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Volumn 6, Issue 2, 2015, Pages 162-167

Potent irreversible inhibitors of LasR quorum sensing in Pseudomonas aeruginosa

Author keywords

antivirulence; biofilm inhibition; Pseudomonas aeruginosa; quorum sensing; structure activity relationship

Indexed keywords

ANTIINFECTIVE AGENT; LASR INHIBITOR; PYOCYANINE; UNCLASSIFIED DRUG;

EID: 84922848591     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500459f     Document Type: Article
Times cited : (55)

References (35)
  • 1
    • 0032755655 scopus 로고    scopus 로고
    • Contribution of Quorum Sensing to the Virulence of Pseudomonas aeruginosa in Burn Wound Infections
    • Rumbaugh, K. P.; Griswold, J. A.; Iglewski, B. H.; Hamood, A. N. Contribution of Quorum Sensing to the Virulence of Pseudomonas aeruginosa in Burn Wound Infections Infect. Immun. 1999, 67, 5854-5862
    • (1999) Infect. Immun. , vol.67 , pp. 5854-5862
    • Rumbaugh, K.P.1    Griswold, J.A.2    Iglewski, B.H.3    Hamood, A.N.4
  • 2
    • 0036290198 scopus 로고    scopus 로고
    • Mechanisms of Antibiotic Resistance in Pseudomonas Aeruginosa
    • Lambert, P. A. Mechanisms of Antibiotic Resistance in Pseudomonas Aeruginosa J. R. Soc. Med. 2002, 95, 22
    • (2002) J. R. Soc. Med. , vol.95 , pp. 22
    • Lambert, P.A.1
  • 3
    • 33947197663 scopus 로고    scopus 로고
    • The Epidemiology, Pathogenesis and Treatment of Pseudomonas Aeruginosa Infections
    • 368
    • Driscoll, J.; Brody, S.; Kollef, M. The Epidemiology, Pathogenesis and Treatment of Pseudomonas Aeruginosa Infections Drugs 2007, 67, 351-368-368
    • (2007) Drugs , vol.67 , pp. 351-368
    • Driscoll, J.1    Brody, S.2    Kollef, M.3
  • 4
    • 77955779224 scopus 로고    scopus 로고
    • Impact of Multidrug-Resistant Pseudomonas Aeruginosainfection on Patient Outcomes
    • Hirsch, E. B.; Tam, V. H. Impact of Multidrug-Resistant Pseudomonas Aeruginosainfection on Patient Outcomes Expert Rev. Pharmacoeconomics Outcomes Res. 2010, 10, 441-451
    • (2010) Expert Rev. Pharmacoeconomics Outcomes Res. , vol.10 , pp. 441-451
    • Hirsch, E.B.1    Tam, V.H.2
  • 5
    • 33746521142 scopus 로고    scopus 로고
    • Chemical Countermeasures for the Control of Bacterial Biofilms: Effective Compounds and Promising Targets
    • Musk, J.; Dinty, J.; Hergenrother, P. J. Chemical Countermeasures for the Control of Bacterial Biofilms: Effective Compounds and Promising Targets Curr. Med. Chem. 2006, 13, 2163-2177
    • (2006) Curr. Med. Chem. , vol.13 , pp. 2163-2177
    • Musk, J.1    Dinty, J.2    Hergenrother, P.J.3
  • 6
    • 0036158178 scopus 로고    scopus 로고
    • The Pseudomonas aeruginosa Quorum-Sensing Molecule N -(3-Oxododecanoyl)homoserine Lactone Contributes to Virulence and Induces Inflammation in Vivo
    • Smith, R. S.; Harris, S. G.; Phipps, R.; Iglewski, B. The Pseudomonas aeruginosa Quorum-Sensing Molecule N -(3-Oxododecanoyl)homoserine Lactone Contributes to Virulence and Induces Inflammation in Vivo J. Bacteriol. 2002, 184, 1132-1139
    • (2002) J. Bacteriol. , vol.184 , pp. 1132-1139
    • Smith, R.S.1    Harris, S.G.2    Phipps, R.3    Iglewski, B.4
