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Volumn 11, Issue 7, 2016, Pages 946-963

The international association for the study of lung cancer consensus statement on optimizing management of EGFR mutation-positive non-small cell lung cancer: Status in 2016

(21)  Tan, Daniel S W a   Yom, Sue S b   Tsao, Ming S c   Pass, Harvey I d   Kelly, Karen e   Peled, Nir f   Yung, Rex C g   Wistuba, Ignacio I h   Yatabe, Yasushi i   Unger, Michael j   Mack, Philip C e   Wynes, Murry W k   Mitsudomi, Tetsuya l   Weder, Walter m   Yankelevitz, David n   Herbst, Roy S o   Gandara, David R e   Carbone, David P p   Bunn, Paul A q   Mok, Tony S K r   more..


Author keywords

Brain metastases; EGFR mutation; Non small cell lung cancer; Resistance; Therapy; Tyrosine kinase inhibitor

Indexed keywords

BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; EGFR PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR;

EID: 84978264610     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1016/j.jtho.2016.05.008     Document Type: Review
Times cited : (174)

References (128)
  • 1
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350:2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 2
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304:1497-1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 3
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H, Lin L, Takahashi T, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst. 2005;97:339-346.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3
  • 4
    • 84931571793 scopus 로고    scopus 로고
    • EGFR mutation testing practices within the Asia Pacific region: Results of a multicenter diagnostic survey
    • Yatabe Y, Kerr KM, Utomo A, et al. EGFR mutation testing practices within the Asia Pacific region: results of a multicenter diagnostic survey. J Thorac Oncol. 2015;10:438-445.
    • (2015) J Thorac Oncol , vol.10 , pp. 438-445
    • Yatabe, Y.1    Kerr, K.M.2    Utomo, A.3
  • 5
    • 84954166105 scopus 로고    scopus 로고
    • Cancer genomics: Diversity and disparity across ethnicity and geography
    • Tan DS, Mok TS, Rebbeck TR. Cancer genomics: diversity and disparity across ethnicity and geography. J Clin Oncol. 2016;34:91-101.
    • (2016) J Clin Oncol , vol.34 , pp. 91-101
    • Tan, D.S.1    Mok, T.S.2    Rebbeck, T.R.3
  • 6
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361:947-957.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 7
    • 84861976809 scopus 로고    scopus 로고
    • First-SIGNAL: First-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung
    • Han JY, Park K, Kim SW, et al. First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung. J Clin Oncol. 2012;30:1122-1128.
    • (2012) J Clin Oncol , vol.30 , pp. 1122-1128
    • Han, J.Y.1    Park, K.2    Kim, S.W.3
  • 8
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 2010;11:121-128.
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 9
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutationpositive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutationpositive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 2012;13:239-246.
    • (2012) Lancet Oncol , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 10
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • Sequist LV, Yang JC, Yamamoto N, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31:3327-3334.
    • (2013) J Clin Oncol , vol.31 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3
  • 11
    • 84892997539 scopus 로고    scopus 로고
    • Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): An open-label, randomised phase 3 trial
    • Wu YL, Zhou C, Hu CP, et al. Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial. Lancet Oncol. 2014;15:213-222.
    • (2014) Lancet Oncol , vol.15 , pp. 213-222
    • Wu, Y.L.1    Zhou, C.2    Hu, C.P.3
  • 12
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010;362:2380-2388.
    • (2010) N Engl J Med , vol.362 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 13
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinibversuschemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
    • ZhouC,Wu YL,ChenG, et al. Erlotinibversuschemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2011;12:735-742.
    • (2011) Lancet Oncol , vol.12 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3
  • 14
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med. 2011;3:75ra26.
    • (2011) Sci Transl Med , vol.3 , pp. 75ra26
    • Sequist, L.V.1    Waltman, B.A.2    Dias-Santagata, D.3
  • 15
    • 84889888266 scopus 로고    scopus 로고
    • Rebiopsy of nonsmall cell lung cancer patients with acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor: CComparison between T790M mutationpositive and mutation-negative populations
    • Hata A, Katakami N, Yoshioka H, et al. Rebiopsy of nonsmall cell lung cancer patients with acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor: cComparison between T790M mutationpositive and mutation-negative populations. Cancer. 2013;119:4325-4332.
    • (2013) Cancer , vol.119 , pp. 4325-4332
    • Hata, A.1    Katakami, N.2    Yoshioka, H.3
  • 16
    • 84877100240 scopus 로고    scopus 로고
    • Analysis of tumor specimens at the time of acquired resistance to EGFRTKI therapy in 155 patients with EGFR-mutant lung cancers
    • Yu HA, Arcila ME, Rekhtman N, et al. Analysis of tumor specimens at the time of acquired resistance to EGFRTKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res. 2013;19:2240-2247.
    • (2013) Clin Cancer Res , vol.19 , pp. 2240-2247
    • Yu, H.A.1    Arcila, M.E.2    Rekhtman, N.3
  • 17
    • 72949092456 scopus 로고    scopus 로고
    • Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
    • Zhou W, Ercan D, Chen L, et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature. 2009;462:1070-1074.
    • (2009) Nature , vol.462 , pp. 1070-1074
    • Zhou, W.1    Ercan, D.2    Chen, L.3
  • 18
    • 84928739294 scopus 로고    scopus 로고
    • AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer
    • Janne PA, Yang JC, Kim DW, et al. AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. N Engl J Med. 2015;372:1689-1699.
    • (2015) N Engl J Med , vol.372 , pp. 1689-1699
    • Janne, P.A.1    Yang, J.C.2    Kim, D.W.3
  • 19
    • 36248980204 scopus 로고    scopus 로고
    • Characterizing the cancer genome in lung adenocarcinoma
    • Weir BA, Woo MS, Getz G, et al. Characterizing the cancer genome in lung adenocarcinoma. Nature. 2007;450:893-898.
    • (2007) Nature , vol.450 , pp. 893-898
    • Weir, B.A.1    Woo, M.S.2    Getz, G.3
  • 20
    • 54549094903 scopus 로고    scopus 로고
    • Somatic mutations affect key pathways in lung adenocarcinoma
    • Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 2008;455:1069-1075.
    • (2008) Nature , vol.455 , pp. 1069-1075
    • Ding, L.1    Getz, G.2    Wheeler, D.A.3
  • 21
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature. 2012;489:519-525.
    • (2012) Nature , vol.489 , pp. 519-525
    • Cancer Genome Atlas Research Network1
  • 22
    • 84905029258 scopus 로고    scopus 로고
    • Comprehensive molecular profiling of lung adenocarcinoma
    • Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014;511:543-550.
    • (2014) Nature , vol.511 , pp. 543-550
    • Cancer Genome Atlas Research Network1
  • 23
    • 84874115779 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition in lung cancer: Status
    • 2013
    • Hirsch FR, Janne PA, Eberhardt WE, et al. Epidermal growth factor receptor inhibition in lung cancer: status 2012. J Thorac Oncol. 2013;8:373-384.
    • (2012) J Thorac Oncol. , vol.8 , pp. 373-384
    • Hirsch, F.R.1    Janne, P.A.2    Eberhardt, W.E.3
  • 24
    • 79551563284 scopus 로고    scopus 로고
    • International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma
    • Travis WD, Brambilla E, Noguchi M, et al. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011;6:244-285.
