메뉴 건너뛰기




Volumn 37, Issue 1, 2017, Pages 50-59

The C. elegans model in toxicity testing

Author keywords

alternative model; good C. elegans culture practice; predictive toxicology; screening; toxin ranking

Indexed keywords

CAENORHABDITIS ELEGANS; CELL CULTURE; GOOD CAENORHABDITIS ELEGANS CULTURE PRACTICE; GOOD LABORATORY PRACTICE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TOXICITY ASSAY; TOXICITY TESTING; TOXICOLOGY; ANIMAL; ANIMAL TESTING ALTERNATIVE; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; LD50; PROCEDURES;

EID: 84992700506     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.3357     Document Type: Review
Times cited : (401)

References (91)
  • 1
    • 84906267591 scopus 로고    scopus 로고
    • Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases
    • Alexander AG, Marfil V, Li C. 2014. Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases. Front. Genet. 5: 279.
    • (2014) Front. Genet. , vol.5 , pp. 279
    • Alexander, A.G.1    Marfil, V.2    Li, C.3
  • 2
    • 84878424809 scopus 로고    scopus 로고
    • A C. elegans screening platform for the rapid assessment of chemical disruption of germline function. Environ
    • Allard P, Kleinstreuer NC, Knudsen TB, Colaiacovo MP. 2013. A C. elegans screening platform for the rapid assessment of chemical disruption of germline function. Environ. Health Perspect. 121: 717–724.
    • (2013) Health Perspect. , vol.121 , pp. 717-724
    • Allard, P.1    Kleinstreuer, N.C.2    Knudsen, T.B.3    Colaiacovo, M.P.4
  • 5
    • 0032509484 scopus 로고    scopus 로고
    • Neurobiology of the Caenorhabditis elegans genome
    • Bargmann CI. 1998. Neurobiology of the Caenorhabditis elegans genome. Science 282: 2028–2033.
    • (1998) Science , vol.282 , pp. 2028-2033
    • Bargmann, C.I.1
  • 7
    • 84928236521 scopus 로고    scopus 로고
    • The burrowing behavior of the nematode Caenorhabditis elegans: a new assay for the study of neuromuscular disorders
    • Beron C, Vidal-Gadea AG, Cohn J, Parikh A, Hwang G, Pierce-Shimomura JT. 2015. The burrowing behavior of the nematode Caenorhabditis elegans: a new assay for the study of neuromuscular disorders. Genes Brain Behav. 14: 357–368.
    • (2015) Genes Brain Behav. , vol.14 , pp. 357-368
    • Beron, C.1    Vidal-Gadea, A.G.2    Cohn, J.3    Parikh, A.4    Hwang, G.5    Pierce-Shimomura, J.T.6
  • 8
    • 79959310697 scopus 로고    scopus 로고
    • Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways
    • Bhattacharya S, Zhang Q, Carmichael PL, Boekelheide K, Andersen ME. 2011. Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways. PLoS One 6: e20887.
    • (2011) PLoS One , vol.6
    • Bhattacharya, S.1    Zhang, Q.2    Carmichael, P.L.3    Boekelheide, K.4    Andersen, M.E.5
  • 9
    • 0023880172 scopus 로고
    • Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture
    • Blumberg PM. 1988. Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture. Cancer Res. 48: 1–8.
    • (1988) Cancer Res. , vol.48 , pp. 1-8
    • Blumberg, P.M.1
  • 10
    • 43449087018 scopus 로고    scopus 로고
    • Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: evaluation of a novel, high-throughput screening assay
    • Boyd WA, McBride SJ, Freedman JH. 2007. Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: evaluation of a novel, high-throughput screening assay. PLoS One 2: e1259.
    • (2007) PLoS One , vol.2
    • Boyd, W.A.1    McBride, S.J.2    Freedman, J.H.3
  • 11
    • 77952772868 scopus 로고    scopus 로고
    • A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay
    • Boyd WA, McBride SJ, Rice JR, Snyder DW, Freedman JH. 2010. A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay. Toxicol. Appl. Pharmacol. 245: 153–159.
