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Volumn 13, Issue 1, 2016, Pages 47-60

Androgen-glucocorticoid interactions in the era of novel prostate cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

ABIRATERONE; ANDROGEN; ANDROGEN RECEPTOR; APALUTAMIDE; BICALUTAMIDE; BISPHOSPHONIC ACID DERIVATIVE; DENOSUMAB; DEXAMETHASONE; ENZALUTAMIDE; EPLERENONE; FLUTAMIDE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; HYDROCORTISONE; MESSENGER RNA; MIFEPRISTONE; MITOXANTRONE; NILUTAMIDE; PREDNISONE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SOMATOMEDIN C; SPIRONOLACTONE; TESTOSTERONE; TRIAMCINOLONE; ZOLEDRONIC ACID; ANTIANDROGEN;

EID: 84953368394     PISSN: 17594812     EISSN: 17594820     Source Type: Journal    
DOI: 10.1038/nrurol.2015.254     Document Type: Review
Times cited : (68)

References (144)
  • 1
    • 84875185800 scopus 로고    scopus 로고
    • Association of baseline corticosteroid with outcomes in a multivariate analysis of the phase 3 affirm study of enzalutamide (enza), an androgen receptor signaling inhibitor (ARSI) [abstract]
    • Scher, H. I., et al. Association of baseline corticosteroid with outcomes in a multivariate analysis of the phase 3 affirm study of enzalutamide (enza), an androgen receptor signaling inhibitor (ARSI) [abstract]. Ann. Oncol. 23, 297 (2012).
    • (2012) Ann. Oncol , vol.23 , pp. 297
    • Scher, H.I.1
  • 2
    • 84882656136 scopus 로고    scopus 로고
    • Impact of on-study corticosteroid use on efficacy and safety in the phase III trial of enzalutamide (ENZA), an androgen receptor inhibitor [abstract]
    • Scher, H. I., et al. Impact of on-study corticosteroid use on efficacy and safety in the phase III trial of enzalutamide (ENZA), an androgen receptor inhibitor [abstract]. J. Clin. Oncol. 31, S6 (2013).
    • (2013) J. Clin. Oncol , vol.31 , pp. S6
    • Scher, H.I.1
  • 3
    • 84890078624 scopus 로고    scopus 로고
    • Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade
    • Arora, V. K., et al. Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade. Cell 155,1309-1322 (2013).
    • (2013) Cell , vol.155 , pp. 1309-1322
    • Arora, V.K.1
  • 4
    • 84926177957 scopus 로고    scopus 로고
    • Impact of baseline corticosteroids on survival and steroid androgens in metastatic castration-resistant prostate cancer: Exploratory analysis from COU AA 301
    • Montgomery, B., et al. Impact of baseline corticosteroids on survival and steroid androgens in metastatic castration-resistant prostate cancer: exploratory analysis from COU AA 301. Eur. Urol. 67, 866-873 (2015).
    • (2015) Eur. Urol , vol.67 , pp. 866-873
    • Montgomery, B.1
  • 5
    • 84900513764 scopus 로고    scopus 로고
    • Glucocorticoids and prostate cancer treatment: Friend or foe?
    • Montgomery, B., Cheng, H. H., Drechsler, J., & Mostaghel E. A. Glucocorticoids and prostate cancer treatment: friend or foe?. Asian J. Androl. 16, 354-358 (2014).
    • (2014) Asian J Androl , vol.16 , pp. 354-358
    • Montgomery, B.1    Cheng, H.H.2    Drechsler, J.3    Mostaghel, E.A.4
  • 6
    • 84892446077 scopus 로고    scopus 로고
    • 5a reductase type 3 enzyme in benign and malignant prostate
    • Titus, M A., et al. 5a reductase type 3 enzyme in benign and malignant prostate. Prostate 74 235-249 2014
    • (2014) Prostate , vol.74 , pp. 235-249
    • Titus, M.A.1
  • 7
    • 0012473279 scopus 로고
    • The nuclear receptor superfamily: The second decade
    • Mangelsdorf, D. J., et al. The nuclear receptor superfamily: the second decade. Cell 83, 835-839 (1995).
    • (1995) Cell , vol.83 , pp. 835-839
    • Mangelsdorf, D.J.1
  • 8
    • 0036645414 scopus 로고    scopus 로고
    • Molecular biology of the androgen receptor
    • Gelmann, E. P. Molecular biology of the androgen receptor. J. Clin. Oncol. 20, 3001-3015 (2002).
    • (2002) J. Clin. Oncol , vol.20 , pp. 3001-3015
    • Gelmann, E.P.1
  • 9
    • 2342558431 scopus 로고    scopus 로고
    • Androgen receptor in prostate cancer
    • Heinlein, C. A., & Chang, C. Androgen receptor in prostate cancer. Endocr. Rev. 25, 276-308, (2004).
    • (2004) Endocr. Rev , vol.25 , pp. 276-308
    • Heinlein, C.A.1    Chang, C.2
  • 10
    • 34547931715 scopus 로고    scopus 로고
    • Cell-and gene-specific regulation of primary target genes by the androgen receptor
    • Bolton, E. C., et al. Cell-and gene-specific regulation of primary target genes by the androgen receptor. Genes Dev. 21, 2005-2017 (2007).
    • (2007) Genes Dev , vol.21 , pp. 2005-2017
    • Bolton, E.C.1
  • 11
    • 84898955747 scopus 로고    scopus 로고
    • Androgen receptor uses relaxed response element stringency for selective chromatin binding and transcriptional regulation in vivo
    • Sahu, B., et al. Androgen receptor uses relaxed response element stringency for selective chromatin binding and transcriptional regulation in vivo. Nucleic Acids Res. 42, 4230-4240 (2014).
    • (2014) Nucleic Acids Res , vol.42 , pp. 4230-4240
    • Sahu, B.1
  • 12
    • 82655181898 scopus 로고    scopus 로고
    • Structural basis for nuclear hormone receptor DNA binding
    • Helsen, C., et al. Structural basis for nuclear hormone receptor DNA binding. Mol. Cell. Endocrinol. 348, 411-417 (2012).
    • (2012) Mol. Cell. Endocrinol , vol.348 , pp. 411-417
    • Helsen, C.1
  • 13
    • 84874918445 scopus 로고    scopus 로고
    • FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells
    • Sahu, B., et al. FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells. Cancer Res. 73, 1570-1580 (2013).
    • (2013) Cancer Res , vol.73 , pp. 1570-1580
    • Sahu, B.1
  • 14
    • 84897883825 scopus 로고    scopus 로고
    • Tissue-specific pioneer factors associate with androgen receptor cistromes and transcription programs
    • Pihlajamaa, P., et al. Tissue-specific pioneer factors associate with androgen receptor cistromes and transcription programs. EMBO J. 33, 312-326 (2014).
    • (2014) EMBO J. , vol.33 , pp. 312-326
    • Pihlajamaa, P.1
  • 15
    • 84902124644 scopus 로고    scopus 로고
    • Modulation of androgen receptor by FOXA1 and FOXO1 factors in prostate cancer
    • Zhao, Y., Tindall, D. J., & Huang, H. Modulation of androgen receptor by FOXA1 and FOXO1 factors in prostate cancer. Int. J. Biol. Sci. 10, 614-619 (2014).
