Validation of PqsD as an anti-biofilm target in pseudomonas aeruginosa by development of small-molecule inhibitors

Journal of the American Chemical Society

Volumn 134, Issue 39, 2012, Pages 16143-16146

  Storz, Michael P ^a   Maurer, Christine K ^a   Zimmer, Christina ^a   Wagner, Nathalie ^a   Brengel, Christian ^a   De Jong, Johannes C ^a   Lucas, Simon ^a,e   Müsken, Mathias ^c,d   Häussler, Susanne ^c,d   Steinbach, Anke ^a   Hartmann, Rolf W ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^e GRÜNENTHAL GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-BIOFILM; ANTI-INFECTIVES; BIOFILM FORMATION; KEY ENZYMES; P.AERUGINOSA; PSEUDOMONAS AERUGINOSA; QUINOLONES; RIGIDIZATION; SIGNAL MOLECULES; SMALL MOLECULES; SMALL-MOLECULE INHIBITORS; VIRULENCE FACTORS;

BACTERIA; BIOCHEMISTRY; LIGANDS; MOLECULES;

BIOFILMS;

2 HEPTYL 4 QUINOLINOL; BACTERIAL ENZYME; PQSD ENZYME; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CHEMICAL REACTION; NONHUMAN; PSEUDOMONAS AERUGINOSA; RIGIDIZATION; SIMPLIFICATION; VALIDATION PROCESS;

BIOFILMS; ENZYME INHIBITORS; HYDROXYQUINOLINES; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; SMALL MOLECULE LIBRARIES;

EID: 84867073873     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3072397     Document Type: Article

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