  • 8
    • 0033515018 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa Killing of Caenorhabditis elegans Used to Identify P. Aeruginosa Virulence Factors
    • Tan, M. W.; Rahme, L. G.; Sternberg, J. A.; Tompkins, R. G.; Ausubel, F. M. Pseudomonas aeruginosa Killing of Caenorhabditis elegans Used to Identify P. aeruginosa Virulence Factors Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 2408-2413
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 2408-2413
    • Tan, M.W.1    Rahme, L.G.2    Sternberg, J.A.3    Tompkins, R.G.4    Ausubel, F.M.5
  • 9
    • 0030045365 scopus 로고    scopus 로고
    • Contribution of Specific Pseudomonas aeruginosa Virulence Factors to Pathogenesis of Pneumonia in a Neonatal Mouse Model of Infection
    • Tang, H. B.; DiMango, E.; Bryan, R.; Gambello, M.; Iglewski, B. H.; Goldberg, J. B.; Prince, A. Contribution of Specific Pseudomonas aeruginosa Virulence Factors to Pathogenesis of Pneumonia in a Neonatal Mouse Model of Infection Infect. Immun. 1996, 64, 37-43
    • (1996) Infect. Immun. , vol.64 , pp. 37-43
    • Tang, H.B.1    Dimango, E.2    Bryan, R.3    Gambello, M.4    Iglewski, B.H.5    Goldberg, J.B.6    Prince, A.7
  • 10
    • 33644849230 scopus 로고    scopus 로고
    • Quorum-Sensing Inhibitors as Anti-Pathogenic Drugs
    • Rasmussen, T. B.; Givskov, M. Quorum-Sensing Inhibitors as Anti-Pathogenic Drugs Int. J. Med. Microbiol. 2006, 296, 149-161
    • (2006) Int. J. Med. Microbiol. , vol.296 , pp. 149-161
    • Rasmussen, T.B.1    Givskov, M.2
  • 11
    • 75949092121 scopus 로고    scopus 로고
    • Anti-Virulence Strategies to Combat Bacteria-Mediated Disease
    • Rasko, D. A.; Sperandio, V. Anti-Virulence Strategies to Combat Bacteria-Mediated Disease Nat. Rev. Drug Discovery 2010, 9, 117-128
    • (2010) Nat. Rev. Drug Discovery , vol.9 , pp. 117-128
    • Rasko, D.A.1    Sperandio, V.2
  • 12
    • 34548108138 scopus 로고    scopus 로고
    • Targeting Virulence: A New Paradigm for Antimicrobial Therapy
    • Clatworthy, A. E.; Pierson, E.; Hung, D. T. Targeting Virulence: a New Paradigm for Antimicrobial Therapy Nat. Chem. Biol. 2007, 3, 541-548
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 541-548
    • Clatworthy, A.E.1    Pierson, E.2    Hung, D.T.3
  • 13
    • 33646510530 scopus 로고    scopus 로고
    • Quorum Sensing Regulation of Gene Expression: A Promising Target for Drugs Against Bacterial Pathogenicity
    • Khmel, I. A.; Metlitskaya, A. Z. Quorum Sensing Regulation of Gene Expression: a Promising Target for Drugs Against Bacterial Pathogenicity Mol. Biol. 2006, 40, 169-182
    • (2006) Mol. Biol. , vol.40 , pp. 169-182
    • Khmel, I.A.1    Metlitskaya, A.Z.2
  • 14
    • 84875597802 scopus 로고    scopus 로고
    • Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control
    • Rutherford, S. T.; Bassler, B. L. Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control. Cold Spring Harbor Perspect. Med. 2012, 2.
    • (2012) Cold Spring Harbor Perspect. Med. , vol.2
    • Rutherford, S.T.1    Bassler, B.L.2
  • 15
    • 84874904560 scopus 로고    scopus 로고
    • Exploiting Quorum Sensing to Confuse Bacterial Pathogens