    • (2010) Toxicol. Appl. Pharmacol. , vol.245 , pp. 153-159
    • Boyd, W.A.1    McBride, S.J.2    Rice, J.R.3    Snyder, D.W.4    Freedman, J.H.5
  • 12
    • 84964800584 scopus 로고    scopus 로고
    • Developmental Effects of the ToxCast™ Phase I and II chemicals in Caenorhabditis elegans and corresponding responses in zebrafish, rats, and rabbits
    • Boyd WA, Smith MV, Co CA, Pirone JR, Rice JR, Shockley KR, Freedman JH. 2016. Developmental Effects of the ToxCast™ Phase I and II chemicals in Caenorhabditis elegans and corresponding responses in zebrafish, rats, and rabbits. Environ. Health Perspect. 124: 586–593.
    • (2016) Environ. Health Perspect. , vol.124 , pp. 586-593
    • Boyd, W.A.1    Smith, M.V.2    Co, C.A.3    Pirone, J.R.4    Rice, J.R.5    Shockley, K.R.6    Freedman, J.H.7
  • 13
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner S. 1974. The genetics of Caenorhabditis elegans. Genetics 77: 71–94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 14
    • 0032509302 scopus 로고    scopus 로고
    • Genome sequence of the nematode C. elegans: a platform for investigating biology
    • C. elegans Sequencing Consortium. 1998. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282: 2012–2018.
    • (1998) Science , vol.282 , pp. 2012-2018
  • 15
    • 77953320474 scopus 로고    scopus 로고
    • Roles of CUP-5, the Caenorhabditis elegans orthologue of human TRPML1, in lysosome and gut granule biogenesis
    • Campbell EM, Fares H. 2010. Roles of CUP-5, the Caenorhabditis elegans orthologue of human TRPML1, in lysosome and gut granule biogenesis. BMC Cell Biol. 11: 40.
    • (2010) BMC Cell Biol. , vol.11 , pp. 40
    • Campbell, E.M.1    Fares, H.2
  • 16
    • 84926687913 scopus 로고    scopus 로고
    • A new path forward: the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and National Toxicology Program's Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)
    • Casey W, Jacobs A, Maull E, Matheson J, Clarke C, Lowit A. 2015. A new path forward: the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and National Toxicology Program's Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). J. Am. Assoc. Lab. Anim. Sci. 54: 170–173.
    • (2015) J. Am. Assoc. Lab. Anim. Sci. , vol.54 , pp. 170-173
    • Casey, W.1    Jacobs, A.2    Maull, E.3    Matheson, J.4    Clarke, C.5    Lowit, A.6
  • 17
    • 84879652969 scopus 로고    scopus 로고
    • Mapping the pharyngeal and intestinal pH of Caenorhabditis elegans and real-time luminal pH oscillations using extended dynamic range pH-sensitive nanosensors
    • Chauhan VM, Orsi G, Brown A, Pritchard DI, Aylott JW. 2013. Mapping the pharyngeal and intestinal pH of Caenorhabditis elegans and real-time luminal pH oscillations using extended dynamic range pH-sensitive nanosensors. ACS Nano 7: 5577–5587.
    • (2013) ACS Nano , vol.7 , pp. 5577-5587
    • Chauhan, V.M.1    Orsi, G.2    Brown, A.3    Pritchard, D.I.4    Aylott, J.W.5
  • 19
    • 0022585682 scopus 로고
    • The autofluorescent "lipofuscin granules" in the intestinal cells of Caenorhabditis elegans are secondary lysosomes
    • Clokey GV, Jacobson LA. 1986. The autofluorescent "lipofuscin granules" in the intestinal cells of Caenorhabditis elegans are secondary lysosomes. Mech. Ageing Dev. 35: 79–94.
    • (1986) Mech. Ageing Dev. , vol.35 , pp. 79-94
    • Clokey, G.V.1    Jacobson, L.A.2
  • 20
    • 0842264757 scopus 로고    scopus 로고
    • The nematode Caenorhabditis elegans as a model of organophosphate-induced mammalian neurotoxicity
    • Cole RD, Anderson GL, Williams PL. 2004. The nematode Caenorhabditis elegans as a model of organophosphate-induced mammalian neurotoxicity. Toxicol. Appl. Pharmacol. 194: 248–256.
