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Volumn 7, Issue 39, 2016, Pages 64447-64470

Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer

Author keywords

ADT; Androgen receptor; Castrate recurrent; Prostate cancer; Splice variant

Indexed keywords

ABIRATERONE; ANDROGEN RECEPTOR; ANDROSTENEDIONE; BICALUTAMIDE; CABAZITAXEL; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CYPROTERONE ACETATE; CYTOCHROME P450 17; DOCETAXEL; ENZALUTAMIDE; EPIDERMAL GROWTH FACTOR; ESTRAMUSTINE; FLUTAMIDE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN; HISTONE H2AX; MICRORNA 21; MICRORNA 221; MICRORNA 222; MITOXANTRONE; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PRASTERONE; PREDNISONE; PREGNENOLONE; PROTEIN KINASE B; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1A2; UNINDEXED DRUG; ANTIANDROGEN; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; AR PROTEIN, HUMAN; KALLIKREIN; KALLIKREIN-RELATED PEPTIDASE 3, HUMAN; PROSTATE SPECIFIC ANTIGEN;

EID: 84994049260     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.10901     Document Type: Review
Times cited : (129)

References (185)
  • 1
  • 2
    • 84969139874 scopus 로고    scopus 로고
    • Society AC, ed. (Atlanta: American Cancer Society)
    • (2015). Cancer Facts & Figures 2015. In: Society AC, ed. (Atlanta: American Cancer Society).
    • (2015) Cancer Facts & Figures 2015
  • 4
    • 0028256194 scopus 로고
    • Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men
    • Catalona WJ, Richie JP, Ahmann FR, Hudson MA, Scardino PT, Flanigan RC, deKernion JB, RatliffTL, Kavoussi LR, Dalkin BL, et al. Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men. J Urol. 1994; 151: 1283-90. doi:
    • (1994) J Urol , vol.151 , pp. 1283-1290
    • Catalona, W.J.1    Richie, J.P.2    Ahmann, F.R.3    Hudson, M.A.4    Scardino, P.T.5    Flanigan, R.C.6    deKernion, J.B.7    Ratliff, T.L.8    Kavoussi, L.R.9    Dalkin, B.L.10
  • 5
    • 84863961968 scopus 로고    scopus 로고
    • Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement
    • Moyer VA, Force USPST. Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2012; 157: 120-34. doi: 10.7326/0003-4819-157-2-201207170-00459.
    • (2012) Ann Intern Med , vol.157 , pp. 120-134
    • Moyer, V.A.1
  • 8
    • 84901519024 scopus 로고    scopus 로고
    • Implications of the new AUA guidelines on prostate cancer detection in the U.S
    • Cooperberg MR. Implications of the new AUA guidelines on prostate cancer detection in the U.S. Curr Urol Rep. 2014; 15: 420. doi: 10.1007/s11934-014-0420-7.
    • (2014) Curr Urol Rep , vol.15 , pp. 420
    • Cooperberg, M.R.1
  • 9
    • 84864088954 scopus 로고    scopus 로고
    • Prostate cancer screening: facts, statistics, and interpretation in response to the US Preventive Services Task Force Review
    • Carlsson S, Vickers AJ, Roobol M, Eastham J, Scardino P, Lilja H, Hugosson J. Prostate cancer screening: facts, statistics, and interpretation in response to the US Preventive Services Task Force Review. J Clin Oncol. 2012; 30: 2581-4. doi: 10.1200/JCO.2011.40.4327.
    • (2012) J Clin Oncol , vol.30 , pp. 2581-2584
    • Carlsson, S.1    Vickers, A.J.2    Roobol, M.3    Eastham, J.4    Scardino, P.5    Lilja, H.6    Hugosson, J.7
  • 10
    • 77956810216 scopus 로고    scopus 로고
    • Screening for prostate cancer: systematic review and meta-analysis of randomised controlled trials
    • Djulbegovic M, Beyth RJ, Neuberger MM, Stoffs TL, Vieweg J, Djulbegovic B, Dahm P. Screening for prostate cancer: systematic review and meta-analysis of randomised controlled trials. BMJ. 2010; 341: c4543. doi: 10.1136/bmj. c4543.
    • (2010) BMJ , vol.341
    • Djulbegovic, M.1    Beyth, R.J.2    Neuberger, M.M.3    Stoffs, T.L.4    Vieweg, J.5    Djulbegovic, B.6    Dahm, P.7
  • 11
    • 79952604359 scopus 로고    scopus 로고
    • Screening for prostate cancer: an updated Cochrane systematic review
    • Ilic D, O'Connor D, Green S, Wilt TJ. Screening for prostate cancer: an updated Cochrane systematic review. BJU Int. 2011; 107: 882-91. doi: 10.1111/j.1464-410X.2010.10032.x.
    • (2011) BJU Int , vol.107 , pp. 882-891
    • Ilic, D.1    O'Connor, D.2    Green, S.3    Wilt, T.J.4
  • 14
    • 84941191269 scopus 로고    scopus 로고
    • Initial prostate cancer diagnosis and disease staging-the role of choline-PET-CT
    • Mapelli P, Picchio M. Initial prostate cancer diagnosis and disease staging-the role of choline-PET-CT. Nat Rev Urol. 2015; 12: 510-8. doi: 10.1038/nrurol.2015.191.
    • (2015) Nat Rev Urol , vol.12 , pp. 510-518
    • Mapelli, P.1    Picchio, M.2
  • 15
    • 0013890366 scopus 로고
    • Classification of prostatic carcinomas
    • Gleason DF. Classification of prostatic carcinomas. Cancer Chemother Rep. 1966; 50: 125-8. doi:
    • (1966) Cancer Chemother Rep , vol.50 , pp. 125-128
    • Gleason, D.F.1
  • 16
    • 0015950349 scopus 로고
    • Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging
    • Gleason DF, Mellinger GT. Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol. 1974; 111: 58-64. doi:
    • (1974) J Urol , vol.111 , pp. 58-64
    • Gleason, D.F.1    Mellinger, G.T.2
  • 17
    • 7444271447 scopus 로고    scopus 로고
    • Gleason grading and prognostic factors in carcinoma of the prostate
    • Humphrey PA. Gleason grading and prognostic factors in carcinoma of the prostate. Mod Pathol. 2004; 17: 292-306. doi: 10.1038/modpathol.3800054.
    • (2004) Mod Pathol , vol.17 , pp. 292-306
    • Humphrey, P.A.1
  • 18
    • 73749085949 scopus 로고    scopus 로고
    • An update of the Gleason grading system
    • Epstein JI. An update of the Gleason grading system. J Urol. 2010; 183: 433-40. doi: 10.1016/j.juro.2009.10.046.
    • (2010) J Urol , vol.183 , pp. 433-440
    • Epstein, J.I.1
  • 19
    • 84958752395 scopus 로고    scopus 로고
    • Changes in prostate cancer grading: Including a new patient-centric grading system
    • Kryvenko ON, Epstein JI. Changes in prostate cancer grading: Including a new patient-centric grading system. Prostate. 2015. doi: 10.1002/pros.23142.
    • (2015) Prostate
    • Kryvenko, O.N.1    Epstein, J.I.2
  • 20
    • 84958033425 scopus 로고    scopus 로고
    • The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System
    • Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA, and the Grading C. The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System. Am J Surg Pathol. 2015. doi: 10.1097/PAS.0000000000000530.