    • (2014) Int. J. Biol. Sci , vol.10 , pp. 614-619
    • Zhao, Y.1    Tindall, D.J.2    Huang, H.3
  • 16
    • 84904886900 scopus 로고    scopus 로고
    • Androgen receptor and its splice variant, AR V7, differentially regulate FOXA1 sensitive genes in LNCaP prostate cancer cells
    • Krause, W. C., Shafi, A. A., Nakka, M., & Weigel N. L. Androgen receptor and its splice variant, AR V7, differentially regulate FOXA1 sensitive genes in LNCaP prostate cancer cells. Int. J. Biochem. Cell Biol. 54, 49-59 (2014).
    • (2014) Int. J. Biochem. Cell Biol , vol.54 , pp. 49-59
    • Krause, W.C.1    Shafi, A.A.2    Nakka, M.3    Weigel, N.L.4
  • 17
    • 0015370976 scopus 로고
    • Studies on prostatic cancer i the effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate
    • Huggins, C., & Hodges, C. V. Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate. CA Cancer J. Clin. 22, 232-240 (1972).
    • (1972) CA Cancer J. Clin , vol.22 , pp. 232-240
    • Huggins, C.1    Hodges, C.V.2
  • 18
    • 0020040070 scopus 로고
    • Tumor growth inhibition in patients with prostatic carcinoma treated with luteinizing hormone-releasing hormone agonists
    • Tolis, G., et al. Tumor growth inhibition in patients with prostatic carcinoma treated with luteinizing hormone-releasing hormone agonists. Proc. Natl Acad. Sci. USA 79, 1658-1662 (1982).
    • (1982) Proc. Natl Acad. Sci. USA , vol.79 , pp. 1658-1662
    • Tolis, G.1
  • 19
    • 84879134376 scopus 로고    scopus 로고
    • Molecular pathways: Inhibiting steroid biosynthesis in prostate cancer
    • Ferraldeschi, R., et al. Molecular pathways: Inhibiting steroid biosynthesis in prostate cancer. Clin. Cancer Res. 19, 3353-3359 (2013).
    • (2013) Clin. Cancer Res , vol.19 , pp. 3353-3359
    • Ferraldeschi, R.1
  • 20
    • 0035496220 scopus 로고    scopus 로고
    • The development of androgen-independent prostate cancer
    • Feldman, B. J., & Feldman, D. The development of androgen-independent prostate cancer. Nat. Rev. Cancer 1, 34-45 (2001).
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 34-45
    • Feldman, B.J.1    Feldman, D.2
  • 21
    • 79957640371 scopus 로고    scopus 로고
    • Minireview: Alternative activation pathways for the androgen receptor in prostate cancer
    • Lamont, K. R., & Tindall, D. J. Minireview: Alternative activation pathways for the androgen receptor in prostate cancer. Mol. Endocrinol. 25, 897-907 (2011).
    • (2011) Mol. Endocrinol , vol.25 , pp. 897-907
    • Lamont, K.R.1    Tindall, D.J.2
  • 22
    • 84886534301 scopus 로고    scopus 로고
    • Mechanisms of androgen receptor activation in castration-resistant prostate cancer
    • Sharifi, N. Mechanisms of androgen receptor activation in castration-resistant prostate cancer. Endocrinology 154, 4010-4017 (2013).
    • (2013) Endocrinology , vol.154 , pp. 4010-4017
    • Sharifi, N.1
  • 23
    • 84879459053 scopus 로고    scopus 로고
    • Molecular pathogenesis and progression of prostate cancer
    • Schrecengost, R., & Knudsen, K. E. Molecular pathogenesis and progression of prostate cancer. Semin. Oncol. 40, 244-258 (2013).
    • (2013) Semin. Oncol , vol.40 , pp. 244-258
    • Schrecengost, R.1    Knudsen, K.E.2
  • 24
    • 1842612441 scopus 로고    scopus 로고
    • Molecular determinants of resistance to antiandrogen therapy
    • Chen, C. D., et al. Molecular determinants of resistance to antiandrogen therapy. Nat. Med. 10, 33-39 (2004).
    • (2004) Nat. Med , vol.10 , pp. 33-39
    • Chen, C.D.1
  • 25
    • 84907057471 scopus 로고    scopus 로고
    • AR V7 and resistance to enzalutamide and abiraterone in prostate cancer
    • Antonarakis, E. S., et al. AR V7 and resistance to enzalutamide and abiraterone in prostate cancer. N. Engl. J. Med. 371, 1028-1038 (2014).
    • (2014) N. Engl. J. Med , vol.371 , pp. 1028-1038
    • Antonarakis, E.S.1
  • 26
    • 0022386057 scopus 로고
    • Adrenal androgen blockade in relapsed prostate cancer
    • Geller, J., & Albert, J. D. Adrenal androgen blockade in relapsed prostate cancer. Eur. J. Cancer Clin. Oncol. 21, 1127-1131 (1985).
    • (1985) Eur. J. Cancer Clin. Oncol , vol.21 , pp. 1127-1131
    • Geller, J.1    Albert, J.D.2
  • 27
    • 84905994042 scopus 로고    scopus 로고
    • Androgen receptor antagonists for prostate cancer therapy
    • Helsen, C., et al. Androgen receptor antagonists for prostate cancer therapy. Endocr. Relat. Cancer 21, T105-T118 2014
    • (2014) Endocr. Relat. Cancer , vol.21 , pp. T105-T118
    • Helsen, C.1
  • 28
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    • Tran, C., et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 324,787-790 (2009).
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1
  • 29
    • 0022815983 scopus 로고
    • Ketoconazole and other imidazole derivatives as inhibitors of steroidogenesis
    • Feldman, D. Ketoconazole and other imidazole derivatives as inhibitors of steroidogenesis. Endocr. Rev. 7, 409-420 (1986).
    • (1986) Endocr. Rev , vol.7 , pp. 409-420
    • Feldman, D.1
  • 30
    • 84856852718 scopus 로고    scopus 로고
    • Re: Contemporary experience with ketoconazole in patients with metastatic castration-resistant prostate cancer: Clinical factors associated with PSA response and disease progression
    • Walsh, P. C. Re: contemporary experience with ketoconazole in patients with metastatic castration-resistant prostate cancer: clinical factors associated with PSA response and disease progression. J. Urol. 187, 912 (2012).
    • (2012) J. Urol , vol.187 , pp. 912
    • Walsh, P.C.1
  • 32
    • 84872078210 scopus 로고    scopus 로고
    • Abiraterone in metastatic prostate cancer without previous chemotherapy
    • Ryan, C. J., et al. Abiraterone in metastatic prostate cancer without previous chemotherapy. N. Engl. J. Med. 368, 138-148 (2013).
    • (2013) N. Engl. J. Med , vol.368 , pp. 138-148
    • Ryan, C.J.1
  • 33
    • 84893359951 scopus 로고    scopus 로고
    • Abiraterone in the treatment of metastatic castration-resistant prostate cancer
    • Mostaghel, E. A. Abiraterone in the treatment of metastatic castration-resistant prostate cancer. Cancer Manag. Res. 6, 39-51 (2014).
    • (2014) Cancer Manag. Res , vol.6 , pp. 39-51
    • Mostaghel, E.A.1
  • 34
    • 84873804087 scopus 로고    scopus 로고
    • Agents that target androgen synthesis in castration-resistant prostate cancer
    • Ferraldeschi, R., & de Bono, J. Agents that target androgen synthesis in castration-resistant prostate cancer. Cancer J. 19, 34-42 (2013).
