A C. elegans screening platform for the rapid assessment of chemical disruption of germline function

Environmental Health Perspectives

Volumn 121, Issue 6, 2013, Pages 717-724

  Allard, Patrick ^a,b   Kleinstreuer, Nicole C ^c   Knudsen, Thomas B ^c   Colaiácovo, Monica P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Aneuploidy; C. elegans; Chromosome segregation; Germline; Pesticides

Indexed keywords

4 (3 CHLOROANILINO) 6, 7 DIMETHOXYQUINAZOLINE; BORTEZOMIB; DACTINOMYCIN; METHOTREXATE; NOCODAZOLE; TOPOTECAN; TRETAMINE; UNCLASSIFIED DRUG; VINBLASTINE SULFATE; VINCRISTINE;

ANEUPLOIDY; APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CELL VIABILITY; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; EMBRYO; ENVIRONMENTAL EXPOSURE; FEMALE FERTILITY; FLUORESCENCE; GENETIC SCREENING; NONHUMAN; PREDICTIVE VALUE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCTIVE TOXICITY;

ANEUGENS; ANIMALS; CAENORHABDITIS ELEGANS; CHROMOSOME SEGREGATION; ENVIRONMENTAL POLLUTANTS; GERM CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; MEIOSIS; REPRODUCTION;

ANIMALIA; CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 84878424809     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1206301     Document Type: Article

References (33)