    • (2011) J Thorac Oncol , vol.6 , pp. 244-285
    • Travis, W.D.1    Brambilla, E.2    Noguchi, M.3
  • 25
    • 84946737759 scopus 로고    scopus 로고
    • Biomarker testing and time to treatment decision in patients with advanced nonsmall-cell lung cancer
    • Lim C, Tsao MS, Le LW, et al. Biomarker testing and time to treatment decision in patients with advanced nonsmall-cell lung cancer. Ann Oncol. 2015;26: 1415-1421.
    • (2015) Ann Oncol , vol.26 , pp. 1415-1421
    • Lim, C.1    Tsao, M.S.2    Le, L.W.3
  • 26
    • 84892718835 scopus 로고    scopus 로고
    • A comparison of methods for EGFR mutation testing in non-small cell lung cancer
    • Young EC, Owens MM, Adebiyi I, et al. A comparison of methods for EGFR mutation testing in non-small cell lung cancer. Diagn Mol Pathol. 2013;22:190-195.
    • (2013) Diagn Mol Pathol , vol.22 , pp. 190-195
    • Young, E.C.1    Owens, M.M.2    Adebiyi, I.3
  • 27
    • 77954566882 scopus 로고    scopus 로고
    • Rapid targeted mutational analysis of human tumours: A clinical platform to guide personalized cancer medicine
    • Dias-Santagata D, Akhavanfard S, David SS, et al. Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine. EMBO Mol Med. 2010;2:146-158.
    • (2010) EMBO Mol Med , vol.2 , pp. 146-158
    • Dias-Santagata, D.1    Akhavanfard, S.2    David, S.S.3
  • 28
    • 84876755651 scopus 로고    scopus 로고
    • Comparison of molecular testing methods for the detection of EGFR mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer
    • Lopez-Rios F, Angulo B, Gomez B, et al. Comparison of molecular testing methods for the detection of EGFR mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer. J Clin Pathol. 2013;66:381-385.
    • (2013) J Clin Pathol , vol.66 , pp. 381-385
    • Lopez-Rios, F.1    Angulo, B.2    Gomez, B.3
  • 29
    • 32944468710 scopus 로고    scopus 로고
    • A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screening
    • Janne PA, Borras AM, Kuang Y, et al. A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screening. Clin Cancer Res. 2006;12:751-758.
    • (2006) Clin Cancer Res , vol.12 , pp. 751-758
    • Janne, P.A.1    Borras, A.M.2    Kuang, Y.3
  • 30
    • 79952259564 scopus 로고    scopus 로고
    • Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay
    • Arcila ME, Oxnard GR, Nafa K, et al. Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay. Clin Cancer Res. 2011;17:1169-1180.
    • (2011) Clin Cancer Res , vol.17 , pp. 1169-1180
    • Arcila, M.E.1    Oxnard, G.R.2    Nafa, K.3
  • 31
    • 84903537631 scopus 로고    scopus 로고
    • Panel based MALDI-TOF tumour profiling is a sensitive method for detecting mutations in clinical non small cell lung cancer tumour
    • Sherwood JL, Muller S, Orr MC, et al. Panel based MALDI-TOF tumour profiling is a sensitive method for detecting mutations in clinical non small cell lung cancer tumour. PLoS One. 2014;9:e100566.
    • (2014) PLoS One , vol.9 , pp. e100566
    • Sherwood, J.L.1    Muller, S.2    Orr, M.C.3
  • 32
    • 84942519785 scopus 로고    scopus 로고
    • Diagnostic accuracy of noninvasive genotyping of EGFR in lung cancer patients by deep sequencing of plasma cell-free DNA
    • Uchida J, Kato K, Kukita Y, et al. Diagnostic accuracy of noninvasive genotyping of EGFR in lung cancer patients by deep sequencing of plasma cell-free DNA. Clin Chem. 2015;61:1191-1196.
    • (2015) Clin Chem , vol.61 , pp. 1191-1196
    • Uchida, J.1    Kato, K.2    Kukita, Y.3
  • 33
    • 84891787489 scopus 로고    scopus 로고
    • Clinical characteristics and treatment outcomes of lung adenocarcinomas with discrepant EGFR mutation testing results derived from PCR-direct sequencing and real-time PCR-based assays
    • Chiu CH, Ho HL, Chiang CL, et al. Clinical characteristics and treatment outcomes of lung adenocarcinomas with discrepant EGFR mutation testing results derived from PCR-direct sequencing and real-time PCR-based assays. J Thorac Oncol. 2014;9:91-96.
    • (2014) J Thorac Oncol , vol.9 , pp. 91-96
    • Chiu, C.H.1    Ho, H.L.2    Chiang, C.L.3
  • 34
    • 84898726862 scopus 로고    scopus 로고
    • The impact of EGFR T790M mutations and BIM mRNA expression on outcome in patients with EGFR-mutant NSCLC treated with erlotinib or chemotherapy in the randomized phase III EURTAC trial
    • Costa C, Molina MA, Drozdowskyj A, et al. The impact of EGFR T790M mutations and BIM mRNA expression on outcome in patients with EGFR-mutant NSCLC treated with erlotinib or chemotherapy in the randomized phase III EURTAC trial. Clin Cancer Res. 2014;20:2001-2010.
    • (2014) Clin Cancer Res , vol.20 , pp. 2001-2010
    • Costa, C.1    Molina, M.A.2    Drozdowskyj, A.3
  • 35
    • 84861746437 scopus 로고    scopus 로고
    • Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA
    • Forshew T, Murtaza M, Parkinson C, et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci Transl Med. 2012;4:136ra168.
    • (2012) Sci Transl Med , vol.4 , pp. 136ra168
    • Forshew, T.1    Murtaza, M.2    Parkinson, C.3
  • 36
    • 81855208762 scopus 로고    scopus 로고
    • Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas
    • Taniguchi K, Uchida J, Nishino K, et al. Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas. Clin Cancer Res. 2011;17:7808-7815.
    • (2011) Clin Cancer Res , vol.17 , pp. 7808-7815
    • Taniguchi, K.1    Uchida, J.2    Nishino, K.3
  • 37
    • 84942942154 scopus 로고    scopus 로고
    • Ultra-sensitive detection of the pretreatment EGFR T790M mutation in non-small cell lung cancer patients with an EGFRactivating mutation using droplet digital PCR
    • Watanabe M, Kawaguchi T, Isa S, et al. Ultra-sensitive detection of the pretreatment EGFR T790M mutation in non-small cell lung cancer patients with an EGFRactivating mutation using droplet digital PCR. Clin Cancer Res. 2015;21:3552-3560.
    • (2015) Clin Cancer Res , vol.21 , pp. 3552-3560
    • Watanabe, M.1    Kawaguchi, T.2    Isa, S.3
  • 38
    • 84903218109 scopus 로고    scopus 로고
    • An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
    • Newman AM, Bratman SV, To J, et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med. 2014;20:548-554.
    • (2014) Nat Med , vol.20 , pp. 548-554
    • Newman, A.M.1    Bratman, S.V.2    To, J.3
  • 39
    • 84930755018 scopus 로고    scopus 로고
    • Acquired EGFR C797S mutation mediates resistance to AZD9291 in nonsmall cell lung cancer harboring EGFR T790M
    • Thress KS, Paweletz CP, Felip E, et al. Acquired EGFR C797S mutation mediates resistance to AZD9291 in nonsmall cell lung cancer harboring EGFR T790M. Nat Med. 2015;21:560-562.