    • (2015) Am J Surg Pathol
    • Epstein, J.I.1    Egevad, L.2    Amin, M.B.3    Delahunt, B.4    Srigley, J.R.5    Humphrey, P.A.6
  • 21
    • 84878865937 scopus 로고    scopus 로고
    • Prognostic factors for newly diagnosed prostate cancer and their role in treatment selection
    • Crook J, Ots AF. Prognostic factors for newly diagnosed prostate cancer and their role in treatment selection. Semin Radiat Oncol. 2013; 23: 165-72. doi: 10.1016/j.semradonc.2013.01.002.
    • (2013) Semin Radiat Oncol , vol.23 , pp. 165-172
    • Crook, J.1    Ots, A.F.2
  • 22
    • 84993931619 scopus 로고    scopus 로고
    • AJCC Cancer Staging Manual: Springer-Verlag New York)
    • (2010). AJCC Cancer Staging Manual: Springer-Verlag New York).
    • (2010)
  • 24
    • 77949898163 scopus 로고    scopus 로고
    • Time trends and local variation in primary treatment of localized prostate cancer
    • Cooperberg MR, Broering JM, Carroll PR. Time trends and local variation in primary treatment of localized prostate cancer. J Clin Oncol. 2010; 28: 1117-23. doi: 10.1200/JCO.2009.26.0133.
    • (2010) J Clin Oncol , vol.28 , pp. 1117-1123
    • Cooperberg, M.R.1    Broering, J.M.2    Carroll, P.R.3
  • 25
    • 34250012314 scopus 로고    scopus 로고
    • Updated nomogram to predict pathologic stage of prostate cancer given prostate-specific antigen level, clinical stage, and biopsy Gleason score (Partin tables) based on cases from 2000 to 2005
    • Makarov DV, Trock BJ, Humphreys EB, Mangold LA, Walsh PC, Epstein JI, Partin AW. Updated nomogram to predict pathologic stage of prostate cancer given prostate-specific antigen level, clinical stage, and biopsy Gleason score (Partin tables) based on cases from 2000 to 2005. Urology. 2007; 69: 1095-101. doi: 10.1016/j.urology.2007.03.042.
    • (2007) Urology , vol.69 , pp. 1095-1101
    • Makarov, D.V.1    Trock, B.J.2    Humphreys, E.B.3    Mangold, L.A.4    Walsh, P.C.5    Epstein, J.I.6    Partin, A.W.7
  • 28
    • 67449126769 scopus 로고    scopus 로고
    • Risk assessment for prostate cancer metastasis and mortality at the time of diagnosis
    • Cooperberg MR, Broering JM, Carroll PR. Risk assessment for prostate cancer metastasis and mortality at the time of diagnosis. J Natl Cancer Inst. 2009; 101: 878-87. doi: 10.1093/jnci/djp122.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 878-887
    • Cooperberg, M.R.1    Broering, J.M.2    Carroll, P.R.3
  • 30
    • 84871706840 scopus 로고    scopus 로고
    • How to select the optimal therapy for early-stage prostate cancer
    • Kollmeier MA, Zelefsky MJ. How to select the optimal therapy for early-stage prostate cancer. Crit Rev Oncol Hematol. 2012; 84 Suppl 1: e6-e15. doi: 10.1016/j.critrevonc.2012.12.002.
    • (2012) Crit Rev Oncol Hematol , vol.84 , pp. e6-e15
    • Kollmeier, M.A.1    Zelefsky, M.J.2
  • 33
    • 84960355151 scopus 로고    scopus 로고
    • Therapeutic Rationales, Progresses, Failures, and Future Directions for Advanced Prostate Cancer
    • Wadosky KM, Koochekpour S. Therapeutic Rationales, Progresses, Failures, and Future Directions for Advanced Prostate Cancer. Int J Biol Sci. 2016; 12: 409-26. doi: doi:10.7150/ijbs.14090.
    • (2016) Int J Biol Sci , vol.12 , pp. 409-426
    • Wadosky, K.M.1    Koochekpour, S.2
  • 35
    • 37349061111 scopus 로고    scopus 로고
    • An analysis of radical prostatectomy in advanced stage and high-grade prostate cancer
    • Van Poppel H, Joniau S. An analysis of radical prostatectomy in advanced stage and high-grade prostate cancer. Eur Urol. 2008; 53: 253-9. doi: 10.1016/j.eururo.2007.10.009.
    • (2008) Eur Urol , vol.53 , pp. 253-259
    • Van Poppel, H.1    Joniau, S.2
  • 36
    • 84946217842 scopus 로고    scopus 로고
    • Optimal management of prostate cancer with lethal biology-state-of-the-art local therapy
    • Chapin BF. Optimal management of prostate cancer with lethal biology-state-of-the-art local therapy. Asian J Androl. 2015; 17: 888-91. doi: 10.4103/1008-682X.156855.
    • (2015) Asian J Androl , vol.17 , pp. 888-891
    • Chapin, B.F.1
  • 38
    • 60149089419 scopus 로고    scopus 로고
    • Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion
    • Harris WP, Mostaghel EA, Nelson PS, Montgomery B. Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat Clin Pract Urol. 2009; 6: 76-85. doi: 10.1038/ncpuro1296.
    • (2009) Nat Clin Pract Urol , vol.6 , pp. 76-85
    • Harris, W.P.1    Mostaghel, E.A.2    Nelson, P.S.3    Montgomery, B.4
  • 39
    • 84961215473 scopus 로고    scopus 로고
    • Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial
    • James ND, Sydes MR, Clarke NW, Mason MD, Dearnaley DP, Spears MR, Ritchie AW, Parker CC, Russell JM, Attard G, de Bono J, Cross W, Jones RJ, et al. Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial. Lancet. 2015. doi: 10.1016/S0140-6736(15)01037-5.
    • (2015) Lancet
    • James, N.D.1    Sydes, M.R.2    Clarke, N.W.3    Mason, M.D.4    Dearnaley, D.P.5    Spears, M.R.6    Ritchie, A.W.7    Parker, C.C.8    Russell, J.M.9    Attard, G.10    de Bono, J.11    Cross, W.12    Jones, R.J.13
  • 43
    • 84927935871 scopus 로고    scopus 로고
    • Androgendeprivation-associated bone disease
    • Skolarus TA, Caram MV, Shahinian VB. Androgendeprivation-associated bone disease. Curr Opin Urol. 2014; 24: 601-7. doi: 10.1097/MOU.0000000000000101.
    • (2014) Curr Opin Urol , vol.24 , pp. 601-607
    • Skolarus, T.A.1    Caram, M.V.2    Shahinian, V.B.3
  • 44
    • 84907482751 scopus 로고    scopus 로고
    • Muscle and bone effects of androgen deprivation therapy: current and emerging therapies
    • Cheung AS, Zajac JD, Grossmann M. Muscle and bone effects of androgen deprivation therapy: current and emerging therapies. Endocr Relat Cancer. 2014; 21: R371-94.doi: 10.1530/ERC-14-0172.
    • (2014) Endocr Relat Cancer , vol.21 , pp. R371-R394
    • Cheung, A.S.1    Zajac, J.D.2    Grossmann, M.3
  • 46
    • 84922664851 scopus 로고    scopus 로고
    • The effects of androgen deprivation therapy on cardiac function and heart failure: implications for management of prostate cancer
    • Edelman S, Butler J, Hershatter BW, Khan MK. The effects of androgen deprivation therapy on cardiac function and heart failure: implications for management of prostate cancer. Clin Genitourin Cancer. 2014; 12: 399-407. doi: 10.1016/j.clgc.2014.07.009.