    • (2013) Cancer J. , vol.19 , pp. 34-42
    • Ferraldeschi, R.1    De Bono, J.2
  • 35
    • 84902141056 scopus 로고    scopus 로고
    • Roles for the backdoor pathway of androgen metabolism in prostate cancer response to castration and drug treatment
    • Fiandalo, M. V., Wilton, J., & Mohler, J. L. Roles for the backdoor pathway of androgen metabolism in prostate cancer response to castration and drug treatment. Int. J. Biol. Sci. 10, 596-601 (2014).
    • (2014) Int. J. Biol. Sci , vol.10 , pp. 596-601
    • Fiandalo, M.V.1    Wilton, J.2    Mohler, J.L.3
  • 36
    • 0026802011 scopus 로고
    • Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle
    • Colombel, M., Olsson, C. A., Ng, P. Y., & Buttyan, R. Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle. Cancer Res. 52, 4313-4319 (1992).
    • (1992) Cancer Res , vol.52 , pp. 4313-4319
    • Colombel, M.1    Olsson, C.A.2    Ng, P.Y.3    Buttyan, R.4
  • 37
    • 79955975429 scopus 로고    scopus 로고
    • Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    • Carver, B. S., et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 19, 575-586 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 575-586
    • Carver, B.S.1
  • 38
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies, H., et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002).
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1
  • 39
    • 33748504546 scopus 로고    scopus 로고
    • BRAF and KRAS mutations in prostatic adenocarcinoma
    • Cho, N. Y., et al. BRAF and KRAS mutations in prostatic adenocarcinoma. Int. J. Cancer 119, 1858-1862 2006
    • (2006) Int. J. Cancer , vol.119 , pp. 1858-1862
    • Cho, N.Y.1
  • 40
    • 84863723010 scopus 로고    scopus 로고
    • The mutational landscape of lethal castration-resistant prostate cancer
    • Grasso, C. S., et al. The mutational landscape of lethal castration-resistant prostate cancer. Nature 487, 239-243 (2012).
    • (2012) Nature , vol.487 , pp. 239-243
    • Grasso, C.S.1
  • 41
    • 0028944138 scopus 로고
    • In vivo amplification of the androgen receptor gene and progression of human prostate cancer
    • Visakorpi, T., et al. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat. Genet. 9, 401-406 (1995).
    • (1995) Nat. Genet , vol.9 , pp. 401-406
    • Visakorpi, T.1
  • 42
    • 0029011116 scopus 로고
    • Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer
    • Taplin, M. E., et al. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N. Engl. J. Med. 332, 1393-1398 (1995).
    • (1995) N. Engl. J. Med , vol.332 , pp. 1393-1398
    • Taplin, M.E.1
  • 43
    • 0035893393 scopus 로고    scopus 로고
    • Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer
    • Chang, C. Y., Walther, P. J., & McDonnell, D. P. Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer. Cancer Res. 61, 8712-8717 (2001).
    • (2001) Cancer Res , vol.61 , pp. 8712-8717
    • Chang, C.Y.1    Walther, P.J.2    McDonnell, D.P.3
  • 44
    • 85003173512 scopus 로고
    • Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone
    • Culig, Z., et al. Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone. Mol. Endocrinol. 7, 1541-1550 (1993).
    • (1993) Mol. Endocrinol , vol.7 , pp. 1541-1550
    • Culig, Z.1
  • 45
    • 0034125195 scopus 로고    scopus 로고
    • Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
    • Zhao, X. Y., et al. Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Nat. Med. 6, 703-706 (2000).
    • (2000) Nat. Med , vol.6 , pp. 703-706
    • Zhao, X.Y.1
  • 46
    • 0036225315 scopus 로고    scopus 로고
    • A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: Therapeutic implications for androgen-independent prostate cancer
    • Krishnan, A V., et al. A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer. Endocrinology 143 1889-1900 2002
    • (2002) Endocrinology , vol.143 , pp. 1889-1900
    • Krishnan, A.V.1
  • 47
    • 0026562430 scopus 로고
    • The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens
    • Veldscholte, J., et al. The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens. J. Steroid Biochem. Mol. Biol. 41, 665-669 (1992).
    • (1992) J. Steroid Biochem. Mol. Biol , vol.41 , pp. 665-669
    • Veldscholte, J.1
  • 48
    • 84885210324 scopus 로고    scopus 로고
    • A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN 509
    • Joseph, J. D., et al. A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN 509. Cancer Discov. 3 2013 1020-1029
    • (2013) Cancer Discov , vol.1020-1029 , Issue.3
    • Joseph, J.D.1
  • 49
    • 34250331066 scopus 로고    scopus 로고
    • Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: Therapeutic implications for castration-resistant prostate cancer
    • Mostaghel, E. A., et al. Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res. 67, 5033-5041 (2007).
    • (2007) Cancer Res , vol.67 , pp. 5033-5041
    • Mostaghel, E.A.1
  • 50
    • 33749550602 scopus 로고    scopus 로고
    • Persistent intraprostatic androgen concentrations after medical castration in healthy men
    • Page, S. T., et al. Persistent intraprostatic androgen concentrations after medical castration in healthy men. J. Clin. Endocrinol. Metab. 91, 3850-3856 (2006).
    • (2006) J. Clin. Endocrinol. Metab , vol.91 , pp. 3850-3856
    • Page, S.T.1
  • 51
    • 84876724319 scopus 로고    scopus 로고
    • The role of intracrine androgen metabolism, androgen receptor and apoptosis in the survival and recurrence of prostate cancer during androgen deprivation therapy
    • Fiandalo, M. V., Wu, W., & Mohler, J. L. The role of intracrine androgen metabolism, androgen receptor and apoptosis in the survival and recurrence of prostate cancer during androgen deprivation therapy. Curr. Drug Targets 14, 420-440 (2013).
    • (2013) Curr. Drug Targets , vol.14 , pp. 420-440
    • Fiandalo, M.V.1    Wu, W.2    Mohler, J.L.3
  • 52
    • 84883367616 scopus 로고    scopus 로고
    • A gain of function mutation in DHT synthesis in castration-resistant prostate cancer
    • Chang, K H., et al. A gain of function mutation in DHT synthesis in castration-resistant prostate cancer. Cell 154 1074-1084 2013
    • (2013) Cell , vol.154 , pp. 1074-1084
    • Chang, K.H.1
  • 53
    • 84926160408 scopus 로고    scopus 로고
    • Molecular characterization of enzalutamide-treated bone metastatic castration-resistant prostate cancer
    • Efstathiou, E., et al. Molecular characterization of enzalutamide-treated bone metastatic castration-resistant prostate cancer. Eur. Urol. 67, 53-60 (2015).
    • (2015) Eur. Urol , vol.67 , pp. 53-60
    • Efstathiou, E.1
  • 54
    • 70350109641 scopus 로고    scopus 로고
    • ETS gene fusions in prostate cancer
    • Clark, J. P., & Cooper, C. S. ETS gene fusions in prostate cancer. Nat. Rev. Urol. 6, 429-439, (2009).
    • (2009) Nat. Rev. Urol , vol.6 , pp. 429-439
    • Clark, J.P.1    Cooper, C.S.2
  • 55
    • 0028113415 scopus 로고
    • Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor I, keratinocyte growth factor, and epidermal growth factor
    • Culig, Z., et al. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor I, keratinocyte growth factor, and epidermal growth factor. Cancer Res. 54, 5474-5478, (1994).