    • (2004) Toxicol. Appl. Pharmacol. , vol.194 , pp. 248-256
    • Cole, R.D.1    Anderson, G.L.2    Williams, P.L.3
  • 22
    • 0033544844 scopus 로고    scopus 로고
    • Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters
    • Daniels GM, Amara SG. 1999. Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters. J. Biol. Chem. 274: 35794–35801.
    • (1999) J. Biol. Chem. , vol.274 , pp. 35794-35801
    • Daniels, G.M.1    Amara, S.G.2
  • 23
    • 49649113915 scopus 로고    scopus 로고
    • Caenorhabditis elegans as a model for lysosomal storage disorders
    • de Voer G, Peters D, Taschner PE. 2008. Caenorhabditis elegans as a model for lysosomal storage disorders. Biochim. Biophys. Acta 1782: 433–446.
    • (2008) Biochim. Biophys. Acta , vol.1782 , pp. 433-446
    • de Voer, G.1    Peters, D.2    Taschner, P.E.3
  • 24
    • 0033544893 scopus 로고    scopus 로고
    • Comparison of lethality, reproduction, and behavior as toxicological endpoints in the nematode Caenorhabditis elegans
    • Dhawan R, Dusenbery DB, Williams PL. 1999. Comparison of lethality, reproduction, and behavior as toxicological endpoints in the nematode Caenorhabditis elegans. J. Toxicol. Environ. Health A 58: 451–462.
    • (1999) J. Toxicol. Environ. Health A , vol.58 , pp. 451-462
    • Dhawan, R.1    Dusenbery, D.B.2    Williams, P.L.3
  • 26
    • 0022497852 scopus 로고
    • Genetic control of programmed cell death in the nematode C. elegans
    • Ellis HM, Horvitz HR. 1986. Genetic control of programmed cell death in the nematode C. elegans. Cell 44: 817–829.
    • (1986) Cell , vol.44 , pp. 817-829
    • Ellis, H.M.1    Horvitz, H.R.2
  • 27
    • 33750478660 scopus 로고    scopus 로고
    • A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels
    • Feng Z, Li W, Ward A, Piggott BJ, Larkspur ER, Sternberg PW, Xu XZ. 2006. A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels. Cell 127: 621–633.
    • (2006) Cell , vol.127 , pp. 621-633
    • Feng, Z.1    Li, W.2    Ward, A.3    Piggott, B.J.4    Larkspur, E.R.5    Sternberg, P.W.6    Xu, X.Z.7
  • 28
    • 84865185468 scopus 로고    scopus 로고
    • A method for ranking compounds based on their relative toxicity using neural networking, C. elegans, axenic liquid culture, and the COPAS parameters TOF and EXT
    • Ferguson M, Boyer M, Sprando R. 2010. A method for ranking compounds based on their relative toxicity using neural networking, C. elegans, axenic liquid culture, and the COPAS parameters TOF and EXT. Open Access Bioinformatics 2010: 139–144.
    • (2010) Open Access Bioinformatics , vol.2010 , pp. 139-144
    • Ferguson, M.1    Boyer, M.2    Sprando, R.3
  • 29
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span--from yeast to humans
    • Fontana L, Partridge L, Longo VD. 2010. Extending healthy life span--from yeast to humans. Science 328: 321–326.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 30
    • 84888240373 scopus 로고    scopus 로고
    • WormBook, ed. The, C. elegans, Research Community, WormBook, (accessed May 16, 2016)
    • Gartner A, Boag PR, Blackwell TK. 2008. Germline Survival and Apoptosis. WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.145.1, http://www.wormbook.org (accessed May 16, 2016).
    • (2008) Germline Survival and Apoptosis
    • Gartner, A.1    Boag, P.R.2    Blackwell, T.K.3
  • 31
    • 23844436700 scopus 로고    scopus 로고
    • In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans
    • Gerstbrein B, Stamatas G, Kollias N, Driscoll M. 2005. In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans. Aging Cell 4: 127–137.