    • (2014) Clin Genitourin Cancer , vol.12 , pp. 399-407
    • Edelman, S.1    Butler, J.2    Hershatter, B.W.3    Khan, M.K.4
  • 47
    • 77952568266 scopus 로고    scopus 로고
    • Androgen-deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American Heart Association, American Cancer Society, and American Urological Association: endorsed by the American Society for Radiation Oncology
    • Levine GN, D'Amico AV, Berger P, Clark PE, Eckel RH, Keating NL, Milani RV, Sagalowsky AI, Smith MR, Zakai N, American Heart Association Council on Clinical C, Council on E, Prevention tACS, et al. Androgen-deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American Heart Association, American Cancer Society, and American Urological Association: endorsed by the American Society for Radiation Oncology. CA Cancer J Clin. 2010; 60: 194-201. doi: 10.3322/caac.20061.
    • (2010) CA Cancer J Clin , vol.60 , pp. 194-201
    • Levine, G.N.1    D'Amico, A.V.2    Berger, P.3    Clark, P.E.4    Eckel, R.H.5    Keating, N.L.6    Milani, R.V.7    Sagalowsky, A.I.8    Smith, M.R.9    Zakai, N.10
  • 51
    • 84955184312 scopus 로고    scopus 로고
    • No increased risk of coronary heart disease for patients receiving androgen deprivation therapy for prostate cancer in Chinese/Taiwanese men
    • Wang LH, Liu CK, Chen CH, Kao LT, Lin HC, Huang CY. No increased risk of coronary heart disease for patients receiving androgen deprivation therapy for prostate cancer in Chinese/Taiwanese men. Andrology. 2015. doi: 10.1111/andr.12141.
    • (2015) Andrology
    • Wang, L.H.1    Liu, C.K.2    Chen, C.H.3    Kao, L.T.4    Lin, H.C.5    Huang, C.Y.6
  • 52
    • 84870901336 scopus 로고    scopus 로고
    • Metabolic complications of androgen deprivation therapy for prostate cancer
    • discussion S3-4
    • Saylor PJ, Smith MR. Metabolic complications of androgen deprivation therapy for prostate cancer. J Urol. 2013; 189: S34-42; discussion S3-4. doi: 10.1016/j.juro.2012.11.017.
    • (2013) J Urol , vol.189 , pp. S34-S42
    • Saylor, P.J.1    Smith, M.R.2
  • 55
    • 84948717393 scopus 로고    scopus 로고
    • Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer
    • Watson PA, Arora VK, Sawyers CL. Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer. Nat Rev Cancer. 2015; 15: 701-11. doi: 10.1038/nrc4016.
    • (2015) Nat Rev Cancer , vol.15 , pp. 701-711
    • Watson, P.A.1    Arora, V.K.2    Sawyers, C.L.3
  • 62
    • 38349167518 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer: updated survival in the TAX 327 study
    • Berthold DR, Pond GR, Soban F, de Wit R, Eisenberger M, Tannock IF. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer: updated survival in the TAX 327 study. J Clin Oncol. 2008; 26: 242-5 doi: 10.1200/JCO.2007.12.4008.
    • (2008) J Clin Oncol , vol.26 , pp. 242-245
    • Berthold, D.R.1    Pond, G.R.2    Soban, F.3    de Wit, R.4    Eisenberger, M.5    Tannock, I.F.6
  • 64
    • 84902294377 scopus 로고    scopus 로고
    • Targeting the androgen receptor in prostate cancer
    • Culig Z. Targeting the androgen receptor in prostate cancer. Expert Opin Pharmacother. 2014; 15: 1427-37. doi: 10.1517/14656566.2014.915313.
    • (2014) Expert Opin Pharmacother , vol.15 , pp. 1427-1437
    • Culig, Z.1
  • 65
    • 84953368394 scopus 로고    scopus 로고
    • Androgenglucocorticoid interactions in the era of novel prostate cancer therapy
    • Narayanan S, Srinivas S, Feldman D. Androgenglucocorticoid interactions in the era of novel prostate cancer therapy. Nat Rev Urol. 2015. doi: 10.1038/nrurol.2015.254.
    • (2015) Nat Rev Urol
    • Narayanan, S.1    Srinivas, S.2    Feldman, D.3
  • 66
    • 84930084362 scopus 로고    scopus 로고
    • DNA damage response and prostate cancer: defects, regulation and therapeutic implications
    • Karanika S, Karantanos T, Li L, Corn PG, Thompson TC. DNA damage response and prostate cancer: defects, regulation and therapeutic implications. Oncogene. 2015; 34: 2815-22. doi: 10.1038/onc.2014.238.
    • (2015) Oncogene , vol.34 , pp. 2815-2822
    • Karanika, S.1    Karantanos, T.2    Li, L.3    Corn, P.G.4    Thompson, T.C.5
  • 67
    • 8444231965 scopus 로고    scopus 로고
    • The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer
    • Nishiyama T, Hashimoto Y, Takahashi K. The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer. Clin Cancer Res. 2004; 10: 7121-6. doi: 10.1158/1078-0432. CCR-04-0913.
    • (2004) Clin Cancer Res , vol.10 , pp. 7121-7126
    • Nishiyama, T.1    Hashimoto, Y.2    Takahashi, K.3
  • 68
    • 27644452640 scopus 로고    scopus 로고
    • Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
    • Titus MA, Schell MJ, Lih FB, Tomer KB, Mohler JL. Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer. Clin Cancer Res. 2005; 11: 4653-7 doi: 10.1158/1078-0432.CCR-05-0525.
    • (2005) Clin Cancer Res , vol.11 , pp. 4653-4657
    • Titus, M.A.1    Schell, M.J.2    Lih, F.B.3    Tomer, K.B.4    Mohler, J.L.5
  • 69
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
    • Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, True LD, Nelson PS. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res. 2008; 68: 4447-54. doi: 10.1158/0008-5472.CAN-08-0249.
    • (2008) Cancer Res , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1    Mostaghel, E.A.2    Vessella, R.3    Hess, D.L.4    Kalhorn, T.F.5    Higano, C.S.6    True, L.D.7    Nelson, P.S.8
  • 71
    • 0035300409 scopus 로고    scopus 로고
    • Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen
    • Gregory CW, Johnson RT, Jr., Mohler JL, French FS, Wilson EM. Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen. Cancer Res. 2001; 61: 2892-8. doi:
    • (2001) Cancer Res , vol.61 , pp. 2892-2898
    • Gregory, C.W.1    Johnson, R.T.2    Mohler, J.L.3    French, F.S.4    Wilson, E.M.5
  • 72
    • 84893720016 scopus 로고    scopus 로고
    • CYP17 inhibitors-abiraterone, C17,20-lyase inhibitors and multi-targeting agents
    • Yin L, Hu Q. CYP17 inhibitors-abiraterone, C17,20-lyase inhibitors and multi-targeting agents. Nat Rev Urol. 2014; 11: 32-42. doi: 10.1038/nrurol.2013.274.
