Pseudomonas aeruginosa in cystic fibrosis: Pathogenesis and persistence

Paediatric Respiratory Reviews

Volumn 3, Issue 2, 2002, Pages 128-134

  Davies, Jane C ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Adherence; Airway surface liquid; AsialoGMI; Biofilm; CFTR; Cystic fibrosis; Defensin; High salt hypothesis; Low volume hypothesis; Mucociliary clearance; Mucoidy; Pseudomonas aeruginosa

Indexed keywords

BACTERIUM RECEPTOR; GLUTATHIONE; NITRIC OXIDE; POLYPEPTIDE ANTIBIOTIC AGENT; RECEPTOR; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL SURVIVAL; BIOFILM; CHRONICITY; CONTROLLED STUDY; CYSTIC FIBROSIS; HOST RESISTANCE; HUMAN; HYPOTHESIS; MUCOCILIARY CLEARANCE; PATHOGENESIS; PHAGOCYTOSIS; PREVALENCE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT INFECTION; STAGING; SURFACE PROPERTY;

EID: 0036431716     PISSN: 15260550     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1526-0550(02)00003-3     Document Type: Article

References (35)

1. Rommens JM, Iannuzzi MC, Kerem BS et al. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 1989; 245: 1059-1065,
2. Welsh MJ, Smith AE. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell 1993; 73: 1251-1254.
3. Ismailov II, Awayda MS, Jovov B et al. Regulation of epithelial sodium channels by the cystic fibrosis transmembrane conductance regulator. J Biol Chem 1996; 271: 4725 4732.
4. Koch C, Hoiby N. Pathogenesis of cystic fibrosis. Lancet 1993; 341: 1065-1069.
5. Oppenheimer EH, Esterly JR. Pathology of cystic fibrosis; review of the literature and comparison with 146 autopsied cases. Perspect Pediatr Pathol 1975; 2: 241-278.
6. Chow CW, Landau LI, Taussig LM. Bronchial mucous glands in the newborn with cystic fibrosis. Eur J Pediatr 1982; 139: 240-243.
7. Larson JE, Morrow SL, Happel L, Sharp JF, Cohen JC. Reversal of cystic fibrosis phenotype in mice by gene therapy in utero. Lancet 1997; 349: 619-620,
8. Larson JE, Delcarpio JB, Farberman MM, Morrow SL, Cohen JC. CFTR modulates lung secretory cell proliferation and differentiation. Am J Physiol Lung Cell Moll Physiol 2000; 279: L333-L341
9. Abman SH, Ogle JW, Harbeck RJ, Butler-Simon N, Hammond KB, Accurso FJ. Early bacteriologic, immunologic, and clinical courses of young infants with cystic fibrosis identified by neonatal screening. J Pediatr 1991; 119: 211-217.
10. Tirouvanziam R, de Bentzmann S, Hubeau C et al. Inflammation and infection in naive human cystic fibrosis airway grafts. Am J Respir Cell Mol 2000; 23: 121-127.
11. Armstrong DS, Grimwood K, Carzino R, Carlin JB, Olinsky A, Phelan PD. Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis. BMJ 1995; 310: 1571-1572,
12. Matsui H, Grubb BR, Tarran R et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 1998; 95: 1005- 1015.
13. Smith JJ, Travis SM, Greenberg EP, Welsh MJ. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 1996; 85: 229-236.
14. Knowles MR, Robinson JM, Wood RE et al. Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects. J Clin Invest 1997; 100: 2588-2595.
15. Ballard ST, Trout L, Bebok Z, Sorscher EJ, Crews A. CFTR involvement in chloride, bicarbonate, and liquid secretion by airway submucosal glands. Am J Physiol 1999; 277: L694-L699.
16. Tang H, Kays M, Prince A. Role of Pseudomonas aeruginosa pili in acute pulmonary infection. Infect Immun 1995; 63: 1278-1285.
17. Saiman L, Prince A. Pseudomonas aeruginosa pili bind to asialoGMI which is increased on the surface of cystic fibrosis epithelial cells. J Clin Invest 1993; 92: 1875-1880.
18. Davies JC, Stern M, Dewar A et al. CFTR gene transfer reduces the binding of Pseudomonas aeruginosa to cystic fibrosis respiratory epithelium. Am J Respir Cell Mol Biol 1997; 16: 657-663.
19. Baltimore RS, Christie CDC, Smith GJW. Immunohistopathologic localization of Pseudomonos aeruginosa in lungs from patients with cystic fibrosis. Implications for the pathogenesis of progressive lung deterioration. Am Rev Respir Dis 1989; 140: 1650-1661.
20. 2+-dependent mitogen-activated protein kinase signaling pathways in airway epithelial cells. J Biol Chem 2001; 22: 19267-19275.
21. Pier GB, Grout M, Zaidi TS et al. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections.Science 1996; 271: 64-67.
22. Kelley TJ, Drumm ML. Inducible nitric oxide synthase is reduced in cystic fibrosis murine and human airway epithelial cells. J Clin Invest 1998; 102: 1200-1207.
23. Gao L, Kim KJ, Yankaskas JR, Forman HJ. Abnormal glutathione transport in cystic fibrosis airway epithelia. Am J Physiol 1999; 277: LII3-L118.
24. Haas B, Kraut J, Marks J, Zanker SC, Castignetti D. Siderophore presence in sputa of cystic fibrosis patients. Infect Immun 1991; 59: 3997-4000.
25. Hancock RE, Speert DP. Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment. Drug Resist Updat 2000; 3: 247-255.
26. Oliver A, Canton R, Campo P, Baquero F, Blazquez J. High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science 2000; 288: 1251-1254.
27. Pedersen SS, Lung infection with alginate-producing, mucoid Psedomonas aeruginosa in cystic fibrosis. APMIS Suppl 1992; 28: 1-79.
28. Singh PK, Schaefer AL, Parsek MR, Moninger TO, Welsh MJ, Greenberg EP. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 2000; 407: 762-764.
29. Pesci EC, Iglewski BH. The chain of command in Pseudomonas quorum sensing. Trends Microbiol 1997; 5: 132-135.
30. Robinson M, Daviskas F, Eberl S et al. The effect of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: a pilot study. Eur Respir J 1999; 14: 678-685.
31. Zeitlin PL. Future pharmacological treatment of cystic fibrosis. Respiration 2000; 67: 351-357.
32. Bryan R, Feldman M, Jawetz SC et al. The effects of aerosolized dextran in a mouse model of Pseudomonas aeruginosa pulmonary infection. J Infect Dis 1999; 179: 1449-1458.
33. Davies JC, Geddes DM, Alton EW. Gene therapy for cystic fibrosis. J Gene Med 2001; 3: 409-417.
34. Kobayashi H. Airway biofilm disease. Int J Antimicrob Agents 2001; 17: 351-356.
35. Dong Y-H, Wang L-H, Xu J-L, Zhang X-F, Zhang L-H. Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase. Nature 2001; 411: 813-817.