    • (2005) Aging Cell , vol.4 , pp. 127-137
    • Gerstbrein, B.1    Stamatas, G.2    Kollias, N.3    Driscoll, M.4
  • 32
    • 63649123680 scopus 로고    scopus 로고
    • Cold Spring Harbor Laboratory Press, Cold Spring Harbor
    • Hall DH, Altun ZF. 2008. C. elegans Atlas. Cold Spring Harbor Laboratory Press: Cold Spring Harbor.
    • (2008) C. elegans Atlas
    • Hall, D.H.1    Altun, Z.F.2
  • 33
    • 74449088292 scopus 로고    scopus 로고
    • A cellular memory of developmental history generates phenotypic diversity in C. elegans
    • Hall SE, Beverly M, Russ C, Nusbaum C, Sengupta P. 2010. A cellular memory of developmental history generates phenotypic diversity in C. elegans. Curr. Biol. 20: 149–155.
    • (2010) Curr. Biol. , vol.20 , pp. 149-155
    • Hall, S.E.1    Beverly, M.2    Russ, C.3    Nusbaum, C.4    Sengupta, P.5
  • 34
    • 84961827459 scopus 로고    scopus 로고
    • The nematode Caenorhabditis elegans as a tool to predict chemical activity on mammalian development and identify mechanisms influencing toxicological outcome
    • Harlow PH, Perry SJ, Widdison S, Daniels S, Bondo E, Lamberth C, Currie RA, Flemming AJ. 2016. The nematode Caenorhabditis elegans as a tool to predict chemical activity on mammalian development and identify mechanisms influencing toxicological outcome. Sci. Rep. 6: 22965.
    • (2016) Sci. Rep. , vol.6 , pp. 22965
    • Harlow, P.H.1    Perry, S.J.2    Widdison, S.3    Daniels, S.4    Bondo, E.5    Lamberth, C.6    Currie, R.A.7    Flemming, A.J.8
  • 35
    • 67650445156 scopus 로고    scopus 로고
    • Toxicology for the twenty-first century
    • Hartung T. 2009. Toxicology for the twenty-first century. Nature 460: 208–212.
    • (2009) Nature , vol.460 , pp. 208-212
    • Hartung, T.1
  • 37
  • 38
    • 0037007142 scopus 로고    scopus 로고
    • The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types
    • Hersh BM, Hartwieg E, Horvitz HR. 2002. The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types. Proc. Natl. Acad. Sci. U. S. A. 99: 4355–4360.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 4355-4360
    • Hersh, B.M.1    Hartwieg, E.2    Horvitz, H.R.3
  • 41
    • 84864145718 scopus 로고    scopus 로고
    • Toxicity ranking of heavy metals with screening method using adult Caenorhabditis elegans and propidium iodide replicates toxicity ranking in rat
    • Hunt PR, Olejnik N, Sprando RL. 2012. Toxicity ranking of heavy metals with screening method using adult Caenorhabditis elegans and propidium iodide replicates toxicity ranking in rat. Food Chem. Toxicol. 50: 3280–3290.
    • (2012) Food Chem. Toxicol. , vol.50 , pp. 3280-3290
    • Hunt, P.R.1    Olejnik, N.2    Sprando, R.L.3
  • 42
    • 84941200676 scopus 로고    scopus 로고
    • Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans
    • Jobson MA, Jordan JM, Sandrof MA, Hibshman JD, Lennox AL, Baugh LR. 2015. Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans. Genetics 201: 201–212.
    • (2015) Genetics , vol.201 , pp. 201-212
    • Jobson, M.A.1    Jordan, J.M.2    Sandrof, M.A.3    Hibshman, J.D.4    Lennox, A.L.5    Baugh, L.R.6
  • 44
    • 33745223646 scopus 로고    scopus 로고
    • Finding function in novel targets: C. elegans as a model organism. Nat. Rev
    • Kaletta T, Hengartner MO. 2006. Finding function in novel targets: C. elegans as a model organism. Nat. Rev. Drug Discov. 5: 387–398.
