Mild and Catalyst-Free Microwave-Assisted Synthesis of 4,6-Disubstituted 2-Methylthiopyrimidines - Exploiting Tetrazole as an Efficient Leaving Group

Synlett

Volumn 26, Issue 18, 2015, Pages 2606-2610

  Thomann, Andreas ^a   Eberhard, Jens ^a   Allegretta, Giuseppe ^a   Empting, Martin ^a   Hartmann, Rolf W ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

combinatorial chemistry; medicinal chemistry; nucleophilic aromatic substitution; pyrimidine; tetrazole

Indexed keywords

2 (METHYLTHIO) 4,6 DI(1H TETRAZOL 1 YL)PYRIMIDINE DERIVATIVE; 2 METHYLTHIOPHENOL; 4 CHLOROTHIOPHENOL; 4 METHOXYTHIOPHENOL; AMMONIA; BENZYLAMINE; BENZYLTHIOL; DIMETHYLAMINE; ETHYLMERCAPTAN; IMIDAZOLE; METHANOL; METHANOLATE; METHYLAMINE; MORPHOLINE; NUCLEOPHILE; PHENOL; PIPERIDINE; PYRIMIDINE DERIVATIVE; PYRROLIDINE; SODIUM ETHOXIDE; SODIUM HYDROXIDE; TERT BUTYLMERCAPTAN; TETRAZOLE DERIVATIVE; THIOPHENOL; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; COMBINATORIAL CHEMISTRY; CRYSTAL STRUCTURE; HEATING; MICROWAVE RADIATION; NUCLEAR MAGNETIC RESONANCE; ONE POT SYNTHESIS; X RAY CRYSTALLOGRAPHY;

EID: 84946222439     PISSN: 09365214     EISSN: 14372096     Source Type: Journal    
DOI: 10.1055/s-0035-1560577     Document Type: Article

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