    • (1994) Cancer Res , vol.54 , pp. 5474-5478
    • Culig, Z.1
  • 56
    • 21244450722 scopus 로고    scopus 로고
    • Mechanisms of endocrine therapy-responsive and -unresponsive prostate tumours
    • Culig, Z., Steiner, H., Bartsch, G., & Hobisch A. Mechanisms of endocrine therapy-responsive and -unresponsive prostate tumours. Endocr. Relat. Cancer 12, 229-244 (2005).
    • (2005) Endocr. Relat. Cancer , vol.12 , pp. 229-244
    • Culig, Z.1    Steiner, H.2    Bartsch, G.3    Hobisch, A.4
  • 57
    • 84902189647 scopus 로고    scopus 로고
    • Androgen receptor activation in castration-recurrent prostate cancer: The role of Src-family and Ack1 tyrosine kinases
    • Gelman, I. H. Androgen receptor activation in castration-recurrent prostate cancer: the role of Src-family and Ack1 tyrosine kinases. Int. J. Biol. Sci. 10, 620-626 (2014).
    • (2014) Int. J. Biol. Sci , vol.10 , pp. 620-626
    • Gelman, I.H.1
  • 58
    • 48549089747 scopus 로고    scopus 로고
    • Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
    • Dehm, S. M., Schmidt, L. J., Heemers, H. V., Vessella, R. L., & Tindall, D. J. Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res. 68, 5469-5477 (2008).
    • (2008) Cancer Res , vol.68 , pp. 5469-5477
    • Dehm, S.M.1    Schmidt, L.J.2    Heemers, H.V.3    Vessella, R.L.4    Tindall, D.J.5
  • 59
    • 77955296562 scopus 로고    scopus 로고
    • Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
    • Sun, S., et al. Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. J. Clin. Invest. 120, 2715-2730 (2010).
    • (2010) J. Clin. Invest , vol.120 , pp. 2715-2730
    • Sun, S.1
  • 60
    • 84904159704 scopus 로고    scopus 로고
    • The link between androgen receptor splice variants and castration-resistant prostate cancer
    • Sprenger, C. C., & Plymate, S. R. The link between androgen receptor splice variants and castration-resistant prostate cancer. Horm. Cancer 5, 207-217 (2014).
    • (2014) Horm. Cancer , vol.5 , pp. 207-217
    • Sprenger, C.C.1    Plymate, S.R.2
  • 61
    • 84907083697 scopus 로고    scopus 로고
    • Androgen receptor splice variants in the era of enzalutamide and abiraterone
    • Nakazawa, M., Antonarakis, E. S., & Luo, J. Androgen receptor splice variants in the era of enzalutamide and abiraterone. Horm. Cancer 5, 265-273 (2014).
    • (2014) Horm. Cancer , vol.5 , pp. 265-273
    • Nakazawa, M.1    Antonarakis, E.S.2    Luo, J.3
  • 62
    • 84879671701 scopus 로고    scopus 로고
    • A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer
    • Lunardi, A., et al. A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. Nat. Genet. 45, 747-755 (2013).
    • (2013) Nat Genet , vol.45 , pp. 747-755
    • Lunardi, A.1
  • 63
    • 0038721560 scopus 로고    scopus 로고
    • Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone
    • Roudier, M. P., et al. Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone. Hum. Pathol. 34, 646-653 (2003).
    • (2003) Hum. Pathol , vol.34 , pp. 646-653
    • Roudier, M.P.1
  • 64
    • 84923623092 scopus 로고    scopus 로고
    • Genomic, pathological, and clinical heterogeneity as drivers of personalized medicine in prostate cancer
    • Fraser, M., Berlin, A., Bristow, R. G., & van Der Kwast, T. Genomic, pathological, and clinical heterogeneity as drivers of personalized medicine in prostate cancer. Urol. Oncol. 33, 85-94 (2014).
    • (2014) Urol. Oncol , vol.33 , pp. 85-94
    • Fraser, M.1    Berlin, A.2    Bristow, R.G.3    Van Der Kwast, T.4
  • 65
    • 84964313410 scopus 로고    scopus 로고
    • Heterogeneity in the inter-tumor transcriptome of high risk prostate cancer
    • Wyatt, A. W., et al. Heterogeneity in the inter-tumor transcriptome of high risk prostate cancer. Genome Biol. 15, 426 (2014).
    • (2014) Genome Biol , vol.15 , pp. 426
    • Wyatt, A.W.1
  • 66
    • 84890798275 scopus 로고    scopus 로고
    • The prostate cancer genome: Perspectives and potential
    • Barbieri, C. E., & Tomlins, S. A. The prostate cancer genome: perspectives and potential. Urol. Oncol. 32, e15-e22 (2014).
    • (2014) Urol. Oncol , vol.32 , pp. e15-e22
    • Barbieri, C.E.1    Tomlins, S.A.2
  • 67
    • 84927578341 scopus 로고    scopus 로고
    • Emerging mechanisms of enzalutamide resistance in prostate cancer
    • Claessens, F., et al. Emerging mechanisms of enzalutamide resistance in prostate cancer. Nat. Rev. Urol. 11, 712-716 (2014).
    • (2014) Nat. Rev. Urol , vol.11 , pp. 712-716
    • Claessens, F.1
  • 68
    • 84861194295 scopus 로고    scopus 로고
    • Cancer stem cells and metastasis
    • Sampieri K, Fodde R: Cancer stem cells and metastasis. Semin. Cancer Biol. 22, 187-193 (2012).
    • (2012) Semin Cancer Biol. , vol.22 , pp. 187-193
    • Sampieri, K.1    Fodde, R.2
  • 69
    • 84904387881 scopus 로고    scopus 로고
    • Functional characteristics of cancer stem cells and their role in drug resistance of prostate cancer
    • Castillo, V., Valenzuela, R., Huidobro, C., Contreras, H. R., & Castellon, E. A. Functional characteristics of cancer stem cells and their role in drug resistance of prostate cancer. Int. J. Oncol. 45, 985-994 (2014).
    • (2014) Int. J. Oncol , vol.45 , pp. 985-994
    • Castillo, V.1    Valenzuela, R.2    Huidobro, C.3    Contreras, H.R.4    Castellon, E.A.5
  • 70
    • 84897541659 scopus 로고    scopus 로고
    • Contributions of epithelial-mesenchymal transition and cancer stem cells to the development of castration resistance of prostate cancer
    • Li, P., Yang, R., & Gao, W. Q. Contributions of epithelial-mesenchymal transition and cancer stem cells to the development of castration resistance of prostate cancer. Mol. Cancer 13, 55 (2014).
    • (2014) Mol. Cancer , vol.13 , pp. 55
    • Li, P.1    Yang, R.2    Gao, W.Q.3
  • 71
    • 84905976059 scopus 로고    scopus 로고
    • Influence of stromal-epithelial interactions on androgen action
    • Nieto, C. M., Rider, L. C., & Cramer, S. D. Influence of stromal-epithelial interactions on androgen action. Endocr. Relat. Cancer 21, T147-T160 (2014).