    • (2015) Nat Med , vol.21 , pp. 560-562
    • Thress, K.S.1    Paweletz, C.P.2    Felip, E.3
  • 40
    • 84902546788 scopus 로고    scopus 로고
    • Sample features associated with success rates in populationbased EGFR mutation testing
    • Shiau CJ, Babwah JP, da Cunha Santos G, et al. Sample features associated with success rates in populationbased EGFR mutation testing. J Thorac Oncol. 2014;9:947-956.
    • (2014) J Thorac Oncol , vol.9 , pp. 947-956
    • Shiau, C.J.1    Babwah, J.P.2    Da Cunha Santos, G.3
  • 41
    • 83255193971 scopus 로고    scopus 로고
    • Establishing an EGFR mutation screening service for non-small cell lung cancer - Sample quality criteria and candidate histological predictors
    • Leary AF, Castro DG, Nicholson AG, et al. Establishing an EGFR mutation screening service for non-small cell lung cancer - sample quality criteria and candidate histological predictors. Eur J Cancer. 2012;48: 61-67.
    • (2012) Eur J Cancer , vol.48 , pp. 61-67
    • Leary, A.F.1    Castro, D.G.2    Nicholson, A.G.3
  • 42
    • 84879924913 scopus 로고    scopus 로고
    • Evaluation of 2- year experience with EGFR mutation analysis of small diagnostic samples
    • Hlinkova K, Babal P, Berzinec P, et al. Evaluation of 2- year experience with EGFR mutation analysis of small diagnostic samples. Diagn Mol Pathol. 2013;22:70-75.
    • (2013) Diagn Mol Pathol , vol.22 , pp. 70-75
    • Hlinkova, K.1    Babal, P.2    Berzinec, P.3
  • 43
    • 84863992604 scopus 로고    scopus 로고
    • The positive impact of cytological specimens for EGFR mutation testing in non-small cell lung cancer: A single South East Asian laboratory's analysis of 670 cases
    • Pang B, Dettmer M, Ong CW, et al. The positive impact of cytological specimens for EGFR mutation testing in non-small cell lung cancer: a single South East Asian laboratory's analysis of 670 cases. Cytopathology. 2012;23:229-236.
    • (2012) Cytopathology , vol.23 , pp. 229-236
    • Pang, B.1    Dettmer, M.2    Ong, C.W.3
  • 44
    • 84874606355 scopus 로고    scopus 로고
    • EGFR mutation testing in lung cancer: A review of available methods and their use for analysis of tumour tissue and cytology samples
    • Ellison G, Zhu G, Moulis A, et al. EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples. J Clin Pathol. 2013;66:79-89.
    • (2013) J Clin Pathol , vol.66 , pp. 79-89
    • Ellison, G.1    Zhu, G.2    Moulis, A.3
  • 45
    • 84864045330 scopus 로고    scopus 로고
    • EGFR mutation heterogeneity and the mixed response to EGFR tyrosine kinase inhibitors of lung adenocarcinomas
    • Chen ZY, Zhong WZ, Zhang XC, et al. EGFR mutation heterogeneity and the mixed response to EGFR tyrosine kinase inhibitors of lung adenocarcinomas. Oncologist. 2012;17:978-985.
    • (2012) Oncologist , vol.17 , pp. 978-985
    • Chen, Z.Y.1    Zhong, W.Z.2    Zhang, X.C.3
  • 46
    • 84880240161 scopus 로고    scopus 로고
    • Next-generation sequencing reveals high concordance of recurrent somatic alterations between primary tumor and metastases from patients with non-small-cell lung cancer
    • Vignot S, Frampton GM, Soria JC, et al. Next-generation sequencing reveals high concordance of recurrent somatic alterations between primary tumor and metastases from patients with non-small-cell lung cancer. J Clin Oncol. 2013;31:2167-2172.
    • (2013) J Clin Oncol , vol.31 , pp. 2167-2172
    • Vignot, S.1    Frampton, G.M.2    Soria, J.C.3
  • 47
    • 84902549992 scopus 로고    scopus 로고
    • Intertumor heterogeneity of non-small-cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics
    • Tan DS, Camilleri-Broet S, Tan EH, et al. Intertumor heterogeneity of non-small-cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics. Int J Cancer. 2014;135:1092-1100.
    • (2014) Int J Cancer , vol.135 , pp. 1092-1100
    • Tan, D.S.1    Camilleri-Broet, S.2    Tan, E.H.3
  • 48
    • 82355191818 scopus 로고    scopus 로고
    • Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice
    • Sequist LV, Heist RS, Shaw AT, et al. Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice. Ann Oncol. 2011;22: 2616-2624.
    • (2011) Ann Oncol , vol.22 , pp. 2616-2624
    • Sequist, L.V.1    Heist, R.S.2    Shaw, A.T.3
  • 49
    • 84887491073 scopus 로고    scopus 로고
    • Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing
    • Frampton GM, Fichtenholtz A, Otto GA, et al. Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. Nat Biotechnol. 2013;31:1023-1031.
    • (2013) Nat Biotechnol , vol.31 , pp. 1023-1031
    • Frampton, G.M.1    Fichtenholtz, A.2    Otto, G.A.3
  • 50
    • 84983535287 scopus 로고    scopus 로고
    • Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors
    • Hovelson DH, McDaniel AS, Cani AK, et al. Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors. Neoplasia. 2015;17:385-399.
    • (2015) Neoplasia , vol.17 , pp. 385-399
    • Hovelson, D.H.1    McDaniel, A.S.2    Cani, A.K.3
  • 51
    • 84870040449 scopus 로고    scopus 로고
    • Repeat biopsy for mutational analysis of non-small cell lung cancers resistant to previous chemotherapy: Adequacy and complications
    • Yoon HJ, Lee HY, Lee KS, et al. Repeat biopsy for mutational analysis of non-small cell lung cancers resistant to previous chemotherapy: adequacy and complications. Radiology. 2012;265:939-948.
    • (2012) Radiology , vol.265 , pp. 939-948
    • Yoon, H.J.1    Lee, H.Y.2    Lee, K.S.3
  • 52
    • 84921032852 scopus 로고    scopus 로고
    • Circulating tumor DNA is effective for the detection of EGFR mutation in non-small cell lung cancer: A meta-analysis
    • Qiu M, Wang J, Xu Y, et al. Circulating tumor DNA is effective for the detection of EGFR mutation in non-small cell lung cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2015;24:206-212.
    • (2015) Cancer Epidemiol Biomarkers Prev , vol.24 , pp. 206-212
    • Qiu, M.1    Wang, J.2    Xu, Y.3
  • 53
    • 84965092386 scopus 로고    scopus 로고
    • Association of EGFR L858R mutation in circulating free DNA with survival in the EURTAC trial
    • Karachaliou N, Mayo-de las Casas C, Queralt C, et al. Association of EGFR L858R mutation in circulating free DNA with survival in the EURTAC trial. JAMA Oncol. 2015;1:149-157.
    • (2015) JAMA Oncol , vol.1 , pp. 149-157
    • Karachaliou, N.1    Mayo-De Las Casas, C.2    Queralt, C.3
  • 54
    • 84938399710 scopus 로고    scopus 로고
    • Detection and dynamic changes of EGFR mutations from circulating tumor DNA as a predictor of survival outcomes in NSCLC patients treated with first-line intercalated erlotinib and chemotherapy
    • Mok T, Wu YL, Lee JS, et al. Detection and dynamic changes of EGFR mutations from circulating tumor DNA as a predictor of survival outcomes in NSCLC patients treated with first-line intercalated erlotinib and chemotherapy. Clin Cancer Res. 2015;21:3196-3203.
