Gap junction modifier rotigaptide decreases the susceptibility to ventricular arrhythmia by enhancing conduction velocity and suppressing discordant alternans during therapeutic hypothermia in isolated rabbit hearts

Heart Rhythm

Volumn 13, Issue 1, 2016, Pages 251-261

  Hsieh, Yu Cheng ^a,b   Lin, Jiunn Cherng ^a   Hung, Chen Ying ^a   Li, Cheng Hung ^a   Lin, Shien Fong ^c,d   Yeh, Hung I ^e   Huang, Jin Long ^a   Lo, Chu Pin ^b   Haugan, Ketil ^f   Larsen, Bjarne D ^g   Wu, Tsu Juey ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b PROVIDENCE UNIVERSITY   (Taiwan)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^e MACKAY MEMORIAL HOSPITAL   (Taiwan)

^f ROSKILDE HOSPITAL   (Denmark)

^g Zealand Pharma AS   (Denmark)

Author keywords

Cardiac alternans; Conduction velocity; Gap junction; Hypothermia; Optical mapping

Indexed keywords

CONNEXIN 43; ROTIGAPTIDE; ANTIARRHYTHMIC AGENT; GJA1 PROTEIN, HUMAN; OLIGOPEPTIDE;

ACTION POTENTIAL DURATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GAP JUNCTION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE CONDUCTION; IMMUNOBLOTTING; INDUCED HYPOTHERMIA; ISOLATED HEART; NONHUMAN; P WAVE; PACING INDUCED VENTRICULAR FIBRILLATION; PR INTERVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QRS INTERVAL; RABBIT; RR INTERVAL; ADVERSE EFFECTS; ANIMAL; BIOLOGICAL MODEL; DRUG EFFECTS; HEART MUSCLE CONDUCTION SYSTEM; HEART VENTRICLE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME; VENTRICULAR FIBRILLATION; VOLTAGE SENSITIVE DYE IMAGING;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CONNEXIN 43; GAP JUNCTIONS; HEART CONDUCTION SYSTEM; HEART VENTRICLES; HYPOTHERMIA, INDUCED; MODELS, CARDIOVASCULAR; OLIGOPEPTIDES; RABBITS; TREATMENT OUTCOME; VENTRICULAR FIBRILLATION; VOLTAGE-SENSITIVE DYE IMAGING;

EID: 84955701215     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2015.07.023     Document Type: Article

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