A 50% reduction of excitability but not of intercellular coupling affects conduction velocity restitution and activation delay in the mouse heart

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Stein, Mèra ^a   van Veen, Toon A B ^a   Hauer, Richard N W ^a   de Bakker, Jacques M T ^a,b,c   van Rijen, Harold V M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; SODIUM CHANNEL NAV1.5; SODIUM CHANNEL; SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPICARDIUM MAPPING; HEART CONDUCTION; HEART LEFT VENTRICLE; HEART MUSCLE EXCITABILITY; HEART PACING; HEART RIGHT VENTRICLE; MOUSE; NONHUMAN; REFRACTORY PERIOD; RETROSPECTIVE STUDY; WILD TYPE; ANIMAL; CELL MEMBRANE; CYTOLOGY; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION; HEART MUSCLE; HEART MUSCLE CONDUCTION SYSTEM; METABOLISM; PHYSIOLOGY; TIME;

ANIMALIA; MUS;

ANIMALS; CELL MEMBRANE; CONNEXIN 43; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION; HEART CONDUCTION SYSTEM; MICE; MYOCARDIUM; SODIUM CHANNELS; TIME FACTORS;

EID: 79957835117     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020310     Document Type: Article

References (27)

1. Kleber AG, Rudy Y, (2004) Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev 84: 431-488.
2. Spach MS, Heidlage JF, Dolber PC, Barr RC, (2000) Electrophysiological effects of remodeling cardiac gap junctions and cell size. Experimental and model studies of normal cardiac growth. Circulation Research 86: 302-311.
3. Roberts DE, Hersh LT, Scher AM, (1979) Influence of cardiac fiber orientation on wavefront voltage, conduction velocity, and tissue resistivity in the dog. Circ Res 44: 701-712.
4. Stein M, Noorman M, van Veen TA, Herold E, Engelen MA, et al. (2008) Dominant arrhythmia vulnerability of the right ventricle in senescent mice. Heart Rhythm 5: 438-448.
5. van Veen TA, Stein M, Royer A, Le Quang K, Charpentier F, et al. (2005) Impaired Impulse Propagation in Scn5a-Knockout Mice. Combined Contribution of Excitability, Connexin Expression, and Tissue Architecture in Relation to Aging. Circulation 112: 1927-1935.
6. van Rijen HVM, Eckardt D, Degen J, Theis M, Ott T, et al. (2004) Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43. Circulation 109: 1048-1055.
7. Remme CA, Verkerk AO, Nuyens D, van Ginneken AC, van Brunschot S, et al. (2006) Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD. Circulation 114: 2584-2594.
8. Stein M, Boulaksil M, Engelen MA, Van Veen AAB, Hauer RN, et al. (2006) Conduction reserve and arrhythmias. Netherlands Heart Journal 14.
9. van Rijen HV, de Bakker JM, van Veen TA, (2005) Hypoxia, electrical uncoupling, and conduction slowing: Role of conduction reserve. Cardiovasc Res 66: 9-11.
10. van Rijen HV, van Veen TA, Gros D, Wilders R, de Bakker JM, (2006) Connexins and cardiac arrhythmias. Adv Cardiol 42: 150-160.
11. Saumarez RC, Heald S, Gill J, Slade AK, de Belder M, et al. (1995) Primary ventricular fibrillation is associated with increased paced right ventricular electrogram fractionation. Circulation 92: 2565-2571.
12. Frame LH, Simson MB, (1988) Oscillations of conduction, action potential duration, and refractoriness. A mechanism for spontaneous termination of reentrant tachycardias. Circulation 78: 1277-1287.
13. Peters NS, Green CR, Poole-Wilson PA, Severs NJ, (1993) Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts. Circulation 88: 864-875.
14. Borlak J, Thum T, (2003) Hallmarks of ion channel gene expression in end-stage heart failure. Faseb J 17: 1592-1608.
15. Valdivia CR, Chu WW, Pu J, Foell JD, Haworth RA, et al. (2005) Increased late sodium current in myocytes from a canine heart failure model and from failing human heart. J Mol Cell Cardiol 38: 475-483.
16. Kostin S, Rieger M, Dammer S, Hein S, Richter M, et al. (2003) Gap junction remodeling and altered connexin43 expression in the failing human heart. Mol Cell Biochem 242: 135-144.
17. Shaw RM, Rudy Y, (1997) Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res 81: 727-741.
18. Leoni AL, Gavillet B, Rougier JS, Marionneau C, Probst V, et al. (2010) Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model. PloS one 5: e9298.
19. Potse M, Linnenbank A, Grimbergen C, (2002) Software design for analysis of multichannel intracardial and body surface electrocardiograms. Comput Methods Programs Biomed 69: 225.
20. Qu Z, Weiss JN, Garfinkel A, (1999) Cardiac electrical restitution properties and stability of reentrant spiral waves: a simulation study. Am J Physiol 276: H269-283.
21. Pinski SL, (2000) The right ventricular tachycardias. J Electrocardiol 33 (Suppl): 103-114.
22. Spach MS, Miller WT 3rd, Geselowitz DB, Barr RC, Kootsey JM, et al. (1981) The discontinuous nature of propagation in normal canine cardiac muscle. Evidence for recurrent discontinuities of intracellular resistance that affect the membrane currents. Circ Res 48: 39-54.
23. Spach MS, Heidlage JF, Dolber PC, Barr RC, (2001) Changes in anisotropic conduction caused by remodeling cell size and the cellular distribution of gap junctions and Na(+) channels. J Electrocardiol 34 (Suppl): 69-76.
24. Jongsma HJ, Wilders R, (2000) Gap junctions in cardiovascular disease. CircRes 86: 1193-1197.
25. Morley GE, Vaidya D, Samie FH, Lo C, Delmar M, et al. (1999) Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping. J Cardiovasc Electrophysiol 10: 1361-1375.
26. Stein M, van Veen TA, Remme CA, Boulaksil M, Noorman M, et al. (2009) Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction. Cardiovasc Res 83: 52-60.
27. Remme CA, Verkerk AO, Nuyens D, van Ginneken AC, van Brunschot S, et al. (2006) Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD. Circulation 114: 2584-2594.