    • (2015) Clin Cancer Res , vol.21 , pp. 3196-3203
    • Mok, T.1    Wu, Y.L.2    Lee, J.S.3
  • 55
    • 84901983989 scopus 로고    scopus 로고
    • Comparison of clinical outcomes following gefitinib and erlotinib treatment in non-small-cell lung cancer patients harboring an epidermal growth factor receptor mutation in either exon 19 or 21
    • Lim SH, Lee JY, Sun JM, et al. Comparison of clinical outcomes following gefitinib and erlotinib treatment in non-small-cell lung cancer patients harboring an epidermal growth factor receptor mutation in either exon 19 or 21. J Thorac Oncol. 2014;9:506-511.
    • (2014) J Thorac Oncol , vol.9 , pp. 506-511
    • Lim, S.H.1    Lee, J.Y.2    Sun, J.M.3
  • 56
    • 84921892043 scopus 로고    scopus 로고
    • Afatinib versus cisplatin-based chemotherapy for EGFR mutationpositive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): Analysis of overall survival data from two randomised, phase 3 trials
    • Yang JC, Wu YL, Schuler M, et al. Afatinib versus cisplatin-based chemotherapy for EGFR mutationpositive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials. Lancet Oncol. 2015;16:141-151.
    • (2015) Lancet Oncol , vol.16 , pp. 141-151
    • Yang, J.C.1    Wu, Y.L.2    Schuler, M.3
  • 57
    • 84964389363 scopus 로고    scopus 로고
    • Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): A phase 2B, open-label, randomised controlled trial
    • Park K, Tan EH, O'Byrne K, et al. Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial. Lancet Oncol. 2016;17:577-589.
    • (2016) Lancet Oncol , vol.17 , pp. 577-589
    • Park, K.1    Tan, E.H.2    O'Byrne, K.3
  • 58
    • 84865076205 scopus 로고    scopus 로고
    • The impact of initial gefitinib or erlotinib versus chemotherapy on central nervous system progression in advanced nonsmall cell lung cancer with EGFR mutations
    • Heon S, Yeap BY, Lindeman NI, et al. The impact of initial gefitinib or erlotinib versus chemotherapy on central nervous system progression in advanced nonsmall cell lung cancer with EGFR mutations. Clin Cancer Res. 2012;18:4406-4414.
    • (2012) Clin Cancer Res , vol.18 , pp. 4406-4414
    • Heon, S.1    Yeap, B.Y.2    Lindeman, N.I.3
  • 59
    • 77953541527 scopus 로고    scopus 로고
    • Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study
    • Cappuzzo F, Ciuleanu T, Stelmakh L, et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol. 2010;11:521-529.
    • (2010) Lancet Oncol , vol.11 , pp. 521-529
    • Cappuzzo, F.1    Ciuleanu, T.2    Stelmakh, L.3
  • 60
    • 84937513065 scopus 로고    scopus 로고
    • Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: A combined post-hoc analysis of LUX-Lung 2 LUX-Lung 3 and LUX-Lung 6
    • Yang JC, Sequist LV, Geater SL, et al. Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: a combined post-hoc analysis of LUX-Lung 2, LUX-Lung 3, and LUX-Lung 6. Lancet Oncol. 2015;16:830-838.
    • (2015) Lancet Oncol , vol.16 , pp. 830-838
    • Yang, J.C.1    Sequist, L.V.2    Geater, S.L.3
  • 61
    • 84895450705 scopus 로고    scopus 로고
    • Rare EGFR exon 18 and exon 20 mutations in non-small-cell lung cancer on 10 117 patients: A multicentre observational study by the French ERMETIC-IFCT network
    • Beau-Faller M, Prim N, Ruppert AM, et al. Rare EGFR exon 18 and exon 20 mutations in non-small-cell lung cancer on 10 117 patients: a multicentre observational study by the French ERMETIC-IFCT network. Ann Oncol. 2014;25:126-131.
    • (2014) Ann Oncol , vol.25 , pp. 126-131
    • Beau-Faller, M.1    Prim, N.2    Ruppert, A.M.3
  • 62
    • 79957916527 scopus 로고    scopus 로고
    • Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer
    • Wu JY, Yu CJ, Chang YC, et al. Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer. Clin Cancer Res. 2011;17:3812-3821.
    • (2011) Clin Cancer Res , vol.17 , pp. 3812-3821
    • Wu, J.Y.1    Yu, C.J.2    Chang, Y.C.3
  • 63
    • 84893344277 scopus 로고    scopus 로고
    • Effectiveness of gefitinib against non-small-cell lung cancer with the uncommon EGFR mutations G719X and L861Q
    • Watanabe S, Minegishi Y, Yoshizawa H, et al. Effectiveness of gefitinib against non-small-cell lung cancer with the uncommon EGFR mutations G719X and L861Q. J Thorac Oncol. 2014;9:189-194.
    • (2014) J Thorac Oncol , vol.9 , pp. 189-194
    • Watanabe, S.1    Minegishi, Y.2    Yoshizawa, H.3
  • 64
    • 84892631191 scopus 로고    scopus 로고
    • Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer
    • Yasuda H, Park E, Yun CH, et al. Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer. Sci Transl Med. 2013;5:216ra177.
    • (2013) Sci Transl Med , vol.5 , pp. 216ra177
    • Yasuda, H.1    Park, E.2    Yun, C.H.3
  • 65
    • 84893206526 scopus 로고    scopus 로고
    • Combination of EGFRTKIs and chemotherapy as first-line therapy for advanced NSCLC: A meta-analysis
    • OuYang PY, Su Z, Mao YP, et al. Combination of EGFRTKIs and chemotherapy as first-line therapy for advanced NSCLC: a meta-analysis. PLoS One. 2013;8:e79000.
    • (2013) PLoS One , vol.8 , pp. e79000
    • OuYang, P.Y.1    Su, Z.2    Mao, Y.P.3
  • 66
    • 84908127948 scopus 로고    scopus 로고
    • Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): An open-label, randomised, multicentre, phase 2 study
    • Seto T, Kato T, Nishio M, et al. Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study. Lancet Oncol. 2014;15:1236-1244.
    • (2014) Lancet Oncol , vol.15 , pp. 1236-1244
    • Seto, T.1    Kato, T.2    Nishio, M.3
  • 67
    • 84906911022 scopus 로고    scopus 로고
    • Dual inhibition of EGFR with afatinib and cetuximab in kinase inhibitor-resistant EGFR-mutant lung cancer with and without T790M mutations
    • Janjigian YY, Smit EF, Groen HJ, et al. Dual inhibition of EGFR with afatinib and cetuximab in kinase inhibitor-resistant EGFR-mutant lung cancer with and without T790M mutations. Cancer Discov. 2014;4:1036-1045.
    • (2014) Cancer Discov , vol.4 , pp. 1036-1045
    • Janjigian, Y.Y.1    Smit, E.F.2    Groen, H.J.3
  • 68
    • 84907561441 scopus 로고    scopus 로고
    • Safety and efficacy of INC280 in combination with gefitinib (gef) in patients with EGFR-mutated (mut), MET-positive NSCLC: A single-arm phase lb/ll study [abstract]
    • Wu Y-L, Yang JC-H, Kim D-W, et al. Safety and efficacy of INC280 in combination with gefitinib (gef) in patients with EGFR-mutated (mut), MET-positive NSCLC: A single-arm phase lb/ll study [abstract]. J Clin Oncol. 2014;32(suppl):8017.
