Bacteroides fragilis lipopolysaccharide and inflammatory signaling in alzheimer's disease

Frontiers in Microbiology

Volumn 7, Issue SEP, 2016, Pages

  Lukiw, Walter J ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

42 amino acid amyloid beta (A 42) peptides; Alzheimer's disease; Bacteroidetes; DAMPs and PAMPs; Lipopolysaccharides; Microbiome; NF B; systemic inflammation

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; CD14 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NEUROTOXIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR;

AGING; ALZHEIMER DISEASE; ARTICLE; BACTEROIDES FRAGILIS; BLOOD BRAIN BARRIER; CYTOKINE PRODUCTION; ECOSYSTEM; GASTROINTESTINAL TRACT; GRAM NEGATIVE BACTERIUM; HUMAN; IMMUNE RESPONSE; MICROBIOME; MICROGLIA; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROLOGIC DISEASE; NONHUMAN; SIGNAL TRANSDUCTION;

EID: 84993971803     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2016.01544     Document Type: Article

References (48)

1. Asti, A., and Gioglio, L. (2014). Can a bacterial endotoxin be a key factor in the kinetics of amyloid fibril formation? J. Alzheimers Dis. 39, 169-179. doi: 10.3233/JAD-131394
2. Bhattacharjee, S., and Lukiw, W. J. (2013). Alzheimer's disease and the microbiome. Front. Cell. Neurosci. 7:153. doi: 10.3389/fncel.2013.00153
3. Calsolaro, V., and Edison, P. (2016). Neuroinflammation in Alzheimer's disease: current evidence and future directions. Alzheimers Dement. 12, 719-732. doi: 10.1016/j.jalz.2016.02.010
4. Choi, V. M., Herrou, J., Hecht, A. L., Teoh, W. P., Turner, J. R., Crosson, S., et al. (2016). Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice. Nat. Med. 22, 563-567. doi: 10.1038/nm.4077
5. Clark, I. A., and Vissel, B. (2015). Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease. Br. J. Pharmacol. 172, 3714-3727. doi: 10.1111/bph.13181
6. Clement, C., Hill, J. M., Dua, P., Culicchia, F., and Lukiw, W. J. (2016). Analysis of RNA from Alzheimer's disease post-mortem brain tissues. Mol. Neurobiol. 53, 1322-1328. doi: 10.1007/s12035-015-9105-6
7. Devier, D. J., Lovera, J. F., and Lukiw, W. J. (2015). Increase in NF-κB-sensitive miRNA-146a and miRNA-155 in multiple sclerosis (MS) and pro-inflammatory neurodegeneration. Front. Mol. Neurosci. 8:5. doi: 10.3389/fnmol.2015.00005
8. Eidhin, D. N., and Mouton, C. (1993). A rapid method for preparation of rough and smooth lipopolysaccharide from Bacteroides, Porphyromonas and Prevotella. FEMS Microbiol. Lett. 110, 133-138. doi: 10.1111/j.1574-6968.1993.tb06309.x
9. Fathi, P., and Wu, S. (2016). Isolation, detection, and characterization of enterotoxigenic Bacteroides fragilis in clinical samples. Open Microbiol. J. 10, 57-63. doi: 10.2174/1874285801610010057
10. Foster, J. A., Lyte, M., Meyer, E., and Cryan, J. F. (2016). Gut microbiota and brain function: an evolving field in neuroscience. Int. J. Neuropsychopharmacol. 19, yv114. doi: 10.1093/ijnp/pyv114
11. Gustot, A., Raussens, V., Dehousse, M., Dumoulin, M., Bryant, C. E., Ruysschaert, J. M., et al. (2013). Activation of innate immunity by lysozyme fibrils is critically dependent on cross-β sheet structure. Cell. Mol. Life. Sci. 70, 2999-3012. doi: 10.1007/s00018-012-1245-5
12. Hakansson, A., and Molin, G. (2011). Gut microbiota and inflammation. Nutrients 3, 637-682. doi: 10.3390/nu3060637
13. Halmer, R., Davies, L., Liu, Y., Fassbender, K., and Walter, S. (2015). The innate immune receptor CD14 mediates lymphocyte migration in EAE. Cell. Physiol. Biochem. 37, 269-275. doi: 10.1159/000430351
