCOPY; AUTOPHOSPHORYLATION; BREAST CANCER CELL LINE; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; FIBROBLAST; FOCAL ADHESION; GENE EXPRESSION; HUMAN; HUMAN CELL; MECHANICS; MOUSE; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; STRESS FIBER; SURFACE PROPERTY; ANIMAL; CELL ADHESION; CELL LINE; CELL MOTION; CELL NUCLEUS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MECHANOTRANSDUCTION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; POINT MUTATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL ADHESION; CELL LINE; CELL MOVEMENT; CELL NUCLEUS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOSKELETAL PROTEINS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; FOCAL ADHESIONS; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIM DOMAIN PROTEINS; LIM-HOMEODOMAIN PROTEINS; MECHANOTRANSDUCTION, CELLULAR; MICE; MUSCLE PROTEINS; MYOSIN TYPE II; PHOSPHORYLATION; POINT MUTATION; RNA POLYMERASE II; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TYROSINE;

EID: 84994234540     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1608210113     Document Type: Article

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