    • (2014) Endocr. Relat. Cancer , vol.21 , pp. T147-T160
    • Nieto, C.M.1    Rider, L.C.2    Cramer, S.D.3
  • 72
    • 84883499684 scopus 로고    scopus 로고
    • 12th edn Ch. 15 Eds Kronenberg, H., & Williams R. H.) Saunders/Elsevier, 2011
    • Stewart, P. M., & Krone, N. P. In Williams textbook of endocrinology, 12th edn Ch. 15 (Eds Kronenberg, H., & Williams R. H.) 479-544 (Saunders/Elsevier, 2011)
    • In Williams textbook of endocrinology , pp. 479-544
    • Stewart, P.M.1    Krone, N.P.2
  • 73
    • 0036774934 scopus 로고    scopus 로고
    • Glucocorticoids and treatment of prostate cancer: A preclinical and clinical review
    • Fakih, M., Johnson, C. S., & Trump, D. L. Glucocorticoids and treatment of prostate cancer: a preclinical and clinical review. Urology 60, 553-561 (2002).
    • (2002) Urology , vol.60 , pp. 553-561
    • Fakih, M.1    Johnson, C.S.2    Trump, D.L.3
  • 74
    • 84883769810 scopus 로고    scopus 로고
    • Glucocorticoid receptor signaling in health and disease
    • Kadmiel, M., & Cidlowski, J. A. Glucocorticoid receptor signaling in health and disease. Trends Pharmacol. Sci. 34, 518-530 (2013).
    • (2013) Trends Pharmacol. Sci , vol.34 , pp. 518-530
    • Kadmiel, M.1    Cidlowski, J.A.2
  • 75
    • 84905034984 scopus 로고    scopus 로고
    • Comprehensive overview of the structure and regulation of the glucocorticoid receptor
    • Vandevyver, S., Dejager, L., & Libert, C. Comprehensive overview of the structure and regulation of the glucocorticoid receptor. Endocr. Rev. 35, 671-693 (2014).
    • (2014) Endocr. Rev , vol.35 , pp. 671-693
    • Vandevyver, S.1    Dejager, L.2    Libert, C.3
  • 76
    • 34547872322 scopus 로고    scopus 로고
    • The glucocorticoid responses are shaped by molecular chaperones
    • Grad, I., & Picard, D. The glucocorticoid responses are shaped by molecular chaperones. Mol. Cell. Endocrinol. 275, 2-12 (2007).
    • (2007) Mol. Cell. Endocrinol , vol.275 , pp. 2-12
    • Grad, I.1    Picard, D.2
  • 78
    • 0041324898 scopus 로고    scopus 로고
    • The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein 1: Molecular mechanisms for gene repression
    • De Bosscher, K., Vanden Berghe, W., & Haegeman, G. The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein 1: molecular mechanisms for gene repression. Endocr. Rev. 24, 488-522 (2003).
    • (2003) Endocr. Rev , vol.24 , pp. 488-522
    • De Bosscher, K.1    Vanden Berghe, W.2    Haegeman, G.3
  • 79
    • 79251594820 scopus 로고    scopus 로고
    • Glucocorticoid receptor signaling and prostate cancer
    • Kassi, E., & Moutsatsou, P. Glucocorticoid receptor signaling and prostate cancer. Cancer Lett. 302, 1-10 (2011).
    • (2011) Cancer Lett , vol.302 , pp. 1-10
    • Kassi, E.1    Moutsatsou, P.2
  • 80
    • 26844433194 scopus 로고    scopus 로고
    • Antiinflammatory action of glucocorticoids new mechanisms for old drugs
    • Rhen, T., & Cidlowski, J. A. Antiinflammatory action of glucocorticoids new mechanisms for old drugs. N. Engl. J. Med. 353, 1711-1723 (2005).
    • (2005) N. Engl. J. Med , vol.353 , pp. 1711-1723
    • Rhen, T.1    Cidlowski, J.A.2
  • 81
    • 14844353662 scopus 로고    scopus 로고
    • Rapid actions of steroid receptors in cellular signaling pathways
    • Cato, A. C., Nestl, A., & Mink, S. Rapid actions of steroid receptors in cellular signaling pathways. Sci. STKE re9 (2002).
    • (2002) Sci. STKE re9
    • Cato, A.C.1    Nestl, A.2    Mink, S.3
  • 82
    • 0028987183 scopus 로고
    • Quantitative differences in androgen and glucocorticoid receptor DNA binding properties contribute to receptor-selective transcriptional regulation
    • Rundlett, S. E., & Miesfeld, R. L. Quantitative differences in androgen and glucocorticoid receptor DNA binding properties contribute to receptor-selective transcriptional regulation. Mol. Cell. Endocrinol. 109, 1-10 (1995).
    • (1995) Mol. Cell. Endocrinol , vol.109 , pp. 1-10
    • Rundlett, S.E.1    Miesfeld, R.L.2
  • 83
    • 79951578573 scopus 로고    scopus 로고
    • The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights
    • Coutinho, A. E., & Chapman, K. E. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol. Cell. Endocrinol. 335, 2-13 (2011).
    • (2011) Mol. Cell. Endocrinol , vol.335 , pp. 2-13
    • Coutinho, A.E.1    Chapman, K.E.2
  • 84
    • 0034073222 scopus 로고    scopus 로고
    • Glucocorticoid hormones in the regulation of cell death
    • Riccardi, C., et al. Glucocorticoid hormones in the regulation of cell death. Therapie 55, 165-169 (2000).
    • (2000) Therapie , vol.55 , pp. 165-169
    • Riccardi, C.1
  • 85
    • 0031016271 scopus 로고    scopus 로고
    • Glucocorticoids induce apoptosis in acute myeloid leukemia cell lines with A t(8;21) chromosome translocation
    • Miyoshi, H., Ohki, M., Nakagawa, T., & Honma, Y., et al. Glucocorticoids induce apoptosis in acute myeloid leukemia cell lines with A t(8;21) chromosome translocation. Leuk. Res. 21, 45-50 (1997).
    • (1997) Leuk. Res , vol.21 , pp. 45-50
    • Miyoshi, H.1    Ohki, M.2    Nakagawa, T.3    Honma, Y.4
  • 87
    • 84871537492 scopus 로고    scopus 로고
    • Management and challenges of corticosteroid therapy in men with metastatic castrate-resistant prostate cancer
    • Dorff, T. B., & Crawford, E. D. Management and challenges of corticosteroid therapy in men with metastatic castrate-resistant prostate cancer. Ann. Oncol. 24, 31-38 (2013).
    • (2013) Ann. Oncol , vol.24 , pp. 31-38
    • Dorff, T.B.1    Crawford, E.D.2
  • 88
    • 84871780940 scopus 로고    scopus 로고
    • Dexamethasone premedication for prophylaxis of taxane toxicities: Can the doses be reduced when paclitaxel or docetaxel are given weekly?
    • Schwartz, J. R. Dexamethasone premedication for prophylaxis of taxane toxicities: can the doses be reduced when paclitaxel or docetaxel are given weekly?. J. Oncol. Pharm. Pract. 18, 250-256, (2012).
    • (2012) J. Oncol. Pharm. Pract , vol.18 , pp. 250-256
    • Schwartz, J.R.1
  • 89
    • 0024535895 scopus 로고
    • Treatment of metastatic prostatic cancer with low-dose prednisone: Evaluation of pain and quality of life as pragmatic indices of response
    • Tannock, I., et al. Treatment of metastatic prostatic cancer with low-dose prednisone: evaluation of pain and quality of life as pragmatic indices of response. J. Clin. Oncol. 7, 590-597 (1989).
