Activation of innate immunity by lysozyme fibrils is critically dependent on cross-β sheet structure

Cellular and Molecular Life Sciences

Volumn 70, Issue 16, 2013, Pages 2999-3012

  Gustot, Adelin ^a   Raussens, Vincent ^a   Dehousse, Morgane ^b   Dumoulin, Mireille ^b   Bryant, Clare E ^c   Ruysschaert, Jean Marie ^a   Lonez, Caroline ^a,c  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Amyloid induced inflammation; Cross structure; NLRP3 inflammasome; Toll like receptors

Indexed keywords

AMYLOID; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2;

ARTICLE; BETA SHEET; CELL AGGREGATION; CELL STRUCTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; LYSOSOME; MOLECULAR DYNAMICS; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN MOTIF; STRUCTURE ANALYSIS;

AMYLOID; AMYLOIDOSIS; ANIMALS; CARRIER PROTEINS; CELL LINE; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; MURAMIDASE; PROTEIN STRUCTURE, SECONDARY; TOLL-LIKE RECEPTOR 2;

BACTERIA (MICROORGANISMS);

EID: 84881163373     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1245-5     Document Type: Article

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