    • (2014) Nat Rev Urol , vol.11 , pp. 32-42
    • Yin, L.1    Hu, Q.2
  • 73
    • 84902141056 scopus 로고    scopus 로고
    • Roles for the backdoor pathway of androgen metabolism in prostate cancer response to castration and drug treatment
    • Fiandalo MV, Wilton J, Mohler JL. Roles for the backdoor pathway of androgen metabolism in prostate cancer response to castration and drug treatment. Int J Biol Sci. 2014; 10: 596-601. doi: 10.7150/ijbs.8780.
    • (2014) Int J Biol Sci , vol.10 , pp. 596-601
    • Fiandalo, M.V.1    Wilton, J.2    Mohler, J.L.3
  • 74
    • 84939955986 scopus 로고    scopus 로고
    • The DHEAsulfate depot following P450c17 inhibition supports the case for AKR1C3 inhibition in high risk localized and advanced castration resistant prostate cancer
    • Tamae D, Mostaghel E, Montgomery B, Nelson PS, Balk SP, KantoffPW, Taplin ME, Penning TM. The DHEAsulfate depot following P450c17 inhibition supports the case for AKR1C3 inhibition in high risk localized and advanced castration resistant prostate cancer. Chem Biol Interact. 2015; 234: 332-8. doi: 10.1016/j.cbi.2014.12.012.
    • (2015) Chem Biol Interact , vol.234 , pp. 332-338
    • Tamae, D.1    Mostaghel, E.2    Montgomery, B.3    Nelson, P.S.4    Balk, S.P.5    Kantoff, P.W.6    Taplin, M.E.7    Penning, T.M.8
  • 75
    • 84890352958 scopus 로고    scopus 로고
    • Organic anion-transporting polypeptides: a novel approach for cancer therapy
    • Liu T, Li Q. Organic anion-transporting polypeptides: a novel approach for cancer therapy. J Drug Target. 2014; 22: 14-22. doi: 10.3109/1061186X.2013.832767.
    • (2014) J Drug Target , vol.22 , pp. 14-22
    • Liu, T.1    Li, Q.2
  • 76
    • 84866125863 scopus 로고    scopus 로고
    • Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions
    • Arakawa H, Nakanishi T, Yanagihara C, Nishimoto T, Wakayama T, Mizokami A, Namiki M, Kawai K, Tamai I. Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions. Biochem Pharmacol. 2012; 84: 1070-7. doi: 10.1016/j.bcp.2012.07.026.
    • (2012) Biochem Pharmacol , vol.84 , pp. 1070-1077
    • Arakawa, H.1    Nakanishi, T.2    Yanagihara, C.3    Nishimoto, T.4    Wakayama, T.5    Mizokami, A.6    Namiki, M.7    Kawai, K.8    Tamai, I.9
  • 77
    • 0034895297 scopus 로고    scopus 로고
    • DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology
    • Labrie F, Luu-The V, Labrie C, Simard J. DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology. Front Neuroendocrinol. 2001; 22: 185-212. doi: 10.1006/frne.2001.0216.
    • (2001) Front Neuroendocrinol , vol.22 , pp. 185-212
    • Labrie, F.1    Luu-The, V.2    Labrie, C.3    Simard, J.4
  • 78
    • 80054021222 scopus 로고    scopus 로고
    • Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
    • Cai C, Chen S, Ng P, Bubley GJ, Nelson PS, Mostaghel EA, Marck B, Matsumoto AM, Simon NI, Wang H, Chen S, Balk SP. Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. Cancer Res. 2011; 71: 6503-13. doi: 10.1158/0008-5472. CAN-11-0532.
    • (2011) Cancer Res , vol.71 , pp. 6503-6513
    • Cai, C.1    Chen, S.2    Ng, P.3    Bubley, G.J.4    Nelson, P.S.5    Mostaghel, E.A.6    Marck, B.7    Matsumoto, A.M.8    Simon, N.I.9    Wang, H.10    Chen, S.11    Balk, S.P.12
  • 79
    • 51049098138 scopus 로고    scopus 로고
    • Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
    • Locke JA, Guns ES, Lubik AA, Adomat HH, Hendy SC, Wood CA, Ettinger SL, Gleave ME, Nelson CC. Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. Cancer Res. 2008; 68: 6407-15. doi: 10.1158/0008-5472. CAN-07-5997.
    • (2008) Cancer Res , vol.68 , pp. 6407-6415
    • Locke, J.A.1    Guns, E.S.2    Lubik, A.A.3    Adomat, H.H.4    Hendy, S.C.5    Wood, C.A.6    Ettinger, S.L.7    Gleave, M.E.8    Nelson, C.C.9
  • 81
    • 84906790584 scopus 로고    scopus 로고
    • Concept and viability of androgen annihilation for advanced prostate cancer
    • Mohler JL. Concept and viability of androgen annihilation for advanced prostate cancer. Cancer. 2014; 120: 2628-37. doi: 10.1002/cncr.28675.
    • (2014) Cancer , vol.120 , pp. 2628-2637
    • Mohler, J.L.1
  • 82
    • 54849435425 scopus 로고    scopus 로고
    • Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol
    • Dillard PR, Lin MF, Khan SA. Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol. Mol Cell Endocrinol. 2008; 295: 115-20. doi: 10.1016/j.mce.2008.08.013.
    • (2008) Mol Cell Endocrinol , vol.295 , pp. 115-120
    • Dillard, P.R.1    Lin, M.F.2    Khan, S.A.3
  • 83
    • 76149137405 scopus 로고    scopus 로고
    • Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model
    • Leon CG, Locke JA, Adomat HH, Etinger SL, Twiddy AL, Neumann RD, Nelson CC, Guns ES, Wasan KM. Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model. Prostate. 2010; 70: 390-400. doi: 10.1002/pros.21072.
    • (2010) Prostate , vol.70 , pp. 390-400
    • Leon, C.G.1    Locke, J.A.2    Adomat, H.H.3    Etinger, S.L.4    Twiddy, A.L.5    Neumann, R.D.6    Nelson, C.C.7    Guns, E.S.8    Wasan, K.M.9
  • 84
    • 84946590676 scopus 로고    scopus 로고
    • Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer
    • Perner S, Cronauer MV, Schrader AJ, Klocker H, Culig Z, Baniahmad A. Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer. Oncotarget. 2015; 6: 35542-35555. doi: 10.18632/oncotarget.4689
    • (2015) Oncotarget , vol.6 , pp. 35542-35555
    • Perner, S.1    Cronauer, M.V.2    Schrader, A.J.3    Klocker, H.4    Culig, Z.5    Baniahmad, A.6
  • 85
    • 0023929785 scopus 로고
    • Molecular cloning of human and rat complementary DNA encoding androgen receptors
    • Chang CS, Kokontis J, Liao ST. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science. 1988; 240: 324-6. doi:
    • (1988) Science , vol.240 , pp. 324-326
    • Chang, C.S.1    Kokontis, J.2    Liao, S.T.3
  • 86
    • 0023910355 scopus 로고
    • Cloning of human androgen receptor complementary DNA and localization to the X chromosome
    • Lubahn DB, Joseph DR, Sullivan PM, Willard HF, French FS, Wilson EM. Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science. 1988; 240: 327-30. doi:
    • (1988) Science , vol.240 , pp. 327-330
    • Lubahn, D.B.1    Joseph, D.R.2    Sullivan, P.M.3    Willard, H.F.4    French, F.S.5    Wilson, E.M.6
  • 89
    • 0034656678 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization evaluation of c-myc and androgen receptor gene amplification and chromosomal anomalies in prostate cancer in Japanese patients
    • Miyoshi Y, Uemura H, Fujinami K, Mikata K, Harada M, Kitamura H, Koizumi Y, Kubota Y. Fluorescence in situ hybridization evaluation of c-myc and androgen receptor gene amplification and chromosomal anomalies in prostate cancer in Japanese patients. Prostate. 2000; 43: 225-32. doi:
    • (2000) Prostate , vol.43 , pp. 225-232
    • Miyoshi, Y.1    Uemura, H.2    Fujinami, K.3    Mikata, K.4    Harada, M.5    Kitamura, H.6    Koizumi, Y.7    Kubota, Y.8
  • 92
    • 0036141411 scopus 로고    scopus 로고
    • Androgen receptor expression and cellular proliferation during transition from androgen-dependent to recurrent growth after castration in the CWR22 prostate cancer xenograft
    • Kim D, Gregory CW, French FS, Smith GJ, Mohler JL. Androgen receptor expression and cellular proliferation during transition from androgen-dependent to recurrent growth after castration in the CWR22 prostate cancer xenograft. Am J Pathol. 2002; 160: 219-26. doi: 10.1016/S0002-9440(10)64365-9.