    • (2014) J Clin Oncol , vol.32 , pp. 8017
    • Wu, Y.-L.1    Yang, J.C.-H.2    Kim, D.-W.3
  • 69
    • 85028478698 scopus 로고    scopus 로고
    • Phase Ib trial of afatinib and BI 836845 in advanced non-small cell lung cancer (NSCLC)
    • Tan D, Lin C-C, Huang DC-L, et al. Phase Ib trial of afatinib and BI 836845 in advanced non-small cell lung cancer (NSCLC). Ann Oncol. 2015;26:ix147.
    • (2015) Ann Oncol. , vol.26 , pp. ix147
    • Tan, D.1    Lin, C.-C.2    Huang, D.C.-L.3
  • 70
    • 84907651085 scopus 로고    scopus 로고
    • Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO- 4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC
    • Rizvi NA, Chow LQM, Borghaei H, et al. Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO- 4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC. J Clin Oncol. 2014;32:8022.
    • (2014) J Clin Oncol , vol.32 , pp. 8022
    • Rizvi, N.A.1    Chow, L.Q.M.2    Borghaei, H.3
  • 71
    • 74949110711 scopus 로고    scopus 로고
    • Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
    • Jackman D, Pao W, Riely GJ, et al. Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J Clin Oncol. 2010;28:357-360.
    • (2010) J Clin Oncol , vol.28 , pp. 357-360
    • Jackman, D.1    Pao, W.2    Riely, G.J.3
  • 72
    • 84979503381 scopus 로고    scopus 로고
    • First-line erlotinib therapy until and beyond response evaluation criteria in solid tumors progression in asian patients with epidermal growth factor receptor mutation-positive non-smallcell lung cancer: The ASPIRATION study
    • Park K, Yu CJ, Kim SW, et al. First-line erlotinib therapy until and beyond response evaluation criteria in solid tumors progression in asian patients with epidermal growth factor receptor mutation-positive non-smallcell lung cancer: the ASPIRATION study. JAMA Oncol. 2016;2:305-312.
    • (2016) JAMA Oncol , vol.2 , pp. 305-312
    • Park, K.1    Yu, C.J.2    Kim, S.W.3
  • 73
    • 84978312392 scopus 로고    scopus 로고
    • AZD3759, an EGFR inhibitor with blood brain barrier (BBB) penetration for the treatment of non-small cell lung cancer (NSCLC) with brain metastasis (BM): Preclinical evidence and clinical cases [abstract]
    • Kim D-W, Yang JC-H, Chen K, et al. AZD3759, an EGFR inhibitor with blood brain barrier (BBB) penetration for the treatment of non-small cell lung cancer (NSCLC) with brain metastasis (BM): preclinical evidence and clinical cases [abstract]. J Clin Oncol. 2015;33(suppl):8016.
    • (2015) J Clin Oncol , vol.33 , pp. 8016
    • Kim, D.-W.1    Yang, J.C.-H.2    Chen, K.3
  • 74
    • 40049099220 scopus 로고    scopus 로고
    • The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
    • Yun CH, Mengwasser KE, Toms AV, et al. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A. 2008;105:2070-2075.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2070-2075
    • Yun, C.H.1    Mengwasser, K.E.2    Toms, A.V.3
  • 75
    • 84864524696 scopus 로고    scopus 로고
    • Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1
    • Ohashi K, Sequist LV, Arcila ME, et al. Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proc Natl Acad Sci U S A. 2012;109:E2127-E2133.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E2127-E2133
    • Ohashi, K.1    Sequist, L.V.2    Arcila, M.E.3
  • 76
    • 84962815723 scopus 로고    scopus 로고
    • Squamous Cell carcinoma "transformation" concurrent with secondary T790M mutation in resistant EGFR-mutated adenocarcinomas
    • Jukna A, Montanari G, Mengoli MC, et al. Squamous Cell carcinoma "transformation" concurrent with secondary T790M mutation in resistant EGFR-mutated adenocarcinomas. J Thorac Oncol. 2016;11:e49-e51.
    • (2016) J Thorac Oncol , vol.11 , pp. e49-e51
    • Jukna, A.1    Montanari, G.2    Mengoli, M.C.3
  • 77
    • 84924590266 scopus 로고    scopus 로고
    • RBloss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer
    • NiederstMJ, Sequist LV, Poirier JT, et al. RBloss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer. Nat Commun. 2015;6:6377.
    • (2015) Nat Commun , vol.6 , pp. 6377
    • Niederst, M.J.1    Sequist, L.V.2    Poirier, J.T.3
  • 78
    • 33751292685 scopus 로고    scopus 로고
    • Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors
    • Balak MN, Gong Y, Riely GJ, et al. Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors. Clin Cancer Res. 2006;12:6494-6501.
    • (2006) Clin Cancer Res , vol.12 , pp. 6494-6501
    • Balak, M.N.1    Gong, Y.2    Riely, G.J.3
  • 79
    • 58149333768 scopus 로고    scopus 로고
    • Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma
    • Bean J, Riely GJ, Balak M, et al. Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma. Clin Cancer Res. 2008;14:7519-7525.
    • (2008) Clin Cancer Res , vol.14 , pp. 7519-7525
    • Bean, J.1    Riely, G.J.2    Balak, M.3
  • 80
    • 35648949422 scopus 로고    scopus 로고
    • BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations
    • [discussion 1680]
    • Costa DB, Halmos B, Kumar A, et al. BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. PLoS Med. 2007;4:1669-1679 [discussion 1680].
    • (2007) PLoS Med , vol.4 , pp. 1669-1679
    • Costa, D.B.1    Halmos, B.2    Kumar, A.3
  • 81
    • 84867760241 scopus 로고    scopus 로고
    • HER2 amplification: A potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation
    • Takezawa K, Pirazzoli V, Arcila ME, et al. HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation. Cancer Discov. 2012;2:922-933.
    • (2012) Cancer Discov , vol.2 , pp. 922-933
    • Takezawa, K.1    Pirazzoli, V.2    Arcila, M.E.3
  • 82
    • 84864402225 scopus 로고    scopus 로고
    • Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
    • Zhang Z, Lee JC, Lin L, et al. Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nat Genet. 2012;44:852-860.
    • (2012) Nat Genet , vol.44 , pp. 852-860
    • Zhang, Z.1    Lee, J.C.2    Lin, L.3
  • 83
    • 81755185464 scopus 로고    scopus 로고
    • Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort
    • Yano S, Yamada T, Takeuchi S, et al. Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort. J Thorac Oncol. 2011;6:2011-2017.
    • (2011) J Thorac Oncol , vol.6 , pp. 2011-2017
    • Yano, S.1    Yamada, T.2    Takeuchi, S.3
  • 84
    • 78449283888 scopus 로고    scopus 로고
    • Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations
    • Yamamoto C, Basaki Y, Kawahara A, et al. Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations. Cancer Res. 2010;70:8715-8725.
    • (2010) Cancer Res , vol.70 , pp. 8715-8725
    • Yamamoto, C.1    Basaki, Y.2    Kawahara, A.3
  • 85
    • 84928746232 scopus 로고    scopus 로고
    • Rociletinib in EGFR-mutated non-small-cell lung cancer
    • Sequist LV, Soria JC, Goldman JW, et al. Rociletinib in EGFR-mutated non-small-cell lung cancer. N Engl J Med. 2015;372:1700-1709.
