Gap junction inhibition by heptanol increases ventricular arrhythmogenicity by reducing conduction velocity without affecting repolarization properties or myocardial refractoriness in Langendorff-perfused mouse hearts

Molecular Medicine Reports

Volumn 14, Issue 5, 2016, Pages 4069-4074

  Tse, Gary ^a   Yeo, Jie Ming ^b   Tse, Vivian ^c   Kwan, Joseph ^d   Sun, Bing ^e  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e TONGJI HOSPITAL OF TONGJI UNIVERSITY   (China)

Author keywords

Arrhythmia; Conduction; Conduction velocity; Gap junction; Refractory period; Repolarization; Wavelength

Indexed keywords

HEPTANOL;

ACTION POTENTIAL; ACTION POTENTIAL DURATION; ANIMAL MODEL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; EPICARDIUM; FEMALE; GAP JUNCTION; HEART EXCITATION; HEART LEFT VENTRICLE; HEART MUSCLE REFRACTORY PERIOD; HEART REPOLARIZATION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE TACHYCARDIA; ISOLATED HEART; LATENT PERIOD; MALE; MOUSE; NERVE CONDUCTION VELOCITY; NONHUMAN; ANIMAL; ARRHYTHMIAS, CARDIAC; CARDIAC MUSCLE; DISEASE MODEL; DRUG EFFECTS; HEART; HEART MUSCLE CONDUCTION SYSTEM; HEART VENTRICLE; HUMAN; PATHOLOGY; PATHOPHYSIOLOGY; TACHYCARDIA, VENTRICULAR;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; DISEASE MODELS, ANIMAL; GAP JUNCTIONS; HEART; HEART CONDUCTION SYSTEM; HEART VENTRICLES; HEPTANOL; HUMANS; MICE; MYOCARDIUM; TACHYCARDIA, VENTRICULAR;

EID: 84992401781     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.5738     Document Type: Article

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