    • (1989) J. Clin. Oncol , vol.7 , pp. 590-597
    • Tannock, I.1
  • 90
    • 0034672087 scopus 로고    scopus 로고
    • Low doses of oral dexamethasone for hormone-refractory prostate carcinoma
    • Nishimura K., et al. Low doses of oral dexamethasone for hormone-refractory prostate carcinoma. Cancer 89, 2570-2576 (2000).
    • (2000) Cancer , vol.89 , pp. 2570-2576
    • Nishimura, K.1
  • 91
    • 0029077920 scopus 로고
    • Prostate specific antigen levels and clinical response to low dose dexamethasone for hormone-refractory metastatic prostate carcinoma
    • Storlie, J. A., et al. Prostate specific antigen levels and clinical response to low dose dexamethasone for hormone-refractory metastatic prostate carcinoma. Cancer 76, 96-100 (1995).
    • (1995) Cancer , vol.76 , pp. 96-100
    • Storlie, J.A.1
  • 92
    • 0032145378 scopus 로고    scopus 로고
    • Effect of prednisone on prostate-specific antigen in patients with hormone-refractory prostate cancer
    • Sartor, O., Weinberger, M., Moore, A., Li, A., & Figg, W. D. Effect of prednisone on prostate-specific antigen in patients with hormone-refractory prostate cancer. Urology 52, 252-256 (1998).
    • (1998) Urology , vol.52 , pp. 252-256
    • Sartor, O.1    Weinberger, M.2    Moore, A.3    Li, A.4    Figg, W.D.5
  • 93
    • 8944220720 scopus 로고    scopus 로고
    • Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: A Canadian randomized trial with palliative end points
    • Tannock, I. F., et al. Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points. J. Clin. Oncol. 14, 1756-1764 (1996).
    • (1996) J. Clin. Oncol , vol.14 , pp. 1756-1764
    • Tannock, I.F.1
  • 94
    • 0032784113 scopus 로고    scopus 로고
    • Hydrocortisone with or without mitoxantrone in men with hormone-refractory prostate cancer: Results of the cancer and leukemia group B 9182 study
    • Kantoff, P. W., et al. Hydrocortisone with or without mitoxantrone in men with hormone-refractory prostate cancer: results of the cancer and leukemia group B 9182 study. J. Clin. Oncol. 17, 2506-2513 (1999).
    • (1999) J. Clin. Oncol , vol.17 , pp. 2506-2513
    • Kantoff, P.W.1
  • 95
    • 0036895169 scopus 로고    scopus 로고
    • Phase III study of mitoxantrone plus low dose prednisone versus low dose prednisone alone in patients with asymptomatic hormone refractory prostate cancer
    • Berry, W., Dakhil, S., Modiano, M., Gregurich, M., & Asmar, L. Phase III study of mitoxantrone plus low dose prednisone versus low dose prednisone alone in patients with asymptomatic hormone refractory prostate cancer. J. Urol. 168, 2439-2443 (2002).
    • (2002) J. Urol , vol.168 , pp. 2439-2443
    • Berry, W.1    Dakhil, S.2    Modiano, M.3    Gregurich, M.4    Asmar, L.5
  • 96
    • 0028208515 scopus 로고
    • Use of palliative end points to evaluate the effects of mitoxantrone and low-dose prednisone in patients with hormonally resistant prostate cancer
    • Moore, M. J., et al. Use of palliative end points to evaluate the effects of mitoxantrone and low-dose prednisone in patients with hormonally resistant prostate cancer. J. Clin. Oncol. 12, 689-694 (1994).
    • (1994) J. Clin. Oncol , vol.12 , pp. 689-694
    • Moore, M.J.1
  • 97
    • 77957682309 scopus 로고    scopus 로고
    • Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: A randomised open-label trial
    • de Bono, J. S., et al. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet 376, 1147-1154 (2010).
    • (2010) Lancet , vol.376 , pp. 1147-1154
    • De Bono, J.S.1
  • 98
    • 4744366279 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
    • Tannock, I. F., et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N. Engl. J. Med. 351, 1502-1512 (2004).
    • (2004) N. Engl. J. Med , vol.351 , pp. 1502-1512
    • Tannock, I.F.1
  • 99
    • 84882616849 scopus 로고    scopus 로고
    • Real-world corticosteroid utilization patterns in patients with metastatic castration-resistant prostate cancer in 2 large US administrative claims databases
    • Lafeuille, M. H., et al. Real-world corticosteroid utilization patterns in patients with metastatic castration-resistant prostate cancer in 2 large US administrative claims databases. Am. Health Drug Benefits 6, 307-316 (2013).
    • (2013) Am. Health Drug Benefits , vol.6 , pp. 307-316
    • Lafeuille, M.H.1
  • 100
    • 0025150875 scopus 로고
    • A phase II randomized trial of megestrol acetate or dexamethasone in the treatment of hormonally refractory advanced carcinoma of the prostate
    • Patel, S R., et al. A phase II randomized trial of megestrol acetate or dexamethasone in the treatment of hormonally refractory advanced carcinoma of the prostate. Cancer 66 1990 655-658
    • (1990) Cancer , vol.66 , pp. 655-658
    • Patel, S.R.1
  • 101
    • 0029101785 scopus 로고
    • Prospective evaluation of hydrocortisone and suramin in patients with androgen-independent prostate cancer
    • Kelly, W. K., et al. Prospective evaluation of hydrocortisone and suramin in patients with androgen-independent prostate cancer. J. Clin. Oncol. 13, 2208-2213 (1995).
    • (1995) J. Clin. Oncol , vol.13 , pp. 2208-2213
    • Kelly, W.K.1
  • 102
    • 0031929708 scopus 로고    scopus 로고
    • Hormone/antihormone withdrawal and dexamethasone for hormone-refractory prostate cancer
    • Nishiyama, T., & Terunuma, M. Hormone/antihormone withdrawal and dexamethasone for hormone-refractory prostate cancer. Int. J. Urol. 5, 44-47 (1998).
    • (1998) Int. J. Urol , vol.5 , pp. 44-47
    • Nishiyama, T.1    Terunuma, M.2
  • 103
    • 0033968439 scopus 로고    scopus 로고
    • Dexamethasone does not significantly contribute to the response rate of docetaxel and estramustine in androgen independent prostate cancer
    • Weitzman, A. L., et al. Dexamethasone does not significantly contribute to the response rate of docetaxel and estramustine in androgen independent prostate cancer. J. Urol. 163, 834-837 (2000).
    • (2000) J. Urol , vol.163 , pp. 834-837
    • Weitzman, A.L.1
  • 104
    • 33646822618 scopus 로고    scopus 로고
    • Phase II study evaluating oral triamcinolone in patients with androgen-independent prostate cancer
    • Srinivas, S., Krishnan, A. V., Colocci, N., & Feldman, D. Phase II study evaluating oral triamcinolone in patients with androgen-independent prostate cancer. Urology 67, 1001-1006 (2006).
    • (2006) Urology , vol.67 , pp. 1001-1006
    • Srinivas, S.1    Krishnan, A.V.2    Colocci, N.3    Feldman, D.4
  • 105
    • 0035148171 scopus 로고    scopus 로고
    • Flutamide versus prednisone in patients with prostate cancer symptomatically progressing after androgen-ablative therapy: A phase III study of the European organization for research and treatment of cancer genitourinary group
    • Fossa, S. D., et al. Flutamide versus prednisone in patients with prostate cancer symptomatically progressing after androgen-ablative therapy: a phase III study of the European organization for research and treatment of cancer genitourinary group. J. Clin. Oncol. 19, 62-71 (2001).
