Restitution analysis of alternans using dynamic pacing and its comparison with S1S2 restitution in heptanol-treated, hypokalaemic langendorff-perfused mouse hearts

Biomedical Reports

Volumn 4, Issue 6, 2016, Pages 673-680

  Tse, Gary ^a   Wong, Sheung Ting ^b   Tse, Vivian ^c   Yeo, Jie Ming ^b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Dynamic restitution; Heptanol; Hypokalaemia; S1S2 restitution

Indexed keywords

HEPTANOL;

ACTION POTENTIAL DURATION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; ENDOCARDIUM; EPICARDIUM; HEART PACING; HEART PERFUSION; HYPOKALEMIA; ISOLATED HEART; MOUSE; NERVE CONDUCTION VELOCITY; NONHUMAN;

EID: 84974639564     PISSN: 20499434     EISSN: 20499442     Source Type: Journal    
DOI: 10.3892/br.2016.659     Document Type: Article

References (24)

1. Wilson LD and Rosenbaum DS: Mechanisms of arrythmogenic cardiac alternans. Europace 9 (Suppl 6): vi77-vi82, 2007.
2. Tolkacheva EG, Schaeffer DG, Gauthier DJ and Krassowska W: Condition for alternans and stability of the 1:1 response pattern in a ‘memory’ model of paced cardiac dynamics. Phys Rev E Stat Nonlin Soft Matter Phys 67: 031904, 2003.
3. Kalb SS, Dobrovolny HM, Tolkacheva EG, Idriss SF, Krassowska W and Gauthier DJ: The restitution portrait: A new method for investigating rate-dependent restitution. J Cardiovasc Electrophysiol 15: 698-709, 2004.
4. Tse G: Mechanisms of Cardiac Arrhythmias. J Arrhythmia: Dec 16, 2015 (Epub ahead of print).
5. Sabir IN, Li LM, Grace AA and Huang CL: Restitution analysis of alternans and its relationship to arrhythmogenicity in hypoka-laemic Langendorff-perfused murine hearts. Pflugers Arch 455: 653-666, 2008.
6. Tse G, Tse V and Yeo JM: Ventricular anti-arrhythmic effects of heptanol in hypokalaemic, Langendorff-perfused mouse hearts. Biomed Rep 4: 313-324, 2016.
7. Tse G, Tse V, Yeo JM and Sun B. Atrial anti-arrhythmic effects of heptanol in Langendorff-perfused mouse hearts. PLoS One 11: e0148858, 2016.
8. Sun D, Samuelson LC, Yang T, Huang Y, Paliege A, Saunders T, Briggs J and Schnermann J: Mediation of tubuloglomerular feedback by adenosine: Evidence from mice lacking adenosine 1 receptors. Proc Natl Acad Sci USA 98: 9983-9988, 2001.
9. Sabir IN, Fraser JA, Killeen MJ, Grace AA and Huang CL: The contribution of refractoriness to arrhythmic substrate in hypo-kalemic Langendorff-perfused murine hearts. Pflugers Arch 454: 209-222, 2007.
10. Hothi SS, Gurung IS, Heathcote JC, Zhang Y, Booth SW, Skepper JN, Grace AA and Huang CL: Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart. Pflugers Arch 457: 253-270, 2008.
11. Tse G, Hothi SS, Grace AA and Huang CL: Ventricular arrhythmogenesis following slowed conduction in heptanol-treated, Langendorff-perfused mouse hearts. J Physiol Sci 62: 79-92, 2012.
12. Killeen MJ, Thomas G, Gurung IS, Goddard CA, Fraser JA, Mahaut-Smith MP, Colledge WH, Grace AA and Huang CL: Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart. Acta Physiol (Oxf) 189: 33-46, 2007.
13. Watanabe MA, Fenton FH, Evans SJ, Hastings HM and Karma A: Mechanisms for discordant alternans. J Cardiovasc Electrophysiol 12: 196-206, 2001.
14. Banville I and Gray RA: Effect of action potential duration and conduction velocity restitution and their spatial dispersion on alternans and the stability of arrhythmias. J Cardiovasc Electrophysiol 13: 1141-1149, 2002.
15. Wu TJ, Lin SF, Weiss JN, Ting CT and Chen PS: Two types of ventricular fibrillation in isolated rabbit hearts: Importance of excitability and action potential duration restitution. Circulation 106: 1859-1866, 2002.
16. Tse G and Yeo JM: Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions. Int J Cardiol Heart Vasc 9: 75-82, 2015.
17. Osadchii OE, Larsen AP and Olesen SP: Predictive value of electrical restitution in hypokalemia-induced ventricular arrhythmogenicity. Am J Physiol Heart Circ Physiol 298: H210-H220, 2010.
18. Litovsky SH and Antzelevitch C: Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: Role of the transient outward current. J Am Coll Cardiol 14: 1053-1066, 1989.
19. Osadchii OE: Effects of ventricular pacing protocol on electrical restitution assessments in guinea-pig heart. Exp Physiol 97: 807-821, 2012.
20. Koller ML, Riccio ML and Gilmour RFJ Jr.: Dynamic restitution of action potential duration during electrical alternans and ventricular fibrillation. Am J Physiol 275: H1635-H1642, 1998.
21. Yue AM: Letter regarding article by Koller et al, ‘Altered dynamics of action potential restitution and alternans in humans with structural heart disease’. Circulation 113: e462, 2006.
22. Holmberg S and Varnauskas E: Coronary circulation during pacing-induced tachycardia. Acta Med Scand 190: 481-490, 1971.
23. Graber JD, Conti CR, Lappe DL and Ross RS: Effect of pacing-induced tachycardia and myocardial ischemia on ventricular pressure-velocity relationships in man. Circulation 46: 74-83, 1972.
24. Tse G, Wong ST, Tse V, Lee YT, Lin HY and Yeo JM: Cardiac dynamics: Alternans and arrhythmogenesis. Arrhythmia (In press).