Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity

PLoS Pathogens

Volumn 10, Issue 8, 2014, Pages

  Starkey, Melissa ^a,b,c,e   Lepine, Francois ^d   Maura, Damien ^a,b,c   Bandyopadhaya, Arunava ^a,b,c   Lesic, Biljana ^a,b,c   He, Jianxin ^a,b,c   Kitao, Tomoe ^a,b,c   Righi, Valeria ^a,b   Milot, Sylvain ^d   Tzika, Aria ^a,b   Rahme, Laurence ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c SHRINERS HOSPITALS FOR CHILDREN   (United States)

^d INRS INSTITUT ARMAND FRAPPIER   (Canada)

^e AMERICAN COLLEGE OF PHYSICIANS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; ANTIVIRUS AGENT; BENZAMIDE; BENZIMIDAZOLE; CARBENICILLIN; CIPROFLOXACIN; IMIDAZOLE; LEVOFLOXACIN; MERCAPTOETHANOL; MEROPENEM; PYOCYANINE; RIFAMPICIN; TETRACYCLINE; ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ANTIVIRAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIABILITY; CELL ASSAY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG EFFICACY; DRUG TOLERANCE; GENE; GENE CONSTRUCT; GENE EXPRESSION; GENE MUTATION; HIGH THROUGHPUT SCREENING; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; LUNG INFECTION; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; MVFR GENE; NONHUMAN; PATHOGENICITY; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTIBIOTIC RESISTANCE; DISEASE MODEL; DRUG DEVELOPMENT; DRUG EFFECTS; MICROBIOLOGY; MOUSE; PHYSIOLOGY; PSEUDOMONAS INFECTION; VIRULENCE;

ANIMALS; ANTI-BACTERIAL AGENTS; CHROMATIN IMMUNOPRECIPITATION; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; DRUG RESISTANCE, BACTERIAL; DRUG RESISTANCE, MULTIPLE; MICE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; QUORUM SENSING; VIRULENCE;

EID: 84937901772     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004321     Document Type: Article

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