The innate immune receptor CD14 mediates lymphocyte migration in EAE

Cellular Physiology and Biochemistry

Volumn 37, Issue 1, 2015, Pages 269-275

  Halmer, Ramona ^a   Davies, Laura ^b   Liu, Yang ^a   Fassbender, Klaus ^a   Walter, Silke ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Blood brain barrier; Experimental autoimmune encephalomyelitis; LPS receptor; Multiple sclerosis; T cell activation

Indexed keywords

CD14 ANTIGEN; CD28 ANTIGEN; CELL ADHESION MOLECULE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; T LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL INFILTRATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE EXACERBATION; ENDOTHELIUM CELL; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; IN VITRO STUDY; INNATE IMMUNITY; LEUKOCYTE ADHERENCE; LYMPHOCYTE MIGRATION; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; ANIMAL; C57BL MOUSE; CELL ADHESION; CELL MOTION; IMMUNOLOGY; INFLAMMATION; LYMPHOCYTE ACTIVATION; MULTIPLE SCLEROSIS; PATHOLOGY; SPINAL CORD;

ANIMALS; ANTIGENS, CD14; ANTIGENS, CD28; BLOOD-BRAIN BARRIER; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION; CELL MOVEMENT; CTLA-4 ANTIGEN; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENDOTHELIAL CELLS; FEMALE; IMMUNITY, INNATE; INFLAMMATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MULTIPLE SCLEROSIS; RECEPTORS, IMMUNOLOGIC; SPINAL CORD;

EID: 84941145601     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000430351     Document Type: Article

References (17)

1. Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L: Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998;338:278-285
2. Meuer SC, Acuto O, Hercend T, Schlossman SF, Reinherz EL: The human t-cell receptor. Annu Rev Immunol 1984;2:23-50
3. Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A: T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 1999;283:680-682
4. Linsley PS, Greene JL, Tan P, Bradshaw J, Ledbetter JA, Anasetti C, Damle NK: Coexpression and functional cooperation of ctla-4 and cd28 on activated t lymphocytes. J Exp Med 1992;176:1595-1604
5. Engelhardt B, Ransohoff RM: The ins and outs of t-lymphocyte trafficking to the cns: Anatomical sites and molecular mechanisms. Trends Immunol 2005;26:485-495
6. Ley K, Laudanna C, Cybulsky MI, Nourshargh S: Getting to the site of inflammation: The leukocyte adhesion cascade updated. Nat Rev Immunol 2007;7:678-689
7. Echchannaoui H, Frei K, Letiembre M, Strieter RM, Adachi Y, Landmann R: Cd14 deficiency leads to increased mip-2 production, cxcr2 expression, neutrophil transmigration, and early death in pneumococcal infection. J Leukoc Biol 2005;78:705-715
8. Walter S, Doering A, Letiembre M, Liu Y, Hao W, Diem R, Bernreuther C, Glatzel M, Engelhardt B, Fassbender K: The lps receptor, cd14, in experimental autoimmune encephalomyelitis and multiple sclerosis. Cell Physiol Biochem 2006;17:167-172
9. Engelhardt B, Ransohoff RM: Capture, crawl, cross: The t cell code to breach the blood-brain barriers. Trends Immunol 2012;33:579-589
10. Engelhardt B: The blood-central nervous system barriers actively control immune cell entry into the central nervous system. Curr Pharm Des 2008;14:1555-1565
11. Kerfoot SM, Long EM, Hickey MJ, Andonegui G, Lapointe BM, Zanardo RC, Bonder C, James WG, Robbins SM, Kubes P: Tlr4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease. J Immunol 2004;173:7070-7077
12. Wysocki J, Issekutz TB: Effect of t cell activation on lymphocyte-endothelial cell adherence and the role of vla-4 in the rat. Cell Immunol 1992;140:420-431
13. Selmaj K, Walczak A, Mycko M, Berkowicz T, Kohno T, Raine CS: Suppression of experimental autoimmune encephalomyelitis with a tnf binding protein (tnfbp) correlates with down-regulation of vcam-1/vla-4. Eur J Immunol 1998;28:2035-2044
14. Rothhammer V, Heink S, Petermann F, Srivastava R, Claussen MC, Hemmer B, Korn T: Th17 lymphocytes traffic to the central nervous system independently of alpha4 integrin expression during eae. J Exp Med 2011;208:2465-2476
15. Issazadeh S, Navikas V, Schaub M, Sayegh M, Khoury S: Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo. J Immunol 1998;161:1104-1112
16. Karandikar NJ, Vanderlugt CL, Walunas TL, Miller SD, Bluestone JA: Ctla-4: A negative regulator of autoimmune disease. J Exp Med 1996;184:783-788
17. Pugin J, Heumann ID, Tomasz A, Kravchenko VV, Akamatsu Y, Nishijima M, Glauser MP, Tobias PS, Ulevitch RJ: Cd14 is a pattern recognition receptor. Immunity 1994;1:509-516