    • (2015) N Engl J Med , vol.372 , pp. 1700-1709
    • Sequist, L.V.1    Soria, J.C.2    Goldman, J.W.3
  • 86
    • 84974855072 scopus 로고    scopus 로고
    • Rociletinib: Has the TIGER lost a few of its stripes?
    • Dhingra K. Rociletinib: has the TIGER lost a few of its stripes? Ann Oncol. 2016;27:1161-1164.
    • (2016) Ann Oncol , vol.27 , pp. 1161-1164
    • Dhingra, K.1
  • 87
    • 85049867089 scopus 로고    scopus 로고
    • Highly selective c-Met inhibitor tepotinib plus gefitinib is active in Asian patients with c-Met+ NSCLC
    • Soo R, Kim D-W, Yang JC-H, et al. Highly selective c-Met inhibitor tepotinib plus gefitinib is active in Asian patients with c-Met+ NSCLC. Ann Oncol. 2015;26:ix143.
    • (2015) Ann Oncol. , vol.26 , pp. ix143
    • Soo, R.1    Kim, D.-W.2    Yang, J.C.-H.3
  • 88
    • 84978237351 scopus 로고    scopus 로고
    • Firstin- human study of oral S 49076, a MET/AXL/FGFR inhibitor, in advanced solid tumors
    • Postel-Vinay S, Hollebecque A, Soria J-C, et al. Firstin- human study of oral S 49076, a MET/AXL/FGFR inhibitor, in advanced solid tumors. Ann Oncol. 2015;26(suppl 9):37-39.
    • (2015) Ann Oncol , vol.26 , pp. 37-39
    • Postel-Vinay, S.1    Hollebecque, A.2    Soria, J.-C.3
  • 89
    • 84889089046 scopus 로고    scopus 로고
    • A phase Ib safety and tolerability study of a pan class i PI3K inhibitor buparlisib (BKM120) and gefitinib (gef) in EGFR TKI-resistant NSCLC [abst]
    • Tan DS-W, Lim KH, Tai WM, et al. A phase Ib safety and tolerability study of a pan class I PI3K inhibitor buparlisib (BKM120) and gefitinib (gef) in EGFR TKI-resistant NSCLC [abst]. J Clin Oncol. 2013;31(suppl):8107.
    • (2013) J Clin Oncol , vol.31 , pp. 8107
    • Ds-W, T.1    Lim, K.H.2    Tai, W.M.3
  • 90
    • 84938208051 scopus 로고    scopus 로고
    • Gefitinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation-positive non-small-cell lung cancer after progression on first-line gefitinib (IMPRESS): A phase 3 randomised trial
    • Soria JC, Wu YL, Nakagawa K, et al. Gefitinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation-positive non-small-cell lung cancer after progression on first-line gefitinib (IMPRESS): a phase 3 randomised trial. Lancet Oncol. 2015;16: 990-998.
    • (2015) Lancet Oncol , vol.16 , pp. 990-998
    • Soria, J.C.1    Wu, Y.L.2    Nakagawa, K.3
  • 91
    • 84898542288 scopus 로고    scopus 로고
    • Liquid biopsies: Genotyping circulating tumor DNA
    • Diaz LA Jr, Bardelli A. Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol. 2014;32:579-586.
    • (2014) J Clin Oncol , vol.32 , pp. 579-586
    • Diaz, L.A.1    Bardelli, A.2
  • 92
    • 33748074447 scopus 로고    scopus 로고
    • Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer
    • Inukai M, Toyooka S, Ito S, et al. Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer. Cancer Res. 2006;66:7854-7858.
    • (2006) Cancer Res , vol.66 , pp. 7854-7858
    • Inukai, M.1    Toyooka, S.2    Ito, S.3
  • 93
    • 84954088699 scopus 로고    scopus 로고
    • Impact of smoking and brain metastasis on outcomes of advanced EGFR mutation lung adenocarcinoma patients treated with first line epidermal growth factor receptor tyrosine kinase inhibitors
    • Jain A, Lim C, Gan EM, et al. Impact of smoking and brain metastasis on outcomes of advanced EGFR mutation lung adenocarcinoma patients treated with first line epidermal growth factor receptor tyrosine kinase inhibitors. PLoS One. 2015;10:e0123587.
    • (2015) PLoS One , vol.10 , pp. e0123587
    • Jain, A.1    Lim, C.2    Gan, E.M.3
  • 94
    • 79952264325 scopus 로고    scopus 로고
    • Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations
    • Rosell R, Molina MA, Costa C, et al. Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations. Clin Cancer Res. 2011;17:1160-1168.
    • (2011) Clin Cancer Res , vol.17 , pp. 1160-1168
    • Rosell, R.1    Molina, M.A.2    Costa, C.3
  • 95
    • 47949114668 scopus 로고    scopus 로고
    • Detection of mutations in EGFR in circulating lung-cancer cells
    • Maheswaran S, Sequist LV, Nagrath S, et al. Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med. 2008;359:366-377.
    • (2008) N Engl J Med , vol.359 , pp. 366-377
    • Maheswaran, S.1    Sequist, L.V.2    Nagrath, S.3
  • 96
    • 84893372504 scopus 로고    scopus 로고
    • Poor response to erlotinib in patients with tumors containing baseline EGFR T790M mutations found by routine clinical molecular testing
    • Yu HA, Arcila ME, Hellmann MD, et al. Poor response to erlotinib in patients with tumors containing baseline EGFR T790M mutations found by routine clinical molecular testing. Ann Oncol. 2014;25:423-428.
    • (2014) Ann Oncol , vol.25 , pp. 423-428
    • Yu, H.A.1    Arcila, M.E.2    Hellmann, M.D.3
  • 97
    • 84863011443 scopus 로고    scopus 로고
    • Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer
    • Su KY, Chen HY, Li KC, et al. Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer. J Clin Oncol. 2012;30:433-440.
    • (2012) J Clin Oncol , vol.30 , pp. 433-440
    • Su, K.Y.1    Chen, H.Y.2    Li, K.C.3
  • 98
    • 84883458149 scopus 로고    scopus 로고
    • Detection of epidermal growth factor receptor T790M mutation in plasma DNA from patients refractory to epidermal growth factor receptor tyrosine kinase inhibitor
    • Sakai K, Horiike A, Irwin DL, et al. Detection of epidermal growth factor receptor T790M mutation in plasma DNA from patients refractory to epidermal growth factor receptor tyrosine kinase inhibitor. Cancer Sci. 2013;104:1198-1204.
    • (2013) Cancer Sci , vol.104 , pp. 1198-1204
    • Sakai, K.1    Horiike, A.2    Irwin, D.L.3
  • 99
    • 84896539307 scopus 로고    scopus 로고
    • Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA
    • Oxnard GR, Paweletz CP, Kuang Y, et al. Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA. Clin Cancer Res. 2014;20:1698-1705.
    • (2014) Clin Cancer Res , vol.20 , pp. 1698-1705
    • Oxnard, G.R.1    Paweletz, C.P.2    Kuang, Y.3
  • 100
    • 85028477543 scopus 로고    scopus 로고
    • Noninvasive detection of acquired T790M mutation in NSCLC patients treated with EGFR-TKI using digital PCR of plasma
    • Ishii H, Azuma K, Sakai K, et al. Noninvasive detection of acquired T790M mutation in NSCLC patients treated with EGFR-TKI using digital PCR of plasma. Ann Oncol. 2015;26:vii138.