14. Heinritz, S. N., Weiss, E., Eklund, M., Aumiller, T., Heyer, C. M., Messner, S., et al. (2016). Impact of a high-fat or high-fiber diet on intestinal microbiota and metabolic markers in a pig podel. Nutrients 8:E317. doi: 10.3390/nu8050317
15. Hill, J. M., Clement, C., Pogue, A. I., Bhattacharjee, S., Zhao, Y., and Lukiw, W. J. (2014). Pathogenic microbes, the microbiome, and Alzheimer's disease (AD). Front. Aging Neurosci. 6:127. doi: 10.3389/fnagi.2014.00127
16. Hill, J. M., and Lukiw, W. J. (2015). Microbial-generated amyloids and Alzheimer's disease (AD). Front. Aging Neurosci. 7:9. doi: 10.3389/fnagi.2015.00009
17. Hofer, U. (2014). Microbiome: B. fragilis and the brain. Nat. Rev. Microbiol. 12, 76-77. doi: 10.1038/nrmicro3197
18. Hug, L. A., Baker, B. J., Anantharaman, K., Brown, C. T., Probst, A. J., Castelle, C. J., et al. (2016). A new view of the tree of life. Nat. Microbiol. 1:16048. doi: 10.1038/nmicrobiol.2016.48
19. Hugon, P., Dufour, J. C., Colson, P., Fournier, P. E., Sallah, K., and Raoult, D. (2015). A comprehensive repertoire of prokaryotic species identified in human beings. Lancet Infect. Dis. 15, 1211-1219. doi: 10.1016/S1473-3099(15)00293-5
20. Jiang, Q., Jin, S., Jiang, Y., Liao, M., Feng, R., Zhang, L., et al. (2016). Alzheimer's disease variants with the genome-wide significance are significantly enriched in immune pathways and active in immune cells. Mol. Neurobiol. doi: 10.1007/s12035-015-9670-8 [Epub ahead of print].
21. Khanna, S., and Tosh, P. K. (2014). A clinician's primer on the role of the microbiome in human health and disease. Mayo Clin. Proc. 89, 107-114. doi: 10.1016/j.mayocp.2013.10.011
22. Land, W. G. (2015). The role of damage-associated molecular patterns (DAMPs) in human diseases: part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine. Sultan Qaboos Univ. Med. J. 15, e157-e170.
23. Lee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W., et al. (2008). Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. J. Neuroinflammation 5:37. doi: 10.1186/1742-2094-5-37
24. Leshchyns'ka, I., and Sytnyk, V. (2016). Synaptic cell adhesion molecules in Alzheimer's disease. Neural Plast. 2016, 6427537. doi: 10.1155/2016/6427537
25. Lim, S. L., Rodriguez-Ortiz, C. J., and Kitazawa, M. (2015). Infection, systemic inflammation, and Alzheimer's disease. Microbes Infect. 17, 549-556. doi: 10.1016/j.micinf.2015.04.004
26. Lin, C. S., Chang, C. J., Lu, C. C., Martel, J., Ojcius, D. M., Ko, Y. F., et al. (2014). Impact of the gut microbiota, prebiotics, and probiotics on human health and disease. Biomed. J. 37, 259-268. doi: 10.4103/2319-4170.138314
27. Lukiw, W. J., and Bazan, N. G. (1998). Strong NF-kB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. J. Neurosci. Res. 53, 583-592. doi: 10.1002/(SICI)1097-4547(19980901)53:5<583::AID-JNR8>3.0.CO;2-5
28. Lukiw, W. J., Zhao, Y., and Cui, J. G. (2008). An NF-kB-sensitive microRNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J. Biol. Chem. 283, 31315-31322. doi: 10.1074/jbc.M805371200
29. Maldonado, R. F., Sá-Correia, I., and Valvano, M. A. (2016). Lipopolysaccharide modification in Gram-negative bacteria during chronic infection. FEMS Microbiol. Rev. 40, 480-493. doi: 10.1093/femsre/fuw007
30. Minter, M. R., Taylor, J. M., and Crack, P. J. (2016). The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease. J. Neurochem. 136, 457-474. doi: 10.1111/jnc.13411