    • (2002) Am J Pathol , vol.160 , pp. 219-226
    • Kim, D.1    Gregory, C.W.2    French, F.S.3    Smith, G.J.4    Mohler, J.L.5
  • 94
    • 84880729344 scopus 로고    scopus 로고
    • Posttranslational modification of the androgen receptor in prostate cancer
    • van der Steen T, Tindall DJ, Huang H. Posttranslational modification of the androgen receptor in prostate cancer. Int J Mol Sci. 2013; 14: 14833-59. doi: 10.3390/ijms140714833.
    • (2013) Int J Mol Sci , vol.14 , pp. 14833-14859
    • van der Steen, T.1    Tindall, D.J.2    Huang, H.3
  • 95
    • 84924908864 scopus 로고    scopus 로고
    • Targeting heat shock proteins in metastatic castration-resistant prostate cancer
    • Azad AA, Zoubeidi A, Gleave ME, Chi KN. Targeting heat shock proteins in metastatic castration-resistant prostate cancer. Nat Rev Urol. 2015; 12: 26-36. doi: 10.1038/nrurol.2014.320.
    • (2015) Nat Rev Urol , vol.12 , pp. 26-36
    • Azad, A.A.1    Zoubeidi, A.2    Gleave, M.E.3    Chi, K.N.4
  • 97
    • 84896698522 scopus 로고    scopus 로고
    • Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants
    • An J, Wang C, Deng Y, Yu L, Huang H. Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants. Cell Rep. 2014; 6: 657-69 doi: 10.1016/j.celrep.2014.01.013.
    • (2014) Cell Rep , vol.6 , pp. 657-669
    • An, J.1    Wang, C.2    Deng, Y.3    Yu, L.4    Huang, H.5
  • 99
    • 84891745501 scopus 로고    scopus 로고
    • Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells
    • Sarkar S, Brautigan DL, Parsons SJ, Larner JM. Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells. Oncogene. 2014; 33: 26-33. doi: 10.1038/onc.2012.561.
    • (2014) Oncogene , vol.33 , pp. 26-33
    • Sarkar, S.1    Brautigan, D.L.2    Parsons, S.J.3    Larner, J.M.4
  • 100
    • 70350244512 scopus 로고    scopus 로고
    • Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens
    • Waltering KK, Helenius MA, Sahu B, Manni V, Linja MJ, Janne OA, Visakorpi T. Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens. Cancer Res. 2009; 69: 8141-9. doi: 10.1158/0008-5472.CAN-09-0919.
    • (2009) Cancer Res , vol.69 , pp. 8141-8149
    • Waltering, K.K.1    Helenius, M.A.2    Sahu, B.3    Manni, V.4    Linja, M.J.5    Janne, O.A.6    Visakorpi, T.7
  • 105
    • 77956443521 scopus 로고    scopus 로고
    • Androgen receptor signaling and mutations in prostate cancer
    • Koochekpour S. Androgen receptor signaling and mutations in prostate cancer. Asian J Androl. 2010; 12: 639-57. doi: 10.1038/aja.2010.89.
    • (2010) Asian J Androl , vol.12 , pp. 639-657
    • Koochekpour, S.1
  • 106
    • 0029825669 scopus 로고    scopus 로고
    • Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome
    • Suzuki H, Akakura K, Komiya A, Aida S, Akimoto S, Shimazaki J. Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome. Prostate. 1996; 29: 153-8. doi:
    • (1996) Prostate , vol.29 , pp. 153-158
    • Suzuki, H.1    Akakura, K.2    Komiya, A.3    Aida, S.4    Akimoto, S.5    Shimazaki, J.6
  • 107
    • 0032743557 scopus 로고    scopus 로고
    • Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a
    • Zhao XY, Boyle B, Krishnan AV, Navone NM, Peehl DM, Feldman D. Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a. J Urol. 1999; 162: 2192-9. doi:
    • (1999) J Urol , vol.162 , pp. 2192-2199
    • Zhao, X.Y.1    Boyle, B.2    Krishnan, A.V.3    Navone, N.M.4    Peehl, D.M.5    Feldman, D.6
  • 108
    • 0028321891 scopus 로고
    • Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: role of bone stromal cells
    • Wu HC, Hsieh JT, Gleave ME, Brown NM, Pathak S, Chung LW. Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: role of bone stromal cells. Int J Cancer. 1994; 57: 406-12. doi:
    • (1994) Int J Cancer , vol.57 , pp. 406-412
    • Wu, H.C.1    Hsieh, J.T.2    Gleave, M.E.3    Brown, N.M.4    Pathak, S.5    Chung, L.W.6
  • 109
    • 0034234571 scopus 로고    scopus 로고
    • LNCaP progression model of human prostate cancer: androgen-independence and osseous metastasis
    • Jul 1;44
    • Thalmann GN, Sikes RA, Wu TT, Degeorges A, Chang SM, Ozen M, Pathak S, Chung LW. LNCaP progression model of human prostate cancer: androgen-independence and osseous metastasis. Prostate. 2000; 44: 91-103 Jul 1;44(2). doi:
    • (2000) Prostate , vol.44 , Issue.2 , pp. 91-103
    • Thalmann, G.N.1    Sikes, R.A.2    Wu, T.T.3    Degeorges, A.4    Chang, S.M.5    Ozen, M.6    Pathak, S.7    Chung, L.W.8
  • 112
    • 0034125195 scopus 로고    scopus 로고
    • Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
    • Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D. Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Nat Med. 2000; 6: 703-6. doi: 10.1038/76287.
    • (2000) Nat Med , vol.6 , pp. 703-706
    • Zhao, X.Y.1    Malloy, P.J.2    Krishnan, A.V.3    Swami, S.4    Navone, N.M.5    Peehl, D.M.6    Feldman, D.7
  • 113
    • 0036225315 scopus 로고    scopus 로고
    • A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer
    • Krishnan AV, Zhao XY, Swami S, Brive L, Peehl DM, Ely KR, Feldman D. A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer. Endocrinology. 2002; 143: 1889-900. doi: 10.1210/endo.143.5.8778.
