Identification of small-molecule antagonists of the pseudomonas aeruginosa transcriptional regulator PqsR: Biophysically guided hit discovery and optimization

ACS Chemical Biology

Volumn 7, Issue 9, 2012, Pages 1496-1501

  Klein, Tobias ^a   Henn, Claudia ^a   De Jong, Johannes C ^a   Zimmer, Christina ^a   Kirsch, Benjamin ^a   Maurer, Christine K ^a   Pistorius, Dominik ^a   Müller, Rolf ^a,b   Steinbach, Anke ^a   Hartmann, Rolf W ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; HYDROXAMIC ACID DERIVATIVE; MOLECULAR SCAFFOLD; PYOCYANINE;

ARTICLE; BACTERIAL GENE; BACTERIAL MUTATION; BACTERIAL VIRULENCE; BIOSENSOR; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; ESCHERICHIA COLI; IC 50; LIGAND BINDING; NONHUMAN; PQSR GENE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN INTERACTION; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MUTAGENESIS, SITE-DIRECTED; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; QUINOLONES; SMALL MOLECULE LIBRARIES; THERMODYNAMICS;

NEGIBACTERIA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 84868112328     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb300208g     Document Type: Article

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