31. Montagne, A., Barnes, S. R., Sweeney, M. D., Halliday, M. R., Sagare, A. P., Zhao, Z., et al. (2015). Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85, 296-302. doi: 10.1016/j.neuron.2014.12.032
32. Nishimori, J. H., Newman, T. N., Oppong, G. O., Rapsinski, G. J., Yen, J. H., Biesecker, S. G., et al. (2012). Microbial amyloids induce interleukin 17A and IL-22 rvia TLR2 activation. Infect. Immun. 80, 4398-4408. doi: 10.1128/IAI.00911-12
33. Richards, R. I., Robertson, S. A., O'Keefe, L. V., Fornarino, D., Scott, A., Lardelli, M., et al. (2016). The enemy within: innate surveillance-mediated cell death, the common mechanism of neurodegenerative disease. Front Neurosci. 10:193. doi: 10.3389/fnins.2016.00193
34. Rogers, M. A., and Aronoff, D. M. (2016). The influence of non-steroidal anti-inflammatory drugs on the gut microbiome. Clin. Microbiol. Infect. 22,.e1-.e178. doi: 10.1016/j.cmi.2015.10.003
35. Sampson, T. R., and Mazmanian, S. K. (2016). Control of brain development, function, and behavior by the microbiome cell host microbe. Cell Host Microbe 17, 565-576. doi: 10.1016/j.chom.2015.04.011
36. Seksik, P., and Landman, C. (2015). Understanding microbiome data: a primer for clinicians. Dig. Dis. 33(Suppl. 1), 11-16. doi: 10.1159/000437034 [Epub ahead of print]
37. Sender, R., Fuchs, S., and Milo, R. (2016). Revised estimates for the number of human and bacteria cells in the body. PLoS Biol. 14:e1002533. doi: 10.1371/journal.pbio.1002533
38. Seong, E., Yuan, L., and Arikkath, J. (2015). Cadherins and catenins in dendrite and synapse morphogenesis. Cell Adh. Migr. 9, 202-213. doi: 10.4161/19336918.2014.994919
39. Soenen, S., Rayner, C. K., Jones, K. L., and Horowitz, M. (2016). The ageing gastrointestinal tract. Curr. Opin. Clin. Nutr. Metab. Care 19, 12-18. doi: 10.1097/MCO.0000000000000238
40. van de Haar, H. J., Burgmans, S., Jansen, J. F., van Osch, M. J., van Buchem, M. A., Muller, M., et al. (2016). Blood-brain barrier leakage in patients with early Alzheimer disease. Radiology doi: 10.1148/radiol.2016152244 [Epub ahead of print].
41. Varatharaj, A., and Galea, I. (2016). The blood-brain barrier in systemic inflammation. Brain Behav. Immun. doi: 10.1016/j.bbi.2016.03.010 [Epub ahead of print],
42. Youssef, N. H., Couger, M. B., McCully, A. L., Criado, A. E., and Elshahed, M. S. (2015). Assessing the global phylum level diversity within the bacterial domain: a review. J. Adv. Res. 6, 269-282. doi: 10.1016/j.jare.2014.10.005
43. Yu, Y., and Ye, R. D. (2015). Microglial Aβ receptors in Alzheimer's disease. Cell. Mol. Neurobiol. 35, 71-83. doi: 10.1007/s10571-014-0101-6
44. Zhan, L. S., and Davies, S. S. (2016). Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions. Genome Med. 8, 46. doi: 10.1186/s13073-016-0296-x
45. Zhang, J., Ke, K. F., Liu, Z., Qiu, Y. H., and Peng, Y. P. (2013). Th17 cell-mediated neuroinflammation is involved in neurodegeneration of Aβ1-42-induced Alzheimer's disease. PLoS ONE 8:e75786. doi: 10.1371/journal.pone.0075786
46. Zhao, Y., Dua, P., and Lukiw, W. J. (2015). Microbial sources of amyloid and relevance to amyloidogenesis and Alzheimer's disease (AD). J. Alzheimers Dis. Parkinsonism 5, 177.
47. Zhao, Y., Jaber, V., and Lukiw, W. J. (2016). Over-expressed pathogenic miRNAs in Alzheimer's disease (AD) and prion disease (PrD) drive deficits in TREM2-mediated Aβ42 peptide clearance. Fron. Aging Neurosci. 8:140. doi: 10.3389/fnagi.2016.00140
48. Zhao, Y., and Lukiw, W. J. (2015). Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD). J. Nat. Sci. 1:e138.