    • (2002) Endocrinology , vol.143 , pp. 1889-1900
    • Krishnan, A.V.1    Zhao, X.Y.2    Swami, S.3    Brive, L.4    Peehl, D.M.5    Ely, K.R.6    Feldman, D.7
  • 117
    • 84869135796 scopus 로고    scopus 로고
    • Regulation of the androgen receptor by post-translational modifications
    • Coffey K, Robson CN. Regulation of the androgen receptor by post-translational modifications. J Endocrinol. 2012; 215: 221-37. doi: 10.1530/JOE-12-0238.
    • (2012) J Endocrinol , vol.215 , pp. 221-237
    • Coffey, K.1    Robson, C.N.2
  • 118
    • 51049107084 scopus 로고    scopus 로고
    • Sitespecific androgen receptor serine phosphorylation linked to epidermal growth factor-dependent growth of castrationrecurrent prostate cancer
    • Ponguta LA, Gregory CW, French FS, Wilson EM. Sitespecific androgen receptor serine phosphorylation linked to epidermal growth factor-dependent growth of castrationrecurrent prostate cancer. J Biol Chem. 2008; 283: 20989-1001. doi: 10.1074/jbc. M802392200.
    • (2008) J Biol Chem , vol.283 , pp. 20989-21001
    • Ponguta, L.A.1    Gregory, C.W.2    French, F.S.3    Wilson, E.M.4
  • 119
    • 0347696003 scopus 로고    scopus 로고
    • Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers
    • Lin HK, Hu YC, Yang L, Altuwaijri S, Chen YT, Kang HY, Chang C. Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers. J Biol Chem. 2003; 278: 50902-7. doi: 10.1074/jbc. M300676200.
    • (2003) J Biol Chem , vol.278 , pp. 50902-50907
    • Lin, H.K.1    Hu, Y.C.2    Yang, L.3    Altuwaijri, S.4    Chen, Y.T.5    Kang, H.Y.6    Chang, C.7
  • 121
    • 84946087758 scopus 로고    scopus 로고
    • AR-v7 protein expression is regulated by protein kinase and phosphatase
    • Li Y, Xie N, Gleave ME, Rennie PS, Dong X. AR-v7 protein expression is regulated by protein kinase and phosphatase. Oncotarget. 2015; 6: 33743-33754. doi: 10.18632/oncotarget.5608
    • (2015) Oncotarget , vol.6 , pp. 33743-33754
    • Li, Y.1    Xie, N.2    Gleave, M.E.3    Rennie, P.S.4    Dong, X.5
  • 122
    • 40849113286 scopus 로고    scopus 로고
    • Phosphorylation of the androgen receptor is associated with reduced survival in hormone-refractory prostate cancer patients
    • McCall P, Gemmell LK, Mukherjee R, Bartlett JM, Edwards J. Phosphorylation of the androgen receptor is associated with reduced survival in hormone-refractory prostate cancer patients. Br J Cancer. 2008; 98: 1094-101. doi: 10.1038/sj.bjc.6604152.
    • (2008) Br J Cancer , vol.98 , pp. 1094-1101
    • McCall, P.1    Gemmell, L.K.2    Mukherjee, R.3    Bartlett, J.M.4    Edwards, J.5
  • 123
    • 84897365872 scopus 로고    scopus 로고
    • Androgen receptor phosphorylation at serine 308 and serine 791 predicts enhanced survival in castrate resistant prostate cancer patients
    • McCall P, Adams CE, Willder JM, Bennett L, Qayyum T, Orange C, Underwood MA, Edwards J. Androgen receptor phosphorylation at serine 308 and serine 791 predicts enhanced survival in castrate resistant prostate cancer patients. Int J Mol Sci. 2013; 14: 16656-71. doi: 10.3390/ijms140816656.
    • (2013) Int J Mol Sci , vol.14 , pp. 16656-16671
    • McCall, P.1    Adams, C.E.2    Willder, J.M.3    Bennett, L.4    Qayyum, T.5    Orange, C.6    Underwood, M.A.7    Edwards, J.8
  • 124
    • 82255175103 scopus 로고    scopus 로고
    • Androgen receptor and its splice variants in prostate cancer
    • Haile S, Sadar MD. Androgen receptor and its splice variants in prostate cancer. Cell Mol Life Sci. 2011; 68: 3971-81. doi: 10.1007/s00018-011-0766-7.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 3971-3981
    • Haile, S.1    Sadar, M.D.2
  • 125
    • 84901199317 scopus 로고    scopus 로고
    • Decoding the androgen receptor splice variants
    • Lu C, Luo J. Decoding the androgen receptor splice variants. Transl Androl Urol. 2013; 2: 178-86. doi: 10.3978/j.issn.2223-4683.2013.09.08.
    • (2013) Transl Androl Urol , vol.2 , pp. 178-186
    • Lu, C.1    Luo, J.2
  • 126
    • 48549089747 scopus 로고    scopus 로고
    • Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
    • Dehm SM, Schmidt LJ, Heemers HV, Vessella RL, Tindall DJ. Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res. 2008; 68: 5469-77. doi: 10.1158/0008-5472.CAN-08-0594.
    • (2008) Cancer Res , vol.68 , pp. 5469-5477
    • Dehm, S.M.1    Schmidt, L.J.2    Heemers, H.V.3    Vessella, R.L.4    Tindall, D.J.5
  • 128
  • 130
    • 84861728843 scopus 로고    scopus 로고
    • Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal
    • Chan SC, Li Y, Dehm SM. Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal. J Biol Chem. 2012; 287: 19736-49. doi: 10.1074/jbc. M112.352930.
    • (2012) J Biol Chem , vol.287 , pp. 19736-19749
    • Chan, S.C.1    Li, Y.2    Dehm, S.M.3
  • 131
    • 79959312739 scopus 로고    scopus 로고
    • A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities
    • Hu R, Isaacs WB, Luo J. A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities. Prostate. 2011; 71: 1656-67. doi: 10.1002/pros.21382.
    • (2011) Prostate , vol.71 , pp. 1656-1667
    • Hu, R.1    Isaacs, W.B.2    Luo, J.3
  • 132
    • 84944474389 scopus 로고    scopus 로고
    • Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo
    • Kwegyir-Afful AK, Senthilmurugan R, Purushottamachar P, Ramamurthy VP, Njar VC. Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo. Oncotarget. 2015; 6: 27440-27460. doi: 10.18632/oncotarget.4578
    • (2015) Oncotarget , vol.6 , pp. 27440-27460
    • Kwegyir-Afful, A.K.1    Senthilmurugan, R.2    Purushottamachar, P.3    Ramamurthy, V.P.4    Njar, V.C.5
  • 133
    • 84904256379 scopus 로고    scopus 로고
    • Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy
    • Cao B, Qi Y, Zhang G, Xu D, Zhan Y, Alvarez X, Guo Z, Fu X, Plymate SR, Sartor O, Zhang H, Dong Y. Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy. Oncotarget. 2014; 5: 1646-56. doi: 10.18632/oncotarget.1802.
