ALK and crizotinib: After the honeymoon...what else? Resistance mechanisms and new therapies to overcome it

Translational Lung Cancer Research

Volumn 3, Issue 4, 2014, Pages 250-261

  Rolfo, Christian ^a   Passiglia, Francesco ^a,b   Castiglia, Marta ^a,b   Raez, Luis E ^c   Germonpre, Paul ^d   Gil Bazo, Ignacio ^e   Zwaenepoel, Karen ^a   De Wilde, Annemieke ^a   Bronte, Giuseppe ^b   Russo, Antonio ^b   Van Meerbeeck, Jan P ^a   Van Schil, Paul ^a   Pauwels, Patrick ^a  

^a ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^b UNIVERSITY OF PALERMO   (Italy)

^c FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^d Thoracic Oncology Unit   (Belgium)

^e UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

ALK inhibitors; ALK rearrangements; NSCLC; Resistance

Indexed keywords

ALECTINIB; ANAPLASTIC LYMPHOMA KINASE; ANAPLASTIC LYMPHOMA KINASE INHIBITOR; BRIGATINIB; CERITINIB; CRIZOTINIB; EML4 PROTEIN; GANETESPIB; LUMINESPIB; ONALESPIB; ONCOPROTEIN; ROS1 PROTEIN; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

CANCER PATIENT; CANCER RESISTANCE; CHROMOSOME REARRANGEMENT; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME LOCALIZATION; HUMAN; NON SMALL CELL LUNG CANCER; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); REVIEW;

EID: 84906272121     PISSN: 22186751     EISSN: 22264477     Source Type: Journal    
DOI: 10.3978/j.issn.2218-6751.2014.03.01     Document Type: Review

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