1. Allard P, Colaiácovo MP. 2010. Bisphenol A impairs the double- strand break repair machinery in the germline and causes chromosome abnormalities. Proc Natl Acad Sci USA 107:20405-20410.
2. Boyd WA, McBride SJ, Rice JR, Snyder DW, Freedman JH. 2010a. A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay. Toxicol Appl Pharmacol 245:153-159.
3. Boyd WA, Smith MV, Kissling GE, Freedman JH. 2010b. Mediumand high-throughput screening of neurotoxicants using C. elegans. Neurotoxicol Teratol 32:68-73.
4. Brenner S. 1974. The genetics of Caenorhabditis elegans. Genetics 77:71-94.
5. Colaiácovo MP. 2006. The many facets of SC function during C. elegans meiosis. Chromosoma 115:195-211.
6. Dernburg AF, McDonald K, Moulder G, Barstead R, Dresser M, Villeneuve AM. 1998. Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis. Cell 94:387-398.
7. Dix DJ, Houck KA, Martin MT, Richard AM, Setzer RW, Kavlock RJ. 2007. The ToxCast program for prioritizing toxicity testing of environmental chemicals. Toxicol Sci 95:5-12.
8. Gartner A, Boag PR, Blackwell TK. 2008. Germline survival and apoptosis. In: WormBook (Kimble J, Strome S, eds). The C. elegans Research Community, WormBook;;doi:10.1895/wormbook.1.145.1 [Online 4 September 2008].
9. Goldstein P, Magnano L. 1988. Effects of dimethyl sulphoxide on early gametogenesis in Caenorhabditis elegans: ultrastructural aberrations and loss of synaptonemal complexes from pachytene nuclei. Cytobios 56:45-57.
10. Hales BF, Barton TS, Robaire B. 2005. Impact of paternal exposure to chemotherapy on offspring in the rat. J Natl Cancer Inst Monogr 34:28-31.
11. Harkonen K. 2005. Pesticides and the induction of aneuploidy in human sperm. Cytogenet Genome Res 111:378-383.
12. Hassold T, Hunt P. 2001. To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet 2:280-291.
13. Hodgkin J. 2005. Karyotype, ploidy, and gene dosage. In: WormBook (Anderson P, ed). The C. elegans Research Community, WormBook; doi:10.1895/wormbook.1.3.1 [Online 25 June 2005].
14. Hodgkin J, Horvitz HR, Brenner S. 1979. Nondisjunction mutants of the nematode Caenorhabditis elegans. Genetics 91:67-94.
15. Hunt PA, Koehler KE, Susiarjo M, Hodges CA, Ilagan A, Voigt RC, et al. 2003. Bisphenol A exposure causes meiotic aneuploidy in the female mouse. Curr Biol 13:546-553.
16. Jaramillo-Lambert A, Ellefson M, Villeneuve AM, Engebrecht J. 2007. Differential timing of S phases, X chromosome replication, and meiotic prophase in the C. elegans germ line. Dev Biol 308:206-221.
17. Kavlock R, Chandler K, Houck K, Hunter S, Judson R, Kleinstreuer N, et al. 2012. Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management. Chem Res Toxicol 25:1287-1302.
18. Kelly KO, Dernburg AF, Stanfield GM, Villeneuve AM. 2000. Caenorhabditis elegans msh-5 is required for both normal and radiation-induced meiotic crossing over but not for completion of meiosis. Genetics 156:617-630.
19. Kitagawa R, Rose AM. 1999. Components of the spindle- assembly checkpoint are essential in Caenorhabditis elegans. Nat Cell Biol 1:514-521.
20. Knudsen TB, Martin MT, Kavlock RJ, Judson RS, Dix DJ, Singh AV. 2009. Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB. Reprod Toxicol 28:209-219.
21. Kohara Y, Shin-i T. 2013. NEXTDB: The Expression Pattern Map Database for C. elegans. Available: http://nematode.lab.nig.ac.jp/db2/ShowCloneInfo.php?clone=770d12 [accessed 14 April 2013].
22. Krewski D, Acosta D Jr, Andersen M, Anderson H, Bailar JC III, Boekelheide K, et al. 2010. Toxicity testing in the 21st century: a vision and a strategy. J Toxicol Environ Health B Critical Rev 13:51-138.
23. Mailhes JB, Young D, Aardema MJ, London SN. 1997. Thiabendazole-induced cytogenetic abnormalities in mouse oocytes. Environ Mol Mutagen 29:367-371.
24. Martin MT, Mendez E, Corum DG, Judson RS, Kavlock RJ, Rotroff DM, et al. 2009. Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database. Toxicol Sci 110:181-190.
25. Nicoll M, Akerib CC, Meyer BJ. 1997. X-chromosome-counting mechanisms that determine nematode sex [Letter]. Nature 388:200-204.
26. Pazdernik N, Schedl T. 2013. Introduction to germ cell development in Caenorhabditis elegans. Adv Exp Med Biol 757:1-16.
27. Saito TT, Youds JL, Boulton SJ, Colaiácovo MP. 2009. Caenorhabditis elegans HIM-18/SLX-4 interacts with SLX-1 and XPF-1 and maintains genomic integrity in the germ line by processing recombination intermediates. PLoS Genet 5:e1000735; doi:10.1371/journal.pgen.1000735 [Online 20 November 2009].
28. Schmid TE, Xu W, Adler ID. 1999. Detection of aneuploidy by multicolor fish in mouse sperm after in vivo treatment with acrylamide, colchicine, diazepam or thiabendazole. Mutagenesis 14:173-179.
29. Stear JH, Roth MB. 2004. The Caenorhabditis elegans kinetochore reorganizes at prometaphase and in response to checkpoint stimuli. Mol Biol Cell 15:5187-5196.
30. Stiernagle T. 2006. Maintenance of C. elegans. In: WormBook (Fay D, Ambros V, eds). The C. elegans Research Community, WormBook; doi/10.1895/wormbook.1.101.1 [Online 11 February 2006].
31. U.S. EPA (U.S. Environmental Protection Agency). 1996. Guidelines for Reproductive Toxicity Risk Assessment. Washington, DC:U.S. EPA. Available: http://www.epa.gov/raf/publications/pdfs/REPRO51.PDF [accessed 30 April 2013].
32. Watanabe M, Mitani N, Ishii N, Miki K. 2005. A mutation in a cuticle collagen causes hypersensitivity to the endocrine disrupting chemical, bisphenol A, in Caenorhabditis elegans. Mutat Res 570:71-80.
33. Zhou Z, Hartwieg E, Horvitz HR. 2001. CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans. Cell 104:43-56.