    • (2015) Ann Oncol. , vol.26 , pp. vii138
    • Ishii, H.1    Azuma, K.2    Sakai, K.3
  • 101
    • 84962222188 scopus 로고    scopus 로고
    • Detection of T790M, the acquired resistance EGFR mutation, by tumor biopsy versus noninvasive blood-based analyses
    • Sundaresan TK, Sequist LV, Heymach JV, et al. Detection of T790M, the acquired resistance EGFR mutation, by tumor biopsy versus noninvasive blood-based analyses. Clin Cancer Res. 2016;22:1103-1110.
    • (2016) Clin Cancer Res , vol.22 , pp. 1103-1110
    • Sundaresan, T.K.1    Sequist, L.V.2    Heymach, J.V.3
  • 102
    • 84978619027 scopus 로고    scopus 로고
    • Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition
    • Hata AN, Niederst MJ, Archibald HL, et al. Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition. Nat Med. 2016;22:262-269.
    • (2016) Nat Med , vol.22 , pp. 262-269
    • Hata, A.N.1    Niederst, M.J.2    Archibald, H.L.3
  • 103
    • 0024271627 scopus 로고
    • Brain metastases in adenocarcinoma of the lung: Frequency, risk groups, and prognosis
    • Sorensen JB, Hansen HH, Hansen M, et al. Brain metastases in adenocarcinoma of the lung: frequency, risk groups, and prognosis. J Clin Oncol. 1988;6:1474-1480.
    • (1988) J Clin Oncol , vol.6 , pp. 1474-1480
    • Sorensen, J.B.1    Hansen, H.H.2    Hansen, M.3
  • 104
    • 33747500939 scopus 로고    scopus 로고
    • Frequent EGFR mutations in brain metastases of lung adenocarcinoma
    • Matsumoto S, Takahashi K, Iwakawa R, et al. Frequent EGFR mutations in brain metastases of lung adenocarcinoma. Int J Cancer. 2006;119:1491-1494.
    • (2006) Int J Cancer , vol.119 , pp. 1491-1494
    • Matsumoto, S.1    Takahashi, K.2    Iwakawa, R.3
  • 105
    • 84893405392 scopus 로고    scopus 로고
    • EGFR mutation and brain metastasis in pulmonary adenocarcinomas
    • Shin DY, Na II, Kim CH, et al. EGFR mutation and brain metastasis in pulmonary adenocarcinomas. J Thorac Oncol. 2014;9:195-199.
    • (2014) J Thorac Oncol , vol.9 , pp. 195-199
    • Shin, D.Y.1    Na, I.I.2    Kim, C.H.3
  • 106
    • 0031780847 scopus 로고    scopus 로고
    • Prognosis of patients treated for intracranial metastases with whole-brain irradiation
    • Sundstrom JT, Minn H, Lertola KK, et al. Prognosis of patients treated for intracranial metastases with whole-brain irradiation. Ann Med. 1998;30:296-299.
    • (1998) Ann Med , vol.30 , pp. 296-299
    • Sundstrom, J.T.1    Minn, H.2    Lertola, K.K.3
  • 107
    • 58949096573 scopus 로고    scopus 로고
    • A validation study of a new prognostic index for patients with brain metastases: The Graded Prognostic Assessment
    • Sperduto CM, Watanabe Y, Mullan J, et al. A validation study of a new prognostic index for patients with brain metastases: the Graded Prognostic Assessment. J Neurosurg. 2008;109(suppl):87-89.
    • (2008) J Neurosurg , vol.109 , pp. 87-89
    • Sperduto, C.M.1    Watanabe, Y.2    Mullan, J.3
  • 108
    • 84924935661 scopus 로고    scopus 로고
    • Significance of targeted therapy and genetic alterations in EGFR, ALK, or KRAS on survival in patients with non-small cell lung cancer treated with radiotherapy for brain metastases
    • Mak KS, Gainor JF, Niemierko A, et al. Significance of targeted therapy and genetic alterations in EGFR, ALK, or KRAS on survival in patients with non-small cell lung cancer treated with radiotherapy for brain metastases. Neuro Oncol. 2015;17:296-302.
    • (2015) Neuro Oncol , vol.17 , pp. 296-302
    • Mak, K.S.1    Gainor, J.F.2    Niemierko, A.3
  • 109
    • 84899951757 scopus 로고    scopus 로고
    • Erlotinib versus radiation therapy for brain metastases in patients with EGFR-mutant lung adenocarcinoma
    • Gerber NK, Yamada Y, Rimner A, et al. Erlotinib versus radiation therapy for brain metastases in patients with EGFR-mutant lung adenocarcinoma. Int J Radiat Oncol Biol Phys. 2014;89:322-329.
    • (2014) Int J Radiat Oncol Biol Phys , vol.89 , pp. 322-329
    • Gerber, N.K.1    Yamada, Y.2    Rimner, A.3
  • 110
    • 40749142429 scopus 로고    scopus 로고
    • Radiotherapy in lung adenocarcinoma with brain metastases: Effects of activating epidermal growth factor receptor mutations on clinical response
    • Gow CH, Chien CR, Chang YL, et al. Radiotherapy in lung adenocarcinoma with brain metastases: effects of activating epidermal growth factor receptor mutations on clinical response. Clin Cancer Res. 2008;14:162-168.
    • (2008) Clin Cancer Res , vol.14 , pp. 162-168
    • Gow, C.H.1    Chien, C.R.2    Chang, Y.L.3
  • 111
    • 0034940385 scopus 로고    scopus 로고
    • Surgical management of non-small cell lung cancer with synchronous brain metastases
    • Bonnette P, Puyo P, Gabriel C, et al. Surgical management of non-small cell lung cancer with synchronous brain metastases. Chest. 2001;119:1469-1475.
    • (2001) Chest , vol.119 , pp. 1469-1475
    • Bonnette, P.1    Puyo, P.2    Gabriel, C.3
  • 112
    • 84865197331 scopus 로고    scopus 로고
    • Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation
    • Park SJ, Kim HT, Lee DH, et al. Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation. Lung Cancer. 2012;77:556-560.
    • (2012) Lung Cancer , vol.77 , pp. 556-560
    • Park, S.J.1    Kim, H.T.2    Lee, D.H.3
  • 113
    • 84875632711 scopus 로고    scopus 로고
    • Erlotinib as second-line treatment in patients with advanced non-small-cell lung cancer and asymptomatic brain metastases: A phase II study (CTONG-0803)
    • Wu YL, Zhou C, Cheng Y, et al. Erlotinib as second-line treatment in patients with advanced non-small-cell lung cancer and asymptomatic brain metastases: a phase II study (CTONG-0803). Ann Oncol. 2013;24: 993-999.
    • (2013) Ann Oncol , vol.24 , pp. 993-999
    • Wu, Y.L.1    Zhou, C.2    Cheng, Y.3
  • 114
    • 84926168201 scopus 로고    scopus 로고
    • EGFR tyrosine kinase inhibitors versus cranial radiation therapy for EGFR mutant non-small cell lung cancer with brain metastases: A systematic review and meta-analysis
    • Soon YY, Leong CN, Koh WY, et al. EGFR tyrosine kinase inhibitors versus cranial radiation therapy for EGFR mutant non-small cell lung cancer with brain metastases: a systematic review and meta-analysis. Radiother Oncol. 2015;114:167-172.
