Homologous-recombination-deficient tumours are dependent on Polθ -mediated repair

Nature

Volumn 518, Issue 7538, 2015, Pages 258-262

  Ceccaldi, Raphael ^a   Liu, Jessica C ^a,b   Amunugama, Ravindra ^c   Hajdu, Ildiko ^d   Primack, Benjamin ^a   Petalcorin, Mark I R ^e   O'Connor, Kevin W ^a   Konstantinopoulos, Panagiotis A ^f   Elledge, Stephen J ^d   Boulton, Simon J ^e   Yusufzai, Timur ^a   D'Andrea, Alan D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^f DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; HISTONE H2AX; MITOMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; RAD51 PROTEIN; SMALL INTERFERING RNA; DNA DIRECTED DNA POLYMERASE; DNA POLYMERASE THETA; FANCD2 PROTEIN, MOUSE; FANCONI ANEMIA GROUP D2 PROTEIN; PROTEIN BINDING;

CANCER; DISEASE TREATMENT; ENZYME ACTIVITY; GENE EXPRESSION; GENOMICS; HOMOLOGY; RECOMBINATION; TUMOR;

ARTICLE; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GEL MOBILITY SHIFT ASSAY; GENOMIC INSTABILITY; HISTONE PHOSPHORYLATION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CYCLE; CELL DEATH; DEFICIENCY; DNA END JOINING REPAIR; DNA REPLICATION; EMBRYO DEATH; FEMALE; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; MOUSE; NEOPLASM; OVARY TUMOR; PATHOLOGY; PROTEIN MOTIF; RECOMBINATION REPAIR; TUMOR CELL LINE;

MUS;

AMINO ACID MOTIFS; ANIMALS; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; EMBRYO LOSS; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; FEMALE; GENOMIC INSTABILITY; HOMOLOGOUS RECOMBINATION; HUMANS; MICE; MOLECULAR TARGETED THERAPY; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; PROTEIN BINDING; RAD51 RECOMBINASE; RECOMBINATIONAL DNA REPAIR;

EID: 84923082911     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14184     Document Type: Article

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