Relationship between gap-junctional conductance and conduction velocity in mammalian myocardium

Circulation: Arrhythmia and Electrophysiology

Volumn 6, Issue 6, 2013, Pages 1208-1214

  Dhillon, Paramdeep S ^a   Gray, Rosaire ^b   Kojodjojo, Pipin ^a   Jabr, Rita ^c   Chowdhury, Rasheda ^a   Fry, Christopher H ^c   Peters, Nicholas S ^a  

^a IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^b WHITTINGTON HOSPITAL   (United Kingdom)

^c UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Carbenoxolone; Electrophysiology; Gap junctions

Indexed keywords

CARBENOXOLONE;

ANIMAL EXPERIMENT; ARTICLE; CONDUCTANCE; CONTROLLED STUDY; ELECTROGRAPHY; EX VIVO STUDY; GUINEA PIG; HEART CONDUCTION; HEART ELECTROPHYSIOLOGY; HEART LEFT ATRIUM; HEART LEFT VENTRICLE; HEART MUSCLE; HEART RIGHT ATRIUM; HEART RIGHT VENTRICLE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTROPHIC CARDIOMYOPATHY; IMPEDANCE; MICROELECTRODE; NONHUMAN; PRIORITY JOURNAL; VELOCITY;

EID: 84892188566     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.113.000848     Document Type: Article

References (35)