    • (2015) Radiother Oncol , vol.114 , pp. 167-172
    • Soon, Y.Y.1    Leong, C.N.2    Koh, W.Y.3
  • 115
    • 84875720245 scopus 로고    scopus 로고
    • Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer
    • Welsh JW, Komaki R, Amini A, et al. Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer. J Clin Oncol. 2013;31:895-902.
    • (2013) J Clin Oncol , vol.31 , pp. 895-902
    • Welsh, J.W.1    Komaki, R.2    Amini, A.3
  • 116
    • 84875239644 scopus 로고    scopus 로고
    • A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320
    • Sperduto PW, Wang M, Robins HI, et al. A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320. Int J Radiat Oncol Biol Phys. 2013;85: 1312-1318.
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , pp. 1312-1318
    • Sperduto, P.W.1    Wang, M.2    Robins, H.I.3
  • 117
    • 33749046899 scopus 로고    scopus 로고
    • Response and resistance in a non-small-cell lung cancer patient with an epidermal growth factor receptor mutation and leptomeningeal metastases treated with high-dose gefitinib
    • Jackman DM, Holmes AJ, Lindeman N, et al. Response and resistance in a non-small-cell lung cancer patient with an epidermal growth factor receptor mutation and leptomeningeal metastases treated with high-dose gefitinib. J Clin Oncol. 2006;24:4517-4520.
    • (2006) J Clin Oncol , vol.24 , pp. 4517-4520
    • Jackman, D.M.1    Holmes, A.J.2    Lindeman, N.3
  • 118
    • 84885469577 scopus 로고    scopus 로고
    • Impact of EGFR tyrosine kinase inhibitors versus chemotherapy on the development of leptomeningeal metastasis in never smokers with advanced adenocarcinoma of the lung
    • Lee Y, Han JY, Kim HT, et al. Impact of EGFR tyrosine kinase inhibitors versus chemotherapy on the development of leptomeningeal metastasis in never smokers with advanced adenocarcinoma of the lung. J Neurooncol. 2013;115:95-101.
    • (2013) J Neurooncol , vol.115 , pp. 95-101
    • Lee, Y.1    Han, J.Y.2    Kim, H.T.3
  • 119
    • 84875250073 scopus 로고    scopus 로고
    • High-dose, pulsatile erlotinib in two NSCLC patients with leptomeningeal metastases - One with a remarkable thoracic response as well
    • Kuiper JL, Smit EF. High-dose, pulsatile erlotinib in two NSCLC patients with leptomeningeal metastases - one with a remarkable thoracic response as well. Lung Cancer. 2013;80:102-105.
    • (2013) Lung Cancer , vol.80 , pp. 102-105
    • Kuiper, J.L.1    Smit, E.F.2
  • 120
    • 77956060394 scopus 로고    scopus 로고
    • High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer
    • Clarke JL, Pao W, Wu N, et al. High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer. J Neurooncol. 2010;99:283-286.
    • (2010) J Neurooncol , vol.99 , pp. 283-286
    • Clarke, J.L.1    Pao, W.2    Wu, N.3
  • 121
    • 84856304068 scopus 로고    scopus 로고
    • "Pulsatile" high-dose weekly erlotinib for CNS metastases from EGFR mutant non-small cell lung cancer
    • Grommes C, Oxnard GR, Kris MG, et al. "Pulsatile" high-dose weekly erlotinib for CNS metastases from EGFR mutant non-small cell lung cancer. Neuro Oncol. 2011;13:1364-1369.
    • (2011) Neuro Oncol , vol.13 , pp. 1364-1369
    • Grommes, C.1    Oxnard, G.R.2    Kris, M.G.3
  • 122
    • 84978219666 scopus 로고    scopus 로고
    • AZD9291 activity in patients with leptomeningeal disease from non-small cell lung cancer: A phase i study
    • Lee DH, Kim D-W, Ahn M-J, et al. AZD9291 activity in patients with leptomeningeal disease from non-small cell lung cancer: a phase I study. Mol Cancer Ther. 2015;14:PR07.
    • (2015) Mol Cancer Ther. , vol.14 , pp. PR07
    • Lee, D.H.1    Kim, D.-W.2    Ahn, M.-J.3
  • 123
    • 84858327540 scopus 로고    scopus 로고
    • Leptomeningeal metastasis from non-small cell lung cancer: Survival and the impact of whole brain radiotherapy
    • Morris PG, Reiner AS, Szenberg OR, et al. Leptomeningeal metastasis from non-small cell lung cancer: survival and the impact of whole brain radiotherapy. J Thorac Oncol. 2012;7:382-385.
    • (2012) J Thorac Oncol , vol.7 , pp. 382-385
    • Morris, P.G.1    Reiner, A.S.2    Szenberg, O.R.3
  • 124
    • 84908249715 scopus 로고    scopus 로고
    • An individual patient data metaanalysis of outcomes and prognostic factors after treatment of oligometastatic nonsmall- cell lung cancer
    • Ashworth AB, Senan S, Palma DA, et al. An individual patient data metaanalysis of outcomes and prognostic factors after treatment of oligometastatic nonsmall- cell lung cancer. Clin Lung Cancer. 2014;15: 346-355.
    • (2014) Clin Lung Cancer , vol.15 , pp. 346-355
    • Ashworth, A.B.1    Senan, S.2    Palma, D.A.3
  • 125
    • 84870317390 scopus 로고    scopus 로고
    • Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer
    • Weickhardt AJ, Scheier B, Burke JM, et al. Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer. J Thorac Oncol. 2012;7:1807-1814.
    • (2012) J Thorac Oncol , vol.7 , pp. 1807-1814
    • Weickhardt, A.J.1    Scheier, B.2    Burke, J.M.3
  • 126
    • 84871495757 scopus 로고    scopus 로고
    • Local therapy as a treatment strategy in EGFR-mutant advanced lung cancers that have developed acquired resistance to EGFR tyrosine kinase inhibitors [abst]
    • Yu HA, Sima CS, Drilon AEDC, et al. Local therapy as a treatment strategy in EGFR-mutant advanced lung cancers that have developed acquired resistance to EGFR tyrosine kinase inhibitors [abst]. J Clin Oncol. 2012;30(suppl):7527.
    • (2012) J Clin Oncol , vol.30 , pp. 7527
    • Yu, H.A.1    Sima, C.S.2    Drilon, A.E.D.C.3
  • 127
    • 45149102984 scopus 로고    scopus 로고
    • Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023
    • Kelly K, Chansky K, Gaspar LE, et al. Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023. J Clin Oncol. 2008;26:2450-2456.
    • (2008) J Clin Oncol , vol.26 , pp. 2450-2456
    • Kelly, K.1    Chansky, K.2    Gaspar, L.E.3
  • 128
    • 84948384227 scopus 로고    scopus 로고
    • Adjuvant erlotinib versus placebo in patients with stage IB-IIIA non-small-cell lung cancer (RADIANT): A randomized, double-blind, phase III trial
    • Kelly K, Altorki NK, Eberhardt WE, et al. Adjuvant erlotinib versus placebo in patients with stage IB-IIIA non-small-cell lung cancer (RADIANT): a randomized, double-blind, phase III trial. J Clin Oncol. 2015;33: 4007-4014.
    • (2015) J Clin Oncol , vol.33 , pp. 4007-4014
    • Kelly, K.1    Altorki, N.K.2    Eberhardt, W.E.3


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