    • (2001) J. Clin. Oncol , vol.19 , pp. 62-71
    • Fossa, S.D.1
  • 106
    • 79957443342 scopus 로고    scopus 로고
    • Abiraterone and increased survival in metastatic prostate cancer
    • de Bono, J. S., et al. Abiraterone and increased survival in metastatic prostate cancer. N. Engl. J. Med. 364, 1995-2005 (2011).
    • (2011) N. Engl. J. Med , vol.364 , pp. 1995-2005
    • De Bono, J.S.1
  • 107
    • 0028273838 scopus 로고
    • Low dose long-term corticosteroid therapy in rheumatoid arthritis: An analysis of serious adverse events
    • Saag, K. G., et al. Low dose long-term corticosteroid therapy in rheumatoid arthritis: an analysis of serious adverse events. Am. J. Med. 96, 115-123 (1994).
    • (1994) Am. J. Med , vol.96 , pp. 115-123
    • Saag, K.G.1
  • 108
    • 70449417568 scopus 로고    scopus 로고
    • Glucocorticoid signaling in the cell Expanding clinical implications to complex human behavioral and somatic disorders
    • Chrousos, G. P., & Kino, T. Glucocorticoid signaling in the cell. Expanding clinical implications to complex human behavioral and somatic disorders. Ann. N. Y. Acad. Sci. 1179, 153-166, (2009).
    • (2009) Ann. N. Y. Acad. Sci , vol.1179 , pp. 153-166
    • Chrousos, G.P.1    Kino, T.2
  • 109
    • 84868611737 scopus 로고    scopus 로고
    • New mechanisms of glucocorticoid-induced insulin resistance: Make no bones about it
    • Ferris, H. A., & Kahn, C. R. New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it. J. Clin. Invest. 122, 3854-3857 (2012).
    • (2012) J. Clin. Invest , vol.122 , pp. 3854-3857
    • Ferris, H.A.1    Kahn, C.R.2
  • 111
  • 112
    • 84905843716 scopus 로고    scopus 로고
    • Bone health in cancer patients: ESMO clinical practice guidelines
    • Coleman, R., et al. Bone health in cancer patients: ESMO clinical practice guidelines. Ann. Oncol. S3 124-127 2014
    • (2014) Ann. Oncol , Issue.S3 , pp. 124-127
    • Coleman, R.1
  • 113
    • 84867571938 scopus 로고    scopus 로고
    • Randomised phase II/III study of docetaxel with or without risedronate in patients with metastatic castration resistant prostate cancer (CRPC), the Netherlands Prostate Study (NePro)
    • Meulenbeld, H. J., et al. Randomised phase II/III study of docetaxel with or without risedronate in patients with metastatic castration resistant prostate cancer (CRPC), the Netherlands Prostate Study (NePro). Eur. J. Cancer 48, 2993-3000 (2012).
    • (2012) Eur. J. Cancer , vol.48 , pp. 2993-3000
    • Meulenbeld, H.J.1
  • 114
    • 84855516339 scopus 로고    scopus 로고
    • Denosumab and bone metastasis free survival in men with castration-resistant prostate cancer: Results of a phase 3, randomised, placebo-controlled trial
    • Smith, M. R., et al. Denosumab and bone metastasis free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial. Lancet 379, 39-46, (2012).
    • (2012) Lancet , vol.379 , pp. 39-46
    • Smith, M.R.1
  • 115
    • 84922251300 scopus 로고    scopus 로고
    • Prevention of bone metastases in patients with high-risk nonmetastatic prostate cancer treated with zoledronic acid: Efficacy and safety results of the Zometa European Study (ZEUS)
    • Wirth, M., et al. Prevention of bone metastases in patients with high-risk nonmetastatic prostate cancer treated with zoledronic acid: efficacy and safety results of the Zometa European Study (ZEUS). Eur. Urol. 67, 482-491 (2015).
    • (2015) Eur. Urol , vol.67 , pp. 482-491
    • Wirth, M.1
  • 116
    • 33750483635 scopus 로고    scopus 로고
    • Bone related events in high risk prostate cancer
    • Srinivas, S., & Colocci, N. Bone related events in high risk prostate cancer. J. Urol. 176, S50-S54 (2006).
    • (2006) J. Urol , vol.176 , pp. S50-S54
    • Srinivas, S.1    Colocci, N.2
  • 117
    • 0035445644 scopus 로고    scopus 로고
    • Non-melanoma skin cancers and glucocorticoid therapy
    • Karagas, M. R., et al. Non-melanoma skin cancers and glucocorticoid therapy. Br. J. Cancer 85, 683-686 (2001).
    • (2001) Br. J. Cancer , vol.85 , pp. 683-686
    • Karagas, M.R.1
  • 118
    • 0024762524 scopus 로고
    • Risk of infectious complications in patients taking glucocorticosteroids
    • Stuck, A. E., Minder, C. E., & Frey, F. J. Risk of infectious complications in patients taking glucocorticosteroids. Rev. Infect. Dis. 11, 954-963 (1989).
    • (1989) Rev. Infect. Dis , vol.11 , pp. 954-963
    • Stuck, A.E.1    Minder, C.E.2    Frey, F.J.3
  • 119
    • 84883519515 scopus 로고    scopus 로고
    • Neuropsychiatric findings in Cushing syndrome and exogenous glucocorticoid administration
    • Starkman, M. N. Neuropsychiatric findings in Cushing syndrome and exogenous glucocorticoid administration. Endocrinol. Metab. Clin. North Am. 42, 477-488 (2013).
    • (2013) Endocrinol. Metab. Clin. North Am. , vol.42 , pp. 477-488
    • Starkman, M.N.1
  • 120
    • 84866770294 scopus 로고    scopus 로고
    • Increased survival with enzalutamide in prostate cancer after chemotherapy
    • Scher, H. I., et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N. Engl. J. Med. 367, 1187-1197 (2012).
    • (2012) N. Engl. J. Med , vol.367 , pp. 1187-1197
    • Scher, H.I.1
  • 121
    • 84907506307 scopus 로고    scopus 로고
    • Mechanisms of acquired resistance to androgen receptor targeting drugs in castration-resistant prostate cancer
    • Chism, D. D., De Silva, D., & Whang, Y. E. Mechanisms of acquired resistance to androgen receptor targeting drugs in castration-resistant prostate cancer. Expert Rev. Anticancer Ther. 14, 1369-1378 (2014).
    • (2014) Expert Rev. Anticancer Ther , vol.14 , pp. 1369-1378
    • Chism, D.D.1    De Silva, D.2    Whang, Y.E.3
  • 122
    • 84860523917 scopus 로고    scopus 로고
    • Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: A rationale for increasing abiraterone exposure or combining with MDV3100
    • Richards, J., et al. Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100. Cancer Res. 72, 2176-2182 (2012).
    • (2012) Cancer Res , vol.72 , pp. 2176-2182
    • Richards, J.1
  • 123
    • 84877767791 scopus 로고    scopus 로고
    • Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: A rationale for increasing abiraterone exposure or combining with MDV3100
    • End, D., Molina, A., Todd, M., & Meyers, M. L. Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100. Cancer Res. 73, 2926 (2013).