    • (2006) Drug Discov. , vol.5 , pp. 387-398
    • Kaletta, T.1    Hengartner, M.O.2
  • 46
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. 1993. A C. elegans mutant that lives twice as long as wild type. Nature 366: 461–464.
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 47
    • 84908348035 scopus 로고    scopus 로고
    • ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline
    • Kim HM, Colaiacovo MP. 2014. ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline. PLoS Genet. 10: e1004723.
    • (2014) PLoS Genet. , vol.10
    • Kim, H.M.1    Colaiacovo, M.P.2
  • 48
    • 84874842249 scopus 로고    scopus 로고
    • Silver nanoparticle toxicity in the embryonic zebrafish is governed by particle dispersion and ionic environment
    • Kim K-T, Truong L, Wehmas L, Tanguay RL. 2013. Silver nanoparticle toxicity in the embryonic zebrafish is governed by particle dispersion and ionic environment. Nanotechnology 24: 1–8.
    • (2013) Nanotechnology , vol.24 , pp. 1-8
    • Kim, K.-T.1    Truong, L.2    Wehmas, L.3    Tanguay, R.L.4
  • 49
    • 21544473568 scopus 로고    scopus 로고
    • Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity
    • Kirkland D, Aardema M, Henderson L, Muller L. 2005. Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity. Mutat. Res. 584: 1–256.
    • (2005) Mutat. Res. , vol.584 , pp. 1-256
    • Kirkland, D.1    Aardema, M.2    Henderson, L.3    Muller, L.4
  • 51
    • 62749109092 scopus 로고    scopus 로고
    • Toxicity testing in the 21st century: implications for human health risk assessment
    • Krewski D, Andersen ME, Mantus E, Zeise L. 2009. Toxicity testing in the 21st century: implications for human health risk assessment. Risk Anal. 29: 474–479.
    • (2009) Risk Anal. , vol.29 , pp. 474-479
    • Krewski, D.1    Andersen, M.E.2    Mantus, E.3    Zeise, L.4
  • 52
    • 0034999073 scopus 로고    scopus 로고
    • The use of functional genomics in C. elegans for studying human development and disease
    • Kuwabara PE, O'Neil N. 2001. The use of functional genomics in C. elegans for studying human development and disease. J. Inherit. Metab. Dis. 24: 127–138.
    • (2001) J. Inherit. Metab. Dis. , vol.24 , pp. 127-138
    • Kuwabara, P.E.1    O'Neil, N.2
  • 54
    • 70350365110 scopus 로고    scopus 로고
    • Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression
    • Lee SJ, Murphy CT, Kenyon C. 2009. Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 10: 379–391.
    • (2009) Cell Metab. , vol.10 , pp. 379-391
    • Lee, S.J.1    Murphy, C.T.2    Kenyon, C.3
  • 56
    • 0029116848 scopus 로고
    • Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
    • Levitan D, Greenwald I. 1995. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377: 351–354.
    • (1995) Nature , vol.377 , pp. 351-354
    • Levitan, D.1    Greenwald, I.2
  • 57
    • 0032968777 scopus 로고    scopus 로고
    • Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug–drug interaction potential
    • Li AP, Lu C, Brent JA, Pham C, Fackett A, Ruegg CE, Silber PM. 1999. Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug–drug interaction potential. Chem. Biol. Interact. 121: 17–35.
    • (1999) Chem. Biol. Interact. , vol.121 , pp. 17-35
    • Li, A.P.1    Lu, C.2    Brent, J.A.3    Pham, C.4    Fackett, A.5    Ruegg, C.E.6    Silber, P.M.7
  • 61
    • 21344489200 scopus 로고
    • Fluoroacetic Acid Is a Potent and Specific Inhibitor of Reproduction in the Nematode Caenorhabditis elegans
    • Middendorf PJ, Dusenbery DB. 1993. Fluoroacetic Acid Is a Potent and Specific Inhibitor of Reproduction in the Nematode Caenorhabditis elegans. J. Nematol. 25: 573–577.
