Structure–Activity Relationships of 2-Sufonylpyrimidines as Quorum-Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release of Pseudomonas aeruginosa

ChemMedChem

Volumn 11, Issue 22, 2016, Pages 2522-2533

  Thomann, Andreas ^a   Brengel, Christian ^a   Börger, Carsten ^b   Kail, Dagmar ^b   Steinbach, Anke ^a   Empting, Martin ^a   Hartmann, Rolf W ^a,c  

^a SAARLAND UNIVERSITY   (Germany)

^b PharmBioTec GmbH   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

biofilms; drug design; Hansch analysis; medicinal chemistry; nitrogen heterocycles; P. aeruginosa

Indexed keywords

1 [ 2 (METHYLSULFONYL)PYRIMIDIN 4 YL] 1H BENZO[D]IMIDAZOLE; 1 [ 2 (METHYLSULFONYL)PYRIMIDIN 4 YL] 1H BENZO[D][ 1,2,3 ]TRIAZOLE; 2 (METHYLSULFONYL) 4 ( 1H 1,2,4 TRIAZOL 1 YL)PYRIMIDINE; 2 (METHYLSULFONYL) 4 ( 1H PYRAZOL 1 YL)PYRIMIDINE; 2 (METHYLSULFONYL) 4 ( 1H TETRAZOL 5 YL)PYRIMIDINE; 2 (METHYLSULFONYL) 4 ( 4 PHENYL 1H 1,2,3 TRIAZOL 1 YL)PYRIMIDINE; 2 (METHYLSULFONYL) 4 (THIOPHEN 3 YL)PYRIMIDINE; 2 (METHYLSULFONYL) 4 [ 4 ( 3 TOLYL) 1H 1,2,3 TRIAZOL 1 YL]PYRIMIDINE; 2 (METHYLSULFONYL) 4 [ 4 ( 4 TOLYL) 1H 1,2,3 TRIAZOL 1 YL]PYRIMIDINE; 2 [ 1 [ 2 (METHYLSULFONYL)PYRIMIDIN 4 YL] 1H 1,2,3 TRIAZOL 4 YL]PROPAN 2 OL; 4 ( 1 BENZYL 1H 1,2,3 TRIAZOL 4 YL) 2 (METHYLSULFONYL)PYRIMIDINE; 4 ( 1H IMIDAZOL 1 YL) 2 (METHYLSULFONYL)PYRIMIDINE; 4 ( 4 CYCLOPROPYL 1H 1,2,3 TRIAZOL 1 YL) 2 (METHYLSULFONYL)PYRIMIDINE; 4 ETHYNYL 2 (METHYLTHIO)PYRIMIDINE; 4 [ 4 ( 4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 1 YL] 2 (METHYLSULFONYL)PYRIMIDINE; 4 [ 4 ( 4 METHOXYPHENYL) 1H 1,2,3 TRIAZOL 1 YL] 2 (METHYLSULFONYL)PYRIMIDINE; 4 [ 4 (TERT BUTYL) 1H 1,2,3 TRIAZOL 1 YL] 2 (METHYLSULFONYL)PYRIMIDINE; ANTIBIOTIC AGENT; BACTERIAL PROTEIN; CELL DNA; CYCLOHEXYL [ 1 [ 2 (METHYLSULFONYL)PYRIMIDIN 4 YL] 1H 1,2,3 TRIAZOL 4 YL]METHANOL; EXTRACELLULAR DNA; PQSD SYNTHASE; PQSR PROTEIN; PYRIMIDINE DERIVATIVE; SYNTHETASE; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; [ 1 [ 2 (METHYLSULFONYL)PYRIMIDIN 4 YL] 1H 1,2,3 TRIAZOL 4 YL](PHENYL)METHANOL; [ 1 [ 2 (METHYLSULFONYL)PYRIMIDIN 4 YL] 1H 1,2,3 TRIAZOL 4 YL]METHANOL; ANTIINFECTIVE AGENT; BACTERIAL DNA;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BIOFILM; CHEMICAL ANALYSIS; CONTROLLED STUDY; CYCLOADDITION; DRUG POTENCY; DRUG SYNTHESIS; DRUG TARGETING; HANSCH ANALYSIS; IC50; LIGAND BINDING; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PSEUDOMONAS AERUGINOSA; QUANTITATIVE STRUCTURE ACTIVITY RELATION; QUORUM SENSING; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BIOFILMS; DNA, BACTERIAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MOLECULAR STRUCTURE; PSEUDOMONAS AERUGINOSA; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84992448499     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201600419     Document Type: Article

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