    • (2013) Cancer Res , vol.73 , pp. 2926
    • End, D.1    Molina, A.2    Todd, M.3    Meyers, M.L.4
  • 124
    • 68949094223 scopus 로고    scopus 로고
    • Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer
    • Attard, G., et al. Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer. J. Clin. Oncol. 27, 3742-3748 (2009).
    • (2009) J. Clin. Oncol , vol.27 , pp. 3742-3748
    • Attard, G.1
  • 125
    • 0034484856 scopus 로고    scopus 로고
    • Pregnenolone stimulates LNCaP prostate cancer cell growth via the mutated androgen receptor
    • Grigoryev, D. N., Long, B. J., Njar, V. C., & Brodie, A. H. Pregnenolone stimulates LNCaP prostate cancer cell growth via the mutated androgen receptor. J. Steroid Biochem. Mol. Biol. 75, 1-10, (2000).
    • (2000) J. Steroid Biochem. Mol. Biol , vol.75 , pp. 1-10
    • Grigoryev, D.N.1    Long, B.J.2    Njar, V.C.3    Brodie, A.H.4
  • 126
    • 0042130389 scopus 로고    scopus 로고
    • Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663
    • Taplin, M. E., et al. Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663. J. Clin. Oncol. 21, 2673-2678 (2003).
    • (2003) J. Clin. Oncol , vol.21 , pp. 2673-2678
    • Taplin, M.E.1
  • 127
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01949337 (2015).
    • (2015) US National Library of Medicine
  • 128
    • 84861726854 scopus 로고    scopus 로고
    • Clinical Trials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01709734?term=NCT01709734&rank=1 (2015).
    • (2015) US National Library of Medicine
  • 129
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02025010 (2015).
    • (2015) US National Library of Medicine
  • 130
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01867710 (2015).
    • (2015) US National Library of Medicine
  • 131
    • 84927578069 scopus 로고    scopus 로고
    • Tumour responses following a steroid switch from prednisone to dexamethasone in castration-resistant prostate cancer patients progressing on abiraterone
    • Lorente, D., et al. Tumour responses following a steroid switch from prednisone to dexamethasone in castration-resistant prostate cancer patients progressing on abiraterone. Br. J. Cancer 111, 2248-2253 (2014).
    • (2014) Br. J. Cancer , vol.111 , pp. 2248-2253
    • Lorente, D.1
  • 132
    • 80052827038 scopus 로고    scopus 로고
    • Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants
    • Mostaghel, E. A., et al. Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clin. Cancer Res. 17, 5913-5925 (2011).
    • (2011) Clin. Cancer Res , vol.17 , pp. 5913-5925
    • Mostaghel, E.A.1
  • 133
    • 84879067087 scopus 로고    scopus 로고
    • Overcoming mutation-based resistance to antiandrogens with rational drug design
    • Balbas, M. D., et al. Overcoming mutation-based resistance to antiandrogens with rational drug design. Elife 2, e00499 (2013).
    • (2013) Elife , vol.2 , pp. e00499
    • Balbas, M.D.1
  • 134
    • 84885214146 scopus 로고    scopus 로고
    • An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide)
    • Korpal, M., et al. An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide). Cancer Discov. 3, 1030-1043 (2013).
    • (2013) Cancer Discov , vol.3 , pp. 1030-1043
    • Korpal, M.1
  • 135
    • 84907285681 scopus 로고    scopus 로고
    • Tumor clone dynamics in lethal prostate cancer
    • Carreira, S., et al. Tumor clone dynamics in lethal prostate cancer. Sci. Transl. Med. 6, 254ra125 (2014).
    • (2014) Sci. Transl. Med , vol.6 , pp. 254ra125
    • Carreira, S.1
  • 136
    • 84898002226 scopus 로고    scopus 로고
    • Glucocorticoid receptor activity contributes to resistance to androgen-targeted therapy in prostate cancer
    • Isikbay, M., et al. Glucocorticoid receptor activity contributes to resistance to androgen-targeted therapy in prostate cancer. Horm. Cancer 5, 72-89 (2014).
    • (2014) Horm. Cancer , vol.5 , pp. 72-89
    • Isikbay, M.1
  • 137
    • 33645750799 scopus 로고    scopus 로고
    • TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer
    • Tomlins, S. A., et al. TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res. 66, 3396-4000 (2006).
    • (2006) Cancer Res , vol.66 , pp. 3396-4000
    • Tomlins, S.A.1
  • 138
    • 33847224474 scopus 로고    scopus 로고
    • Ligand-specific dynamics of the androgen receptor at its response element in living cells
    • Klokk, T. I., et al. Ligand-specific dynamics of the androgen receptor at its response element in living cells. Mol. Cell. Biol. 27, 1823-1843 (2007).
    • (2007) Mol. Cell. Biol , vol.27 , pp. 1823-1843
    • Klokk, T.I.1
  • 139
    • 78650016651 scopus 로고    scopus 로고
    • Monoclonal antibody targeting of N cadherin inhibits prostate cancer growth, metastasis and castration resistance
    • Tanaka H., et al. Monoclonal antibody targeting of N cadherin inhibits prostate cancer growth, metastasis and castration resistance. Nat. Med. 16, 1414-1420 (2010).
    • (2010) Nat. Med , vol.16 , pp. 1414-1420
    • Tanaka, H.1
  • 140
    • 84893520397 scopus 로고    scopus 로고
    • Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy
    • Choi, W., et al. Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy. Cancer Cell 25, 152-165 (2014).
    • (2014) Cancer Cell , vol.25 , pp. 152-165
    • Choi, W.1
  • 141
    • 58249110391 scopus 로고    scopus 로고
    • Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
    • Hu, R., et al. Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res. 69, 16-22 (2009).
    • (2009) Cancer Res , vol.69 , pp. 16-22
    • Hu, R.1
  • 142
    • 84904871070 scopus 로고    scopus 로고
    • Enzalutamide in metastatic prostate cancer before chemotherapy
    • Beer, T. M., et al. Enzalutamide in metastatic prostate cancer before chemotherapy. N. Engl. J. Med. 371, 424-433 (2014).
    • (2014) N. Engl. J. Med , vol.371 , pp. 424-433
    • Beer, T.M.1
  • 143
    • 38049081245 scopus 로고    scopus 로고
    • Methotrexate, vinblastine, doxorubicin and cisplatin combination regimen as salvage chemotherapy for patients with advanced or metastatic transitional cell carcinoma after failure of gemcitabine and cisplatin chemotherapy
    • Han, K. S., et al. Methotrexate, vinblastine, doxorubicin and cisplatin combination regimen as salvage chemotherapy for patients with advanced or metastatic transitional cell carcinoma after failure of gemcitabine and cisplatin chemotherapy. Br. J. Cancer 98, 86-90 (2008).
    • (2008) Br. J. Cancer , vol.98 , pp. 86-90
    • Han, K.S.1
  • 144
    • 84921985109 scopus 로고    scopus 로고
    • Quo vadis: Advanced prostate cancer-clinical care and clinical research in the era of multiple androgen receptor-directed therapies
    • Kim, W., & Ryan, C. J. Quo vadis: Advanced prostate cancer-clinical care and clinical research in the era of multiple androgen receptor-directed therapies. Cancer 121, 1 (2014).
    • (2014) Cancer , vol.121 , pp. 1
    • Kim, W.1    Ryan, C.J.2


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