    • (1993) J. Nematol. , vol.25 , pp. 573-577
    • Middendorf, P.J.1    Dusenbery, D.B.2
  • 63
    • 0019971211 scopus 로고
    • Tumor promoters specifically and reversibly disturb development and behavior of Caenorhabditis elegans
    • Miwa J, Tabuse Y, Furusawa M, Yamasaki H. 1982. Tumor promoters specifically and reversibly disturb development and behavior of Caenorhabditis elegans. J. Cancer Res. Clin. Oncol. 104: 81–87.
    • (1982) J. Cancer Res. Clin. Oncol. , vol.104 , pp. 81-87
    • Miwa, J.1    Tabuse, Y.2    Furusawa, M.3    Yamasaki, H.4
  • 65
    • 0036787607 scopus 로고    scopus 로고
    • Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    • Nakae J, Biggs WH, 3rd, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D. 2002. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet. 32: 245–253.
    • (2002) Nat. Genet. , vol.32 , pp. 245-253
    • Nakae, J.1    Biggs, W.H.2    Kitamura, T.3    Cavenee, W.K.4    Wright, C.V.5    Arden, K.C.6    Accili, D.7
  • 66
    • 77955397007 scopus 로고    scopus 로고
    • The nematode C. elegans as an animal model to explore toxicology in vivo: solid and axenic growth culture conditions and compound exposure parameters
    • Chapter 1 Unit1 9
    • Nass R, Hamza I. 2007. The nematode C. elegans as an animal model to explore toxicology in vivo: solid and axenic growth culture conditions and compound exposure parameters. Curr. Protoc. Toxicol. Chapter 1: Unit1 9 doi: 10.1002/0471140856.tx0109s31.
    • (2007) Curr. Protoc. Toxicol.
    • Nass, R.1    Hamza, I.2
  • 67
    • 84995586472 scopus 로고    scopus 로고
    • . National Toxicology Program, [accessed 4 June 2015]
    • NTP. 2015. West Virginia Chemical Spill: NTP Studies and Results. National Toxicology Program. http://ntp.niehs.nih.gov/results/areas/wvspill/studies/index.html [accessed 4 June 2015].
    • (2015) West Virginia Chemical Spill: NTP Studies and Results
  • 68
    • 70350365111 scopus 로고    scopus 로고
    • C. elegans major fats are stored in vesicles distinct from lysosome-related organelles
    • O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G. 2009. C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 10: 430–435.
    • (2009) Cell Metab. , vol.10 , pp. 430-435
    • O'Rourke, E.J.1    Soukas, A.A.2    Carr, C.E.3    Ruvkun, G.4
  • 69
    • 0030659557 scopus 로고    scopus 로고
    • The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
    • Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G. 1997. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389: 994–999.
    • (1997) Nature , vol.389 , pp. 994-999
    • Ogg, S.1    Paradis, S.2    Gottlieb, S.3    Patterson, G.I.4    Lee, L.5    Tissenbaum, H.A.6    Ruvkun, G.7
  • 71
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
    • Onken B, Driscoll M. 2010. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5: e8758.
    • (2010) PLoS One , vol.5
    • Onken, B.1    Driscoll, M.2
  • 74
    • 84855471897 scopus 로고    scopus 로고
    • Lysosome-related organelles in intestinal cells are a zinc storage site in C. elegans
    • Roh HC, Collier S, Guthrie J, Robertson JD, Kornfeld K. 2012. Lysosome-related organelles in intestinal cells are a zinc storage site in C. elegans. Cell Metab. 15: 88–99.
    • (2012) Cell Metab. , vol.15 , pp. 88-99
    • Roh, H.C.1    Collier, S.2    Guthrie, J.3    Robertson, J.D.4    Kornfeld, K.5
  • 76
    • 84875506766 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells and their use in drug discovery for toxicity testing
    • Scott CW, Peters MF, Dragan YP. 2013. Human induced pluripotent stem cells and their use in drug discovery for toxicity testing. Toxicol. Lett. 219: 49–58.