1. Kanno S, Saffitz JE. The role of myocardial gap junctions in electrical conduction and arrhythmogenesis. Cardiovasc Pathol. 2001;10:169-177.
2. Fast VG, Kléber AG. Microscopic conduction in cultured strands of neonatal rat heart cells measured with voltage-sensitive dyes. Circ Res. 1993;73:914-925.
3. Rohr S, Kucera JP, Kléber AG. Slow conduction in cardiac tissue, I: Effects of a reduction of excitability versus a reduction of electrical coupling on microconduction. Circ Res. 1998;83:781-794.
4. Weidmann S. Electrical constants of trabecular muscle from mammalian heart. J Physiol. 1970;210:1041-1054.
5. Cooklin M, Wallis WR, Sheridan DJ, Fry CH. Changes in cell-to-cell electrical coupling associated with left ventricular hypertrophy. Circ Res. 1997;80:765-771.
6. Gutstein DE, Morley GE, Tamaddon H, Vaidya D, Schneider MD, Chen J, Chien KR, Stuhlmann H, Fishman GI. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res. 2001;88:333-339.
7. Vaidya D, Tamaddon HS, Lo CW, Taffet SM, Delmar M, Morley GE, Jalife J. Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development. Circ Res. 2001;88:1196-1202.
8. van Rijen HV, Eckardt D, Degen J, Theis M, Ott T, Willecke K, Jongsma HJ, Opthof T, de Bakker JM. Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43. Circulation. 2004;109:1048-1055.
9. Kaprielian RR, Gunning M, Dupont E, Sheppard MN, Rothery SM, Underwood R, Pennell DJ, Fox K, Pepper J, Poole-Wilson PA, Severs NJ. Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle. Circulation. 1998;97:651-660.
10. Kostin S, Rieger M, Dammer S, Hein S, Richter M, Klövekorn WP, Bauer EP, Schaper J. Gap junction remodeling and altered connexin43 expression in the failing human heart. Mol Cell Biochem. 2003;242:135-144.
11. Peters NS, Green CR, Poole-Wilson PA, Severs NJ. Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts. Circulation. 1993;88:864-875.
12. Poelzing S, Akar FG, Baron E, Rosenbaum DS. Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall. Am J Physiol Heart Circ Physiol. 2004;286:H2001-H2009.
13. Glukhov AV, Fedorov VV, Kalish PW, Ravikumar VK, Lou Q, Janks D, Schuessler RB, Moazami N, Efimov IR. Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy. Circulation. 2012;125:1835-1847.
14. Gray RP, Turner MA, Sheridan DJ, Fry CH. The role of angiotensin receptor-1 blockade on electromechanical changes induced by left ventricular hypertrophy and its regression. Cardiovasc Res. 2007;73:539-548.
15. Ho SY, Anderson RH, Sánchez-Quintana D. Atrial structure and fibres: Morphologic bases of atrial conduction. Cardiovasc Res. 2002;54:325-336.
16. Robinson TF, Cohen-Gould L, Factor SM. Skeletal framework of mammalian heart muscle. Arrangement of inter-and pericellular connective tissue structures. Lab Invest. 1983;49:482-498.
17. Baandrup U, Olsen EG. Critical analysis of endomyocardial biopsies from patients suspected of having cardiomyopathy. I: Morphological and morphometric aspects. Br Heart J. 1981;45:475-486.
18. Chapman RA, Fry CH. An analysis of the cable properties of frog ventricular myocardium. J Physiol. 1978;283:263-282.
19. Freygang WH, Trautwein W. The structural implications of the linear electrical properties of cardiac Purkinje strands. J Gen Physiol. 1970;55:524-547.
20. Baron JH, Gribble JN, Rhodes C, Wright PA. Serum carbenoxolone in patients with gastric and duodenal ulcer: Absorption, efficacy and sideeffects. Gut. 1978;19:330-335.
21. Weidmann S. Electrical constants of trabecular muscle from mammalian heart. J Physiol. 1970;210:1041-1054.
22. Veeraraghavan R, Salama ME, Poelzing S. Interstitial volume modulates the conduction velocity-gap junction relationship. Am J Physiol Heart Circ Physiol. 2012;302:H278-H286.
23. Sheets MF, Hanck DA, Fozzard HA. Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells. Circ Res. 1988;63:386-398.
24. Yao JA, Gutstein DE, Liu F, Fishman GI, Wit AL. Cell coupling between ventricular myocyte pairs from connexin43-deficient murine hearts. Circ Res. 2003;93:736-743.
25. Thomas SP, Kucera JP, Bircher-Lehmann L, Rudy Y, Saffitz JE, Kléber AG. Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43. Circ Res. 2003;92:1209-1216.
26. Beauchamp P, Choby C, Desplantez T, de Peyer K, Green K, Yamada KA, Weingart R, Saffitz JE, Kléber AG. Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice. Circ Res. 2004;95:170-178.
27. van Rijen HV, de Bakker JM, van Veen TA. Hypoxia, electrical uncoupling, and conduction slowing: Role of conduction reserve. Cardiovasc Res. 2005;66:9-11.
28. Fry CH, Salvage SC, Manazza A, Dupont E, Labeed FH, Hughes MP, Jabr RI. Cytoplasm resistivity of mammalian atrial myocardium determined by dielectrophoresis and impedance methods. Biophys J. 2012;103:2287-2294.
29. Hiramatsu Y, Buchanan JW, Knisley SB, Gettes LS. Rate-dependent effects of hypoxia on internal longitudinal resistance in guinea pig papillary muscles. Circ Res. 1988;63:923-929.
30. Kléber AG, Riegger CB, Janse MJ. Electrical uncoupling and increase of extracellular resistance after induction of ischemia in isolated, arterially perfused rabbit papillary muscle. Circ Res. 1987;61:271-279.
31. de Groot JR, Veenstra T, Verkerk AO, Wilders R, Smits JP, Wilms-Schopman FJ, Wiegerinck RF, Bourier J, Belterman CN, Coronel R, Verheijck EE. Conduction slowing by the gap junctional uncoupler carbenoxolone. Cardiovasc Res. 2003;60:288-297.
32. Kojodjojo P, Kanagaratnam P, Segal OR, Hussain W, Peters NS. The effects of carbenoxolone on human myocardial conduction: A tool to investigate the role of gap junctional uncoupling in human arrhythmogenesis. J Am Coll Cardiol. 2006;48:1242-1249.
33. Spach MS, Dolber PC. Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle. Evidence for electrical uncoupling of side-to-side fiber connections with increasing age. Circ Res. 1986;58:356-371.
34. Lesh MD, Spear JF, Simson MB. A computer model of the electrogram: What causes fractionation? J Electrocardiol. 1988;21 suppl:S69-S73.
35. Eloff BC, Lerner DL, Yamada KA, Schuessler RB, Saffitz JE, Rosenbaum DS. High resolution optical mapping reveals conduction slowing in connexin43 deficient mice. Cardiovasc Res. 2001;51:681-690.