    • LaSarre, B.; Federle, M. J. Exploiting Quorum Sensing to Confuse Bacterial Pathogens Microbiol. Mol. Biol. Rev. 2013, 77, 73-111
    • (2013) Microbiol. Mol. Biol. Rev. , vol.77 , pp. 73-111
    • Lasarre, B.1    Federle, M.J.2
  • 18
  • 19
    • 70349182304 scopus 로고    scopus 로고
    • Molecular Basis for the Recognition of Structurally Distinct Autoinducer Mimics by the Pseudomonas aeruginosa LasR Quorum-Sensing Signaling Receptor
    • Zou, Y.; Nair, S. K. Molecular Basis for the Recognition of Structurally Distinct Autoinducer Mimics by the Pseudomonas aeruginosa LasR Quorum-Sensing Signaling Receptor Chem. Biol. 2009, 16, 961-970
    • (2009) Chem. Biol. , vol.16 , pp. 961-970
    • Zou, Y.1    Nair, S.K.2
  • 21
    • 70349917806 scopus 로고    scopus 로고
    • Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
    • Sletten, E. M.; Bertozzi, C. R. Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality Angew. Chem., Int. Ed. 2009, 48, 6974-6998
    • (2009) Angew. Chem., Int. Ed. , vol.48 , pp. 6974-6998
    • Sletten, E.M.1    Bertozzi, C.R.2
  • 22
    • 33750582503 scopus 로고    scopus 로고
    • Novel Pseudomonas aeruginosa Quorum-Sensing Inhibitors Identified in an Ultra-High-Throughput Screen
    • Müh, U.; Schuster, M.; Heim, R.; Singh, A.; Olson, E. R.; Greenberg, E. P. Novel Pseudomonas aeruginosa Quorum-Sensing Inhibitors Identified in an Ultra-High-Throughput Screen Antimicrob. Agents Chemother. 2006, 50, 3674-3679
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 3674-3679
    • Müh, U.1    Schuster, M.2    Heim, R.3    Singh, A.4    Olson, E.R.5    Greenberg, E.P.6
  • 23
    • 45749124990 scopus 로고    scopus 로고
    • Comparative Analyses of N-Acylated Homoserine Lactones Reveal Unique Structural Features That Dictate Their Ability to Activate or Inhibit Quorum Sensing
    • Geske, G. D.; O'Neill, J. C.; Miller, D. M.; Wezeman, R. J.; Mattmann, M. E.; Lin, Q.; Blackwell, H. E. Comparative Analyses of N-Acylated Homoserine Lactones Reveal Unique Structural Features That Dictate Their Ability to Activate or Inhibit Quorum Sensing ChemBioChem 2008, 9, 389-400
    • (2008) ChemBioChem , vol.9 , pp. 389-400
    • Geske, G.D.1    O'Neill, J.C.2    Miller, D.M.3    Wezeman, R.J.4    Mattmann, M.E.5    Lin, Q.6    Blackwell, H.E.7
  • 24
    • 35948991561 scopus 로고    scopus 로고
    • Modulation of Bacterial Quorum Sensing with Synthetic Ligands: Systematic Evaluation of N-Acylated Homoserine Lactones in Multiple Species and New Insights into Their Mechanisms of Action
    • Geske, G. D.; O'Neill, J. C.; Miller, D. M.; Mattmann, M. E.; Blackwell, H. E. Modulation of Bacterial Quorum Sensing with Synthetic Ligands: Systematic Evaluation of N-Acylated Homoserine Lactones in Multiple Species and New Insights Into Their Mechanisms of Action J. Am. Chem. Soc. 2007, 129, 13613-13625
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 13613-13625
    • Geske, G.D.1    O'Neill, J.C.2    Miller, D.M.3    Mattmann, M.E.4    Blackwell, H.E.5
  • 25
    • 77957917687 scopus 로고    scopus 로고
    • Small Molecules That Modulate Quorum Sensing and Control Virulence in Pseudomonas aeruginosa