    • (2013) Toxicol. Lett. , vol.219 , pp. 49-58
    • Scott, C.W.1    Peters, M.F.2    Dragan, Y.P.3
  • 78
    • 0031468610 scopus 로고    scopus 로고
    • Analysis of protein domain families in Caenorhabditis elegans
    • Sonnhammer EL, Durbin R. 1997. Analysis of protein domain families in Caenorhabditis elegans. Genomics 46: 200–216.
    • (1997) Genomics , vol.46 , pp. 200-216
    • Sonnhammer, E.L.1    Durbin, R.2
  • 79
    • 1642514804 scopus 로고    scopus 로고
    • Death and more: DNA damage response pathways in the nematode C. elegans
    • Stergiou L, Hengartner MO. 2004. Death and more: DNA damage response pathways in the nematode C. elegans. Cell Death Differ. 11: 21–28.
    • (2004) Cell Death Differ. , vol.11 , pp. 21-28
    • Stergiou, L.1    Hengartner, M.O.2
  • 80
    • 84936863599 scopus 로고    scopus 로고
    • Disruption of the C. elegans Intestinal Brush Border by the Fungal Lectin CCL2 Phenocopies Dietary Lectin Toxicity in Mammals
    • Stutz K, Kaech A, Aebi M, Kunzler M, Hengartner MO. 2015. Disruption of the C. elegans Intestinal Brush Border by the Fungal Lectin CCL2 Phenocopies Dietary Lectin Toxicity in Mammals. PLoS One 10: e0129381.
    • (2015) PLoS One , vol.10
    • Stutz, K.1    Kaech, A.2    Aebi, M.3    Kunzler, M.4    Hengartner, M.O.5
  • 82
    • 0020507248 scopus 로고
    • A gene involved in action of tumor promoters is identified and mapped in Caenorhabditis elegans
    • Tabuse Y, Miwa J. 1983. A gene involved in action of tumor promoters is identified and mapped in Caenorhabditis elegans. Carcinogenesis 4: 783–786.
    • (1983) Carcinogenesis , vol.4 , pp. 783-786
    • Tabuse, Y.1    Miwa, J.2
  • 83
    • 0024981819 scopus 로고
    • Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans
    • Tabuse Y, Nishiwaki K, Miwa J. 1989. Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans. Science 243: 1713–1716.
    • (1989) Science , vol.243 , pp. 1713-1716
    • Tabuse, Y.1    Nishiwaki, K.2    Miwa, J.3
  • 86
    • 0027050145 scopus 로고
    • Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2
    • Vaux DL, Weissman IL, Kim SK. 1992. Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2. Science 258: 1955–1957.
    • (1992) Science , vol.258 , pp. 1955-1957
    • Vaux, D.L.1    Weissman, I.L.2    Kim, S.K.3
  • 89
    • 0023701377 scopus 로고
    • Using the nematode Caenorhabditis elegans to predict mammalian acute lethality to metallic salts
    • Williams PL, Dusenbery DB. 1988. Using the nematode Caenorhabditis elegans to predict mammalian acute lethality to metallic salts. Toxicol. Ind. Health 4: 469–478.
    • (1988) Toxicol. Ind. Health , vol.4 , pp. 469-478
    • Williams, P.L.1    Dusenbery, D.B.2
  • 90
    • 0034691513 scopus 로고    scopus 로고
    • Presenilin is required for proper morphology and function of neurons in C. elegans
    • Wittenburg N, Eimer S, Lakowski B, Rohrig S, Rudolph C, Baumeister R. 2000. Presenilin is required for proper morphology and function of neurons in C. elegans. Nature 406: 306–309.
    • (2000) Nature , vol.406 , pp. 306-309
    • Wittenburg, N.1    Eimer, S.2    Lakowski, B.3    Rohrig, S.4    Rudolph, C.5    Baumeister, R.6
  • 91
    • 84874805056 scopus 로고    scopus 로고
    • Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans
    • Zhang Y, Zou X, Ding Y, Wang H, Wu X, Liang B. 2013. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. BMC Genomics 14: 164.
    • (2013) BMC Genomics , vol.14 , pp. 164
    • Zhang, Y.1    Zou, X.2    Ding, Y.3    Wang, H.4    Wu, X.5    Liang, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.