    • (2014) Oncotarget , vol.5 , pp. 1646-1656
    • Cao, B.1    Qi, Y.2    Zhang, G.3    Xu, D.4    Zhan, Y.5    Alvarez, X.6    Guo, Z.7    Fu, X.8    Plymate, S.R.9    Sartor, O.10    Zhang, H.11    Dong, Y.12
  • 134
    • 78049280194 scopus 로고    scopus 로고
    • Constitutively active androgen receptor splice variants expressed in castrationresistant prostate cancer require full-length androgen receptor
    • Watson PA, Chen YF, Balbas MD, Wongvipat J, Socci ND, Viale A, Kim K, Sawyers CL. Constitutively active androgen receptor splice variants expressed in castrationresistant prostate cancer require full-length androgen receptor. Proc Natl Acad Sci U S A. 2010; 107: 16759-65. doi: 10.1073/pnas.1012443107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 16759-16765
    • Watson, P.A.1    Chen, Y.F.2    Balbas, M.D.3    Wongvipat, J.4    Socci, N.D.5    Viale, A.6    Kim, K.7    Sawyers, C.L.8
  • 136
    • 79955719838 scopus 로고    scopus 로고
    • Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival
    • Hornberg E, Ylitalo EB, Crnalic S, Antti H, Stattin P, Widmark A, Bergh A, Wikstrom P. Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival. PLoS One. 2011; 6: e19059. doi: 10.1371/journal. pone.0019059.
    • (2011) PLoS One , vol.6
    • Hornberg, E.1    Ylitalo, E.B.2    Crnalic, S.3    Antti, H.4    Stattin, P.5    Widmark, A.6    Bergh, A.7    Wikstrom, P.8
  • 141
    • 0028987183 scopus 로고
    • Quantitative differences in androgen and glucocorticoid receptor DNA binding properties contribute to receptor-selective transcriptional regulation
    • Rundlett SE, Miesfeld RL. Quantitative differences in androgen and glucocorticoid receptor DNA binding properties contribute to receptor-selective transcriptional regulation. Mol Cell Endocrinol. 1995; 109: 1-10. doi:
    • (1995) Mol Cell Endocrinol , vol.109 , pp. 1-10
    • Rundlett, S.E.1    Miesfeld, R.L.2
  • 142
    • 84874918445 scopus 로고    scopus 로고
    • FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells
    • Sahu B, Laakso M, Pihlajamaa P, Ovaska K, Sinielnikov I, Hautaniemi S, Janne OA. FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells. Cancer Res. 2013; 73: 1570-80. doi: 10.1158/0008-5472.CAN-12-2350.
    • (2013) Cancer Res , vol.73 , pp. 1570-1580
    • Sahu, B.1    Laakso, M.2    Pihlajamaa, P.3    Ovaska, K.4    Sinielnikov, I.5    Hautaniemi, S.6    Janne, O.A.7
  • 144
    • 0028997479 scopus 로고
    • Genomic instability of microsatellite repeats in prostate cancer: relationship to clinicopathological variables
    • Egawa S, Uchida T, Suyama K, Wang C, Ohori M, Irie S, Iwamura M, Koshiba K. Genomic instability of microsatellite repeats in prostate cancer: relationship to clinicopathological variables. Cancer Res. 1995; 55: 2418-21
    • (1995) Cancer Res , vol.55 , pp. 2418-2421
    • Egawa, S.1    Uchida, T.2    Suyama, K.3    Wang, C.4    Ohori, M.5    Irie, S.6    Iwamura, M.7    Koshiba, K.8
  • 146
    • 0033564817 scopus 로고    scopus 로고
    • Microsatellite instability and loss of heterozygosity in prostatic carcinomas: comparison of primary tumors, and of corresponding recurrences after androgen-deprivation therapy and lymph-node metastases
    • Rohrbach H, Haas CJ, Baretton GB, Hirschmann A, Diebold J, Behrendt RP, Lohrs U. Microsatellite instability and loss of heterozygosity in prostatic carcinomas: comparison of primary tumors, and of corresponding recurrences after androgen-deprivation therapy and lymph-node metastases. Prostate. 1999; 40: 20-7. doi:
    • (1999) Prostate , vol.40 , pp. 20-27
    • Rohrbach, H.1    Haas, C.J.2    Baretton, G.B.3    Hirschmann, A.4    Diebold, J.5    Behrendt, R.P.6    Lohrs, U.7
  • 149
    • 0033791172 scopus 로고    scopus 로고
    • The mismatch repair gene hMSH2 is mutated in the prostate cancer cell line LNCaP
    • Leach FS, Velasco A, Hsieh JT, Sagalowsky AI, McConnell JD. The mismatch repair gene hMSH2 is mutated in the prostate cancer cell line LNCaP. J Urol. 2000; 164: 1830-3. doi:
    • (2000) J Urol , vol.164 , pp. 1830-1833
    • Leach, F.S.1    Velasco, A.2    Hsieh, J.T.3    Sagalowsky, A.I.4    McConnell, J.D.5
  • 150
    • 84875090043 scopus 로고    scopus 로고
    • Mismatch repair proteins in recurrent prostate cancer
    • Jarzen J, Diamanduros A, Scarpinato KD. Mismatch repair proteins in recurrent prostate cancer. Adv Clin Chem. 2013; 60: 65-84. doi:
    • (2013) Adv Clin Chem , vol.60 , pp. 65-84
    • Jarzen, J.1    Diamanduros, A.2    Scarpinato, K.D.3
  • 151
    • 84957439807 scopus 로고    scopus 로고
    • Prostate cancer in men of African origin
    • McGinley KF, Tay KJ, Moul JW. Prostate cancer in men of African origin. Nat Rev Urol. 2015. doi: 10.1038/nrurol.2015.298.
    • (2015) Nat Rev Urol
    • McGinley, K.F.1    Tay, K.J.2    Moul, J.W.3
  • 153
    • 0030858967 scopus 로고    scopus 로고
    • Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
    • Gu Y, Jin S, Gao Y, Weaver DT, Alt FW. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci U S A. 1997; 94: 8076-81. doi:
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 8076-8081
    • Gu, Y.1    Jin, S.2    Gao, Y.3    Weaver, D.T.4    Alt, F.W.5
  • 154
    • 15444375185 scopus 로고    scopus 로고
    • Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells
    • Mayeur GL, Kung WJ, Martinez A, Izumiya C, Chen DJ, Kung HJ. Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells. J Biol Chem. 2005; 280: 10827-33. doi: 10.1074/jbc. M413336200.
    • (2005) J Biol Chem , vol.280 , pp. 10827-10833
    • Mayeur, G.L.1    Kung, W.J.2    Martinez, A.3    Izumiya, C.4    Chen, D.J.5    Kung, H.J.6
  • 155
    • 45949109186 scopus 로고    scopus 로고
    • Gamma-H2AX-a novel biomarker for DNA double-strand breaks
    • Kuo LJ, Yang LX. Gamma-H2AX-a novel biomarker for DNA double-strand breaks. In Vivo. 2008; 22: 305-9. doi:
    • (2008) In Vivo , vol.22 , pp. 305-309
    • Kuo, L.J.1    Yang, L.X.2
  • 159
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116: 281-97. doi:
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 162
    • 84937978756 scopus 로고    scopus 로고
    • Microdissecting the role of microRNAs in the pathogenesis of prostate cancer
    • Ayub SG, Kaul D, Ayub T. Microdissecting the role of microRNAs in the pathogenesis of prostate cancer. Cancer Genet. 2015; 208: 289-302. doi: 10.1016/j.cancergen.2015.02.010.
    • (2015) Cancer Genet , vol.208 , pp. 289-302
    • Ayub, S.G.1    Kaul, D.2    Ayub, T.3
  • 163
    • 85008699079 scopus 로고    scopus 로고
    • The roles of microRNAs in the progression of castration-resistant prostate cancer
    • Kojima S, Goto Y, Naya Y. The roles of microRNAs in the progression of castration-resistant prostate cancer. J Hum Genet. 2016. doi: 10.1038/jhg.2016.69.