    • Mattmann, M. E.; Blackwell, H. E. Small Molecules That Modulate Quorum Sensing and Control Virulence in Pseudomonas aeruginosa J. Org. Chem. 2010, 75, 6737-6746
    • (2010) J. Org. Chem. , vol.75 , pp. 6737-6746
    • Mattmann, M.E.1    Blackwell, H.E.2
  • 26
    • 55249095744 scopus 로고    scopus 로고
    • Evaluation of a Focused Library of N -Aryl l -Homoserine Lactones Reveals a New Set of Potent Quorum Sensing Modulators
    • Geske, G. D.; Mattmann, M. E.; Blackwell, H. E. Evaluation of a Focused Library of N -Aryl l -Homoserine Lactones Reveals a New Set of Potent Quorum Sensing Modulators Bioorg. Med. Chem. Lett. 2008, 18, 5978-5981
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 5978-5981
    • Geske, G.D.1    Mattmann, M.E.2    Blackwell, H.E.3
  • 27
    • 58849121024 scopus 로고    scopus 로고
    • Inhibitors and Antagonists of Bacterial Quorum Sensing
    • Ni, N.; Li, M.; Wang, J.; Wang, B. Inhibitors and Antagonists of Bacterial Quorum Sensing Med. Res. Rev. 2009, 29, 65-124
    • (2009) Med. Res. Rev. , vol.29 , pp. 65-124
    • Ni, N.1    Li, M.2    Wang, J.3    Wang, B.4
  • 29
    • 79960029361 scopus 로고    scopus 로고
    • SwissDock, a Protein-Small Molecule Docking Web Service Based on EADock DSS
    • Grosdidier, A.; Zoete, V.; Michielin, O. SwissDock, a Protein-Small Molecule Docking Web Service Based on EADock DSS Nucleic Acids Res. 2011, 39, W270-W277
    • (2011) Nucleic Acids Res. , vol.39 , pp. 270-W277
    • Grosdidier, A.1    Zoete, V.2    Michielin, O.3
  • 30
    • 13844320566 scopus 로고    scopus 로고
    • LigandScout: 3-D Pharmacophores Derived from Protein-Bound Ligands and Their Use as Virtual Screening Filters
    • Wolber, G.; Langer, T. LigandScout: 3-D Pharmacophores Derived From Protein-Bound Ligands and Their Use as Virtual Screening Filters J. Chem. Inf. Model. 2005, 45, 160-169
    • (2005) J. Chem. Inf. Model. , vol.45 , pp. 160-169
    • Wolber, G.1    Langer, T.2
  • 31
  • 32
    • 0033534534 scopus 로고    scopus 로고
    • Molecular Mechanisms of Bacterial Virulence Elucidated Using a Pseudomonas aeruginosa - Caenorhabditis elegans Pathogenesis Model
    • Mahajan-Miklos, S.; Tan, M. W.; Rahme, L. G.; Ausubel, F. M. Molecular Mechanisms of Bacterial Virulence Elucidated Using a Pseudomonas aeruginosa-Caenorhabditis elegans Pathogenesis Model Cell 1999, 96, 47-56
    • (1999) Cell , vol.96 , pp. 47-56
    • Mahajan-Miklos, S.1    Tan, M.W.2    Rahme, L.G.3    Ausubel, F.M.4
  • 33
    • 77955212404 scopus 로고    scopus 로고
    • A 96-Well-Plate-Based Optical Method for the Quantitative and Qualitative Evaluation of Pseudomonas aeruginosa Biofilm Formation and Its Application to Susceptibility Testing
    • Müsken, M.; Di Fiore, S.; Römling, U.; Häussler, S. A 96-Well-Plate-Based Optical Method for the Quantitative and Qualitative Evaluation of Pseudomonas aeruginosa Biofilm Formation and Its Application to Susceptibility Testing Nat. Protoc. 2010, 5, 1460-1469
    • (2010) Nat. Protoc. , vol.5 , pp. 1460-1469
    • Müsken, M.1    Di Fiore, S.2    Römling, U.3    Häussler, S.4


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