Reversibility of both sinus node dysfunction and reduced HCN4 mRNA expression level in an atrial tachycardia pacing model of tachycardia-bradycardia syndrome in rabbit hearts

International Journal of Clinical and Experimental Pathology

Volumn 9, Issue 8, 2016, Pages 8526-8531

  Chen, Zhisong ^a   Sun, Bing ^a   Tse, Gary ^b   Jiang, Jinfa ^a   Xu, Wenjun ^a  

^a TONGJI HOSPITAL OF TONGJI UNIVERSITY   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cardiac electrophysiological; Hyperpolarization activated cyclic nucleotide gated cation channel 4; Rapid atrial pacing; Sinus node dysfunction

Indexed keywords

EID: 84994314492     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Ferrer MI. The sick sinus syndrome in atrial disease. JAMA 1968; 206: 645-646.
2. Kaplan BM, Langendorf R, Lev M, Pick A. Tachycardia-bradycardia syndrome (so-called "sick sinus syndrome"). Pathology, mechanisms and treatment. Am J Cardiol 1973; 31: 497-508.
3. Thery C, Gosselin B, Lekieffre J, Warembourg H. Pathology of sinoatrial node. Correlations with electrocardiographic findings in 111 patients. Am Heart J 1977; 93: 735-740.
4. Maltsev VA, Lakatta EG. Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cells. Heart Lung Circ 2007; 16: 335-348.
5. Baruscotti M, Bucchi A, Difrancesco D. Physiology and pharmacology of the cardiac pacemaker ("funny") current. Pharmacol Ther 2005; 107: 59-79.
6. Yeh YH, Burstein B, Qi XY, Sakabe M, Chartier D, Comtois P, Wang Z, Kuo CT, Nattel S. Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome. Circulation 2009; 119: 1576-1585.
7. Lakatta EG, Vinogradova T, Lyashkov A, Sirenko S, Zhu W, Ruknudin A, Maltsev VA. The integration of spontaneous intracellular Ca2+ cycling and surface membrane ion channel activation entrains normal automaticity in cells of the heart's pacemaker. Ann N Y Acad Sci 2006; 1080: 178-206.
8. DiFrancesco D. Pacemaker mechanisms in cardiac tissue. Annu Rev Physiol 1993; 55: 455-472.
9. Tellez JO, Dobrzynski H, Greener ID, Graham GM, Laing E, Honjo H, Hubbard SJ, Boyett MR, Billeter R. Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit. Circ Res 2006; 99: 1384-1393.
10. Schulze-Bahr E, Neu A, Friederich P, Kaupp UB, Breithardt G, Pongs O, Isbrandt D. Pacemaker channel dysfunction in a patient with sinus node disease. J Clin Invest 2003; 111: 1537-1545.
11. Baruscotti M, Bucchi A, Viscomi C, Mandelli G, Consalez G, Gnecchi-Rusconi T, Montano N, Casali KR, Micheloni S, Barbuti A, DiFrancesco D. Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4. Proc Natl Acad Sci U S A 2011; 108: 1705-1710.
12. Lee JM, Kalman JM. Sinus node dysfunction and atrial fibrillation: two sides of the same coin? Europace 2013; 15: 161-162.
13. Hadian D, Zipes DP, Olgin JE, Miller JM. Short-term rapid atrial pacing produces electrical remodeling of sinus node function in humans. J Cardiovasc Electrophysiol 2002; 13: 584-586.
14. Gomes JA, Kang PS, Matheson M, Gough WB Jr, El-Sherif N. Coexistence of sick sinus rhythm and atrial flutter-fibrillation. Circulation 1981; 63: 80-86.
15. Elvan A, Wylie K, Zipes DP. Pacing-induced chronic atrial fibrillation impairs sinus node function in dogs. Electrophysiological remodeling. Circulation 1996; 94: 2953-2960.
16. Li G, Liu E, Liu T, Wang J, Dai J, Xu G, Korantzopoulos P, Yang W. Atrial electrical remodeling in a canine model of sinus node dysfunction. Int J Cardiol 2011; 146: 32-36.
17. Uhm JS, Mun HS, Wi J, Shim J, Joung B, Lee MH, Pak HN. Prolonged atrial effective refrac tory periods in atrial fibrillation patients associated with structural heart disease or sinus node dysfunction compared with lone atrial fibrillation. Pacing Clin Electrophysiol 2013; 36: 163-171.
18. Chang HY, Lin YJ, Lo LW, Chang SL, Hu YF, Li CH, Chao TF, Yin WH, Chen SA. Sinus node dysfunction in atrial fibrillation patients: the evidence of regional atrial substrate remodelling. Europace 2013; 15: 205-211.
19. Sparks PB, Jayaprakash S, Vohra JK, Kalman JM. Electrical remodeling of the atria associated with paroxysmal and chronic atrial flutter. Circulation 2000; 102: 1807-1813.
20. Hocini M, Sanders P, Deisenhofer I, Jais P, Hsu LF, Scavee C, Weerasoriya R, Raybaud F, Macle L, Shah DC, Garrigue S, Le Metayer P, Clementy J, Haissaguerre M. Reverse remodeling of sinus node function after catheter ablation of atrial fibrillation in patients with prolonged sinus pauses. Circulation 2003; 108: 1172-1175.
21. Ohkubo K, Watanabe I, Okumura Y, Ashino S, Kofune M, Hashimoto K, Shindo A, Sugimura H, Nakai T, Kasamaki Y, Saito S. Pulmonary vein isolation for atrial fibrillation in patients with paroxysmal atrial fibrillation and prolonged sinus pause. Int Heart J 2007; 48: 247-252.
22. Sairaku A, Nakano Y, Oda N, Makita Y, Kajihara K, Tokuyama T, Motoda C, Fujiwara M, Kihara Y. Prediction of sinus node dysfunction in patients with long-standing persistent atrial fibrillation using the atrial fibrillatory cycle length. J Electrocardiol 2012; 45: 141-147.
23. Zupan I, Kozelj M, Butinar J, Rakovec P. Impaired sinus node function and global atrial conduction time after high rate atrial pacing in dogs. Cell Mol Biol Lett 2002; 7: 383-384.
24. Boyett MR. 'And the beat goes on.' The cardiac conduction system: the wiring system of the heart. Exp Physiol 2009; 94: 1035-1049.
25. Vinogradova TM, Maltsev VA, Bogdanov KY, Lyashkov AE, Lakatta EG. Rhythmic Ca2+ oscillations drive sinoatrial nodal cell pacemaker function to make the heart tick. Ann N Y Acad Sci 2005; 1047: 138-156.
26. Joung B, Lin SF, Chen Z, Antoun PS, Maruyama M, Han S, Piccirillo G, Stucky M, Zipes DP, Chen PS, Das MK. Mechanisms of sinoatrial node dysfunction in a canine model of pacing-induced atrial fibrillation. Heart Rhythm 2010; 7: 88-95.