    • (2016) J Hum Genet
    • Kojima, S.1    Goto, Y.2    Naya, Y.3
  • 165
    • 84868011894 scopus 로고    scopus 로고
    • Inactivation of AR and Notch-1 signaling by miR-34a attenuates prostate cancer aggressiveness
    • Kashat M, Azzouz L, Sarkar SH, Kong D, Li Y, Sarkar FH. Inactivation of AR and Notch-1 signaling by miR-34a attenuates prostate cancer aggressiveness. Am J Transl Res. 2012; 4: 432-42. doi:
    • (2012) Am J Transl Res , vol.4 , pp. 432-442
    • Kashat, M.1    Azzouz, L.2    Sarkar, S.H.3    Kong, D.4    Li, Y.5    Sarkar, F.H.6
  • 170
    • 84862863817 scopus 로고    scopus 로고
    • Biochemical relapse following radical prostatectomy and miR-200a levels in prostate cancer
    • Barron N, Keenan J, Gammell P, Martinez VG, Freeman A, Masters JR, Clynes M. Biochemical relapse following radical prostatectomy and miR-200a levels in prostate cancer. Prostate. 2012; 72: 1193-9. doi: 10.1002/pros.22469.
    • (2012) Prostate , vol.72 , pp. 1193-1199
    • Barron, N.1    Keenan, J.2    Gammell, P.3    Martinez, V.G.4    Freeman, A.5    Masters, J.R.6    Clynes, M.7
  • 172
    • 84861576642 scopus 로고    scopus 로고
    • The altered expression of MiR-221/-222 and MiR-23b/-27b is associated with the development of human castration resistant prostate cancer
    • Sun T, Yang M, Chen S, Balk S, Pomerantz M, Hsieh CL, Brown M, Lee GS, KantoffPW. The altered expression of MiR-221/-222 and MiR-23b/-27b is associated with the development of human castration resistant prostate cancer. Prostate. 2012; 72: 1093-103. doi: 10.1002/pros.22456.
    • (2012) Prostate , vol.72 , pp. 1093-1103
    • Sun, T.1    Yang, M.2    Chen, S.3    Balk, S.4    Pomerantz, M.5    Hsieh, C.L.6    Brown, M.7    Lee, G.S.8    Kantoff, P.W.9
  • 173
    • 84862828919 scopus 로고    scopus 로고
    • miR-21 as an independent biochemical recurrence predictor and potential therapeutic target for prostate cancer
    • Li T, Li RS, Li YH, Zhong S, Chen YY, Zhang CM, Hu MM, Shen ZJ. miR-21 as an independent biochemical recurrence predictor and potential therapeutic target for prostate cancer. J Urol. 2012; 187: 1466-72. doi: 10.1016/j.juro.2011.11.082.
    • (2012) J Urol , vol.187 , pp. 1466-1472
    • Li, T.1    Li, R.S.2    Li, Y.H.3    Zhong, S.4    Chen, Y.Y.5    Zhang, C.M.6    Hu, M.M.7    Shen, Z.J.8
  • 174
    • 78951483439 scopus 로고    scopus 로고
    • Serum miRNA-21: elevated levels in patients with metastatic hormonerefractory prostate cancer and potential predictive factor for the efficacy of docetaxel-based chemotherapy
    • Zhang HL, Yang LF, Zhu Y, Yao XD, Zhang SL, Dai B, Zhu YP, Shen YJ, Shi GH, Ye DW. Serum miRNA-21: elevated levels in patients with metastatic hormonerefractory prostate cancer and potential predictive factor for the efficacy of docetaxel-based chemotherapy. Prostate. 2011; 71: 326-31. doi: 10.1002/pros.21246.
    • (2011) Prostate , vol.71 , pp. 326-331
    • Zhang, H.L.1    Yang, L.F.2    Zhu, Y.3    Yao, X.D.4    Zhang, S.L.5    Dai, B.6    Zhu, Y.P.7    Shen, Y.J.8    Shi, G.H.9    Ye, D.W.10
  • 175
    • 84962557036 scopus 로고    scopus 로고
    • Resistance to Novel Antiandrogen Therapies in Metastatic Castration-Resistant Prostate Cancer
    • Boudadi K, Antonarakis ES. Resistance to Novel Antiandrogen Therapies in Metastatic Castration-Resistant Prostate Cancer. Clin Med Insights Oncol. 2016; 10: 1-9. doi: 10.4137/CMO.S34534.
    • (2016) Clin Med Insights Oncol , vol.10 , pp. 1-9
    • Boudadi, K.1    Antonarakis, E.S.2
  • 176
  • 179
    • 84959311037 scopus 로고    scopus 로고
    • Precision oncology: origins, optimism, and potential
    • Prasad V, Fojo T, Brada M. Precision oncology: origins, optimism, and potential. Lancet Oncol. 2016; 17: e81-6. doi: 10.1016/S1470-2045(15)00620-8.
    • (2016) Lancet Oncol , vol.17 , pp. e81-e86
    • Prasad, V.1    Fojo, T.2    Brada, M.3
  • 180
    • 84870526559 scopus 로고    scopus 로고
    • Personalized oncology: recent advances and future challenges
    • Kalia M. Personalized oncology: recent advances and future challenges. Metabolism. 2013; 62 Suppl 1: S11-4. doi: 10.1016/j.metabol.2012.08.016.
    • (2013) Metabolism , vol.62 , pp. S11-S14
    • Kalia, M.1
  • 181
    • 84973664512 scopus 로고    scopus 로고
    • Getting Personal with Prostate Cancer: DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer
    • Raison N, Elhage O, Dasgupta P. Getting Personal with Prostate Cancer: DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. BJU Int. 2016. doi: 10.1111/bju.13522.
    • (2016) BJU Int
    • Raison, N.1    Elhage, O.2    Dasgupta, P.3
  • 182
    • 84961199136 scopus 로고    scopus 로고
    • Moving Beyond the Androgen Receptor in Advanced Prostate Cancer Commentary on: DNA-repair Defects and Olaparib in Metastatic Prostate Cancer
    • Chedgy EC, Black PC. Moving Beyond the Androgen Receptor in Advanced Prostate Cancer Commentary on: DNA-repair Defects and Olaparib in Metastatic Prostate Cancer. Urology. 2016; 89: 10-1. doi: 10.1016/j.urology.2015.12.002.
    • (2016) Urology , vol.89 , pp. 10-11
    • Chedgy, E.C.1    Black, P.C.2
  • 183
    • 84993933629 scopus 로고    scopus 로고
    • Olaparib Targets Some Advanced Prostate Cancers
    • Olaparib Targets Some Advanced Prostate Cancers. Cancer Discov. 2016; 6: OF1. doi: 10.1158/2159-8290.CDNB2015-161.
    • (2016) Cancer Discov , vol.6
  • 184
  • 185
    • 84994030342 scopus 로고    scopus 로고
    • When Prostate Cancer Circulates in the Bloodstream
    • Vlaeminck-Guillem V. When Prostate Cancer Circulates in the Bloodstream. Diagnostics (Basel). 2015; 5: 428-74. doi: 10.3390/diagnostics5040428.
    • (2015) Diagnostics (Basel) , vol.5 , pp. 428-474
    • Vlaeminck-Guillem, V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.